Molecular genetic analysis of the cytochrome P450-debrisoquine hydroxylase locus and association with cancer susceptibility

scientific article published on November 1, 1992

Molecular genetic analysis of the cytochrome P450-debrisoquine hydroxylase locus and association with cancer susceptibility is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1289/EHP.9298107
P953full work available at URLhttps://europepmc.org/articles/PMC1519624
https://europepmc.org/articles/PMC1519624?pdf=render
P932PMC publication ID1519624
P698PubMed publication ID1486838
P5875ResearchGate publication ID21668559

P2093author name stringN. K. Spurr
C. A. Smith
C. R. Wolf
A. C. Gough
J. E. Moss
P2860cites workPrimer-directed enzymatic amplification of DNA with a thermostable DNA polymeraseQ26778389
15 Genetic analysis of cytochrome P450 systemQ33251404
Two mutant alleles of the human cytochrome P-450db1 gene (P450C2D1) associated with genetically deficient metabolism of debrisoquine and other drugsQ33632924
Characterization of the common genetic defect in humans deficient in debrisoquine metabolismQ34049056
Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture.Q34270623
The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogeneQ35197475
Metabolic factors in cancer susceptibilityQ37804084
Lung cancer and the debrisoquine metabolic phenotypeQ41235407
Genetic predisposition to bladder cancer: ability to hydroxylate debrisoquine and mephenytoin as risk factorsQ41463151
Identification of the primary gene defect at the cytochrome P450 CYP2D locusQ48250898
Polymorphic oxidation of debrisoquine in women with breast cancerQ57586085
Lung cancer risk, occupational exposure, and the debrisoquine metabolic phenotypeQ58047534
Metabolic oxidation phenotypes as markers for susceptibility to lung cancerQ59082319
Absence of hepatic cytochrome P450bufI causes genetically deficient debrisoquine oxidation in manQ70219763
P407language of work or nameEnglishQ1860
P304page(s)107-112
P577publication date1992-11-01
P1433published inEnvironmental Health PerspectivesQ1345904
P1476titleMolecular genetic analysis of the cytochrome P450-debrisoquine hydroxylase locus and association with cancer susceptibility
P478volume98

Reverse relations

cites work (P2860)
Q42133366A simplified assay for the arylamine N-acetyltransferase 2 polymorphism validated by phenotyping with isoniazid
Q34387297An analysis of phenotypic variation in the familial cancer syndrome von Hippel-Lindau disease: evidence for modifier effects
Q42982276Cytochrome P450 2D6 polymorphism is a molecular genetic marker of liver cirrhosis progression
Q38303763DNA haplotype-dependent differences in the amino acid sequence of debrisoquine 4-hydroxylase (CYP2D6): evidence for two major allozymes in extensive metabolisers
Q24679438Genes other than BRCA1 and BRCA2 involved in breast cancer susceptibility
Q36927094Heterogeneity of tumor-induced gene expression changes in the human metabolic network
Q38482554Heterogeneous expression and polymorphic genotype of glutathione S-transferases in human lung
Q37608402Preventive oncology in the postmenopausal woman.
Q63225023The cytochrome P450 2D6 (CYP2D6) gene polymorphism among breast and head and neck cancer patients
Q41570913The molecular epidemiology of lung cancer

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