Development of a high-throughput screening-compatible assay for the discovery of inhibitors of the AF4-AF9 interaction using AlphaScreen technology

scientific article

Development of a high-throughput screening-compatible assay for the discovery of inhibitors of the AF4-AF9 interaction using AlphaScreen technology is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1089/ADT.2012.495
P932PMC publication ID3656630
P698PubMed publication ID23679849

P2093author name stringYu Peng
Andrew D Napper
Katherine M Drake
Venita Gresham Watson
P2860cites workThe mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodelingQ40202913
The synthetic peptide PFWT disrupts AF4-AF9 protein complexes and induces apoptosis in t(4;11) leukemia cellsQ40532537
New insights to the MLL recombinome of acute leukemiasQ44945193
The MLL recombinome of acute leukemiasQ56965972
An atlas of chromosomes in hematological malignancies. Example: 11q23 and MLL partnersQ74060943
Rational design of the first small-molecule antagonists of NHERF1/EBP50 PDZ domainsQ80459449
The minimum significant ratio: a statistical parameter to characterize the reproducibility of potency estimates from concentration-response assays and estimation by replicate-experiment studiesQ82615309
Leukemia fusion target AF9 is an intrinsically disordered transcriptional regulator that recruits multiple partners via coupled folding and binding.Q27675570
A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening AssaysQ28145712
The use of differential scanning fluorimetry to detect ligand interactions that promote protein stabilityQ29547634
New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassaysQ29615588
BioAssay ontology annotations facilitate cross-analysis of diverse high-throughput screening data setsQ33864494
MLL fusion partners AF4 and AF9 interact at subnuclear fociQ34275143
MLL-AF9 and MLL-ENL alter the dynamic association of transcriptional regulators with genes critical for leukemiaQ34571591
MLL-rearranged leukemias: insights from gene expression profilingQ35569555
In search of targeted therapies for childhood cancerQ35971733
Peptide, peptidomimetic and small-molecule drug discovery targeting HIV-1 host-cell attachment and entry through gp120, gp41, CCR5 and CXCR4.Q36402572
The AF4-mimetic peptide, PFWT, induces necrotic cell death in MV4-11 leukemia cellsQ36502377
Xenograft models for the preclinical evaluation of new therapies in acute leukemiaQ36799846
HOXA9 is required for survival in human MLL-rearranged acute leukemiasQ37129652
Molecular targeting of MLL-rearranged leukemia cell lines with the synthetic peptide PFWT synergistically enhances the cytotoxic effect of established chemotherapeutic agentsQ37260555
The molecular biology of mixed lineage leukemiaQ37522825
MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemiaQ38294261
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)253-268
P577publication date2013-05-01
P1433published inAssay and Drug Development TechnologiesQ15767279
P1476titleDevelopment of a high-throughput screening-compatible assay for the discovery of inhibitors of the AF4-AF9 interaction using AlphaScreen technology
P478volume11

Reverse relations

cites work (P2860)
Q35571730Binding cavities and druggability of intrinsically disordered proteins
Q38728681Current Experimental Methods for Characterizing Protein-Protein Interactions
Q64087496Modulation of Disordered Proteins with a Focus on Neurodegenerative Diseases and Other Pathologies
Q91789005Peptidomimetics for Targeting Protein-Protein Interactions between DOT1L and MLL Oncofusion Proteins AF9 and ENL
Q35824701Protein-protein interactions as drug targets
Q36989223Targeted drug discovery for pediatric leukemia

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