Genetic variations in the α(2A)-adrenoreceptor are associated with blood pressure response to the agonist dexmedetomidine

scientific article

Genetic variations in the α(2A)-adrenoreceptor are associated with blood pressure response to the agonist dexmedetomidine is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1161/CIRCGENETICS.110.957662
P932PMC publication ID3080459
P698PubMed publication ID21325151

P50authorMordechai MuszkatQ43141188
Mika ScheininQ60732950
Chun LiQ64183498
Alastair S. WoodQ80142712
Daniel KurnikQ85342261
Gbenga G SofoworaQ117270558
P2093author name stringC Michael Stein
Eitan A Friedman
P2860cites workAn asn to lys polymorphism in the third intracellular loop of the human alpha 2A-adrenergic receptor imparts enhanced agonist-promoted Gi couplingQ24290107
Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetesQ24336126
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controlsQ24550675
The effects of increasing plasma concentrations of dexmedetomidine in humansQ28141747
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes riskQ28270700
Genome-wide association study identifies eight loci associated with blood pressureQ29614414
Targeting 160 candidate genes for blood pressure regulation with a genome-wide genotyping arrayQ33475633
Leveraging genetic variability across populations for the identification of causal variants.Q33571814
Effects of variation in the human alpha2A- and alpha2C-adrenoceptor genes on cognitive tasks and pain perception.Q33625202
Two functionally distinct alpha2-adrenergic receptors regulate sympathetic neurotransmissionQ33887636
Haplotype-based analysis of alpha 2A, 2B, and 2C adrenergic receptor genes captures information on common functional loci at each geneQ34375677
Complex haplotypes derived from noncoding polymorphisms of the intronless alpha2A-adrenergic gene diversify receptor expressionQ34600291
Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonistsQ34674600
Alpha2-adrenoceptor subtypes--unexpected functions for receptors and ligands derived from gene-targeted mouse models.Q36896725
Beta-1-adrenoceptor genetic variants and ethnicity independently affect response to beta-blockade.Q37375138
Abnormal regulation of the sympathetic nervous system in alpha2A-adrenergic receptor knockout mice.Q41675919
Alpha 2-adrenergic receptor gene polymorphism and hypertension in blacksQ41676928
The effect of common polymorphisms of the beta2-adrenergic receptor on agonist-mediated vascular desensitizationQ43756517
Simultaneous quantitation of dexmedetomidine and glucuronide metabolites (G-Dex-1 and G-Dex-2) in human plasma utilizing liquid chromatography with tandem mass spectrometric detectionQ44999526
Comparative analgesic and mental effects of increasing plasma concentrations of dexmedetomidine and alfentanil in humansQ45030653
Ethnic and genetic determinants of cardiovascular response to the selective alpha 2-adrenoceptor agonist dexmedetomidineQ46741321
Variations in the alpha2A-adrenergic receptor gene and their functional effects.Q46972798
Sympathoinhibitory function of the alpha(2A)-adrenergic receptor subtypeQ48111063
Effects of low and high plasma concentrations of dexmedetomidine on myocardial perfusion and cardiac function in healthy male subjects.Q53514987
Optimization of high-performance liquid chromatographic assay for catecholamines. Determination of optimal mobile phase composition and elimination of species-dependent differences in extraction recovery of 3,4-dihydroxybenzylamineQ68184917
Association of hypertension with beta2- and alpha2c10-adrenergic receptor genotypeQ71104692
Functional correlates of alpha(2A)-adrenoceptor gene polymorphism in the HANE studyQ73114914
SNP genotyping by the 5'-nuclease reactionQ78689385
Do allelic variants in alpha2A and alpha2C adrenergic receptors predispose to hypertension in blacks?Q83195219
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectdexmedetomidineQ412133
P304page(s)179-187
P577publication date2011-02-15
P1433published inCirculation: Cardiovascular GeneticsQ15816430
P1476titleGenetic variations in the α(2A)-adrenoreceptor are associated with blood pressure response to the agonist dexmedetomidine
P478volume4

Reverse relations

cites work (P2860)
Q41127855ADRA2A Germline Gene Polymorphism is Associated to the Severity, but not to the Risk, of Breast Cancer
Q36004385Alpha2A adrenergic receptor genetic variation contributes to hyperglycemia after myocardial infarction
Q33753508Alpha2A-adrenergic receptor and eNOS genetic polymorphisms are associated with exercise muscle vasodilatation in apparently healthy individuals
Q36408110Evaluation of the association between the ADRA2A genetic polymorphisms and type 2 diabetes in a Chinese Han population
Q33844872Inhibitory G proteins and their receptors: emerging therapeutic targets for obesity and diabetes
Q26994769Interpatient variability in dexmedetomidine response: a survey of the literature
Q92554978Relationship between genetic variation in the α2A-adrenergic receptor and the cardiovascular effects of dexmedetomidine in the Chinese Han population
Q100381629Safety and cardiovascular effects of multiple-dose administration of aripiprazole and olanzapine in a randomised clinical trial
Q37209353Variation in the α(2A) adrenoceptor gene and the effect of dexmedetomidine on plasma insulin and glucose.

Search more.