Large-scale chemical dissection of mitochondrial function

scientific article

Large-scale chemical dissection of mitochondrial function is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/NBT1387
P932PMC publication ID2715872
P698PubMed publication ID18297058
P5875ResearchGate publication ID5555281

P50authorStuart SchreiberQ906562
Todd GolubQ7812388
Vamsi MoothaQ7913059
P2093author name stringArvind Ramanathan
Bridget K Wagner
David Peck
Toshimori Kitami
Tamara J Gilbert
P2860cites workErralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscleQ24564824
Sequence and organization of the human mitochondrial genomeQ27860659
Functional discovery via a compendium of expression profilesQ27938962
Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1Q28131760
Myotonia precipitated by propranolol therapyQ28318015
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetesQ29547229
Mitochondria, oxidants, and agingQ29547594
The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and diseaseQ29547614
Mitochondrial respiratory-chain diseasesQ29614474
Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanismQ29616055
Dysfunction of mitochondria in human skeletal muscle in type 2 diabetesQ29616567
Mitochondrial dysfunction in the elderly: possible role in insulin resistanceQ29618783
Reactive oxygen species have a causal role in multiple forms of insulin resistanceQ29619831
Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurementsQ33771214
Control genes and variability: absence of ubiquitous reference transcripts in diverse mammalian expression studiesQ34112750
Incidence of hospitalized rhabdomyolysis in patients treated with lipid-lowering drugsQ34372448
Statin-induced apoptosis and skeletal myopathyQ34553711
Transcription of the mammalian mitochondrial genomeQ34709007
Increased expression of mitochondrial-encoded genes in skeletal muscle of humans with diabetes mellitusQ35554282
A method for high-throughput gene expression signature analysisQ35606004
Transcriptional regulatory circuits controlling mitochondrial biogenesis and functionQ35683727
Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitusQ35751965
Initiation and beyond: multiple functions of the human mitochondrial transcription machineryQ36692560
Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1.Q37494492
Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulatorsQ40225712
Oxidative stress-induced depolymerization of microtubules and alteration of mitochondrial mass in human cellsQ40407467
Calcium-regulated changes in mitochondrial phenotype in skeletal muscle cellsQ40568387
Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cellsQ40658370
Phase I and pharmacologic study of paclitaxel and cisplatin with granulocyte colony-stimulating factor: neuromuscular toxicity is dose-limitingQ40712739
Molecular genetic aspects of human mitochondrial disordersQ41000631
Interactions between bioenergetics and mitochondrial biogenesisQ41015290
An information-intensive approach to the molecular pharmacology of cancer.Q41134023
Characterization of the cellular reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT): subcellular localization, substrate dependence, and involvement of mitochondrial electron transport in MTT reductionQ41549753
The use of ATP bioluminescence as a measure of cell proliferation and cytotoxicityQ41566049
PGC-1alpha regulates the mitochondrial antioxidant defense system in vascular endothelial cellsQ42478723
Myositis associated with griseofulvin therapy.Q42567329
Metallothionein prevents diabetes-induced deficits in cardiomyocytes by inhibiting reactive oxygen species productionQ44328981
Rhabdomyolysis associated with pentamidine isethionate therapy for American cutaneous leishmaniasisQ44385707
ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's diseaseQ47754186
Improvement of metabolic control in diabetic patients during mebendazole administration: preliminary studies.Q51642198
Respiratory enzymes in oxidative phosphorylation. III. The steady state.Q55037006
Acute renal failure secondary to non-traumatic rhabdomyolysis following amoxapine overdoseQ69845638
Action of lovastatin, simvastatin, and pravastatin on sterol synthesis and their antiproliferative effect in cultured myoblasts from human striated muscleQ71820030
Gene expression-based high-throughput screening(GE-HTS) and application to leukemia differentiationQ75447880
Insulin-regulated mitochondrial gene expression is associated with glucose flux in human skeletal muscleQ78060340
Coordinate induction of energy gene expression in tissues of mitochondrial disease patientsQ78101648
Synthesis and cellular profiling of diverse organosilicon small moleculesQ79689467
Relationship of stereochemical and skeletal diversity of small molecules to cellular measurement spaceQ80983833
P433issue3
P304page(s)343-351
P577publication date2008-02-24
P1433published inNature BiotechnologyQ1893837
P1476titleLarge-scale chemical dissection of mitochondrial function
P478volume26