Dendritic cell recovery post-lymphodepletion: a potential mechanism for anti-cancer adoptive T cell therapy and vaccination

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Dendritic cell recovery post-lymphodepletion: a potential mechanism for anti-cancer adoptive T cell therapy and vaccination is …
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scholarly articleQ13442814
review articleQ7318358

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P6179Dimensions Publication ID1035038918
P356DOI10.1007/S00262-009-0792-6
P932PMC publication ID3070377
P698PubMed publication ID19921513
P5875ResearchGate publication ID38097270

P50authorMohamed L. SalemQ52145954
P2093author name stringDavid J Cole
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Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cellsQ24530100
Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cellsQ24540135
CD8+ T cell immunity against a tumor/self-antigen is augmented by CD4+ T helper cells and hindered by naturally occurring T regulatory cells.Q24540429
Adoptive immunotherapy for cancer: building on successQ24546258
IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cellsQ24621753
Adoptive cell transfer: a clinical path to effective cancer immunotherapyQ24644774
Myeloid-derived suppressor cells as regulators of the immune systemQ28131637
Nitric oxide-producing CD11b(+)Ly-6G(Gr-1)(+)CD31(ER-MP12)(+) cells in the spleen of cyclophosphamide-treated mice: implications for T-cell responses in immunosuppressed miceQ28377964
Subsets of myeloid-derived suppressor cells in tumor-bearing miceQ29614297
Molecular identification of a danger signal that alerts the immune system to dying cellsQ29619497
Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapyQ29619961
Cyclophosphamide induces bone marrow to yield higher numbers of precursor dendritic cells in vitro capable of functional antigen presentation to T cells in vivoQ33653210
Mechanism regulating reactive oxygen species in tumor-induced myeloid-derived suppressor cellsQ33707270
In vivo cyclophosphamide and IL-2 treatment impedes self-antigen-induced effector CD4 cell tolerization: implications for adoptive immunotherapyQ33756565
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Apoptosis, cross-presentation, and the fate of the antigen specific immune response.Q34167296
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Increased tumor necrosis factor alpha mRNA after cellular exposure to ionizing radiationQ34326827
Sinks, suppressors and antigen presenters: how lymphodepletion enhances T cell-mediated tumor immunotherapy.Q34422330
Cytokines as a link between innate and adaptive antitumor immunity.Q34581798
Interleukin-2-dependent mechanisms of tolerance and immunity in vivoQ34655265
Cyclophosphamide induces dynamic alterations in the host microenvironments resulting in a Flt3 ligand-dependent expansion of dendritic cells.Q34732294
Recovery from cyclophosphamide-induced lymphopenia results in expansion of immature dendritic cells which can mediate enhanced prime-boost vaccination antitumor responses in vivo when stimulated with the TLR3 agonist poly(I:C)Q34732473
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Combined IL-21 and low-dose IL-2 therapy induces anti-tumor immunity and long-term curative effects in a murine melanoma tumor modelQ34770289
Cyclophosphamide augments antitumor immunity: studies in an autochthonous prostate cancer modelQ34887495
The in vivo expansion rate of properly stimulated transferred CD8+ T cells exceeds that of an aggressively growing mouse tumor.Q34999698
Cyclophosphamide resets dendritic cell homeostasis and enhances antitumor immunity through effects that extend beyond regulatory T cell eliminationQ35012887
Increased intensity lymphodepletion and adoptive immunotherapy--how far can we go?Q35594089
Hematopoietic stem cells promote the expansion and function of adoptively transferred antitumor CD8 T cellsQ35613477
Ligands for L-selectin: homing, inflammation, and beyondQ35698423
A sense of danger from radiation.Q35820333
Microbial translocation augments the function of adoptively transferred self/tumor-specific CD8+ T cells via TLR4 signaling.Q35901034
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Cyclophosphamide/granulocyte colony-stimulating factor induces hematopoietic stem cells to proliferate prior to mobilizationQ36027708
Less is more: lymphodepletion followed by hematopoietic stem cell transplant augments adoptive T-cell-based anti-tumor immunotherapy.Q36070720
Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin-cyclophosphamide chemotherapyQ36108095
Priming of naive CD8+ T cells in the presence of IL-12 selectively enhances the survival of CD8+CD62Lhi cells and results in superior anti-tumor activity in a tolerogenic murine model.Q36121187
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T cells compete for access to antigen-bearing antigen-presenting cellsQ36376071
gp100/pmel 17 is a murine tumor rejection antigen: induction of "self"-reactive, tumoricidal T cells using high-affinity, altered peptide ligandQ36401461
Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function.Q36402501
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Interleukin-7-dependent expansion and persistence of melanoma-specific T cells in lymphodepleted mice lead to tumor regression and editing.Q36456753
Dendritic cells strongly boost the antitumor activity of adoptively transferred T cells in vivo.Q36456769
Immunological and antitumor effects of IL-23 as a cancer vaccine adjuvantQ36459340
Treatment of established lung metastases with tumor-infiltrating lymphocytes derived from a poorly immunogenic tumor engineered to secrete human TNF-alphaQ36470718
Dendritic cells in a mature age.Q36475977
Reshaping the past: Strategies for modulating T-cell memory immune responses.Q36568931
Administration route-dependent vaccine efficiency of murine dendritic cells pulsed with antigensQ36622359
Roles of sulfated glycans in lymphocyte homingQ36672292
IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapyQ36677310
Molecular characteristics of immunogenic cancer cell death.Q37002804
Anti-tumor activity and trafficking of self, tumor-specific T cells against tumors located in the brainQ37037932
Radiation therapy and Toll-like receptor signaling: implications for the treatment of cancerQ37051019
Chemotherapy followed by syngeneic dendritic cell injection in the mouse: findings and implications for human treatmentQ37056817
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Tumor-induced tolerance and immune suppression by myeloid derived suppressor cells.Q37118160
Combined modality immunotherapy and chemotherapy: a new perspectiveQ37167300
Immune-potentiating effects of the chemotherapeutic drug cyclophosphamideQ37186715
OX40 engagement and chemotherapy combination provides potent antitumor immunity with concomitant regulatory T cell apoptosis.Q37273138
Immunogenic cell death modalities and their impact on cancer treatmentQ37368966
Regulatory myeloid suppressor cells in health and diseaseQ37373257
Myeloid-derived suppressor cells: a novel therapeutic targetQ37393000
CpG oligodeoxynucleotides as immunotherapy in cancer.Q38570179
Preterminal host dendritic cells in irradiated mice prime CD8+ T cell-mediated acute graft-versus-host diseaseQ39737912
Importance of cyclophosphamide-induced bystander effect on T cells for a successful tumor eradication in response to adoptive immunotherapy in miceQ39797630
Dendritic cell-based therapeutic vaccination against myeloma: vaccine formulation determines efficacy against light chain myelomaQ39893082
Anti-tumour effects of exosomes in combination with cyclophosphamide and polyinosinic-polycytidylic acidQ39903777
Complete regression of advanced primary and metastatic mouse melanomas following combination chemoimmunotherapy.Q39961463
Activation and route of administration both determine the ability of bone marrow-derived dendritic cells to accumulate in secondary lymphoid organs and prime CD8+ T cells against tumorsQ40111834
Radiation-induced apoptosis along with local and systemic cytokine elaboration is associated with DC plus radiotherapy-mediated renal cell tumor regressionQ40142911
Cyclophosphamide enhances the antitumor efficacy of adoptively transferred immune cells through the induction of cytokine expression, B-cell and T-cell homeostatic proliferation, and specific tumor infiltrationQ40178764
Cutting edge: elimination of an endogenous adjuvant reduces the activation of CD8 T lymphocytes to transplanted cells and in an autoimmune diabetes modelQ40302449
Cyclophosphamide enhances anti-tumor effect of wild-type p53-specific CTL.Q40872634
Immediate-early, transient induction of the interleukin-1 beta gene in mouse spleen macrophages by ionizing radiationQ41343263
Tumor rejection by disturbing tumor stroma cell interactionsQ42944518
Cyclophosphamide/granulocyte colony-stimulating factor causes selective mobilization of bone marrow hematopoietic stem cells into the blood after M phase of the cell cycleQ43567029
Alterations in dendritic cell phenotype and function associated with immunoenhancing effects of a subcutaneously administered cyclophosphamide derivativeQ43618750
Combined intratumoral injection of bone marrow-derived dendritic cells and systemic chemotherapy to treat pre-existing murine tumors.Q43770332
Priming of CTLs by lymphocytic choriomeningitis virus depends on dendritic cellsQ43845179
Mobilization of dendritic cells in cancer patients treated with granulocyte colony-stimulating factor and chemotherapyQ44163505
Effects of cyclophosphamide and soluble tumor-associated antigens on lymphoid infiltration, proliferative activity and rate of apoptosis in chemically-induced rat mammary tumorsQ44258086
Cyclophosphamide induces type I interferon and augments the number of CD44(hi) T lymphocytes in mice: implications for strategies of chemoimmunotherapy of cancerQ44527902
Irradiation up-regulates CD80 expression through two different mechanisms in spleen B cells, B lymphoma cells, and dendritic cellsQ44899128
Cyclophosphamide and abrogation of tumor-induced suppressor T cell activityQ44963979
Uric acid promotes tumor immune rejectionQ45003959
The impact of imiquimod, a Toll-like receptor-7 ligand (TLR7L), on the immunogenicity of melanoma peptide vaccination with adjuvant Flt3 ligandQ45072204
Results of clinical trials with the administration of interleukin 2 and adoptive immunotherapy with activated cells in patients with cancerQ45790670
Cyclophosphamide (Cy)-facilitated adoptive immunotherapy of a Cy-resistant tumour. Evidence that Cy permits the expression of adoptive T-cell mediated immunity by removing suppressor T cells rather than by reducing tumour burden.Q45972793
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Cyclophosphamide decreases the number, percentage and the function of CD25+ CD4+ regulatory T cells, which suppress induction of contact hypersensitivityQ46495467
Allogeneic dendritic cell vaccination against metastatic renal cell carcinoma with or without cyclophosphamide.Q46511479
Nonmyeloablative chemotherapy followed by T-cell adoptive transfer and dendritic cell-based vaccination results in rejection of established melanomaQ46662100
X-ray-induced P-selectin localization to the lumen of tumor blood vesselsQ48346185
CD11chigh dendritic cell ablation impairs lymphopenia-driven proliferation of naive and memory CD8+ T cells.Q51987412
Cutting edge: differential self-peptide/MHC requirement for maintaining CD8 T cell function versus homeostatic proliferation.Q51988170
Anti-tumor T cell response and protective immunity in mice that received sublethal irradiation and immune reconstitution.Q52006526
CD8+ memory T cells (CD44high, Ly-6C+) are more sensitive than naive cells to (CD44low, Ly-6C-) to TCR/CD8 signaling in response to antigen.Q52040001
Anamnestic responses induced by antigen persisting on follicular dendritic cells from cyclophosphamide-treated mice.Q52211900
Response of the immune system of mammary tumor-bearing rats to cyclophosphamide and soluble low-molecular-mass tumor-associated antigens: the bone marrow and thymus.Q53386805
Response of the immune system of mammary tumor-bearing rats to cyclophosphamide and soluble low-molecular-mass tumor-associated antigens: rate of lymphoid infiltration and distribution of T lymphocytes in tumors.Q53391717
Importance of signaling via the IFN-alpha/beta receptor on host cells for the realization of the therapeutic benefits of cyclophosphamide for mice bearing a large MOPC-315 tumor.Q53854175
Cyclophosphamide induces the development of early myeloid cells suppressing tumor cell growth by a nitric oxide-dependent mechanism.Q54009397
Cyclophosphamide-induced bacterial translocation in Escherichia coli C25-monoassociated specific pathogen-free mice.Q54573207
Candida albicans infection enhances immunosuppression induced by cyclophosphamide by selective priming of suppressive myeloid progenitors for NO productionQ57080076
Granulocyte-colony stimulating factor increases CD123hi blood dendritic cells with altered CD62L and CCR7 expressionQ57252639
Biodistribution and vaccine efficiency of murine dendritic cells are dependent on the route of administrationQ57779785
Chemoimmunotherapy of Tumors: Cyclophosphamide Synergizes with Exosome Based VaccinesQ58326930
Single administration of low dose cyclophosphamide augments the antitumor effect of dendritic cell vaccineQ61788033
Kinetics of dendritic cells reconstitution and costimulatory molecules expression after myeloablative allogeneic haematopoetic stem cell transplantation: Implications for the development of acute graft-versus host diseaseQ61939939
Syngeneic adoptive immunotherapy and chemoimmunotherapy of a Friend leukemia: requirement for T cellsQ66878121
Use of tumor-infiltrating lymphocytes and interleukin-2 in the immunotherapy of patients with metastatic melanoma. A preliminary reportQ68100559
Immunotherapy of cancer by systemic administration of lymphoid cells plus interleukin-2Q70396686
Expression of IL-1 beta mRNA in mice after whole body X-irradiationQ71513741
Mobilization of hematopoietic stem and progenitor cell subpopulations from the marrow to the blood of mice following cyclophosphamide and/or granulocyte colony-stimulating factorQ72075255
Effect of total body irradiation, busulfan-cyclophosphamide, or cyclophosphamide conditioning on inflammatory cytokine release and development of acute and chronic graft-versus-host disease in H-2-incompatible transplanted SCID miceQ72372127
Analysis of mouse dendritic cell migration in vivo upon subcutaneous and intravenous injectionQ73128948
Rapid induction of cytokine gene expression in the lung after single and fractionated doses of radiationQ73272095
Increased production of immature myeloid cells in cancer patients: a mechanism of immunosuppression in cancerQ73311980
The granulocyte colony-stimulating factor receptor is required for the mobilization of murine hematopoietic progenitors into peripheral blood by cyclophosphamide or interleukin-8 but not flt-3 ligandQ73774723
Increased presence of CD34+ cells in the peripheral blood of head and neck cancer patients and their differentiation into dendritic cellsQ73939950
CD34+ immune suppressive cells in the peripheral blood of patients with head and neck cancerQ74232367
Cyclophosphamide enhances the CTL precursor frequency in mice immunized with MUC1-mannan fusion protein (M-FP)Q74462400
Accumulation of P-selectin in the lumen of irradiated blood vesselsQ77921698
Total lymphoid irradiation nonmyeloablative preconditioning enriches for IL-4-producing CD4+-TNK cells and skews differentiation of immunocompetent donor CD4+ cellsQ78447807
Defining the ability of cyclophosphamide preconditioning to enhance the antigen-specific CD8+ T-cell response to peptide vaccination: creation of a beneficial host microenvironment involving type I IFNs and myeloid cellsQ79467930
Activated circulating dendritic cells after hematopoietic stem cell transplantation predict acute graft-versus-host diseaseQ80220196
Eradication of large tumors in mice by a tritherapy targeting the innate, adaptive, and regulatory components of the immune systemQ81310240
Sequential expression of adhesion and costimulatory molecules in graft-versus-host disease target organs after murine bone marrow transplantation across minor histocompatibility antigen barriersQ81676892
MHC class I-positive dendritic cells (DC) control CD8 T cell homeostasis in vivo: T cell lymphopenia as a prerequisite for DC-mediated homeostatic proliferation of naive CD8 T cellsQ81880335
No polarization of type 1 or type 2 precursor dendritic cells in peripheral blood stem cell collections of non-hodgkin's lymphoma patients mobilized with cyclophosphamide plus G-CSF, GM-CSF, or GM-CSF followed by G-CSFQ83218256
Immunosuppressive myeloid-derived suppressor cells can be converted into immunogenic APCs with the help of activated NKT cells: an alternative cell-based antitumor vaccineQ83314104
The adjuvant effects of the toll-like receptor 3 ligand polyinosinic-cytidylic acid poly (I:C) on antigen-specific CD8+ T cell responses are partially dependent on NK cells with the induction of a beneficial cytokine milieuQ83356122
Adoptive T cell therapy of cancerQ83574527
P433issue3
P921main subjectdendritic cellQ506253
P304page(s)341-353
P577publication date2009-11-18
P1433published inCancer Immunology, ImmunotherapyQ5031409
P1476titleDendritic cell recovery post-lymphodepletion: a potential mechanism for anti-cancer adoptive T cell therapy and vaccination
P478volume59

Reverse relations

cites work (P2860)
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