Aberrant DNA hypermethylation patterns lead to transcriptional silencing of tumor suppressor genes in UVB-exposed skin and UVB-induced skin tumors of mice

scientific article

Aberrant DNA hypermethylation patterns lead to transcriptional silencing of tumor suppressor genes in UVB-exposed skin and UVB-induced skin tumors of mice is …
instance of (P31):
scholarly articleQ13442814
retracted paperQ45182324

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P356DOI10.1093/CARCIN/BGQ282
P932PMC publication ID3066413
P698PubMed publication ID21186298
P5875ResearchGate publication ID49709867

P50authorTrygve O. TollefsbolQ59697628
P2093author name stringSantosh K Katiyar
Mudit Vaid
Vijayalakshmi Nandakumar
P2860cites workCloning, expression and chromosome locations of the human DNMT3 gene familyQ22010469
DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian developmentQ22010765
Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcriptionQ24534441
Tumor susceptibility of Rassf1a knockout miceQ45234570
Sunlight induces pyrimidine dimers preferentially at 5-methylcytosine basesQ46848797
Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumorsQ48263741
Orally administered green tea polyphenols prevent ultraviolet radiation-induced skin cancer in mice through activation of cytotoxic T cells and inhibition of angiogenesis in tumorsQ50746638
Dietary grape seed proanthocyanidins inhibit UVB-induced oxidative stress and activation of mitogen-activated protein kinases and nuclear factor-kappaB signaling in in vivo SKH-1 hairless mice.Q53565713
The fundamental role of epigenetic events in cancerQ56421597
DNA methylation inhibits transcription indirectly via a methyl-CpG binding proteinQ64441635
Photocarcinogenesis: mechanisms, models and human health implicationsQ71814735
DNA methylation and cancerQ74559063
Involvement of p53 and p16 tumor suppressor genes in recessive dystrophic epidermolysis bullosa-associated squamous cell carcinomaQ80576662
What is the role of radiotherapy in bladder-preserving cancer therapy?Q81430718
Chronic oral exposure to inorganic arsenate interferes with methylation status of p16INK4a and RASSF1A and induces lung cancer in A/J miceQ82858067
Active repression of methylated genes by the chromosomal protein MBD1Q24554311
Worms gang up on bacteriaQ27860588
CpG-rich islands and the function of DNA methylationQ28131800
A component of the transcriptional repressor MeCP1 shares a motif with DNA methyltransferase and HRX proteinsQ28242685
Toxic effects of ultraviolet radiation on the skinQ28250343
RASSF6 is a novel member of the RASSF family of tumor suppressorsQ28509722
DNA methylation and human diseaseQ29615417
Gene silencing in cancer in association with promoter hypermethylationQ29617274
Cancer epigenetics comes of ageQ29617275
Methylation-induced repression--belts, braces, and chromatinQ29617487
Aging and chronic sun exposure cause distinct epigenetic changes in human skinQ33594466
Predictive utility of circulating methylated DNA in serum of melanoma patients receiving biochemotherapy.Q33796956
DNA hypermethylation in tumorigenesis: epigenetics joins geneticsQ33870798
Precipitous release of methyl-CpG binding protein 2 and histone deacetylase 1 from the methylated human multidrug resistance gene (MDR1) on activationQ34324051
Obligate roles for p16(Ink4a) and p19(Arf)-p53 in the suppression of murine pancreatic neoplasiaQ34440754
Methyl CpG-binding proteins and transcriptional repressionQ34464674
Altered DNA methylation: a secondary mechanism involved in carcinogenesisQ34504084
DNA methylation in cancer: too much, but also too littleQ34770545
Exceptionally high protection of photocarcinogenesis by topical application of (--)-epigallocatechin-3-gallate in hydrophilic cream in SKH-1 hairless mouse model: relationship to inhibition of UVB-induced global DNA hypomethylationQ34773167
Selective association of the methyl-CpG binding protein MBD2 with the silent p14/p16 locus in human neoplasiaQ35860006
Frequent clones of p53-mutated keratinocytes in normal human skinQ35940911
Interleukin-12 deficiency is permissive for angiogenesis in UV radiation-induced skin tumorsQ36003078
Cellular and molecular events leading to the development of skin cancerQ36062317
DNA methylation and gene silencing in cancerQ36338042
The reactive oxygen-driven tumor: relevance to melanomaQ37126796
Inhibition of UVB-induced skin tumor development by drinking green tea polyphenols is mediated through DNA repair and subsequent inhibition of inflammationQ37160304
Profiling epigenetic inactivation of tumor suppressor genes in tumors and plasma from cutaneous melanoma patientsQ40082103
Alterations in DNA methylation may play a variety of roles in carcinogenesisQ40410595
CpG islands.Q40868362
The role of DNA methylation in expression of the p19/p16 locus in human bladder cancer cell lines.Q41056466
The role of DNA methylation in cancer genetic and epigeneticsQ41291310
Genetic and epigenetic aspects of DNA methylation on genome expression, evolution, mutation and carcinogenesisQ41480764
Sun exposure related methylation in malignant and non-malignant skin lesionsQ42491211
Dnmt3a and Dnmt3b are transcriptional repressors that exhibit unique localization properties to heterochromatinQ42827600
Accelerated age-related CpG island methylation in ulcerative colitisQ43828587
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectgene silencingQ1431332
hypermethylationQ106875739
P304page(s)597-604
P577publication date2010-12-24
P1433published inCarcinogenesisQ326022
P1476titleAberrant DNA hypermethylation patterns lead to transcriptional silencing of tumor suppressor genes in UVB-exposed skin and UVB-induced skin tumors of mice
P478volume32

Reverse relations

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