Application of an Epac activator enhances neurotransmitter release at excitatory central synapses.

scientific article

Application of an Epac activator enhances neurotransmitter release at excitatory central synapses. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1523/JNEUROSCI.0268-08.2008
P932PMC publication ID6670779
P698PubMed publication ID18685024

P50authorErwin NeherQ77126
P2093author name stringIsabella Gekel
P2860cites workEpac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMPQ22008544
A family of cAMP-binding proteins that directly activate Rap1Q22008551
Endocannabinoid-mediated long-term plasticity requires cAMP/PKA signaling and RIM1alphaQ24564778
Epac: A new cAMP-binding protein in support of glucagon-like peptide-1 receptor-mediated signal transduction in the pancreatic beta-cellQ24619138
Brefeldin A: insights into the control of membrane traffic and organelle structureQ24643698
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Q25938983
A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity?Q26269969
Stimulation of phospholipase C-epsilon by the M3 muscarinic acetylcholine receptor mediated by cyclic AMP and the GTPase Rap2BQ28205068
Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle primingQ28504670
Beta phorbol ester- and diacylglycerol-induced augmentation of transmitter release is mediated by Munc13s and not by PKCsQ28511979
cAMP-GEFII is a direct target of cAMP in regulated exocytosisQ28512994
Immunohistochemical localization of Ih channel subunits, HCN1-4, in the rat brainQ28569499
Definition of the readily releasable pool of vesicles at hippocampal synapsesQ29620402
Molecular and functional heterogeneity of hyperpolarization-activated pacemaker channels in the mouse CNS.Q31778271
Differential distribution of four hyperpolarization-activated cation channels in mouse brainQ33874776
Detection of spontaneous synaptic events with an optimally scaled templateQ33907017
A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK.Q34156405
cAMP analog mapping of Epac1 and cAMP kinase. Discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cell neurite extensionQ34207668
cAMP acts on exchange protein activated by cAMP/cAMP-regulated guanine nucleotide exchange protein to regulate transmitter release at the crayfish neuromuscular junction.Q34382059
Epac-selective cAMP analogs: new tools with which to evaluate the signal transduction properties of cAMP-regulated guanine nucleotide exchange factorsQ34667012
RIM1: an edge for presynaptic plasticityQ34701741
PLC-epsilon: a shared effector protein in Ras-, Rho-, and G alpha beta gamma-mediated signalingQ35679578
Regulation of hippocampal synaptic plasticity by cyclic AMP-dependent protein kinasesQ35687788
Two components of transmitter release at a central synapseQ36013914
SUR1 regulates PKA-independent cAMP-induced granule priming in mouse pancreatic B-cellsQ36412388
Intracellular injection of t he catalytic subunit of cyclic AMP-dependent protein kinase simulates facilitation of transmitter release underlying behavioral sensitization in AplysiaQ36420332
Forskolin inhibits and reverses the effects of brefeldin A on Golgi morphology by a cAMP-independent mechanismQ36529188
Excitatory and inhibitory autaptic currents in isolated hippocampal neurons maintained in cell cultureQ37588622
Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartmentsQ37692357
Ca2+ stimulation of adenylyl cyclase generates dynamic oscillations in cyclic AMP.Q40316343
Phosphorylation of presynaptic and postsynaptic calcium channels by cAMP-dependent protein kinase in hippocampal neuronsQ40788634
Munc13-1 is a presynaptic phorbol ester receptor that enhances neurotransmitter releaseQ41017986
Delayed release of transmitter at the frog neuromuscular junctionQ41511940
PKA isoforms, neural pathways, and behaviour: making the connectionQ41541408
Increased transmitter release at excitatory synapses produced by direct activation of adenylate cyclase in rat hippocampal slices.Q41660380
Characterization of protein kinase C isoforms in primary cultured cerebellar granule cellsQ42492306
Modulation of Ca2+ channels by protein kinase C in rat central and peripheral neurons: disruption of G protein-mediated inhibitionQ42497856
Munc13-1 C1 domain activation lowers the energy barrier for synaptic vesicle fusion.Q42507707
Cyclic AMP imaging in neurones in brain slice preparationsQ43691718
Calmodulin mediates rapid recruitment of fast-releasing synaptic vesicles at a calyx-type synapseQ43832090
PKA and PKC enhance excitatory synaptic transmission in human dentate gyrusQ44336785
Developmental increase in vesicular glutamate content does not cause saturation of AMPA receptors at the calyx of Held synapse.Q44433366
Direct modulation of synaptic vesicle priming by GABA(B) receptor activation at a glutamatergic synapseQ44549023
Phorbol esters and adenosine affect the readily releasable neurotransmitter pool by different mechanisms at amphibian motor nerve endingsQ44584000
Regulation of releasable vesicle pool sizes by protein kinase A-dependent phosphorylation of SNAP-25.Q44758007
Presynaptic mechanism underlying cAMP-dependent synaptic potentiation.Q44919613
Binding to Rab3A-interacting molecule RIM regulates the presynaptic recruitment of Munc13-1 and ubMunc13-2.Q45345777
Mediation of hippocampal mossy fiber long-term potentiation by cyclic AMP.Q46090901
Regulation of the readily releasable vesicle pool by protein kinase C.Q46119072
Reluctant vesicles contribute to the total readily releasable pool in glutamatergic hippocampal neurons.Q46437156
Epac mediates a cAMP-to-PKC signaling in inflammatory pain: an isolectin B4(+) neuron-specific mechanism.Q46471284
cAMP increases Ca2+-dependent exocytosis through both PKA and Epac2 in mouse melanotrophs from pituitary tissue slicesQ46580519
Presynaptic mechanism underlying cAMP-induced synaptic potentiation in medial prefrontal cortex pyramidal neuronsQ46818530
Interdependence of PKC-dependent and PKC-independent pathways for presynaptic plasticityQ48198484
Potentiation of synaptic transmission in the hippocampus by phorbol estersQ48344180
Protein kinase A-mediated synapsin I phosphorylation is a central modulator of Ca2+-dependent synaptic activity.Q48375591
Enhancement of calcium current in Aplysia neurones by phorbol ester and protein kinase C.Q48534850
Cyclic AMP endogenously enhances synaptic strength of developing glutamatergic synapses in serum-free microcultures of rat hippocampal neuronsQ48656547
Adenosine 3',5-monophosphate-dependent phosphorylation of a specific protein in synaptic membrane fractions from rat cerebrumQ48727728
Studies on the mechanism of action of cyclic AMP in nervous and other tissuesQ48955844
Munc18-1 phosphorylation by protein kinase C potentiates vesicle pool replenishment in bovine chromaffin cells.Q50714380
The formation of glutamatergic synapses in cultured central neurons: selective increase in miniature synaptic currents.Q51627283
Serotonin and cyclic AMP close single K+ channels in Aplysia sensory neurones.Q52219678
Synaptic NMDA receptor channels have a low open probability.Q54012474
Nonuniform probability of glutamate release at a hippocampal synapseQ58191305
Down regulation of protein kinase C in neuronal cells: effects on neurotransmitter releaseQ68758076
Multiple calcium-dependent processes related to secretion in bovine chromaffin cellsQ70547407
Phorbol esters enhance synaptic transmission by a presynaptic, calcium-dependent mechanism in rat hippocampusQ72274888
Cloning and localization of the hyperpolarization-activated cyclic nucleotide-gated channel family in rat brainQ72989280
Phorbol esters potentiate evoked and spontaneous release by different presynaptic mechanismsQ73119629
Bryostatin 1 and phorbol ester down-modulate protein kinase C-alpha and -epsilon via the ubiquitin/proteasome pathway in human fibroblastsQ73128203
Interaction between Munc13-1 and RIM is critical for glucagon-like peptide-1 mediated rescue of exocytotic defects in Munc13-1 deficient pancreatic beta-cellsQ80636222
P433issue32
P407language of work or nameEnglishQ1860
P921main subjectneurotransmitterQ162657
P304page(s)7991-8002
P577publication date2008-08-01
P1433published inJournal of NeuroscienceQ1709864
P1476titleApplication of an Epac activator enhances neurotransmitter release at excitatory central synapses
P478volume28