The guanylhydrazone CNI-1493: an inhibitor with dual activity against malaria-inhibition of host cell pro-inflammatory cytokine release and parasitic deoxyhypusine synthase

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The guanylhydrazone CNI-1493: an inhibitor with dual activity against malaria-inhibition of host cell pro-inflammatory cytokine release and parasitic deoxyhypusine synthase is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1052307066
P356DOI10.1007/S00436-008-0891-X
P8608Fatcat IDrelease_dnhmafrx45a7nlzoqlpml7ck2a
P698PubMed publication ID18256853

P50authorAnnette KaiserQ40204430
Sabine SpechtQ91075224
P2093author name stringDorian Bevec
Chris Meier
Ilona Hauber
Joachim Hauber
Achim Hoerauf
Salem Ramadan Sarite
Ulf F Görbig
P2860cites workHuman malarial disease: a consequence of inflammatory cytokine releaseQ21034098
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In the human malaria parasite Plasmodium falciparum, polyamines are synthesized by a bifunctional ornithine decarboxylase, S-adenosylmethionine decarboxylaseQ27974128
The spermidine synthase of the malaria parasite Plasmodium falciparum: molecular and biochemical characterisation of the polyamine synthesis enzymeQ27974262
Modification of eukaryotic initiation factor 5A from Plasmodium vivax by a truncated deoxyhypusine synthase from Plasmodium falciparum: An enzyme with dual enzymatic propertiesQ27974776
A new crystal structure of deoxyhypusine synthase reveals the configuration of the active enzyme and of an enzyme.NAD.inhibitor ternary complexQ28257755
Extracellular (axenic) development in vitro of the erythrocytic cycle of Plasmodium falciparumQ30530974
Pathogenesis of cerebral malaria: recent experimental data and possible applications for humansQ30661769
Role of eIF5A in TNF-alpha-mediated apoptosis of lamina cribrosa cellsQ33207418
Cloning, expression and functional activity of deoxyhypusine synthase from Plasmodium vivaxQ33260506
Identification of cellular deoxyhypusine synthase as a novel target for antiretroviral therapyQ33565483
A phase I study of CNI-1493, an inhibitor of cytokine release, in combination with high-dose interleukin-2 in patients with renal cancer and melanoma.Q33941996
CNI-1493 inhibits monocyte/macrophage tumor necrosis factor by suppression of translation efficiency.Q34380078
Suppression of proinflammatory cytokines in monocytes by a tetravalent guanylhydrazoneQ34381322
Immunological processes in malaria pathogenesis.Q34447833
Tumor necrosis factor ? in the pathogenesis of cerebral malariaQ35541025
Semapimod. Cytokine.Q35647135
Biological therapies for inflammatory bowel disease: research drives clinics.Q36536248
Targeting enzymes involved in spermidine metabolism of parasitic protozoa--a possible new strategy for anti-parasitic treatment.Q38349539
Stimulated expression of mRNAs in activated T cells depends on a functional CRM1 nuclear export pathway.Q40297353
The eukaryotic initiation factor 5A is involved in the regulation of proliferation and apoptosis induced by interferon-alpha and EGF in human cancer cellsQ44517465
Screening assay for the identification of deoxyhypusine synthase inhibitorsQ45008583
Antisense suppression of deoxyhypusine synthase in tomato delays fruit softening and alters growth and developmentQ46542243
Specific inhibition of c-Raf activity by semapimod induces clinical remission in severe Crohn's diseaseQ46635950
Crucial role of tumor necrosis factor (TNF) receptor 2 and membrane-bound TNF in experimental cerebral malariaQ48037129
eIF5A binds to translational machinery components and affects translation in yeastQ58322099
Plasmodium falciparum growth in deep cultureQ70278744
P433issue6
P921main subjectmalariaQ12156
P304page(s)1177-1184
P577publication date2008-02-07
P1433published inParasitology ResearchQ15755242
P1476titleThe guanylhydrazone CNI-1493: an inhibitor with dual activity against malaria-inhibition of host cell pro-inflammatory cytokine release and parasitic deoxyhypusine synthase
P478volume102

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cites work (P2860)
Q38943825Design, synthesis, and evaluation of guanylhydrazones as potential inhibitors or reactivators of acetylcholinesterase.
Q38770059Experimental Anti-Inflammatory Drug Semapimod Inhibits TLR Signaling by Targeting the TLR Chaperone gp96.
Q34395707Expression of eukaryotic initiation factor 5A and hypusine forming enzymes in glioblastoma patient samples: implications for new targeted therapies
Q37367535Iminoguanidines as Allosteric Inhibitors of the Iron-Regulated Heme Oxygenase (HemO) of Pseudomonas aeruginosa
Q34303004In vitro and in vivo silencing of plasmodial dhs and eIf-5a genes in a putative, non-canonical RNAi-related pathway
Q41956540New furin inhibitors based on weakly basic amidinohydrazones
Q37817830Peroxisome proliferator activating receptor (PPAR) in cerebral malaria (CM): a novel target for an additional therapy
Q37541047The multi-target effects of CNI-1493: convergence of anti-amylodogenic and anti-inflammatory properties in animal models of Alzheimer's disease

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