The glutamatergic dysfunction hypothesis for schizophrenia

scientific article

The glutamatergic dysfunction hypothesis for schizophrenia is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.3109/10673229609017192
P698PubMed publication ID9384954

P2093author name stringCoyle JT
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectschizophreniaQ41112
P304page(s)241-253
P577publication date1996-01-01
P1433published inHarvard Review of PsychiatryQ5676543
P1476titleThe glutamatergic dysfunction hypothesis for schizophrenia
P478volume3

Reverse relations

cites work (P2860)
Q90141173A Natural Product with High Affinity to Sigma and 5-HT7 Receptors as Novel Therapeutic Drug for Negative and Cognitive Symptoms of Schizophrenia
Q24657918A decrease of reelin expression as a putative vulnerability factor in schizophrenia
Q47161237A magnetic resonance spectroscopy study of the anterior cingulate cortex in youth with emotional dysregulation.
Q48887866A novel mutation in the aristaless domain of the ARX gene leads to Ohtahara syndrome, global developmental delay, and ambiguous genitalia in males and neuropsychiatric disorders in females.
Q28263502A randomized, double-blind, placebo-controlled comparison study of sarcosine (N-methylglycine) and D-serine add-on treatment for schizophrenia
Q24657354A review of MRI findings in schizophrenia
Q38122300A systematic review of the effects of NMDA receptor antagonists on oscillatory activity recorded in vivo
Q34312283AMPA receptor subunit expression in the endoplasmic reticulum in frontal cortex of elderly patients with schizophrenia
Q38568415Abnormal Gamma Oscillations in N-Methyl-D-Aspartate Receptor Hypofunction Models of Schizophrenia
Q37129963Abnormal expression of glutamate transporter and transporter interacting molecules in prefrontal cortex in elderly patients with schizophrenia
Q48273349Abnormal glutamate receptor expression in the medial temporal lobe in schizophrenia and mood disorders.
Q44822535Abnormalities of the NMDA Receptor and Associated Intracellular Molecules in the Thalamus in Schizophrenia and Bipolar Disorder
Q48728126Activation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex.
Q44068198Adaptation to chronic PCP results in hyperfunctional NMDA and hypofunctional GABA(A) synaptic receptors
Q36247426Adding Sarcosine to Antipsychotic Treatment in Patients with Stable Schizophrenia Changes the Concentrations of Neuronal and Glial Metabolites in the Left Dorsolateral Prefrontal Cortex
Q44645833Adenosine A1 Receptor Agonists Block the Neuropathological Changes in Rat Retrosplenial Cortex after Administration of the NMDA Receptor Antagonist Dizocilpine
Q37103350Afferent drive of medial prefrontal cortex by hippocampus and amygdala is altered in MAM-treated rats: evidence for interneuron dysfunction
Q35034774Aggrecan and chondroitin-6-sulfate abnormalities in schizophrenia and bipolar disorder: a postmortem study on the amygdala
Q30476609Allosteric changes of the NMDA receptor trap diffusible dopamine 1 receptors in spines
Q41995548Alteration in the plasma concentration of a DAAO inhibitor, 3-methylpyrazole-5-carboxylic acid, in the ketamine-treated rats and the influence on the pharmacokinetics of plasma D-tryptophan
Q38661176Alterations in glutamatergic signaling in the brain of dopamine supersensitivity psychosis and non-supersensitivity psychosis model rats.
Q44148970Alterations in regional brain metabolism in genetic and pharmacological models of reduced NMDA receptor function
Q34738418Altered center-surround motion inhibition in schizophrenia
Q30409979Altered serine/threonine kinase activity in schizophrenia
Q28590145Amphetamine-induced Fos is reduced in limbic cortical regions but not in the caudate or accumbens in a genetic model of NMDA receptor hypofunction
Q31912055Amygdalar activation alters the hippocampal GABA system: "partial" modelling for postmortem changes in schizophrenia
Q77343245An integrated view of pathophysiological models of schizophrenia
Q42462887Analysis of a gene encoding two glycine transporter variants reveals alternative promoter usage and a novel gene structure
Q49870570Analyzing the genes related to nicotine addiction or schizophrenia via a pathway and network based approach.
Q24674909Animal models of schizophrenia: a critical review
Q34383654Antipsychotic drugs and neuroplasticity: insights into the treatment and neurobiology of schizophrenia
Q30386608Antipsychotic drugs: comparison in animal models of efficacy, neurotransmitter regulation, and neuroprotection
Q30479307Assessment of NMDA receptor NR1 subunit hypofunction in mice as a model for schizophrenia
Q38318294Association analysis of the GRM8 gene with schizophrenia in the Uygur Chinese population
Q34126455Association between the ionotropic glutamate receptor kainate 3 (GRIK3) ser310ala polymorphism and schizophrenia
Q35600223Availability of N-Methyl-d-Aspartate Receptor Coagonists Affects Cocaine-Induced Conditioned Place Preference and Locomotor Sensitization: Implications for Comorbid Schizophrenia and Substance Abuse
Q44386344Behavioral analysis of the consequences of chronic blockade of NMDA-type glutamate receptors in the early postnatal period in rats
Q48225264Behavioral effects of orally administered glycine in socially housed monkeys chronically treated with phencyclidine
Q41729841Bilateral blockade of NMDA receptors in anterior thalamus by dizocilpine (MK-801) injures pyramidal neurons in rat retrosplenial cortex
Q28505790Blunted brain metabolic response to ketamine in mice lacking D(1A) dopamine receptors
Q34470675Brain rhythms connect impaired inhibition to altered cognition in schizophrenia
Q34378802Can long-term outcomes be improved by shortening the duration of untreated illness in psychiatric disorders? A conceptual framework
Q33819365Cannabinoids and Vanilloids in Schizophrenia: Neurophysiological Evidence and Directions for Basic Research.
Q38035216Capturing the angel in "angel dust": twenty years of translational neuroscience studies of NMDA receptor antagonists in animals and humans
Q44551774Chronic neonatal N-methyl-D-aspartate receptor blockade induces learning deficits and transient hypoactivity in young rats
Q33866125Classics in Chemical Neuroscience: Aripiprazole.
Q74097691Clozapine treatment increases serum glutamate and aspartate compared to conventional neuroleptics
Q58164139Cognitive coordination and its neurobiological bases: A new continent to explore
Q33179619Cognitive dysfunction in schizophrenia: unifying basic research and clinical aspects
Q33744368Comparative pharmacology of bipolar disorder and schizophrenia
Q51436028Comparison of brain metabolic activity patterns induced by ketamine, MK-801 and amphetamine in rats: support for NMDA receptor involvement in responses to subanesthetic dose of ketamine.
Q48290612Competitive NMDA receptor antagonists disrupt prepulse inhibition without reduction of startle amplitude in a dopamine receptor-independent manner in mice
Q36834289Conventional and atypical antipsychotics in the elderly : a review.
Q22241679Converging Evidence of NMDA Receptor Hypofunction in the Pathophysiology of Schizophrenia
Q37173934Cortical expression of glial fibrillary acidic protein and glutamine synthetase is decreased in schizophrenia
Q73265133Cortically driven Fos induction in the striatum is amplified by local dopamine D2-class receptor blockade
Q33811831Corticosteroid and neurosteroid dysregulation in an animal model of autism, BTBR mice
Q33845745D-Cycloserine added to risperidone in patients with primary negative symptoms of schizophrenia
Q34068005D-serine added to antipsychotics for the treatment of schizophrenia
Q36785486D-serine as a gliotransmitter and its roles in brain development and disease
Q48215054D2 dopamine receptor but not AMPA and kainate glutamate receptor genes show altered expression in response to long term treatment with trans- and cis-flupenthixol in the rat brain
Q53396523DAOA variants and schizophrenia: influence on diagnosis and treatment outcomes.
Q50023644Defects in Bioenergetic Coupling in Schizophrenia.
Q33813139Development, disease and degeneration in schizophrenia: a unitary pathophysiological model
Q36948546Differential activation patterns of occipital and prefrontal cortices during motion processing: evidence from normal and schizophrenic brains
Q46130769Differential effects of MK-801 on cerebrocortical neuronal injury in C57BL/6J, NSA, and ICR mice
Q44189362Differential regulation of hippocampal BDNF mRNA by typical and atypical antipsychotic administration
Q30592331Diffusion tensor imaging findings of white matter changes in first episode schizophrenia: a systematic review
Q30386868Discordant behavioral effects of psychotomimetic drugs in mice with altered NMDA receptor function
Q95282238Disordered directional brain network interactions during learning dynamics in schizophrenia revealed by multivariate autoregressive models
Q38751249Diverse roles for ionotropic glutamate receptors on inhibitory interneurons in developing and adult brain
Q73593161Dizocilpine-induced neuropathological changes in rat retrosplenial cortex are reversed by subsequent clozapine treatment
Q33541919Do hallucinogens cause residual neuropsychological toxicity?
Q45248983Dopamine is not required for the hyperlocomotor response to NMDA receptor antagonists
Q24631189Downregulated kynurenine 3-monooxygenase gene expression and enzyme activity in schizophrenia and genetic association with schizophrenia endophenotypes
Q45972449Duration of untreated illness (DUI) and schizophrenia sub-types: a collaborative study between the universities of Milan and Moscow.
Q64095132Early Identification and Intervention of Schizophrenia: Insight From Hypotheses of Glutamate Dysfunction and Oxidative Stress
Q43807384Effect of clozapine, haloperidol, or M100907 on phencyclidine-activated glutamate efflux in the prefrontal cortex
Q73901658Effects of antipsychotic drugs on neurotoxicity, expression of fos-like protein and c-fos mRNA in the retrosplenial cortex after administration of dizocilpine
Q48362755Effects of antipsychotics, vitamin E, and MK-801 on dopamine dynamics in the rat brain following discontinuation of cocaine
Q44221553Effects of cocaine and reserpine administration on RNA editing of rat 5-HT2C receptor estimated by primer extension combined with denaturing high-performance liquid chromatography.
Q35089938Effects of estrogen on brain development and neuroprotection--implications for negative symptoms in schizophrenia
Q37662441Effects of glutamate positive modulators on cognitive deficits in schizophrenia: a systematic review and meta-analysis of double-blind randomized controlled trials
Q51009647Effects of low-dose D-serine on recognition and working memory in mice.
Q37438631Effects of novel, high affinity glycine transport inhibitors on frontostriatal dopamine release in a rodent model of schizophrenia
Q48345910Effects of sodium benzoate on pre-pulse inhibition deficits and hyperlocomotion in mice after administration of phencyclidine.
Q30458051Effects of the antioxidant sulforaphane on hyperlocomotion and prepulse inhibition deficits in mice after phencyclidine administration.
Q90728999Electoretinographic evidence of retinal ganglion cell-dependent function in schizophrenia
Q30362188Electrophysiological Endophenotypes for Schizophrenia
Q78228755Electrophysiological effects of E-5842, a sigma1 receptor ligand and potential atypical antipsychotic, on A9 and A10 dopamine neurons
Q35115613Endosomal trafficking of AMPA receptors in frontal cortex of elderly patients with schizophrenia
Q37438984Expression profiles of schizophrenia susceptibility genes during human prefrontal cortical development
Q35603175Extracellular matrix abnormalities in schizophrenia
Q34398564Extracellular matrix-glial abnormalities in the amygdala and entorhinal cortex of subjects diagnosed with schizophrenia
Q73794746Fluoxetine prevents PCP- and MK801-induced HSP70 expression in injured limbic cortical neurons of rats
Q44793030Functional Interaction Between NMDA and mGlu5 Receptors: Effects on Working Memory, Instrumental Learning, Motor Behaviors, and Dopamine Release
Q46170742Functional reactivity of the dopaminergic system following acute and chronic ketamine treatments
Q24597790GABAergic interneuron origin of schizophrenia pathophysiology.
Q34661613Gamma and delta neural oscillations and association with clinical symptoms under subanesthetic ketamine
Q36990973Gamma band oscillations: a key to understanding schizophrenia symptoms and neural circuit abnormalities
Q48496355Gene expression studies of mRNAs encoding the NMDA receptor subunits NMDAR1, NMDAR2A, NMDAR2B, NMDAR2C, and NMDAR2D following long-term treatment with cis-and trans-flupenthixol as a model for understanding the mode of action of schizophrenia drug t
Q34338239Genetic animal models: focus on schizophrenia
Q36925317Genetic associations with schizophrenia: meta-analyses of 12 candidate genes.
Q30478274Gestational methylazoxymethanol acetate administration: a developmental disruption model of schizophrenia
Q34415862Global white matter abnormalities in schizophrenia: a multisite diffusion tensor imaging study
Q55312811Glutamate Concentration in the Superior Temporal Sulcus Relates to Neuroticism in Schizophrenia.
Q36756365Glutamate and schizophrenia: phencyclidine, N-methyl-D-aspartate receptors, and dopamine-glutamate interactions
Q35847653Glutamate as a therapeutic target in psychiatric disorders
Q41673368Glutamate in schizophrenia: clinical and research implications
Q34330678Glutamate modulators as potential therapeutic drugs in schizophrenia and affective disorders.
Q38151703Glutamate receptor abnormalities in schizophrenia: implications for innovative treatments
Q34590422Glutamate receptor genes: susceptibility factors in schizophrenia and depressive disorders?
Q33891806Glutamatergic gene expression is specifically reduced in thalamocortical projecting relay neurons in schizophrenia
Q24555193Glutamatergic modulation of hyperactivity in mice lacking the dopamine transporter
Q30477522Glycine transport inhibitors for the treatment of schizophrenia
Q41181860Glycine-Binding Site Stimulants of NMDA Receptors Alleviate Extrapyramidal Motor Disorders by Activating the Nigrostriatal Dopaminergic Pathway
Q28275290Has an angel shown the way? Etiological and therapeutic implications of the PCP/NMDA model of schizophrenia
Q48411622Heterozygous neuregulin 1 mice are more sensitive to the behavioural effects of Delta9-tetrahydrocannabinol.
Q47734973Hippocampal GABAergic Inhibitory Interneurons
Q73815830Hippocampal pathology in schizophrenia: magnetic resonance imaging and spectroscopy studies
Q36053292Hippocampal temporal-parietal junction interaction in the production of psychotic symptoms: a framework for understanding the schizophrenic syndrome
Q30699614Human metabotropic glutamate receptor 2 gene (GRM2): chromosomal sublocalization (3p21.1-p21.2) and genomic organization
Q30489750Hyperdopaminergia and NMDA receptor hypofunction disrupt neural phase signaling
Q35167939Hypomania after augmenting venlafaxine and olanzapine with sarcosine in a patient with schizophrenia: a case study
Q37944127Hypothesis review: are clathrin-mediated endocytosis and clathrin-dependent membrane and protein trafficking core pathophysiological processes in schizophrenia and bipolar disorder?
Q28078158Iloperidone in the treatment of schizophrenia: an evidence-based review of its place in therapy
Q37320771Imaging frontostriatal function in ultra-high-risk, early, and chronic schizophrenia during executive processing.
Q26769948In Sickness and in Health: Perineuronal Nets and Synaptic Plasticity in Psychiatric Disorders
Q48264745In vivo and ex vivo evidence for ketamine-induced hyperglutamatergic activity in the cerebral cortex of the rat: Potential relevance to schizophrenia
Q37420164Increased D-amino acid oxidase expression in the bilateral hippocampal CA4 of schizophrenic patients: a post-mortem study
Q48284591Increased expression of c-Jun transcription factor in cerebellar vermis of patients with schizophrenia
Q30468818Increased expression of receptor phosphotyrosine phosphatase-β/ζ is associated with molecular, cellular, behavioral and cognitive schizophrenia phenotypes
Q46516683Increased serum G72 protein levels in patients with schizophrenia: a potential candidate biomarker
Q36447192Influence of Genetic Variants of the N-Methyl-D-Aspartate Receptor on Emotion and Social Behavior in Adolescents
Q35892576Influence of kynurenine 3-monooxygenase (KMO) gene polymorphism on cognitive function in schizophrenia
Q33575236Inhibition of NMDARs in the Nucleus Reticularis of the Thalamus Produces Delta Frequency Bursting
Q73816105Inhibition of striatal dopamine release by glycine and glycyldodecylamide
Q40531131Inhibition of system A-mediated glycine transport in cortical synaptosomes by therapeutic concentrations of clozapine: implications for mechanisms of action
Q44247358Interaction of stress and strain on glutamatergic neurotransmission: relevance to schizophrenia
Q35844158Intracerebral adult stem cells transplantation increases brain-derived neurotrophic factor levels and protects against phencyclidine-induced social deficit in mice
Q38376655Is duration of illness really influencing outcome in major psychoses?
Q59355241Is the History of Substance Abuse Correlated with Neuropsychiatric Disorders and Co-morbid HIV Infection? An Urban Population Study
Q48126400Ketamine effects on CNS responses assessed with MEG/EEG in a passive auditory sensory-gating paradigm: an attempt for modelling some symptoms of psychosis in man.
Q34152191LY404187: a novel positive allosteric modulator of AMPA receptors
Q34415609LY503430: pharmacology, pharmacokinetics, and effects in rodent models of Parkinson's disease.
Q35592555Longitudinal loss of gray matter volume in patients with first-episode schizophrenia: DARTEL automated analysis and ROI validation
Q38709794MK-801-Treated Oligodendrocytes as a Cellular Model to Study Schizophrenia
Q24671667Magnocellular contributions to impaired motion processing in schizophrenia
Q38527208Major diencephalic inputs to the hippocampus: supramammillary nucleus and nucleus reuniens. Circuitry and function
Q33932502Meta-analyses of 10 polymorphisms associated with the risk of schizophrenia
Q37463647Metabolic maturation of the human brain from birth through adolescence: insights from in vivo magnetic resonance spectroscopy
Q34113742Metabotropic glutamate receptor 3 (GRM3) gene variation is not associated with schizophrenia or bipolar affective disorder in the German population
Q28510751Mice with reduced NMDA receptor expression display behaviors related to schizophrenia
Q24644849MicroRNA-219 modulates NMDA receptor-mediated neurobehavioral dysfunction
Q28382954MicroRNAs in Neurotoxicity
Q34574117Minocycline attenuates hyperlocomotion and prepulse inhibition deficits in mice after administration of the NMDA receptor antagonist dizocilpine.
Q44563712Modulation of MK-801-elicited mouse popping behavior by galantamine is complex and dose-dependent
Q45249011Modulation of striatal dopamine release by glycine transport inhibitors
Q30428213Molecular aspects of glutamate dysregulation: implications for schizophrenia and its treatment
Q37298159N-Methyl D-Aspartate Receptor Antagonist Kynurenic Acid Affects Human Cortical Development.
Q28285432N-methyl-D-aspartate receptor and calbindin-containing neurons in the anterior cingulate cortex in schizophrenia and bipolar disorder
Q37981289NAAG, NMDA receptor and psychosis
Q42192369NMDA receptor and schizophrenia: a brief history
Q28205016NMDA receptor antagonist effects, cortical glutamatergic function, and schizophrenia: toward a paradigm shift in medication development
Q38578480NMDA receptor function, memory, and brain aging
Q34197064NMDA receptor hypofunction produces opposite effects on prefrontal cortex interneurons and pyramidal neurons
Q36042941NMDAR antagonist action in thalamus imposes δ oscillations on the hippocampus
Q24644168Neural synchrony in schizophrenia: from networks to new treatments
Q28743857Neurexin-1 and frontal lobe white matter: an overlapping intermediate phenotype for schizophrenia and autism spectrum disorders
Q30698640Neuroanatomy and neurophysiology in schizophrenia
Q35042195Neuroleptics ameliorate phencyclidine-induced impairments of short-term memory
Q30403302Neurophysiological and neurochemical animal models of schizophrenia: focus on glutamate
Q37148229Neuroscience and psychopharmacology into the next millennium.
Q35236252Neurotoxicity of NMDA antagonists: a glutamatergic theory of schizophrenia based on selective impairment of local inhibitory feedback circuits.
Q41656936Olanzapine: a new antipsychotic agent with efficacy in the management of schizophrenia
Q64062621Oligodendrocytes: Potential of Discovering New Treatment Targets
Q28588903Overexpression of Reelin prevents the manifestation of behavioral phenotypes related to schizophrenia and bipolar disorder.
Q36409596Overview of Glutamatergic Dysregulation in Central Pathologies
Q34494844Oxidative stress in schizophrenia: an integrated approach
Q34274859Pharmacological treatment of schizophrenia: a critical review of the pharmacology and clinical effects of current and future therapeutic agents
Q46958764Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of fluvoxamine: role of sigma-1 receptors.
Q60439965Phenomenology, context, and self-experience in schizophrenia
Q24602550Positive allosteric modulation of metabotropic glutamate 5 (mGlu5) receptors reverses N-Methyl-D-aspartate antagonist-induced alteration of neuronal firing in prefrontal cortex
Q42027942Possible role for interactions between 5-lipoxygenase (5-LOX) and AMPA GluR1 receptors in depression and in antidepressant therapy
Q89983282Post-translational protein modifications in schizophrenia
Q33556077Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes
Q38958804Potential synergistic action of 19 schizophrenia risk genes in the thalamus.
Q64060513Preclinical characterization of AMPA receptor potentiator TAK-137 as a therapeutic drug for schizophrenia
Q44672168Prepulse inhibition deficits of the startle reflex in neonatal ventral hippocampal-lesioned rats: reversal by glycine and a glycine transporter inhibitor.
Q73405627Presence of NMDA-type glutamate receptors in cingulate corticostriatal terminals and their postsynaptic targets
Q88012630Presynaptic Effects of N-Methyl-D-Aspartate Receptors Enhance Parvalbumin Cell-Mediated Inhibition of Pyramidal Cells in Mouse Prefrontal Cortex
Q30480517Progressive and interrelated functional and structural evidence of post-onset brain reduction in schizophrenia
Q33983993Progressive decrease of left Heschl gyrus and planum temporale gray matter volume in first-episode schizophrenia: a longitudinal magnetic resonance imaging study
Q33754399Progressive decrease of left superior temporal gyrus gray matter volume in patients with first-episode schizophrenia
Q36852122Prolonged exposure to NMDAR antagonist suppresses inhibitory synaptic transmission in prefrontal cortex
Q38903697Proteomics and molecular tools for unveiling missing links in the biochemical understanding of schizophrenia
Q36310867Psychosocial disabilities in patients with schizophrenia
Q64970477Quercetin Reduces Cortical GABAergic Transmission and Alleviates MK-801-Induced Hyperactivity.
Q37979291Recent advances in targeting the ionotropic glutamate receptors in treating schizophrenia
Q37610236Recent advances in the pharmacotherapy of autism
Q30453229Reduced expression of the NMDA receptor-interacting protein SynGAP causes behavioral abnormalities that model symptoms of Schizophrenia
Q44407146Regulation of Glutamate Carboxypeptidase II Function in Corticolimbic Regions of Rat Brain by Phencyclidine, Haloperidol, and Clozapine
Q34235427Reinforcement ambiguity and novelty do not account for transitive inference deficits in schizophrenia
Q28239852Replication of linkage on chromosome 7q22 and association of the regional Reelin gene with working memory in schizophrenia families
Q44618474Reversal of Phencyclidine-Induced Dopaminergic Dysregulation by N-Methyl-D-Aspartate Receptor/Glycine-site Agonists
Q24523918Review of the use of Topiramate for treatment of psychiatric disorders
Q34561031SSR180711, a novel selective alpha7 nicotinic receptor partial agonist: (II) efficacy in experimental models predictive of activity against cognitive symptoms of schizophrenia.
Q36756401Schizophrenia susceptibility genes: in search of a molecular logic and novel drug targets for a devastating disorder
Q34268457Schizophrenia, a neurodegenerative disorder with neurodevelopmental antecedents.
Q38765239Schizophrenia: genetics, prevention and rehabilitation
Q35760205Selective remediation of reversal learning deficits in the neurodevelopmental MAM model of schizophrenia by a novel mGlu5 positive allosteric modulator
Q28577907Selective up-regulation of dopamine D1 receptors in dendritic spines by NMDA receptor activation
Q28343888Semantic disturbance in schizophrenia and its relationship to the cognitive neuroscience of attention
Q34546952Semantics and N400: insights for schizophrenia
Q46459393Sensitization to amphetamine, but not phencyclidine, disrupts prepulse inhibition and latent inhibition
Q41810408Serine racemase deletion disrupts memory for order and alters cortical dendritic morphology
Q50054332Serum levels of interleukin 6 in schizophrenic patients during treatment augmentation with sarcosine (results of the PULSAR study).
Q103011053Serum levels of neuropeptide Y in patients with chronic schizophrenia during treatment augmentation with sarcosine (results of the double-blind randomized controlled PULSAR study)
Q35144764Signaling molecules and receptor transduction cascades that regulate NMDA receptor-mediated synaptic transmission
Q37131036Spatial characteristics of white matter abnormalities in schizophrenia
Q30417394Specific disruption of thalamic inputs to the auditory cortex in schizophrenia models.
Q36246819Supplementation of Antipsychotic Treatment with the Amino Acid Sarcosine Influences Proton Magnetic Resonance Spectroscopy Parameters in Left Frontal White Matter in Patients with Schizophrenia
Q33760635Symptom provocation studies in psychiatric disorders: scientific value, risks, and future
Q91816977Synaptic Plasticity Shapes Brain Connectivity: Implications for Network Topology
Q52173663Synaptic basis of cortical persistent activity: the importance of NMDA receptors to working memory.
Q60037831Synchronous dynamics for cognitive coordination: But how?
Q48561060Synthesis and biological evaluation of novel flavanone derivatives as potential antipsychotic agents.
Q37137008Systemic hypotheses for generalized cognitive deficits in schizophrenia: a new take on an old problem
Q60536516Targeting glutamate to treat schizophrenia: lessons from recent clinical studies
Q38223276Targeting of NMDA receptors in new treatments for schizophrenia
Q50138246The Role of Serine Racemase in the Pathophysiology of Brain Disorders.
Q93359680The Stanley Neuropathology Consortium Integrative Database (SNCID) for Psychiatric Disorders
Q38056122The biochemical womb of schizophrenia: A review
Q48651690The difference in Mismatch negativity between the acute and post-acute phase of schizophrenia.
Q35019122The effects of early and sustained intervention on the long-term morbidity of schizophrenia
Q35186635The glutamate hypothesis of schizophrenia: evidence from human brain tissue studies
Q33578312The group II metabotropic glutamate receptor agonist LY354740 and the D2 receptor antagonist haloperidol reduce locomotor hyperactivity but fail to rescue spatial working memory in GluA1 knockout mice
Q34363257The neurobiology of modafinil as an enhancer of cognitive performance and a potential treatment for substance use disorders
Q40190681The nitric oxide donor sodium nitroprusside attenuates recognition memory deficits and social withdrawal produced by the NMDA receptor antagonist ketamine and induces anxiolytic-like behaviour in rats
Q73553209The role of endogenous sensitization in the pathophysiology of schizophrenia: implications from recent brain imaging studies
Q41885537The stanley neuropathology consortium integrative database: a novel, web-based tool for exploring neuropathological markers in psychiatric disorders and the biological processes associated with abnormalities of those markers
Q47989124Therapeutic effects of metabotropic glutamate receptor 5 positive allosteric modulator CDPPB on phencyclidine-induced cognitive deficits in mice
Q30981438Time-dependent changes in gene expression profiles of midbrain dopamine neurons following haloperidol administration.
Q33845809Topiramate antagonizes MK-801 in an animal model of schizophrenia
Q50677578Tract-based magnetic resonance spectroscopy of the cingulum bundles at 7 T.
Q35739457Translating glutamate: from pathophysiology to treatment
Q36831867Transmembrane AMPA receptor regulatory protein (TARP) dysregulation in anterior cingulate cortex in schizophrenia
Q34338202Treatments for schizophrenia: a critical review of pharmacology and mechanisms of action of antipsychotic drugs
Q41945244Two grams of sarcosine in schizophrenia - is it too much? A potential role of glutamate-serotonin interaction.
Q42949861Validation and pharmacological characterisation of MK-801-induced locomotor hyperactivity in BALB/C mice as an assay for detection of novel antipsychotics
Q59782767Why do schizophrenic patients hallucinate?
Q34003528Why is D-serine nephrotoxic and alpha-aminoisobutyric acid protective?
Q24294371d-Amino acid oxidase and serine racemase in human brain: normal distribution and altered expression in schizophrenia
Q51730519d-Serine administration affects nitric oxide synthase 1 adaptor protein and DISC1 expression in sex-specific manner.

Search more.