Dose-dependent activity of pyrazinamide in animal models of intracellular and extracellular tuberculosis infections.

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Dose-dependent activity of pyrazinamide in animal models of intracellular and extracellular tuberculosis infections. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/AAC.01524-10
P932PMC publication ID3067197
P698PubMed publication ID21282447
P5875ResearchGate publication ID49799500

P50authorMostafa FraigQ47503102
Eric NuermbergerQ88595440
Petros C KarakousisQ90241891
Gregory P BissonQ91276180
Jacques GrossetQ111670048
P2093author name stringZahoor Ahmad
P2860cites workA membrane protein preserves intrabacterial pH in intraphagosomal Mycobacterium tuberculosisQ24650149
Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillusQ28062241
Pyrazinamide inhibits the eukaryotic-like fatty acid synthetase I (FASI) of Mycobacterium tuberculosisQ28145400
The curious characteristics of pyrazinamide: a reviewQ28191713
A mutation in the interferon-gamma-receptor gene and susceptibility to mycobacterial infectionQ28299361
Pyrazinamide and pyrazinoic acid activity against tubercle bacilli in cultured human macrophages and in the BACTEC systemQ28329415
Evidence that vesicles containing living, virulent Mycobacterium tuberculosis or Mycobacterium avium in cultured human macrophages are not acidicQ28333302
An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infectionQ29616521
Lack of acidification in Mycobacterium phagosomes produced by exclusion of the vesicular proton-ATPaseQ29617355
Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primatesQ29618010
Comparison of the 'Denver regimen' against acute tuberculosis in the mouse and guinea pig.Q33723589
Evaluation of standard chemotherapy in the guinea pig model of tuberculosisQ33826439
Fast standardized therapeutic-efficacy assay for drug discovery against tuberculosisQ33826465
Intrapulmonary concentrations of pyrazinamideQ33976873
Role of acid pH and deficient efflux of pyrazinoic acid in unique susceptibility of Mycobacterium tuberculosis to pyrazinamideQ33991596
Biphasic kill curve of isoniazid reveals the presence of drug-tolerant, not drug-resistant, Mycobacterium tuberculosis in the guinea pig.Q34018978
Activities of TMC207, rifampin, and pyrazinamide against Mycobacterium tuberculosis infection in guinea pigsQ34483596
Conditions that may affect the results of susceptibility testing of Mycobacterium tuberculosis to pyrazinamideQ34520476
The antituberculous activity of pyrazinamide in vitro and in the guinea pig.Q34537584
Mode of action of pyrazinamide: disruption of Mycobacterium tuberculosis membrane transport and energetics by pyrazinoic acidQ34542604
Pyrazinamide susceptibility and amidase activity of tubercle bacilliQ34697358
Population pharmacokinetic modeling of isoniazid, rifampin, and pyrazinamideQ35139398
Antagonism between isoniazid and the combination pyrazinamide-rifampin against tuberculosis infection in miceQ35867048
Location of persisting mycobacteria in a Guinea pig model of tuberculosis revealed by r207910.Q36094916
Metronidazole lacks antibacterial activity in guinea pigs infected with Mycobacterium tuberculosisQ36949411
Metronidazole lacks activity against Mycobacterium tuberculosis in an in vivo hypoxic granuloma model of latencyQ37109777
Pharmacokinetics-pharmacodynamics of pyrazinamide in a novel in vitro model of tuberculosis for sterilizing effect: a paradigm for faster assessment of new antituberculosis drugsQ37274688
Paradoxical effect of isoniazid on the activity of rifampin-pyrazinamide combination in a mouse model of tuberculosisQ37392767
Acid resistance in Mycobacterium tuberculosisQ37494077
The role of pyrazinamide in tuberculosis chemotherapyQ39525867
Present aspects of bacterial resistance in tuberculosisQ40028686
Local production of tumor necrosis factor and IFN-gamma in tuberculous pleuritisQ40761026
Clinical and toxicodynamic evidence that high-dose pyrazinamide is not more hepatotoxic than the low doses currently usedQ42111332
The early bactericidal activity of drugs in patients with pulmonary tuberculosisQ42257164
Analysis of nitric oxide synthase and nitrotyrosine expression in human pulmonary tuberculosisQ44064936
Pyrazinamide is not active against Mycobacterium tuberculosis residing in cultured human monocyte-derived macrophages.Q44501313
Anaerobic incubation conditions enhance pyrazinamide activity against Mycobacterium tuberculosisQ44991741
Local production of nitric oxide in patients with tuberculosis.Q45084084
Pyrazinamide (aldinamide) in experimental tuberculosis of the guinea pig.Q46526487
Relapses after stopping chemotherapy for experimental tuberculosis in genetically resistant and susceptible strains of mice.Q54353113
The action of antituberculosis drugs in short-course chemotherapy.Q54445022
Controlled trial of 2, 4, and 6 months of pyrazinamide in 6-month, three-times-weekly regimens for smear-positive pulmonary tuberculosis, including an assessment of a combined preparation of isoniazid, rifampin, and pyrazinamide. Results at 30 monthQ67985481
Controlled clinical trial of 4 short-course regimens of chemotherapy (three 6-month and one 8-month) for pulmonary tuberculosis: final report. East and Central African/British Medical Research Council Fifth Collaborative StudyQ68881337
Experimental short-course preventive therapy of tuberculosis with rifampin and pyrazinamideQ69802479
Long-term follow-up of a clinical trial of six-month and four-month regimens of chemotherapy in the treatment of pulmonary tuberculosis. Singapore Tuberculosis Service/British Medical Research CouncilQ69881424
The treated pulmonary lesion and its tubercle bacillus. II. The death and resurrectionQ74062848
Pyrazinamide (aldinamide) in the treatment of pulmonary tuberculosisQ76088832
Mechanisms of pyrazinamide resistance in mycobacteria: importance of lack of uptake in addition to lack of pyrazinamidase activityQ78015492
Studies on the gaseous content of tuberculous cavitiesQ78723252
Suitability of rifampicin for intermittent administration in the treatment of tuberculosisQ93815424
P433issue4
P407language of work or nameEnglishQ1860
P921main subjecttuberculosisQ12204
pyrazinamideQ417571
P304page(s)1527-1532
P577publication date2011-01-31
P1433published inAntimicrobial Agents and ChemotherapyQ578004
P1476titleDose-dependent activity of pyrazinamide in animal models of intracellular and extracellular tuberculosis infections
P478volume55

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cites work (P2860)
Q36869913A Long-term Co-perfused Disseminated Tuberculosis-3D Liver Hollow Fiber Model for Both Drug Efficacy and Hepatotoxicity in Babies
Q27004482A medicinal chemists' guide to the unique difficulties of lead optimization for tuberculosis
Q41996871A programme to create short-course chemotherapy for pulmonary Mycobacterium avium disease based on pharmacokinetics/pharmacodynamics and mathematical forecasting
Q46650295A rifapentine-containing inhaled triple antibiotic formulation for rapid treatment of tubercular infection
Q35411381Antitubercular effect of 8-[(4-Chloro phenyl) sulfonyl]-7-Hydroxy-4-Methyl-2H-chromen-2-One in guinea pigs
Q36921509Bedaquiline and Pyrazinamide Treatment Responses Are Affected by Pulmonary Lesion Heterogeneity in Mycobacterium tuberculosis Infected C3HeB/FeJ Mice
Q48713291Coadministration of Allopurinol To Increase Antimycobacterial Efficacy of Pyrazinamide as Evaluated in a Whole-Blood Bactericidal Activity Model
Q38039763Comprehensive analysis of methods used for the evaluation of compounds against Mycobacterium tuberculosis
Q37339276Concentration-Dependent Synergy and Antagonism of Linezolid and Moxifloxacin in the Treatment of Childhood Tuberculosis: The Dynamic Duo.
Q34058944Deficiency of double-strand DNA break repair does not impair Mycobacterium tuberculosis virulence in multiple animal models of infection.
Q37619123Drug regimens identified and optimized by output-driven platform markedly reduce tuberculosis treatment time
Q35037392Effectiveness of tuberculosis chemotherapy correlates with resistance to Mycobacterium tuberculosis infection in animal models
Q57095375Efficacy of pyrazinoic acid dry powder aerosols in resolving necrotic and non-necrotic granulomas in a guinea pig model of tuberculosis
Q36018624Evaluation of a mouse model of necrotic granuloma formation using C3HeB/FeJ mice for testing of drugs against Mycobacterium tuberculosis
Q34981779Host targeted activity of pyrazinamide in Mycobacterium tuberculosis infection
Q35743972Host-Mediated Bioactivation of Pyrazinamide: Implications for Efficacy, Resistance, and Therapeutic Alternatives
Q58799356Impact of immunopathology on the antituberculous activity of pyrazinamide
Q40634015Inhaled Pyrazinoic Acid Esters for the Treatment of Tuberculosis.
Q34729493Isoniazid, rifampin, and pyrazinamide plasma concentrations in relation to treatment response in Indonesian pulmonary tuberculosis patients
Q34097641Local ischemia and increased expression of vascular endothelial growth factor following ocular dissemination of Mycobacterium tuberculosis
Q37138650Mycobacterial Protein Tyrosine Phosphatases A and B Inhibitors Augment the Bactericidal Activity of the Standard Anti-tuberculosis Regimen
Q36461593Old drugs, new purpose: retooling existing drugs for optimized treatment of resistant tuberculosis
Q38502298Pharmacokinetic-pharmacodynamic and dose-response relationships of antituberculosis drugs: recommendations and standards for industry and academia
Q45199376Population Pharmacokinetics of Pyrazinamide in Patients with Tuberculosis
Q37036499Potent rifamycin-sparing regimen cures guinea pig tuberculosis as rapidly as the standard regimen
Q28537952Preparation, characterization, and in vitro cytotoxicity evaluation of a novel anti-tuberculosis reconstruction implant
Q58729009Primary Lung Dendritic Cell Cultures to Assess Efficacy of Spectinamide-1599 Against Intracellular
Q38726482Pyrazinoic acid decreases the proton motive force, respiratory ATP synthesis activity, and cellular ATP levels
Q33798280Reduced emergence of isoniazid resistance with concurrent use of thioridazine against acute murine tuberculosis.
Q36086369Rifapentine is not more active than rifampin against chronic tuberculosis in guinea pigs
Q35164284Role of B cells and antibodies in acquired immunity against Mycobacterium tuberculosis
Q36571981Selective Inactivity of Pyrazinamide against Tuberculosis in C3HeB/FeJ Mice Is Best Explained by Neutral pH of Caseum
Q90051715The Bewildering Antitubercular Action of Pyrazinamide
Q21134950The role of the novel exopolyphosphatase MT0516 in Mycobacterium tuberculosis drug tolerance and persistence
Q38213320Therapeutic drug monitoring in the treatment of tuberculosis: an update
Q36844672Thioridazine lacks bactericidal activity in an animal model of extracellular tuberculosis.
Q42281128Treating tuberculosis with high doses of anti-TB drugs: mechanisms and outcomes.

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