Activation of Egr-1 in human lung epithelial cells exposed to silica through MAPKs signaling pathways

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Activation of Egr-1 in human lung epithelial cells exposed to silica through MAPKs signaling pathways is …
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scholarly articleQ13442814

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P819ADS bibcode2013PLoSO...868943C
P356DOI10.1371/JOURNAL.PONE.0068943
P932PMC publication ID3715534
P698PubMed publication ID23874821
P5875ResearchGate publication ID250926332

P2093author name stringTiansheng Wang
Yonghong Gu
Haiying Jiang
Yongbin Hu
Ling Chu
Zanshan Su
P2860cites workPositive regulation of the Egr-1/osteopontin positive feedback loop in rat vascular smooth muscle cells by TGF-beta, ERK, JNK, and p38 MAPK signaling.Q51558541
Egr-1-induced endothelial gene expression: a common theme in vascular injuryQ70990718
Supernatants from quartz dust treated human macrophages stimulate cell proliferation of different human lung cells as well as collagen-synthesis of human diploid lung fibroblasts in vitroQ77574315
Early growth response protein 1 upregulation and nuclear translocation by 2'-benzoyloxycinnamaldehyde induces prostate cancer cell deathQ39239641
Uptake of silica and carbon nanotubes by human macrophages/monocytes induces activation of fibroblasts in vitro -- potential implication for pathogenesis of inflammation and fibrotic diseasesQ39261174
LPA-induced suppression of periostin in human osteosarcoma cells is mediated by the LPA(1)/Egr-1 axisQ39338040
DOCA and TGF-beta induce early growth response gene-1 (Egr-1) expression.Q39904452
Stimulation of macrophage TNFalpha production by orthopaedic wear particles requires activation of the ERK1/2/Egr-1 and NF-kappaB pathways but is independent of p38 and JNK.Q39957832
MAPK pathway mediates EGR-1-HSP70-dependent cigarette smoke-induced chemokine productionQ40134262
Early growth response protein 1 (Egr-1): prototype of a zinc-finger family of transcription factors.Q40527459
Lipopolysaccharide induction of the tumor necrosis factor-alpha promoter in human monocytic cells. Regulation by Egr-1, c-Jun, and NF-kappaB transcription factorsQ41099730
Effect of exposure to silica on human alveolar macrophages in supporting growth activity in type II epithelial cellsQ41206982
Suppression of growth and transformation and induction of apoptosis by EGR-1.Q41708919
Expression of Egr-1 in late stage emphysemaQ41839426
Cigarette smoke-induced Egr-1 upregulates proinflammatory cytokines in pulmonary epithelial cells.Q42053422
Expression of high-mobility groups box-1/receptor for advanced glycation end products/osteopontin/early growth response-1 pathway in proliferative vitreoretinal epiretinal membranes.Q42619210
Angiotensin II induction of PDGF-C expression is mediated by AT1 receptor-dependent Egr-1 transactivation.Q43161089
Hemin upregulates Egr-1 expression in vascular smooth muscle cells via reactive oxygen species ERK-1/2-Elk-1 and NF-kappaB.Q46925619
Role of early growth response-1 (Egr-1) in interleukin-13-induced inflammation and remodelingQ50232244
Mechanisms in the Pathogenesis of Asbestosis and SilicosisQ22299314
Changes in alveolar lavage materials and lung microsomal xenobiotic metabolism following exposures to HCl-washed or unwashed crystalline silicaQ23919073
Pathways of Egr-1-mediated gene transcription in vascular biologyQ24671655
Altered molecular response to adrenoreceptor-induced cardiac hypertrophy in Egr-1-deficient miceQ28372874
An overview of caspase: Apoptotic protein for silicosisQ28384832
A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarizationQ29618351
Evaluation of cytotoxic concentration-time response in A549 cells exposed to respirable alpha-quartzQ33445941
CD4+CD25+Foxp3+ regulatory T cells depletion may attenuate the development of silica-induced lung fibrosis in miceQ33745170
The human transcriptional repressor protein NAB1: expression and biological activityQ33920222
Nerve growth factor induces a gene homologous to the glucocorticoid receptor gene.Q34171602
Hyperglycemia: GDNF-EGR1 pathway target renal epithelial cell migration and apoptosis in diabetic renal embryopathyQ34611546
Cigarette smoke-induced pulmonary inflammatory responses are mediated by EGR-1/GGPPS/MAPK signalingQ34755883
Regulation of life and death by the zinc finger transcription factor Egr-1.Q34972803
Hepatocyte growth factor induces cell scattering through MAPK/Egr-1-mediated upregulation of SnailQ34972866
Early growth response transcription factors: key mediators of fibrosis and novel targets for anti-fibrotic therapyQ35101753
Diurnal regulation of the early growth response 1 (Egr-1) protein expression by hepatocyte nuclear factor 4alpha (HNF4alpha) and small heterodimer partner (SHP) cross-talk in liver fibrosisQ35313620
Lysophosphatidic acid induces early growth response-1 (Egr-1) protein expression via protein kinase Cδ-regulated extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) activation in vascular smooth muscle cellsQ36080532
Transforming growth factor-beta: a key mediator of fibrosisQ36239091
Ethanol-induced liver injury: potential roles for egr-1.Q36339578
Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosisQ36399732
Smad-independent transforming growth factor-beta regulation of early growth response-1 and sustained expression in fibrosis: implications for sclerodermaQ36891532
Early growth response genes regulate B cell development, proliferation, and immune responseQ36992618
Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary diseaseQ37570289
The early-immediate gene EGR-1 is induced by transforming growth factor-beta and mediates stimulation of collagen gene expressionQ38313294
Inhibition of Egr-1 expression reverses transformation of prostate cancer cells in vitro and in vivoQ38353133
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue7
P407language of work or nameEnglishQ1860
P304page(s)e68943
P577publication date2013-07-18
P1433published inPLOS OneQ564954
P1476titleActivation of Egr-1 in human lung epithelial cells exposed to silica through MAPKs signaling pathways
P478volume8

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cites work (P2860)
Q54383842Arecoline stimulated early growth response-1 production in human buccal fibroblasts: suppression by epigallocatechin-3-gallate.
Q38795317DT(270-326) , a Truncated Diphtheria Toxin, Increases Blood-Tumor Barrier Permeability by Upregulating the Expression of Caveolin-1.
Q36078600EGR-1/Bax pathway plays a role in vitamin E δ-tocotrienol-induced apoptosis in pancreatic cancer cells
Q90701287Early Growth Response 1 Deficiency Protects the Host against Pseudomonas aeruginosa Lung Infection
Q40826452Early Growth Response Protein-1 Expression by Insulin-Like Growth Factor-1 Requires ROS-Dependent Activation of ERK1/2 and PKB Pathways in Vascular Smooth Muscle Cells
Q95360262Effects of Estrogen and Estrogen Receptors on Transcriptomes of HepG2 Cells: A Preliminary Study Using RNA Sequencing
Q36690194Epigenetic regulation of diacylglycerol kinase alpha promotes radiation-induced fibrosis
Q48078190Fibroblast growth factor 2 mRNA expression evoked by amitriptyline involves extracellular signal-regulated kinase-dependent early growth response 1 production in rat primary cultured astrocytes
Q40786888IL-33 induces Egr-1-dependent TSLP expression via the MAPK pathways in human keratinocytes
Q28392117Indications for distinct pathogenic mechanisms of asbestos and silica through gene expression profiling of the response of lung epithelial cells
Q36351677Profiling of the silica-induced molecular events in lung epithelial cells using the RNA-Seq approach
Q33675464STAT3 and its phosphorylation are involved in HIV-1 Tat-induced transactivation of glial fibrillary acidic protein
Q92049654Screening of Cellular Stress Responses Induced by Ambient Aerosol Ultrafine Particle Fraction PM0.5 in A549 Cells
Q59794706Targeted migration of bone marrow mesenchymal stem cells inhibits silica-induced pulmonary fibrosis in rats
Q53504176The AKT signaling pathway sustains the osteogenic differentiation in human dental follicle cells.

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