Suppression of gluconeogenic gene expression by LSD1-mediated histone demethylation

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Suppression of gluconeogenic gene expression by LSD1-mediated histone demethylation is …
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scholarly articleQ13442814

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P819ADS bibcode2013PLoSO...866294P
P356DOI10.1371/JOURNAL.PONE.0066294
P932PMC publication ID3673910
P698PubMed publication ID23755305
P5875ResearchGate publication ID237098716

P2093author name stringYong-Xu Wang
Chunxiao Mao
Dongning Pan
P2860cites workGlycogen storage disease type I: diagnosis, management, clinical course and outcome. Results of the European Study on Glycogen Storage Disease Type I (ESGSD I).Q51952874
The glucose-6-phosphatase catalytic subunit gene promoter contains both positive and negative glucocorticoid response elementsQ80411458
Targeted deletion of liver glucose-6 phosphatase mimics glycogen storage disease type 1a including development of multiple adenomasQ82615010
The histone demethylase Jhdm1a regulates hepatic gluconeogenesisQ21144913
LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancerQ24308737
KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprintsQ24312768
Warburg effect revisited: an epigenetic link between glycolysis and gastric carcinogenesisQ24313608
The role of HNF1alpha, HNF3gamma, and cyclic AMP in glucose-6-phosphatase gene activationQ24336697
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1Q24336747
A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced deathQ24644712
High-resolution profiling of histone methylations in the human genomeQ27860906
Coordinated histone modifications mediated by a CtBP co-repressor complexQ28191656
CoREST is an integral component of the CoREST- human histone deacetylase complexQ28199886
Factors that control the tissue-specific transcription of the gene for phosphoenolpyruvate carboxykinase-CQ28252951
Glycogen storage disease in adultsQ28257866
An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylationQ28265681
Opposing LSD1 complexes function in developmental gene activation and repression programmesQ28295495
Glycogen storage disease type I and G6Pase-β deficiency: etiology and therapyQ28296663
The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylationQ28304726
Promoter hypermethylation mediated downregulation of FBP1 in human hepatocellular carcinoma and colon cancerQ28477572
Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's diseaseQ28592482
Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null miceQ29614547
Quantitative contributions of gluconeogenesis to glucose production during fasting in type 2 diabetes mellitusQ31922047
trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1.Q33279148
What is a cAMP response unit?Q33943495
Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medicationsQ33997049
Enhancer decommissioning by LSD1 during embryonic stem cell differentiationQ34088491
CREB and the CRTC co-activators: sensors for hormonal and metabolic signalsQ34166530
Hepatocellular carcinoma in glycogen storage disease type Ia: a case seriesQ34557393
Characterization of the human liver fructose-1,6-bisphosphatase gene promoterQ34646814
Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance studyQ35606593
Stat3-mediated activation of microRNA-23a suppresses gluconeogenesis in hepatocellular carcinoma by down-regulating glucose-6-phosphatase and peroxisome proliferator-activated receptor gamma, coactivator 1 alphaQ35968941
Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemiaQ36515569
Hormonal regulation of hepatic glucose production in health and diseaseQ37896899
LSD1 regulates the balance between self-renewal and differentiation in human embryonic stem cells.Q39538448
Establishment and characterization of a novel method for evaluating gluconeogenesis using hepatic cell lines, H4IIE and HepG2.Q39792281
Insulin represses phosphoenolpyruvate carboxykinase gene transcription by causing the rapid disruption of an active transcription complex: a potential epigenetic effectQ40210118
Hepatocellular adenomas in glycogen storage disease type I and III: a series of 43 patients and review of the literatureQ41460619
Early bioenergetic changes in hepatocarcinogenesis: preneoplastic phenotypes mimic responses to insulin and thyroid hormoneQ41654924
Measurement of fractional whole-body gluconeogenesis in humans from blood samples using 2H nuclear magnetic resonance spectroscopyQ44599785
The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cellsQ45375299
NR4A orphan nuclear receptors are transcriptional regulators of hepatic glucose metabolismQ46057176
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)e66294
P577publication date2013-06-05
P1433published inPLOS OneQ564954
P1476titleSuppression of gluconeogenic gene expression by LSD1-mediated histone demethylation
P478volume8

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cites work (P2860)
Q430944043,5-Diamino-1,2,4-triazoles as a novel scaffold for potent, reversible LSD1 (KDM1A) inhibitors
Q47147249Cofactors As Metabolic Sensors Driving Cell Adaptation in Physiology and Disease
Q58755150FBP1 loss contributes to BET inhibitors resistance by undermining c-Myc expression in pancreatic ductal adenocarcinoma
Q92644570Fructose-1,6-bisphosphatase loss modulates STAT3-dependent expression of PD-L1 and cancer immunity
Q89176324Inhibition of the histone demethylase KDM4B leads to activation of KDM1A, attenuates bacterial-induced pro-inflammatory cytokine release, and reduces osteoclastogenesis
Q28084375Local chromatin microenvironment determines DNMT activity: from DNA methyltransferase to DNA demethylase or DNA dehydroxymethylase
Q51392646Loss of FBP1 facilitates aggressive features of hepatocellular carcinoma cells through the Warburg effect.
Q40796520Lysine-specific demethylase 1-mediated demethylation of histone H3 lysine 9 contributes to interleukin 1β-induced microsomal prostaglandin E synthase 1 expression in human osteoarthritic chondrocytes
Q41522109Lysine-specific demethylase 2 suppresses lipid influx and metabolism in hepatic cells
Q38662691Medicinal chemistry insights in the discovery of novel LSD1 inhibitors
Q92316777Metabolic Dysregulations and Epigenetics: A Bidirectional Interplay that Drives Tumor Progression
Q92701392Metabolic and Epigenetic Action Mechanisms of Antidiabetic Medicinal Plants
Q57816641Metabolism and Epigenetic Interplay in Cancer: Regulation and Putative Therapeutic Targets
Q38929402Perspectives on the interactions between metabolism, redox, and epigenetics in plants
Q57072624Reciprocal Regulation of Metabolic Reprogramming and Epigenetic Modifications in Cancer
Q33917658Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy?
Q59137601Restoration of FBP1 suppressed Snail-induced epithelial to mesenchymal transition in hepatocellular carcinoma
Q52647812Targeting FBPase is an emerging novel approach for cancer therapy.
Q30399200The histone methyltransferase Suv39h2 contributes to nonalcoholic steatohepatitis in mice.
Q47637379Transcription factor 19 interacts with histone 3 lysine 4 trimethylation and controls gluconeogenesis via the nucleosome-remodeling-deacetylase complex
Q61810256Unraveling the Regulation of Hepatic Gluconeogenesis

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