Mice with AS160/TBC1D4-Thr649Ala knockin mutation are glucose intolerant with reduced insulin sensitivity and altered GLUT4 trafficking.

scientific article

Mice with AS160/TBC1D4-Thr649Ala knockin mutation are glucose intolerant with reduced insulin sensitivity and altered GLUT4 trafficking. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.CMET.2010.12.005
P932PMC publication ID3081066
P698PubMed publication ID21195350
P5875ResearchGate publication ID49718431

P50authorCarol MacKintoshQ41528433
P2093author name stringKei Sakamoto
Shuai Chen
David H Wasserman
P2860cites workIncreased phosphorylation of Akt substrate of 160 kDa (AS160) in rat skeletal muscle in response to insulin or contractile activityQ45199120
GLUT4 vesicle recruitment and fusion are differentially regulated by Rac, AS160, and Rab8A in muscle cellsQ46466470
Insulin promotes glycogen synthesis in the absence of GSK3 phosphorylation in skeletal muscleQ46899920
Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activatorsQ46905896
Considerations in the design of hyperinsulinemic-euglycemic clamps in the conscious mouseQ46917058
Measurement of size and turnover rate of body glucose pool by the isotope dilution methodQ47438874
The Rab GTPase-activating protein AS160 integrates Akt, protein kinase C, and AMP-activated protein kinase signals regulating GLUT4 traffic.Q51800214
AS160 regulates insulin- and contraction-stimulated glucose uptake in mouse skeletal muscle.Q52573139
Substrate specificity and effect on GLUT4 translocation of the Rab GTPase-activating protein Tbc1d1Q24683047
Insulin-regulatable tissues express a unique insulin-sensitive glucose transport proteinQ24706529
Rapid activation of Akt2 is sufficient to stimulate GLUT4 translocation in 3T3-L1 adipocytesQ28275582
Rab10, a target of the AS160 Rab GAP, is required for insulin-stimulated translocation of GLUT4 to the adipocyte plasma membraneQ28507956
Insulin-stimulated cytosol alkalinization facilitates optimal activation of glucose transport in cardiomyocytesQ28570493
Cell surface labeling of glucose transporter isoform GLUT4 by bis-mannose photolabel. Correlation with stimulation of glucose transport in rat adipose cells by insulin and phorbol esterQ28573392
Insulin-stimulated phosphorylation of the Rab GTPase-activating protein TBC1D1 regulates GLUT4 translocationQ28591941
Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)Q29615537
Inhibition of GLUT4 translocation by Tbc1d1, a Rab GTPase-activating protein abundant in skeletal muscle, is partially relieved by AMP-activated protein kinase activationQ30439894
Direct quantification of fusion rate reveals a distal role for AS160 in insulin-stimulated fusion of GLUT4 storage vesiclesQ30482233
The GLUT4 codeQ33643340
Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contractionQ33841869
Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocationQ34183649
Characterization of the role of the Rab GTPase-activating protein AS160 in insulin-regulated GLUT4 traffickingQ34449983
TBC1D1 is a candidate for a severe obesity gene and evidence for a gene/gene interaction in obesity predispositionQ34555024
Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 trafficQ34778453
PI 4,5-P2 stimulates glucose transport activity of GLUT4 in the plasma membrane of 3T3-L1 adipocytesQ35055046
Glucose metabolism in vivo in four commonly used inbred mouse strainsQ36756551
Ins (endocytosis) and outs (exocytosis) of GLUT4 traffickingQ36888387
A truncation mutation in TBC1D4 in a family with acanthosis nigricans and postprandial hyperinsulinemia.Q37224233
A common trafficking route for GLUT4 in cardiomyocytes in response to insulin, contraction and energy-status signallingQ37289485
Insulin stimulation of GLUT4 exocytosis, but not its inhibition of endocytosis, is dependent on RabGAP AS160.Q37537923
Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR.Q39252731
Discovery of TBC1D1 as an insulin-, AICAR-, and contraction-stimulated signaling nexus in mouse skeletal muscle.Q39646969
Dissecting multiple steps of GLUT4 trafficking and identifying the sites of insulin action.Q40190336
Kinetics of GLUT4 trafficking in rat and human skeletal muscleQ41995118
14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and traffickingQ42125847
Full intracellular retention of GLUT4 requires AS160 Rab GTPase activating proteinQ42485048
Rab GTPase-activating protein AS160 is a major downstream effector of protein kinase B/Akt signaling in pancreatic beta-cellsQ42524743
A role for 14-3-3 in insulin-stimulated GLUT4 translocation through its interaction with the RabGAP AS160.Q42798386
A method to quantify glucose utilization in vivo in skeletal muscle and white adipose tissue of the anaesthetized rat.Q42849642
P433issue1
P921main subjectpreproinsulinQ7240673
P304page(s)68-79
P577publication date2011-01-01
P1433published inCell MetabolismQ1254684
P1476titleMice with AS160/TBC1D4-Thr649Ala knockin mutation are glucose intolerant with reduced insulin sensitivity and altered GLUT4 trafficking
P478volume13