Implication of the purinergic system in alcohol use disorders.

scientific article

Implication of the purinergic system in alcohol use disorders. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1111/J.1530-0277.2010.01379.X
P932PMC publication ID3076125
P698PubMed publication ID21223299
P5875ResearchGate publication ID49744208

P50authorDaryl L. DaviesQ38328079
P2093author name stringDoo-Sup Choi
Liana Asatryan
Moonnoh R Lee
Mahesh M Thakkar
M Saeed Dar
Hyung W Nam
P2860cites workBehavioral phenotypes of mice lacking purinergic P2X4 receptors in acute and chronic pain assaysQ21203941
Genetical genomic determinants of alcohol consumption in rats and humansQ21245326
Trimeric architecture of homomeric P2X2 and heteromeric P2X1+2 receptor subtypesQ24301398
Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromersQ24304896
Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: implications for striatal neuronal function.Q24305024
Cloning of a human nucleoside transporter implicated in the cellular uptake of adenosine and chemotherapeutic drugsQ24310832
Molecular cloning and characterization of a nitrobenzylthioinosine-insensitive (ei) equilibrative nucleoside transporter from human placentaQ24312794
Stimulation of high-affinity adenosine A2 receptors decreases the affinity of dopamine D2 receptors in rat striatal membranesQ24563287
An evaluation of mu-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence: results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) studyQ24645469
Crystal structure of the ATP-gated P2X(4) ion channel in the closed stateQ24657193
Allosteric control of gating and kinetics at P2X(4) receptor channelsQ28142880
International union of pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunitsQ28199881
Molecular physiology of P2X receptorsQ28203477
Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegansQ28239336
Adenosine A1-A2A receptor heteromers: new targets for caffeine in the brainQ28256105
Cloning of the human equilibrative, nitrobenzylmercaptopurine riboside (NBMPR)-insensitive nucleoside transporter ei by functional expression in a transport-deficient cell lineQ28262991
A-740003 [N-(1-{[(cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a novel and selective P2X7 receptor antagonist, dose-dependently reduces neuropathic pain in the ratQ28264281
Intracellular signaling pathways that regulate behavioral responses to ethanolQ28267487
Adaptations in adenosine signaling in drug dependence: therapeutic implicationsQ28271595
Cloning and tissue distribution of a novel P2X receptor from rat brainQ28282631
Signaling at purinergic P2X receptorsQ28296741
The clock gene Per2 influences the glutamatergic system and modulates alcohol consumptionQ28299078
Adenosine A2A receptor antagonists are potential antidepressants: evidence based on pharmacology and A2A receptor knockout miceQ28346715
Alcohol's effects on sleep in alcoholicsQ28360988
Altered hippocampal synaptic potentiation in P2X4 knock-out miceQ28507640
Adenosine A2a blockade prevents synergy between mu-opiate and cannabinoid CB1 receptors and eliminates heroin-seeking behavior in addicted ratsQ28566486
betagamma Dimers mediate synergy of dopamine D2 and adenosine A2 receptor-stimulated PKA signaling and regulate ethanol consumptionQ28570732
Molecular cloning and functional characterization of nitrobenzylthioinosine (NBMPR)-sensitive (es) and NBMPR-insensitive (ei) equilibrative nucleoside transporter proteins (rENT1 and rENT2) from rat tissuesQ28577258
Addicting drugs utilize a synergistic molecular mechanism in common requiring adenosine and Gi-βγ dimersQ28578407
Increased ethanol resistance and consumption in Eps8 knockout mice correlates with altered actin dynamicsQ28585492
Interactions between metabotropic glutamate 5 and adenosine A2A receptors in normal and parkinsonian miceQ28589507
Impaired flow-dependent control of vascular tone and remodeling in P2X4-deficient miceQ28592374
Function and regulation of CREB family transcription factors in the nervous systemQ29619559
Molecular basis of long-term plasticity underlying addictionQ29620539
The sleep-inducing effect of ethanol microinjection into the medial preoptic area is blocked by flumazenilQ31923674
Ethanol sensitivity: a central role for CREB transcription regulation in the cerebellumQ33265511
Impaired interleukin-1beta and c-Fos expression in the hippocampus is associated with a spatial memory deficit in P2X(7) receptor-deficient miceQ33472721
A postsynaptic interaction between dopamine D1 and NMDA receptors promotes presynaptic inhibition in the rat nucleus accumbens via adenosine release.Q48658263
Possible role of adenosine in the CNS effects of ethanolQ48726572
Mouse cerebellar adenosinergic modulation of ethanol-induced motor incoordination: possible involvement of cAMP.Q48795091
Central adenosinergic system involvement in ethanol-induced motor incoordination in miceQ48843955
Central P2X4 and P2X6 channel subunits coassemble into a novel heteromeric ATP receptor.Q48932842
Effect of rapid eye movement sleep deprivation on 5'-nucleotidase activity in the rat brainQ49056830
Behavioral sensitivity to purinergic drugs parallels ethanol sensitivity in selectively bred miceQ49077287
Chronic ethanol intoxication enhances [3H]CCPA binding and does not reduce A1 adenosine receptor function in rat cerebellumQ49132563
Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor.Q50721295
Autoradiographic analysis of serotonin receptors and transporter in kindled rat brain.Q52032615
Chronic haloperidol treatment leads to an increase in the intramembrane interaction between adenosine A2 and dopamine D2 receptors in the neostriatumQ60050271
Role of Adenosine A1 and A2A Receptors in the Alcohol Withdrawal SyndromeQ60440924
Effect of acute ethanol on uptake of [3H]adenosine by rat cerebellar synaptosomesQ69352835
Adenosine A1 receptor-dopamine D1 receptor interaction in the rat limbic system: modulation of dopamine D1 receptor antagonist binding sitesQ71660122
P2 receptor expression in the dopaminergic system of the rat brain during developmentQ81296867
Purinoceptors in microglia and neuropathic painQ36503400
Adenosine: a mediator of the sleep-inducing effects of prolonged wakefulnessQ36690694
Neurobiology of REM and NREM sleepQ36806073
The role of cholinergic basal forebrain neurons in adenosine-mediated homeostatic control of sleep: lessons from 192 IgG-saporin lesionsQ36917393
Ivermectin: 25 years and still going strongQ37013824
Purinergic systems in microgliaQ37194539
Purinergic signalling and disorders of the central nervous systemQ37203929
P2X1 and P2X5 subunits form the functional P2X receptor in mouse cortical astrocytesQ37352406
Purinergic regulation of hypothalamopituitary functionsQ37397335
The glutamate homeostasis hypothesis of addictionQ37538517
Adenosine receptors as drug targetsQ37691817
Intrastriatal adenosine A1 receptor antisense oligodeoxynucleotide blocks ethanol-induced motor incoordinationQ38346916
An antagonist-insensitive P2X receptor expressed in epithelia and brainQ38362921
Identification of P2X(4) receptor transmembrane residues contributing to channel gating and interaction with ivermectinQ39989811
Purinergic type 2 receptors at GABAergic synapses on ventral tegmental area dopamine neurons are targets for ethanol actionQ40255930
Ethanol differentially affects ATP-gated P2X(3) and P2X(4) receptor subtypes expressed in Xenopus oocytesQ40408692
Subunit Arrangement in P2X ReceptorsQ40629382
Ivermectin, an unconventional agonist of the glycine receptor chloride channelQ40816595
Single and repeated episodes of ethanol withdrawal increase adenosine A1, but not A2A, receptor density in mouse brainQ40854789
Endogenous opioid systems and alcohol addictionQ41353548
Adenosine-dopamine receptor-receptor interactions as an integrative mechanism in the basal gangliaQ41624006
Adenosinergic modulation of rat basal forebrain neurons during sleep and waking: neuronal recording with microdialysisQ41709009
Ethanol increases extracellular adenosine by inhibiting adenosine uptake via the nucleoside transporter.Q41744358
Possible role of mouse cerebellar nitric oxide in the behavioral interaction between chronic intracerebellar nicotine and acute ethanol administration: observation of cross-toleranceQ42167584
A point mutation in the ectodomain-transmembrane 2 interface eliminates the inhibitory effects of ethanol in P2X4 receptorsQ33601789
Nucleoside transporters: molecular biology and implications for therapeutic developmentQ33632764
Altered glutamatergic neurotransmission in the striatum regulates ethanol sensitivity and intake in mice lacking ENT1.Q33699186
Beyond the dopamine receptor: the DARPP-32/protein phosphatase-1 cascadeQ33703262
Interoceptive effects of alcohol require mGlu5 receptor activity in the nucleus accumbensQ33752076
The dopamine hypothesis of reward: past and current statusQ33756130
The mGluR5 antagonist MPEP selectively inhibits the onset and maintenance of ethanol self-administration in C57BL/6J mice.Q33788860
avr-15 encodes a chloride channel subunit that mediates inhibitory glutamatergic neurotransmission and ivermectin sensitivity in Caenorhabditis elegansQ33887549
ENT1 regulates ethanol-sensitive EAAT2 expression and function in astrocytesQ34035612
Reduced effect of NMDA glutamate receptor antagonist on ethanol-induced ataxia and striatal glutamate levels in mice lacking ENT1.Q34035647
Purinergic nervesQ34052179
The neurobiology of slow synaptic transmissionQ34100272
Ivermectin antagonizes ethanol inhibition in purinergic P2X4 receptorsQ34128759
The role and regulation of adenosine in the central nervous systemQ34205330
Adenosine analogs and sleep in ratsQ34266559
The ENT family of eukaryote nucleoside and nucleobase transporters: recent advances in the investigation of structure/function relationships and the identification of novel isoformsQ34276389
Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neuronsQ34296118
Metabotropic mGlu5 receptors regulate adenosine A2A receptor signalingQ34330621
Sleep, sleepiness, and alcohol use.Q34389701
A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat.Q34431207
Ivermectin: a positive allosteric effector of the alpha7 neuronal nicotinic acetylcholine receptor.Q34456094
Adenosine and sleep-wake regulationQ34550187
Identification of P2X4 receptor-specific residues contributing to the ivermectin effects on channel deactivationQ34562779
Combined antagonism of glutamate mGlu5 and adenosine A2A receptors interact to regulate alcohol-seeking in ratsQ34630525
Up-regulation of P2X4 receptors in spinal microglia after peripheral nerve injury mediates BDNF release and neuropathic pain.Q34868702
Inhibition by ethanol of rat P2X(4) receptors expressed in Xenopus oocytesQ35042484
Ivermectin and filariasisQ35095257
Adenosine in the spinal cord and periphery: release and regulation of painQ35145661
Ethanol regulation of adenosine receptor-stimulated cAMP levels in a clonal neural cell line: an in vitro model of cellular tolerance to ethanolQ35597338
Recent advances in the neurobiology of alcoholism: the role of adenosineQ35632063
The role of mesolimbic dopamine in the development and maintenance of ethanol reinforcement.Q35888462
A1 receptor and adenosinergic homeostatic regulation of sleep-wakefulness: effects of antisense to the A1 receptor in the cholinergic basal forebrainQ36029867
Actions of adenosine at its receptors in the CNS: insights from knockouts and drugsQ36094581
Ivermectin 20 years on: maturation of a wonder drugQ36242572
Role of adenosine in behavioral state modulation: a microdialysis study in the freely moving cat.Q42439356
Adenosinergic inhibition of basal forebrain wakefulness-active neurons: a simultaneous unit recording and microdialysis study in freely behaving catsQ42453428
Role of wake-promoting basal forebrain and adenosinergic mechanisms in sleep-promoting effects of ethanol.Q42469923
Effect of acute ethanol on release of endogenous adenosine from rat cerebellar synaptosomesQ42491405
Adenosine inhibits basal forebrain cholinergic and noncholinergic neurons in vitroQ42492222
Release of endogenous glutamate from rat cerebellar synaptosomes: interactions with adenosine and ethanolQ42498493
Adenosine and sleep homeostasis in the Basal forebrain.Q42499140
Distinct regional distribution of human equilibrative nucleoside transporter proteins 1 and 2 (hENT1 and hENT2) in the central nervous systemQ42503104
Effects of ibotenate and 192IgG-saporin lesions of the nucleus basalis magnocellularis/substantia innominata on spontaneous sleep and wake states and on recovery sleep after sleep deprivation in ratsQ42523450
Ivermectin Interaction with transmembrane helices reveals widespread rearrangements during opening of P2X receptor channelsQ42617502
Nicotine administration stimulates the in vivo N-methyl-D-aspartate receptor/nitric oxide/cyclic GMP pathway in rat hippocampus through glutamate releaseQ43186230
Roles of ectodomain and transmembrane regions in ethanol and agonist action in purinergic P2X2 and P2X3 receptorsQ43195222
Motivational effects of ethanol in DARPP-32 knock-out mice.Q43517475
Modulation of ethanol-induced motor incoordination by mouse striatal A(1) adenosinergic receptorQ43728861
Comparative pharmacology and computational modelling yield insights into allosteric modulation of human alpha7 nicotinic acetylcholine receptors.Q43823453
Metabotropic glutamate mGlu5 receptor-mediated modulation of the ventral striopallidal GABA pathway in rats. Interactions with adenosine A(2A) and dopamine D(2) receptors.Q43978573
Ethanol sensitivity in ATP-gated P2X receptors is subunit dependentQ44030560
Role of adenosine receptors in spinal G-protein activation after peripheral nerve injuryQ44096141
Acute ethanol/cannabinoid-induced ataxia and its antagonism by oral/systemic/intracerebellar A1 adenosine receptor antisense in miceQ44223724
Low ethanol sensitivity and increased ethanol consumption in mice lacking adenosine A2A receptors.Q44228562
The diurnal rhythm of adenosine levels in the basal forebrain of young and old ratsQ44708704
Opposite modulatory roles for adenosine A1 and A2A receptors on glutamate and dopamine release in the shell of the nucleus accumbens. Effects of chronic caffeine exposureQ44792331
Alcohol enhances GABAergic transmission to cerebellar granule cells via an increase in Golgi cell excitability.Q44844941
Dual effects of ATP on rat hippocampal synaptic plasticityQ44849613
Partial deletion of the cAMP response element-binding protein gene promotes alcohol-drinking behaviors.Q44911155
The type 1 equilibrative nucleoside transporter regulates ethanol intoxication and preference.Q44982517
Ethanol operant self-administration in rats is regulated by adenosine A2 receptorsQ45057379
Adenosine receptor-mediated modulation of dopamine release in the nucleus accumbens depends on glutamate neurotransmission and N-methyl-D-aspartate receptor stimulationQ45138309
The mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine decreases ethanol consumption via a protein kinase C epsilon-dependent mechanismQ45153616
Biochemical and functional evidence for heteromeric assembly of P2X1 and P2X4 subunitsQ45247897
Behavioral profile of P2X7 receptor knockout mice in animal models of depression and anxiety: relevance for neuropsychiatric disordersQ45365301
Adenosine is required for ethanol-induced heterologous desensitization.Q45950357
Release of adenosine by activation of NMDA receptors in the hippocampus.Q45964014
Transgenic expression of human equilibrative nucleoside transporter 1 in mouse neuronsQ46119603
Inhibition of adenosine uptake by ethanol is specific for one class of nucleoside transporters.Q46497048
Blockade of adenosine and dopamine receptors inhibits the development of rapid tolerance to ethanol in mice.Q46571137
Drugs for relapse prevention of alcoholism: ten years of progressQ46762261
Activation of adenosine A1 receptors reduces anxiety-like behavior during acute ethanol withdrawal (hangover) in mice.Q46890952
Genetic interdependence of adenosine and dopamine receptors: evidence from receptor knockout miceQ46942857
Adenosinergic modulation of ethanol-induced motor incoordination in the rat motor cortexQ47773927
Distribution of equilibrative, nitrobenzylthioinosine-sensitive nucleoside transporters (ENT1) in brainQ48148868
Distribution of mRNA encoding a nitrobenzylthioinosine-insensitive nucleoside transporter (ENT2) in rat brainQ48162008
Co-modulation of acute ethanol-induced motor impairment by mouse cerebellar adenosinergic A1 and GABA(A) receptor systemsQ48365370
The anatomy of the cerebellumQ48396422
Effect of the adenosine A2a receptor antagonist 3,7-dimethyl-propargylxanthine on anxiety-like and depression-like behavior and alcohol consumption in Wistar RatsQ48398090
Nitric oxide-evoked cGMP production in Purkinje cells in rat cerebellum: an immunocytochemical and pharmacological study.Q48448903
Involvement of kappa-opioids in the mouse cerebellar adenosinergic modulation of ethanol-induced motor incoordinationQ48472859
Behavioral interaction between nicotine and ethanol: possible modulation by mouse cerebellar glutamateQ48490410
The striatal adenosinergic modulation of ethanol-induced motor incoordination in rats: possible role of chloride fluxQ48557910
Comparison of ethanol preference and neurochemical measures of mesolimbic dopamine and adenosine systems across different strains of miceQ48599837
P433issue4
P921main subjectalcohol consumptionQ2647488
P304page(s)584-594
P577publication date2011-01-11
P1433published inAlcoholism: Clinical and Experimental ResearchQ4713331
P1476titleImplication of the purinergic system in alcohol use disorders
P478volume35

Reverse relations

cites work (P2860)
Q34155813Acamprosate reduces ethanol drinking behaviors and alters the metabolite profile in mice lacking ENT1
Q48029142Adenosine and glutamate in neuroglial interaction: implications for circadian disorders and alcoholism
Q35951700Adenosine and glutamate signaling in neuron-glial interactions: implications in alcoholism and sleep disorders
Q37462660Adenosine signaling in striatal circuits and alcohol use disorders
Q36754645Adenosine transporter ENT1 regulates the acquisition of goal-directed behavior and ethanol drinking through A2A receptor in the dorsomedial striatum
Q34068934Adenosinergic regulation of striatal clock gene expression and ethanol intake during constant light
Q43200833Alcohol and Caffeine: The Perfect Storm
Q33649945Contribution of P2X4 receptors to ethanol intake in male C57BL/6 mice
Q95943778Cortical astrocytes regulate ethanol consumption and intoxication in mice
Q58791740DPCPX, a selective adenosine A1 receptor antagonist, enhances the antidepressant-like effects of imipramine, escitalopram, and reboxetine in mice behavioral tests
Q61804383Ginsenosides Act As Positive Modulators of P2X4 Receptors
Q90265889Human Peripheral Blood Eosinophils Express High Levels of the Purinergic Receptor P2X4
Q36733426Increased brain uptake and oxidation of acetate in heavy drinkers
Q36024293Ivermectin reduces alcohol intake and preference in mice.
Q37742174Label-Free Neuroproteomics of the Hippocampal-Accumbal Circuit Reveals Deficits in Neurotransmitter and Neuropeptide Signaling in Mice Lacking Ethanol-Sensitive Adenosine Transporter
Q38718932Medications development for the treatment of alcohol use disorder: insights into the predictive value of animal and human laboratory models
Q44313659Metabolic products of [2-(13) C]ethanol in the rat brain after chronic ethanol exposure
Q33718454P2X4 Receptor Function in the Nervous System and Current Breakthroughs in Pharmacology.
Q34403131P2X4 receptor regulates alcohol-induced responses in microglia
Q27021285P2X4 receptors (P2X4Rs) represent a novel target for the development of drugs to prevent and/or treat alcohol use disorders
Q30454042Pharmacological insights into the role of P2X4 receptors in behavioural regulation: lessons from ivermectin
Q37059156Preclinical Medication Development: New Targets and New Drugs
Q50327421Purinergic Signaling in Neuron-Astrocyte Interactions, Circadian Rhythms, and Alcohol Use Disorder
Q27024533Recent advances in the discovery and preclinical testing of novel compounds for the prevention and/or treatment of alcohol use disorders.
Q52686702Reduced expression of purinergic P2X4 receptors increases voluntary ethanol intake in C57BL/6J mice.
Q34671783Regulation of ethanol-sensitive EAAT2 expression through adenosine A1 receptor in astrocytes
Q37576300Role of adenosine and the orexinergic perifornical hypothalamus in sleep-promoting effects of ethanol
Q36340781Sex-Specific Regulation of Depression, Anxiety-Like Behaviors and Alcohol Drinking in Mice Lacking ENT1.
Q27027640The Impact of Caffeine on the Behavioral Effects of Ethanol Related to Abuse and Addiction: A Review of Animal Studies
Q45864839The adenosine A2A receptor agonist CGS 21680 decreases ethanol self-administration in both non-dependent and dependent animals
Q34958402Type 1 equilibrative nucleoside transporter regulates ethanol drinking through accumbal N-methyl-D-aspartate receptor signaling

Search more.