Strategies for controlled delivery of biologics for cartilage repair

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Strategies for controlled delivery of biologics for cartilage repair is …
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scholarly articleQ13442814

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P356DOI10.1016/J.ADDR.2014.06.006
P932PMC publication ID4280354
P698PubMed publication ID24993610

P50authorAntonios MikosQ29887911
P2093author name stringF Kurtis Kasper
Johnny Lam
Steven Lu
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Microfracture and bone morphogenetic protein 7 (BMP-7) synergistically stimulate articular cartilage repairQ43763003
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Parathyroid hormone [1-34] improves articular cartilage surface architecture and integration and subchondral bone reconstitution in osteochondral defects in vivoQ45822285
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Size-dependency of DL-lactide/glycolide copolymer particulates for intra-articular delivery system on phagocytosis in rat synoviumQ47191263
Chondrogenic differentiation of adipose tissue-derived mesenchymal stem cells: greater doses of growth factor are necessaryQ47252733
The effect of molecular weight on hyaluronan's cartilage boundary lubricating ability--alone and in combination with proteoglycan 4.Q47358797
Synergistic effects of growth and differentiation factor-5 (GDF-5) and insulin on expanded chondrocytes in a 3-D environmentQ47724362
In vitro and in vivo chondrogenesis of rabbit bone marrow-derived stromal cells in fibrin matrix mixed with growth factor loaded in nanoparticlesQ47889357
Cyclooxygenases (COX-1 and COX-2) for tissue engineering of articular cartilage--from a developmental model to first results of tissue and scaffold expression.Q47974719
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Gelatin as a delivery vehicle for the controlled release of bioactive moleculesQ34464776
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Blocking vascular endothelial growth factor with soluble Flt-1 improves the chondrogenic potential of mouse skeletal muscle-derived stem cellsQ34786993
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The role of growth factors in cartilage repairQ35209331
Growth factor delivery through self-assembling peptide scaffoldsQ35209334
Engineering endostatin-producing cartilaginous constructs for cartilage repair using nonviral transfection of chondrocyte-seeded and mesenchymal-stem-cell-seeded collagen scaffoldsQ35290727
Differentiation potential of adipose derived adult stem (ADAS) cells.Q35622969
Engineered cartilage via self-assembled hMSC sheets with incorporated biodegradable gelatin microspheres releasing transforming growth factor-β1.Q35803509
Strategies for controlled delivery of growth factors and cells for bone regenerationQ35981629
Self-assembling nanoparticles for intra-articular delivery of anti-inflammatory proteinsQ36162174
A review of the effects of insulin-like growth factor and platelet derived growth factor on in vivo cartilage healing and repairQ36368761
Synthesis of oligo(poly(ethylene glycol) fumarate).Q36443834
Cell-nanofiber-based cartilage tissue engineering using improved cell seeding, growth factor, and bioreactor technologiesQ36574576
Hydrogel drug delivery system with predictable and tunable drug release and degradation ratesQ36598151
A transduced living hyaline cartilage graft releasing transgenic stromal cell-derived factor-1 inducing endogenous stem cell homing in vivoQ36720701
Fibrous hyaluronic acid hydrogels that direct MSC chondrogenesis through mechanical and adhesive cuesQ36839540
Biological impact of the fibroblast growth factor family on articular cartilage and intervertebral disc homeostasisQ36851945
Osteochondral tissue regeneration using a bilayered composite hydrogel with modulating dual growth factor release kinetics in a rabbit model.Q36867889
Cartilage repair in a rat model of osteoarthritis through intraarticular transplantation of muscle-derived stem cells expressing bone morphogenetic protein 4 and soluble Flt-1.Q36934659
Growth differentiation factor-5 enhances in vitro mesenchymal stromal cell chondrogenesis and hypertrophyQ36936637
How to achieve sustained and complete protein release from PLGA-based microparticles?Q37046238
Short-chain fatty acid-modified hexosamine for tissue-engineering osteoarthritic cartilage.Q37052278
Scaffold-based delivery of a clinically relevant anti-angiogenic drug promotes the formation of in vivo stable cartilageQ37052301
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Systematic assessment of growth factor treatment on biochemical and biomechanical properties of engineered articular cartilage constructsQ37137750
Morphogenetic and regulatory mechanisms during developmental chondrogenesis: new paradigms for cartilage tissue engineeringQ37343393
The effect of platelet-rich plasma on pain, function, and quality of life of patients with knee osteoarthritisQ37413313
Repair of osteochondral defects with biodegradable hydrogel composites encapsulating marrow mesenchymal stem cells in a rabbit modelQ37456078
Bioactive factors in platelet-rich plasma obtained by apheresisQ37513903
Signalling molecules and growth factors for tissue engineering of cartilage-what can we learn from the growth plate?Q37539825
Therapeutic trajectory of hyaluronic acid versus corticosteroids in the treatment of knee osteoarthritis: a systematic review and meta-analysisQ37641906
Comparative review of growth factors for induction of three-dimensional in vitro chondrogenesis in human mesenchymal stem cells isolated from bone marrow and adipose tissue.Q37701427
Toward delivery of multiple growth factors in tissue engineeringQ37759486
Role of proinflammatory cytokines in the pathophysiology of osteoarthritisQ37814044
Stromal cell-derived factor-1 (SDF-1): homing factor for engineered regenerative medicine.Q37827159
An update on transforming growth factor-β (TGF-β): sources, types, functions and clinical applicability for cartilage/bone healingQ37846160
Biomaterial-mediated delivery of microenvironmental cues for repair and regeneration of articular cartilageQ37866282
Chondrocytes or adult stem cells for cartilage repair: the indisputable role of growth factorsQ37893257
The use of micro- and nanospheres as functional components for bone tissue regenerationQ37909452
Growth factors and chondrogenic differentiation of mesenchymal stem cells.Q37970150
A portrait of Transforming Growth Factor β superfamily signalling: Background mattersQ37973961
From nano- to macro-scale: nanotechnology approaches for spatially controlled delivery of bioactive factors for bone and cartilage engineeringQ38030641
Osteochondral tissue engineering: current strategies and challenges.Q38061812
Controlled release strategies for bone, cartilage, and osteochondral engineering--Part II: challenges on the evolution from single to multiple bioactive factor deliveryQ38068244
Controlled release strategies for bone, cartilage, and osteochondral engineering--Part I: recapitulation of native tissue healing and variables for the design of delivery systemsQ38069892
Complex articular cartilage restorationQ38073586
Treatment of cartilage lesions: what works and why?Q38076858
Transforming growth factor Beta-releasing scaffolds for cartilage tissue engineeringQ38118362
Basic science and clinical application of platelet-rich plasma for cartilage defects and osteoarthritis: a reviewQ38128123
A chondromimetic microsphere for in situ spatially controlled chondrogenic differentiation of human mesenchymal stem cellsQ39027638
Covalently tethered transforming growth factor beta in PEG hydrogels promotes chondrogenic differentiation of encapsulated human mesenchymal stem cellsQ39269892
Cartilage repair by local delivery of transforming growth factor-β1 or bone morphogenetic protein-2 from a novel, segmented polyurethane/polylactic-co-glycolic bilayered scaffold.Q39402524
Engineering endostatin-expressing cartilaginous constructs using injectable biopolymer hydrogelsQ39647467
In vitro stage-specific chondrogenesis of mesenchymal stem cells committed to chondrocytesQ39889481
Sequential release of bioactive IGF-I and TGF-beta 1 from PLGA microsphere-based scaffoldsQ40029222
Novel scaffolds fabricated from protein-loaded microspheres for tissue engineeringQ40064677
Dual growth factor delivery from degradable oligo(poly(ethylene glycol) fumarate) hydrogel scaffolds for cartilage tissue engineering.Q40461948
NELL-1 promotes cartilage regeneration in an in vivo rabbit modelQ40718621
Development of nano- and microscale chondroitin sulfate particles for controlled growth factor delivery.Q41770188
TGF beta-induced cartilage repair is maintained but fibrosis is blocked in the presence of Smad7.Q41905743
Avidin as a model for charge driven transport into cartilage and drug delivery for treating early stage post-traumatic osteoarthritisQ41958163
Endogenous versus exogenous growth factor regulation of articular chondrocytesQ41982504
Hyaluronan injection in murine osteoarthritis prevents TGFbeta 1-induced synovial neovascularization and fibrosis and maintains articular cartilage integrity by a CD44-dependent mechanismQ42135818
Inhibition of HDAC activity by ITF2357 ameliorates joint inflammation and prevents cartilage and bone destruction in experimental arthritisQ42742359
In vivo comparison of the effects of rhBMP-2 and rhBMP-4 in osteochondral tissue regeneration.Q42779460
Effect of IGF-1 and Uncultured Autologous Bone-Marrow-Derived Mononuclear Cells on Repair of Osteochondral Defect in RabbitsQ43109003
The anti-inflammatory and matrix restorative mechanisms of platelet-rich plasma in osteoarthritis.Q43455239
Exogenous bFGF promotes articular cartilage repair via up-regulation of multiple growth factors.Q50885892
Sulforaphane-PLGA microspheres for the intra-articular treatment of osteoarthritis.Q51059583
Degradable hydrogel scaffolds for in vivo delivery of single and dual growth factors in cartilage repair.Q51134667
The amelioration of cartilage degeneration by ADAMTS-5 inhibitor delivered in a hyaluronic acid hydrogel.Q51758630
Infiltration of plasma rich in growth factors for osteoarthritis of the knee short-term effects on function and quality of life.Q53065821
The effect of platelet-rich plasma on autologous osteochondral transplantation: an in vivo rabbit model.Q53098129
The inductive effect of bone morphogenetic protein-4 on chondral-lineage differentiation and in situ cartilage repair.Q53182600
Effect of double growth factor release on cartilage tissue engineering.Q54339408
Cartilage-like gene expression in differentiated human stem cell spheroids: a comparison of bone marrow-derived and adipose tissue-derived stromal cells.Q54791110
Platelet-rich plasma intra-articular knee injections for the treatment of degenerative cartilage lesions and osteoarthritisQ56986258
Platelet-rich plasma: intra-articular knee injections produced favorable results on degenerative cartilage lesionsQ56988869
Simultaneous regeneration of articular cartilage and subchondral bone induced by spatially presented TGF-beta and BMP-4 in a bilayer affinity binding systemQ56992936
Fibroblast Growth Factor Receptors in In Vitro and In Vivo Chondrogenesis: Relating Tissue Engineering Using Adult Mesenchymal Stem Cells to Embryonic DevelopmentQ61878667
Induction of swelling, synovial hyperplasia and cartilage proteoglycan loss upon intra-articular injection of transforming growth factor beta-2 in the rabbitQ68009649
Osteoarthritis-like changes in the murine knee joint resulting from intra-articular transforming growth factor-beta injectionsQ73294798
Bioabsorbable polymer scaffolds for tissue engineering capable of sustained growth factor deliveryQ73367975
Growth factor expression in cartilage wound healing: temporal and spatial immunolocalization in a rabbit auricular cartilage wound modelQ73998914
Repair of articular cartilage defects: part I. Basic Science of cartilage healingQ74522720
Polymeric system for dual growth factor deliveryQ77106419
Enhanced repair of extensive articular defects by insulin-like growth factor-I-laden fibrin compositesQ78165069
Early events in cartilage repair after subchondral bone microfractureQ78884878
Healing of full-thickness defects of the articular cartilage in rabbits using fibroblast growth factor-2 and a fibrin sealantQ80411926
Overview of the fracture healing cascadeQ81270997
Role of insulin like growth factor-I in repair response in immature cartilageQ81481596
Chondrogenesis of hMSC in affinity-bound TGF-beta scaffoldsQ82145805
Spatiotemporal control over growth factor delivery from collagen-based membraneQ82506603
Repair of rabbit osteochondral defects by an acellular technique with an ultrapurified alginate gel containing stromal cell-derived factor-1Q82581160
Liposomal targeting of glucocorticoids to the inflamed synovium inhibits cartilage matrix destruction during murine antigen-induced arthritisQ83554311
Development of chondroitin sulfate encapsulated PLGA microsphere delivery systems with controllable multiple burst releases for treating osteoarthritisQ83731239
Cartilaginous repair of full-thickness articular cartilage defects is induced by the intermittent activation of PTH/PTHrP signalingQ84099782
Stromal-cell-derived factor (SDF) 1-alpha in combination with BMP-2 and TGF-β1 induces site-directed cell homing and osteogenic and chondrogenic differentiation for tissue engineering without the requirement for cell seedingQ84347109
Repair of an osteochondral defect by sustained delivery of BMP-2 or TGFβ1 from a bilayered alginate-PLGA scaffoldQ84459553
Dual growth factor-releasing nanoparticle/hydrogel system for cartilage tissue engineeringQ84475707
Hylan G-F 20 maintains cartilage integrity and decreases osteophyte formation in osteoarthritis through both anabolic and anti-catabolic mechanismsQ84585876
Continuous gradients of material composition and growth factors for effective regeneration of the osteochondral interfaceQ84680101
Diminished cartilage-lubricating ability of human osteoarthritic synovial fluid deficient in proteoglycan 4: Restoration through proteoglycan 4 supplementationQ84897834
Repair of large osteochondral defects in rabbits using porous hydroxyapatite/collagen (HAp/Col) and fibroblast growth factor-2 (FGF-2)Q84913882
A novel method for the direct fabrication of growth factor-loaded microspheres within porous nondegradable hydrogels: controlled release for cartilage tissue engineeringQ84963556
Repair of osteochondral defects with adipose stem cells and a dual growth factor-releasing scaffold in rabbitsQ84974355
Phenotypic redifferentiation and cell cluster formation of cultured human articular chondrocytes in a three-dimensional oriented gelatin scaffold in the presence of PGE2--first results of a pilot studyQ86048982
Targeted delivery to cartilage is critical for in vivo efficacy of insulin-like growth factor 1 in a rat model of osteoarthritisQ87177493
P407language of work or nameEnglishQ1860
P921main subjectcartilageQ502730
P304page(s)123-134
P577publication date2014-06-30
P1433published inAdvanced Drug Delivery ReviewsQ2825362
P1476titleStrategies for controlled delivery of biologics for cartilage repair
P478volume84

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