DNA binding and protein interactions of the AHR/ARNT heterodimer that facilitate gene activation

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DNA binding and protein interactions of the AHR/ARNT heterodimer that facilitate gene activation is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/S0009-2797(02)00066-2
P698PubMed publication ID12213385

P2093author name stringHollie I Swanson
P2860cites workInteractions of nuclear receptor coactivator/corepressor proteins with the aryl hydrocarbon receptor complexQ22010224
Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular systemQ22253240
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tensionQ24307473
Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathwayQ24310405
Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cellsQ24314526
Crystal structure of PHO4 bHLH domain-DNA complex: flanking base recognitionQ24532538
In vitro analysis of Ah receptor domains involved in ligand-activated DNA recognitionQ24561542
Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factorQ24564124
Structure and function of the b/HLH/Z domain of USFQ24596919
Identification of a novel mechanism of regulation of Ah (dioxin) receptor functionQ24609846
Identification of functional domains of the aryl hydrocarbon receptor nuclear translocator protein (ARNT)Q24609901
A natural classification of the basic helix-loop-helix class of transcription factorsQ24642491
Recognition by Max of its cognate DNA through a dimeric b/HLH/Z domainQ27732150
Differential recruitment of coactivator RIP140 by Ah and estrogen receptors. Absence of a role for LXXLL motifsQ28140877
The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1Q28141845
Analysis of photoaffinity-labeled aryl hydrocarbon receptor heterogeneity by two-dimensional gel electrophoresisQ41728338
Regulation of constitutive gene expression through interactions of Sp1 protein with the nuclear aryl hydrocarbon receptor complexQ42477028
Aromatic hydrocarbon receptor-driven Bax gene expression is required for premature ovarian failure caused by biohazardous environmental chemicalsQ43675933
Eukaryotic transcription: the core of eukaryotic gene activation.Q45983312
Functional characterization of DNA-binding domains of the subunits of the heterodimeric aryl hydrocarbon receptor complex imputing novel and canonical basic helix-loop-helix protein-DNA interactions.Q45988273
Protein kinase C is not involved in Ah receptor transformation and DNA bindingQ46722711
Protein kinase C modulates regulation of the CYP1A1 gene by the aryl hydrocarbon receptorQ46839506
Getting a grip on DNA recognition: structures of the basic region leucine zipper, and the basic region helix-loop-helix DNA-binding domainsQ56031172
Aryl hydrocarbon receptor is required for p300-mediated induction of DNA synthesis by adenovirus E1AQ64380437
Generation of a dominant-negative mutant of endothelial PAS domain protein 1 by deletion of a potent C-terminal transactivation domainQ64381206
Constitutive function of the basic helix-loop-helix/PAS factor Arnt. Regulation of target promoters via the E box motifQ72298748
Lack of an absolute requirement for the native aryl hydrocarbon receptor (AhR) and AhR nuclear translocator transactivation domains in protein kinase C-mediated modulation of the AhR pathwayQ73141811
DNA binding activity of the aryl hydrocarbon receptor is sensitive to redox changes in intact cellsQ77338302
Transcription. Unlocking the gates to gene expressionQ77744307
The mercurial insensitive water channel (AQP-4) forms orthogonal arrays in stably transfected Chinese hamster ovary cellsQ95817895
DNA binding by the heterodimeric Ah receptor. Relationship to dioxin-induced CYP1A1 transcription in vivoQ95819054
DNA sequence determinants for binding of transformed Ah receptor to a dioxin-responsive enhancerQ28210544
Crystal structure of transcription factor E47: E-box recognition by a basic region helix-loop-helix dimerQ28238671
A direct interaction between the aryl hydrocarbon receptor and retinoblastoma protein. Linking dioxin signaling to the cell cycleQ28280266
Cloning of a Factor Required for Activity of the Ah (Dioxin) ReceptorQ28282451
DNA Binding Specificities and Pairing Rules of the Ah Receptor, ARNT, and SIM ProteinsQ28291880
Two murine homologs of the Drosophila single-minded protein that interact with the mouse aryl hydrocarbon receptor nuclear translocator proteinQ28302902
Dioxin-dependent activation of murine Cyp1a-1 gene transcription requires protein kinase C-dependent phosphorylationQ28343069
Cofactor dynamics and sufficiency in estrogen receptor-regulated transcriptionQ29547846
Correlations among amino acid sites in bHLH protein domains: an information theoretic analysisQ30011142
Aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) activity is unaltered by phosphorylation of a periodicity/ARNT/single-minded (PAS)-region serine residueQ31942124
Induction of cytochrome P4501A1.Q33636653
Cellular thiols and redox-regulated signal transduction.Q33937085
Nitrosation and oxidation in the regulation of gene expressionQ34056377
Regulation of transcription factor function by phosphorylation.Q34058495
Mediator complexes and transcription.Q34245346
Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription.Q34290262
Possible function of Ah receptor nuclear translocator (Arnt) homodimer in transcriptional regulationQ34553068
Specificity of DNA binding of the c-Myc/Max and ARNT/ARNT dimers at the CACGTG recognition siteQ34706472
Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexesQ35974510
Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factorQ36562473
Cross-coupling of signal transduction pathways: the dioxin receptor mediates induction of cytochrome P-450IA1 expression via a protein kinase C-dependent mechanismQ36659973
Discrimination between related DNA sites by a single amino acid residue of Myc-related basic-helix-loop-helix proteinsQ36789651
The DNA binding of purified Ah receptor heterodimer is regulated by redox conditionsQ38294555
The basic helix-loop-helix domain of the aryl hydrocarbon receptor nuclear transporter (ARNT) can oligomerize and bind E-box DNA specificallyQ38297838
Short heterodimer partner (SHP) orphan nuclear receptor inhibits the transcriptional activity of aryl hydrocarbon receptor (AHR)/AHR nuclear translocator (ARNT).Q38300545
Regulation of DNA binding activity of the ligand-activated aryl hydrocarbon receptor by tyrosine phosphorylationQ38307552
Repression of dioxin signal transduction in fibroblasts. Identification Of a putative repressor associated with ArntQ38325252
Protein kinase C modulates aryl hydrocarbon receptor nuclear translocator protein-mediated transactivation potential in a dimer contextQ38325710
Ah receptor and NF-kappaB interactions, a potential mechanism for dioxin toxicityQ38330069
Role of the PAS domain in regulation of dimerization and DNA binding specificity of the dioxin receptorQ39575271
Functional involvement of the Brahma/SWI2-related gene 1 protein in cytochrome P4501A1 transcription mediated by the aryl hydrocarbon receptor complexQ40755679
A tetratricopeptide repeat half-site in the aryl hydrocarbon receptor is important for DNA binding and trans-activation potential.Q40840225
Ah receptor signaling pathwaysQ40955603
A mutation in the aryl hydrocarbon receptor (AHR) in a cultured mammalian cell line identifies a novel region of AHR that affects DNA bindingQ41066699
CBP/p300 functions as a possible transcriptional coactivator of Ah receptor nuclear translocator (Arnt).Q41076757
Ah receptor nuclear translocator protein heterogeneity is altered after heterodimerization with the Ah receptorQ41098801
Inhibitors of serine/threonine-specific protein phosphatases stimulate transcription by the Ah receptor/Arnt dimer by affecting a step subsequent to XRE bindingQ41118857
Cooperative interaction between AhR.Arnt and Sp1 for the drug-inducible expression of CYP1A1 gene.Q41197895
Ah receptor phosphorylation: localization of phosphorylation sites to the C-terminal half of the proteinQ41353812
Cross-talk between the aryl hydrocarbon receptor and hypoxia inducible factor signaling pathways. Demonstration of competition and compensationQ41646529
P433issue1-2
P304page(s)63-76
P577publication date2002-09-01
P1433published inChemico-biological InteractionsQ14923137
P1476titleDNA binding and protein interactions of the AHR/ARNT heterodimer that facilitate gene activation
P478volume141

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cites work (P2860)
Q530604552,3,7,8-Tetrachlorodibenzo-p-dioxin promotes astrocyte activation and the secretion of tumor necrosis factor-α via PKC/SSeCKS-dependent mechanisms.
Q397259802,3,7,8-tetrachlorodibenzo-p-dioxin counteracts the p53 response to a genotoxicant by upregulating expression of the metastasis marker agr2 in the hepatocarcinoma cell line HepG2.
Q35163845A 5'-region polymorphism modulates promoter activity of the tumor suppressor gene MFSD2A
Q36098823A dioxin response element in the multiple cloning site of the pGL3 luciferase reporter influences transcriptional activity
Q38340222Altered DNA binding specificity of Arnt by selection of partner bHLH-PAS proteins
Q35682887Aryl hydrocarbon receptor deficiency enhances insulin sensitivity and reduces PPAR-α pathway activity in mice
Q36998074Aryl hydrocarbon receptor nuclear translocator (ARNT) isoforms control lymphoid cancer cell proliferation through differentially regulating tumor suppressor p53 activity
Q38313558Aryl hydrocarbon receptor- and calcium-dependent induction of the chemokine CCL1 by the environmental contaminant benzo[a]pyrene.
Q47254625Aryl hydrocarbon receptor-based bioassays for dioxin detection: Thinking outside the box.
Q35781348Aryl hydrocarbon receptor-deficient mice develop heightened inflammatory responses to cigarette smoke and endotoxin associated with rapid loss of the nuclear factor-kappaB component RelB.
Q35232729Aryl hydrocarbon receptor-dependent upregulation of Cyp1b1 by TCDD and diesel exhaust particles in rat brain microvessels
Q36748834Atypical CTSK transcripts and ARNT transcription read-through into CTSK.
Q91976059Canonical and non-canonical aryl hydrocarbon receptor signaling pathways
Q49483479Curcumin and its derivatives inhibit 2,3,7,8,-tetrachloro-dibenzo-p-dioxin-induced expression of drug metabolizing enzymes through aryl hydrocarbon receptor-mediated pathway
Q34347361Dietary polyphenols increase paraoxonase 1 gene expression by an aryl hydrocarbon receptor-dependent mechanism
Q38816290Differential effects of metal ions on TCDD-induced cytotoxicity and cytochrome P4501A1 gene expression in a zebrafish liver (ZFL) cell-line
Q42694332Diminished Phosphorylation of CREB Is a Key Event in the Dysregulation of Gluconeogenesis and Glycogenolysis in PCB126 Hepatotoxicity
Q28287699Dioxins, the aryl hydrocarbon receptor and the central regulation of energy balance
Q29347268Disruption of CLOCK-BMAL1 transcriptional activity is responsible for aryl hydrocarbon receptor-mediated regulation of Period1 gene
Q40719151Envoy, a PAS/LOV domain protein of Hypocrea jecorina (Anamorph Trichoderma reesei), modulates cellulase gene transcription in response to light
Q28586157For dioxin-induced birth defects, mouse or human CYP1A2 in maternal liver protects whereas mouse CYP1A1 and CYP1B1 are inconsequential
Q36829190Genome Editing of the CYP1A1 Locus in iPSCs as a Platform to Map AHR Expression throughout Human Development
Q30303149Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption
Q38517811Genome-wide screening of dioxin-responsive genes in fetal brain: bioinformatic and experimental approaches
Q36029877High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq.
Q33379104Hybrids of the bHLH and bZIP protein motifs display different DNA-binding activities in vivo vs. in vitro.
Q40549100Hypoxia-dependent regulation of PHD1: cloning and characterization of the human PHD1/EGLN2 gene promoter
Q37011260Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance
Q34338387Identification and analysis of genome-wide SNPs provide insight into signatures of selection and domestication in channel catfish (Ictalurus punctatus).
Q47136316Identification of ARNT-regulated BIRC3 as the target factor in cadmium renal toxicity
Q44395863Identification of novel splice variants of ARNT and ARNT2 in the rat.
Q53065230Identification of small molecules that support human leukemia stem cell activity ex vivo.
Q48731588Induction of proapoptotic gene expression and recruitment of p53 herald ovarian follicle loss caused by polycyclic aromatic hydrocarbons
Q40446912Intestinal glucose-dependent expression of glucose-6-phosphatase: involvement of the aryl receptor nuclear translocator transcription factor.
Q36384825Lack of an association human dioxin detoxification gene polymorphisms with endometriosis in Japanese women: results of a pilot study
Q39176010Mechanisms and therapeutic prospects of polyphenols as modulators of the aryl hydrocarbon receptor
Q52680458Modulation of aryl hydrocarbon receptor transactivation by carbaryl, a nonconventional ligand.
Q37720028Non‑infective occupational risk factors for hepatocellular carcinoma: A review (Review).
Q51246660PCB126 inhibits the activation of AMPK-CREB signal transduction required for energy sensing in liver.
Q36515889PCB126-Induced Disruption in Gluconeogenesis and Fatty Acid Oxidation Precedes Fatty Liver in Male Rats
Q92310282PROTACs: great opportunities for academia and industry
Q38133593Persistent organic pollutants meet adipose tissue hypoxia: does cross-talk contribute to inflammation during obesity?
Q37788635Possible roles of excess tryptophan metabolites in cancer
Q33867432RNAi-based screening identifies kinases interfering with dioxin-mediated up-regulation of CYP1A1 activity
Q33525222Reengineering natural design by rational design and in vivo library selection: the HLH subdomain in bHLHZ proteins is a unique requirement for DNA-binding function
Q33576459Regulation of aryl hydrocarbon receptor function by selective estrogen receptor modulators
Q34624432Steroid receptor co-activator is required for juvenile hormone signal transduction through a bHLH-PAS transcription factor, methoprene tolerant
Q46430695The DNA target determines the dimerization partner selected by bHLHZ-like hybrid proteins AhRJun and ArntFos.
Q92702982The Molecular Evolution of Circadian Clock Genes in Spotted Gar (Lepisosteus oculatus)
Q47822417Tumor hypoxia and malignant progression.
Q39584939Upregulation of ABCG2 by romidepsin via the aryl hydrocarbon receptor pathway.

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