Combined MEK inhibition and BMP2 treatment promotes osteoblast differentiation and bone healing in Nf1Osx -/- mice

scientific article

Combined MEK inhibition and BMP2 treatment promotes osteoblast differentiation and bone healing in Nf1Osx -/- mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/JBMR.2316
P932PMC publication ID4280331
P698PubMed publication ID25043591

P50authorDaniel S. PerrienQ56192217
Florent ElefteriouQ83122994
Jeffry S. NymanQ86839283
P2093author name stringXiangli Yang
Eva Harth
Sasidhar Uppuganti
David M Stevens
Guillaume Vignaux
Jean de la Croix Ndong
P2860cites workAblation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brainQ28506943
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Preliminary experience with the combined use of recombinant bone morphogenetic protein and bisphosphonates in the treatment of congenital pseudarthrosis of the tibiaQ34311779
Local low-dose lovastatin delivery improves the bone-healing defect caused by Nf1 loss of function in osteoblasts.Q35157847
Mice lacking Nf1 in osteochondroprogenitor cells display skeletal dysplasia similar to patients with neurofibromatosis type I.Q35225250
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ATF4 mediation of NF1 functions in osteoblast reveals a nutritional basis for congenital skeletal dysplasiaeQ37374302
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Antitumor activities of JTP-74057 (GSK1120212), a novel MEK1/2 inhibitor, on colorectal cancer cell lines in vitro and in vivoQ39552334
Continuous inhibition of MAPK signaling promotes the early osteoblastic differentiation and mineralization of the extracellular matrixQ40699220
Osx-Cre targets multiple cell types besides osteoblast lineage in postnatal miceQ41874233
Are endogenous BMPs necessary for bone healing during distraction osteogenesis?Q42011174
Distal tibial fracture repair in a neurofibromatosis type 1-deficient mouse treated with recombinant bone morphogenetic protein and a bisphosphonateQ42609566
Hyperactive Ras/MAPK signaling is critical for tibial nonunion fracture in neurofibromin-deficient miceQ42918689
Controlled branching of polyglycidol and formation of protein-glycidol bioconjugates via a graft-from approach with "PEG-like" armsQ43446911
Chemotherapy for hepatoblastoma in childrenQ44985270
Hyperactive transforming growth factor-β1 signaling potentiates skeletal defects in a neurofibromatosis type 1 mouse model.Q46798931
Congenital pseudarthrosis of neurofibromatosis type 1: impaired osteoblast differentiation and function and altered NF1 gene expression.Q50625815
Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors.Q50722204
Treatment of a congenital pseudarthrosis of the tibia by osteogenic protein-1 (bone morphogenetic protein-7): a case report.Q51230929
Bone morphogenetic protein 7 in the treatment of congenital pseudarthrosis of the tibia.Q54213661
Multiple roles for neurofibromin in skeletal development and growthQ56269967
BMP4 Is Dispensable for Skeletogenesis and Fracture-Healing in the LimbQ61758954
MR imaging of spinal tumors in children with neurofibromatosis 1Q78830044
Modeling bone morphogenetic protein and bisphosphonate combination therapy in wild-type and Nf1 haploinsufficient miceQ81042629
Whole-spine magnetic resonance imaging in patients with neurofibromatosis type 1 and spinal deformityQ81073484
Treatment of congenital pseudarthrosis of the tibia with recombinant human bone morphogenetic protein-7 (rhBMP-7). A report of five casesQ82699821
P433issue1
P921main subjectosteoblastQ917177
P304page(s)55-63
P577publication date2015-01-01
P1433published inJournal of Bone and Mineral ResearchQ15750941
P1476titleCombined MEK inhibition and BMP2 treatment promotes osteoblast differentiation and bone healing in Nf1Osx -/- mice
P478volume30

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cites work (P2860)
Q92446396An Update on Neurofibromatosis Type 1-Associated Gliomas
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