The modulation of transthyretin tetramer stability by cysteine 10 adducts and the drug diflunisal. Direct analysis by fluorescence-detected analytical ultracentrifugation

scientific article

The modulation of transthyretin tetramer stability by cysteine 10 adducts and the drug diflunisal. Direct analysis by fluorescence-detected analytical ultracentrifugation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M709638200
P932PMC publication ID2335343
P698PubMed publication ID18326041

P50authorLawreen H ConnorsQ38642447
Catherine CostelloQ42100451
P2093author name stringThomas M Laue
Elena S Klimtchuk
Jonathan S Kingsbury
Roger Théberge
P2860cites workFibril in senile systemic amyloidosis is derived from normal transthyretinQ24558717
An engineered transthyretin monomer that is nonamyloidogenic, unless it is partially denaturedQ27634853
Diflunisal analogues stabilize the native state of transthyretin. Potent inhibition of amyloidogenesisQ27642917
Size-Distribution Analysis of Macromolecules by Sedimentation Velocity Ultracentrifugation and Lamm Equation ModelingQ27860847
On the analysis of protein self-association by sedimentation velocity analytical ultracentrifugationQ29616488
Expression, purification, and in vitro cysteine-10 modification of native sequence recombinant human transthyretinQ30360008
A method for directly fitting the time derivative of sedimentation velocity data and an alternative algorithm for calculating sedimentation coefficient distribution functions.Q30586953
Analysis of weight average sedimentation velocity dataQ30604327
Identification of fluorescein-5'-isothiocyanate-modification sites in proteins by electrospray-ionization mass spectrometryQ30780547
A comparison of weight average and direct boundary fitting of sedimentation velocity data for indefinite polymerizing systemsQ30916009
Characterization of transthyretin variants in familial transthyretin amyloidosis by mass spectrometric peptide mapping and DNA sequence analysisQ31039993
Characterization of transthyretin mutants from serum using immunoprecipitation, HPLC/electrospray ionization and matrix-assisted laser desorption/ionization mass spectrometry.Q31913738
Determination of molecular parameters by fitting sedimentation data to finite-element solutions of the Lamm equationQ32135026
Fluorescence detection for the XLI analytical ultracentrifugeQ33200195
Changes in retention behavior of fluorescently labeled proteins during ion-exchange chromatography caused by different protein surface labeling positionsQ33275246
The systemic amyloidoses: an overviewQ33817482
Small-molecule-mediated stabilization of familial amyotrophic lateral sclerosis-linked superoxide dismutase mutants against unfolding and aggregationQ33928500
Review: TTR amyloidosis-structural features leading to protein aggregation and their implications on therapeutic strategiesQ34001308
D18G transthyretin is monomeric, aggregation prone, and not detectable in plasma and cerebrospinal fluid: a prescription for central nervous system amyloidosis?Q34201956
Sedimentation velocity analysis of heterogeneous protein-protein interactions: sedimentation coefficient distributions c(s) and asymptotic boundary profiles from Gilbert-Jenkins theoryQ34350597
Senile systemic amyloidosis presenting with heart failure: a comparison with light chain-associated amyloidosis.Q34429487
Molecular mechanisms of amyloidosisQ35194628
Design strategies for anti-amyloid agents.Q35209288
Inhibiting transthyretin amyloid fibril formation via protein stabilizationQ37082709
Reduction of the amyloidogenicity of a protein by specific binding of ligands to the native conformationQ38271778
Amyloid and the cardiovascular system: A review of pathogenesis and pathology with clinical correlationsQ38410067
Amyloid in the Aged Heart: Frequency and Clinical SignificanceQ39727675
The most pathogenic transthyretin variant, L55P, forms amyloid fibrils under acidic conditions and protofilaments under physiological conditionsQ41696172
The alternative conformations of amyloidogenic proteins and their multi-step assembly pathwaysQ41728317
Selective binding to transthyretin and tetramer stabilization in serum from patients with familial amyloidotic polyneuropathy by an iodinated diflunisal derivativeQ42806704
Cys10 mixed disulfides make transthyretin more amyloidogenic under mildly acidic conditionsQ44520207
In vitro and in vivo interactions of homocysteine with human plasma transthyretin.Q44595334
Native state stabilization by NSAIDs inhibits transthyretin amyloidogenesis from the most common familial disease variantsQ44767199
Transthyretin aggregation under partially denaturing conditions is a downhill polymerizationQ44925089
The Interaction of Thyroxine with Human Plasma Prealbumin and with the Prealbumin-Retinol-binding Protein ComplexQ47684398
The clinical significance of senile cardiac amyloidosis: a prospective clinico-pathological study.Q50951801
Analysis of reversibly interacting macromolecular systems by time derivative sedimentation velocity.Q52075208
Boundary analysis in sedimentation transport experiments: a procedure for obtaining sedimentation coefficient distributions using the time derivative of the concentration profileQ52420901
Tetramer Dissociation and Monomer Partial Unfolding Precedes Protofibril Formation in Amyloidogenic Transthyretin VariantsQ57665571
Tabulation of human transthyretin (TTR) variants, 2003Q58011075
Transthyretin amyloidosisQ58124877
Impact of age and amyloidosis on thiol conjugation of transthyretin in hereditary transthyretin amyloidosisQ58274191
Frequency and distribution of senile cardiovascular amyloid. A clinicopathologic correlationQ64361284
Clinical significance of histopathologic patterns of cardiac amyloidosisQ71436818
Direct observation of the self-association of dilute proteins in the presence of inert macromolecules at high concentration via tracer sedimentation equilibrium: theory, experiment, and biological significanceQ78021416
P433issue18
P407language of work or nameEnglishQ1860
P1104number of pages10
P304page(s)11887-11896
P577publication date2008-03-06
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe modulation of transthyretin tetramer stability by cysteine 10 adducts and the drug diflunisal. Direct analysis by fluorescence-detected analytical ultracentrifugation
P478volume283