Metabolic and functional differences between brain and spinal cord mitochondria underlie different predisposition to pathology

scientific article

Metabolic and functional differences between brain and spinal cord mitochondria underlie different predisposition to pathology is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1152/AJPREGU.00528.2010
P932PMC publication ID3075084
P698PubMed publication ID21248309
P5875ResearchGate publication ID49768151

P50authorHerbert L BonkovskyQ90073250
P2093author name stringBenjamin R Brooks
Richelle Hemendinger
Natalia Zinchenko
Alexander V Panov
Daisy M Ridings
Nataliya Kubalik
David A Radoff
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Early mitochondrial dysfunction occurs in motor cortex and spinal cord at the onset of disease in the Wobbler mouseQ44535338
Intrinsic differences in brain and spinal cord mitochondria: Implication for therapeutic interventions.Q44918596
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Cytochrome c association with the inner mitochondrial membrane is impaired in the CNS of G93A-SOD1 mice.Q45213388
Mitochondrial alterations in transgenic mice with an H46R mutant Cu/Zn superoxide dismutase geneQ46087823
alpha-Ketoglutarate dehydrogenase contributes to production of reactive oxygen species in glutamate-stimulated hippocampal neurons in situQ46256542
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Neural mitochondrial Ca2+ capacity impairment precedes the onset of motor symptoms in G93A Cu/Zn-superoxide dismutase mutant miceQ46944733
Differences in the activation of the mitochondrial permeability transition among brain regions in the rat correlate with selective vulnerabilityQ48198160
Subcellular distribution of cytochrome P-450 in the brainQ48333411
Species- and tissue-specific relationships between mitochondrial permeability transition and generation of ROS in brain and liver mitochondria of rats and mice.Q48392931
Neurodegeneration in excitotoxicity, global cerebral ischemia, and target deprivation: A perspective on the contributions of apoptosis and necrosisQ48427213
Postsynaptic glutamate transport at the climbing fiber-Purkinje cell synapseQ48630473
CONTROL OF GLUTAMATE METABOLISM. THE EFFECT OF PYRUVATEQ51256181
Motor neuron degeneration in amyotrophic lateral sclerosis mutant superoxide dismutase-1 transgenic mice: mechanisms of mitochondriopathy and cell death.Q53588721
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Tricarboxylic acid cycle in rat brain synaptosomes. Fluxes and interactions with aspartate aminotransferase and malate/aspartate shuttleQ72808469
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Spinal cord mitochondria display lower calcium retention capacity compared with brain mitochondria without inherent differences in sensitivity to cyclophilin D inhibitionQ81294965
P433issue4
P921main subjectpathologyQ7208
mitochondrionQ39572
P304page(s)R844-54
P577publication date2011-01-19
P1433published inAmerican Journal of Physiology - Regulatory, Integrative and Comparative PhysiologyQ2201819
P1476titleMetabolic and functional differences between brain and spinal cord mitochondria underlie different predisposition to pathology
P478volume300

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cites work (P2860)
Q26774824ALS Patient Stem Cells for Unveiling Disease Signatures of Motoneuron Susceptibility: Perspectives on the Deadly Mitochondria, ER Stress and Calcium Triad
Q88774888DNA Damage Response and Repair, DNA Methylation, and Cell Death in Human Neurons and Experimental Animal Neurons Are Different
Q33634475Fatty acids in energy metabolism of the central nervous system
Q58714908Heat shock proteins are differentially expressed in brain and spinal cord: implications for multiple sclerosis
Q26992344Metabolomics of human brain aging and age-related neurodegenerative diseases
Q37999478Misfolded SOD1 and ALS: zeroing in on mitochondria
Q37952528Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis
Q64039992Neurocalcin Delta Knockout Impairs Adult Neurogenesis Whereas Half Reduction Is Not Pathological
Q58557243Oxaloacetic acid mediates ADP-dependent inhibition of mitochondrial complex II-driven respiration
Q36878198The wobbler mouse, an ALS animal model
Q36010913Voltage-Dependent Regulation of Complex II Energized Mitochondrial Oxygen Flux

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