Characteristics of short-chain alcohol dehydrogenases and related enzymes

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Characteristics of short-chain alcohol dehydrogenases and related enzymes is …
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scholarly articleQ13442814

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P356DOI10.1111/J.1432-1033.1991.TB16215.X
P698PubMed publication ID1889416

P50authorBengt PerssonQ38320516
P2093author name stringH Jörnvall
M Krook
P2860cites workComplete amino acid sequence of human placental 17 beta-hydroxysteroid dehydrogenase deduced from cDNA.Q34556123
The complete amino acid sequence of three alcohol dehydrogenase alleloenzymes (AdhN-11, AdhS and AdhUF) from the fruitfly Drosophila melanogasterQ36631836
Secondary-structure prediction from the sequence of Drosophila melanogaster (fruitfly) alcohol dehydrogenaseQ42214443
Ribitol dehydrogenase of Klebsiella aerogenes. Sequence and properties of wild-type and mutant strainsQ42866362
Prokaryotic 20 beta-hydroxysteroid dehydrogenase is an enzyme of the 'short-chain, non-metalloenzyme' alcohol dehydrogenase typeQ45218345
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)537-543
P577publication date1991-09-01
P1433published inFEBS JournalQ1388041
P1476titleCharacteristics of short-chain alcohol dehydrogenases and related enzymes
P478volume200

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cites work (P2860)
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Q46624436Blueberry (Vaccinium ashei Reade) extract ameliorates ovarian damage induced by subchronic cadmium exposure in mice: Potential δ-ALA-D involvement
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Q35967895Characterization and regulation of the NADP-linked 7 alpha-hydroxysteroid dehydrogenase gene from Clostridium sordellii
Q77838112Characterization of a novel cis-benzene dihydrodiol dehydrogenase from Pseudomonas putida ML2
Q24672782Characterization of active recombinant 2,3-dihydro-2,3-dihydroxybiphenyl dehydrogenase from Comamonas testosteroni B-356 and sequence of the encoding gene (bphB)
Q43686038Characterization of hepatic L-threonine dehydrogenase of chicken
Q51540358Characterization of the cinnamoyl-CoA reductase (CCR) gene family in Populus tomentosa reveals the enzymatic active sites and evolution of CCR.
Q28252024Cloning and characterization of the socA locus which restores development to Myxococcus xanthus C-signaling mutants
Q28574097Cloning and expression of the cDNA for rat NAD+-dependent 15-hydroxyprostaglandin dehydrogenase
Q24534167Cloning and production of antisera to human placental 11 beta-hydroxysteroid dehydrogenase type 2
Q28367558Cloning and sequencing of a 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase gene involved in the degradation of gamma-hexachlorocyclohexane in Pseudomonas paucimobilis
Q28307452Cloning and sequencing of a new 15-hydroxyprostaglandin dehydrogenase related mRNA
Q72591695Cloning of a cDNA for liver microsomal retinol dehydrogenase. A tissue-specific, short-chain alcohol dehydrogenase
Q82624757Cloning, expression and characterization of a novel short-chain dehydrogenase/reductase (SDRx) in Comamonas testosteroni
Q47921700Cloning, expression, and molecular characterization of a small pea gene family regulated by low levels of ultraviolet B radiation and other stresses.
Q36855815Cloning, nucleotide sequence and expression of a mannitol dehydrogenase gene from Pseudomonas fluorescens DSM 50106 in Escherichia coli.
Q27732215Common themes in redox chemistry emerge from the X-ray structure of oilseed rape (Brassica napus) enoyl acyl carrier protein reductase
Q33186277Construction and screening of metagenomic libraries derived from enrichment cultures: generation of a gene bank for genes conferring alcohol oxidoreductase activity on Escherichia coli
Q27677286Crystal Structure of Perakine Reductase, Founding Member of a Novel Aldo-Keto Reductase (AKR) Subfamily That Undergoes Unique Conformational Changes during NADPH Binding
Q40589649Crystal structure of AibC, a reductase involved in alternative de novo isovaleryl coenzyme A biosynthesis in Myxococcus xanthus.
Q27643014Crystal structure of a tetrameric GDP-D-mannose 4,6-dehydratase from a bacterial GDP-D-rhamnose biosynthetic pathway
Q36281018Crystal structure of cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase from a PCB degrader at 2.0 A resolution
Q27640003Crystal structure of formaldehyde dehydrogenase from Pseudomonas putida: the structural origin of the tightly bound cofactor in nicotinoprotein dehydrogenases
Q27733290Crystal structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase complexed with 17 beta-estradiol
Q27639087Crystal structure of the alcohol dehydrogenase from the hyperthermophilic archaeon Sulfolobus solfataricus at 1.85 A resolution
Q27733359Crystal structure of the ternary complex of mouse lung carbonyl reductase at 1.8 A resolution: the structural origin of coenzyme specificity in the short-chain dehydrogenase/reductase family
Q41852298Crystallization and preliminary X-ray diffraction studies of an alcohol dehydrogenase from the Antarctic psychrophile Moraxella sp. TAE123.
Q41835477Crystallization, preliminary X-ray diffraction and structure analysis of Thermotoga maritima mannitol dehydrogenase
Q24681799D-arabitol metabolism in Candida albicans: studies of the biosynthetic pathway and the gene that encodes NAD-dependent D-arabitol dehydrogenase
Q33843997DFT-based prediction of reactivity of short-chain alcohol dehydrogenase.
Q40910151Development of daunorubicin resistance in tumour cells by induction of carbonyl reduction
Q52537286Differences in teratogenic and toxic properties of alcohol dehydrogenase inhibitors pyrazole and 4‐methylpyrazole in Drosophila melanogaster: I. ADH allozymes in variable genetic backgrounds
Q40387760Dihydropteridine reductase as an alternative to dihydrofolate reductase for synthesis of tetrahydrofolate in Thermus thermophilus
Q47382748Diversity, taxonomy and evolution of medium-chain dehydrogenase/reductase superfamily
Q38309990Drosophila lebanonensis ADH: analysis of recombinant wild-type enzyme and site-directed mutants. The effect of restoring the consensus sequence in two positions
Q70744267Dual relationships of xylitol and alcohol dehydrogenases in families of two protein types
Q52545867Effect of site-directed mutagenesis on conserved positions of Drosophila alcohol dehydrogenase.
Q42821477Enoyl-acyl-carrier-protein reductase and Mycobacterium tuberculosis InhA do not conserve the Tyr-Xaa-Xaa-Xaa-Lys motif in mammalian 11 β- and 17 β-hydroxysteroid dehydrogenases and Drosophila alcohol dehydrogenase
Q38836633Enzymes useful for chiral compound synthesis: structural biology, directed evolution, and protein engineering for industrial use.
Q36112301Evidence for a common sex determination mechanism for pistil abortion in maize and in its wild relative Tripsacum
Q40743235Evolutionary genetics of the Drosophila alcohol dehydrogenase gene-enzyme system
Q44620280Exploring the Evolutionary History of the Alcohol Dehydrogenase Gene ( Adh ) Duplication in Species of the Family Tephritidae
Q42685392Expression in Escherichia coli and characterization of a bile acid-inducible 3 alpha-hydroxysteroid dehydrogenase from Eubacterium sp. strain VPI 12708.
Q34221083Forms and functions of human SDR enzymes
Q44915751Functional constraints of alcohol dehydrogenase (ADH) of tephritidae and relationships with other Dipteran species
Q28578204Functionally important residues tyrosine-171 and serine-158 in sepiapterin reductase
Q35339121Fundamental molecular differences between alcohol dehydrogenase classes
Q34469235Fundus albipunctatus: review of the literature and report of a novel RDH5 gene mutation affecting the invariant tyrosine (p.Tyr175Phe)
Q44326946Further characterization of Chinese hamster carbonyl reductases (CHCRs).
Q27766039GDP-4-keto-6-deoxy-D-mannose epimerase/reductase from Escherichia coli, a key enzyme in the biosynthesis of GDP-L-fucose, displays the structural characteristics of the RED protein homology superfamily
Q43612086Genetic and biochemical characterization of a short-chain alcohol dehydrogenase from the hyperthermophilic archaeon Pyrococcus furiosus
Q40422416Genetic disorders of steroid hormone synthesis and metabolism
Q48067907Gibberellins regulate the abundance of RNAs with sequence similarity to proteinase inhibitors, dioxygenases and dehydrogenases
Q27634919Glycerol dehydrogenase. structure, specificity, and mechanism of a family III polyol dehydrogenase
Q48914829Hamster sperm protein, p26h: a member of the short-chain dehydrogenase/reductase superfamily
Q27641779Human 20alpha-hydroxysteroid dehydrogenase: crystallographic and site-directed mutagenesis studies lead to the identification of an alternative binding site for C21-steroids
Q71776975Human placental estradiol 17 beta-dehydrogenase: structural and catalytic changes during urea denaturation
Q42680396Identification and sequencing of a cytochrome P450 gene cluster from Bradyrhizobium japonicum
Q28486917Identification of a gene involved in the biosynthesis of cyclopropanated mycolic acids in Mycobacterium tuberculosis
Q74256422Identification of a mechanism to localize generation of retinoic acid in rat embryos
Q42625433Identification of an AfsA homologue (BarX) from Streptomyces virginiae as a pleiotropic regulator controlling autoregulator biosynthesis, virginiamycin biosynthesis and virginiamycin M1 resistance
Q28487366Identification of fur, aconitase, and other proteins expressed by Mycobacterium tuberculosis under conditions of low and high concentrations of iron by combined two-dimensional gel electrophoresis and mass spectrometry
Q52444084Identification of reactive tyrosine residues in cysteine-reactive dehydrogenases. Differences between liver sorbitol, liver alcohol and Drosophila alcohol dehydrogenases.
Q54373587Identification, cloning, heterologous expression, and characterization of a NADPH-dependent 7β-hydroxysteroid dehydrogenase from Collinsella aerofaciens.
Q57161453In silico analysis of class I adenylate-forming enzymes reveals family and group-specific conservations
Q37125188Inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.
Q31085356Insights into the evolution of sorbitol metabolism: phylogenetic analysis of SDR196C family
Q35866225Interaction cloning of NS1-I, a human protein that binds to the nonstructural NS1 proteins of influenza A and B viruses
Q42288774In silico analysis of heme oxygenase structural homologues identifies group-specific conservations
Q48088519Isolation and characterization of a cDNA clone encoding a novel short-chain alcohol dehydrogenase from Norway spruce (Picea abies L. Karst).
Q48040817Isolation and characterization of a novel short chain alcohol dehydrogenase-like isozyme by differential display of distinct smooth muscle cell phenotypes
Q31032562Isolation and expression of a Bacillus cereus gene encoding benzil reductase
Q36859070Isolation of mutants of Acinetobacter calcoaceticus deficient in wax ester synthesis and complementation of one mutation with a gene encoding a fatty acyl coenzyme A reductase
Q36698040Isolation, characterization and expression of the gene that encodes d-arabinitol dehydrogenase in candida tropicalis
Q34395560Lipid biosynthesis as a target for antibacterial agents
Q33474810Maximum-likelihood model averaging to profile clustering of site types across discrete linear sequences
Q27730375Mechanism of inhibition of 3 alpha, 20 beta-hydroxysteroid dehydrogenase by a licorice-derived steroidal inhibitor
Q52442408Mechanisms for dominance: Adh heterodimer formation in heterozygotes between ENU or X-ray induced null alleles and normal alleles in Drosophila melanogaster.
Q24642281Medium- and short-chain dehydrogenase/reductase gene and protein families : the SDR superfamily: functional and structural diversity within a family of metabolic and regulatory enzymes
Q36763121Metabolism of retinol during mammalian placental and embryonic development.
Q73065736Molecular analysis of 11 beta-hydroxysteroid dehydrogenase and its role in the syndrome of apparent mineralocorticoid excess
Q33805097Molecular basis for enantioselectivity in the (R)- and (S)-hydroxypropylthioethanesulfonate dehydrogenases, a unique pair of stereoselective short-chain dehydrogenases/reductases involved in aliphatic epoxide carboxylation
Q24323932Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal
Q40753737Molecular characterization of microbial alcohol dehydrogenases
Q28216677Molecular cloning and characterization of a novel Dehydrogenase/reductase (SDR family) member 1 genea from human fetal brain
Q46349625Molecular cloning and characterization of a tropinone reductase from Dendrobium nobile Lindl.
Q42058924Molecular cloning and characterization of hemolymph 3-dehydroecdysone 3beta-reductase from the cotton leafworm, Spodoptera littoralis. A new member of the third superfamily of oxidoreductases
Q35548145Molecular cloning and characterization of mannitol-1-phosphate dehydrogenase from Vibrio cholerae
Q28512623Molecular cloning and characterization of mouse estradiol 17 beta-dehydrogenase (A-specific), a member of the aldoketoreductase family
Q24303659Molecular cloning of a novel widely expressed human 80 kDa 17 beta-hydroxysteroid dehydrogenase IV
Q45713391Molecular cloning, expression and characterization of tropinone reductase II, an enzyme of the SDR family in Solanum tuberosum (L.).
Q48008397Molecular cloning, overexpression, and characterization of steroid-inducible 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni. A novel member of the short-chain dehydrogenase/reductase superfamily
Q48074558Molecular cloning, sequencing and sequence analysis of the fox-2 gene of Neurospora crassa encoding the multifunctional beta-oxidation protein
Q36065298Monosomy of a specific chromosome determines L-sorbose utilization: a novel regulatory mechanism in Candida albicans
Q42159127Mutation of tyrosine-194 and lysine-198 in the catalytic site of pig 3alpha/beta,20beta-hydroxysteroid dehydrogenase
Q42828562Myxococcus xanthus C-factor, a morphogenetic paracrine signal, is similar to Escherichia coli 3-oxoacyl-[acyl-carrier-protein] reductase and human 17 beta-hydroxysteroid dehydrogenase
Q68229666NADP-dependent 15-hydroxyprostaglandin dehydrogenase is homologous to NAD-dependent 15-hydroxyprostaglandin dehydrogenase and other short-chain alcohol dehydrogenases
Q40999326New 17 beta-hydroxysteroid dehydrogenases. Molecular and cell biology of the type IV porcine and human enzymes
Q43171516Novel insights into mannitol metabolism in the fungal plant pathogen Botrytis cinerea
Q56601346Null mutation in the human 11-cis retinol dehydrogenase gene associated with fundus albipunctatus11The authors have no proprietary interest in any of the materials used in this study
Q33871234Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis
Q42648422Peroxisomal multifunctional enzyme of beta-oxidation metabolizing D-3-hydroxyacyl-CoA esters in rat liver: molecular cloning, expression and characterization
Q27320034Physicochemical characterization of a thermostable alcohol dehydrogenase from Pyrobaculum aerophilum
Q28365779Plasmid-encoded phthalate catabolic pathway in Arthrobacter keyseri 12B
Q37868668Plastid-derived Type II fatty acid biosynthetic enzymes in chromists
Q39494036Poly-3-hydroxybutyrate degradation in Rhizobium (Sinorhizobium) meliloti: isolation and characterization of a gene encoding 3-hydroxybutyrate dehydrogenase.
Q38360617Porcine 80-kDa protein reveals intrinsic 17 beta-hydroxysteroid dehydrogenase, fatty acyl-CoA-hydratase/dehydrogenase, and sterol transfer activities
Q52260817Prediction of membrane protein topology utilizing multiple sequence alignments.
Q52443155Protein engineering of Drosophila alcohol dehydrogenase. The hydroxyl group of Tyr152 is involved in the active site of the enzyme.
Q42834978Protochlorophyllide reductase is homologous to human carbonyl reductase and pig 20 beta-hydroxysteroid dehydrogenase.
Q36051767Purification and characterization of NADP-specific alcohol dehydrogenase and glutamate dehydrogenase from the hyperthermophilic archaeon Thermococcus litoralis
Q35210334Purification and characterization of a novel mannitol dehydrogenase from a newly isolated strain of Candida magnoliae
Q39928353Purification and characterization of an oxygen-labile, NAD-dependent alcohol dehydrogenase from Desulfovibrio gigas
Q70996649Purification and characterization of chlorobenzene cis-dihydrodiol dehydrogenase from Xanthobacter flavus 14p1
Q72269175Purification and characterization of threonine dehydrogenase from Clostridium sticklandii
Q39846440Purification and sequence analysis of a novel NADP(H)-dependent type III alcohol dehydrogenase from Thermococcus strain AN1
Q30868617Rapid mix-quench MALDI-TOF mass spectrometry for analysis of enzymatic systems
Q38124842Recent advances in inhibitors of bacterial fatty acid synthesis type II (FASII) system enzymes as potential antibacterial agents
Q43515755Regulation of the steroid-inducible 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase gene in Comamonas testosteroni
Q36281208Relationships within the aldehyde dehydrogenase extended family
Q41346430Retinoic Acid Synthesis and Degradation
Q46091208Retinoic acid synthesis in mouse embryos during gastrulation and craniofacial development linked to class IV alcohol dehydrogenase gene expression
Q34420138Role of Serine140 in the mode of action of Mycobacterium tuberculosis β-ketoacyl-ACP Reductase (MabA)
Q28513586SRP-35, a newly identified protein of the skeletal muscle sarcoplasmic reticulum, is a retinol dehydrogenase
Q42660209Seabream antiquitin: molecular cloning, tissue distribution, subcellular localization and functional expression.
Q42645735Sequence analysis of an internal 9.72-kb segment from the 30-kb denitrification gene cluster of Pseudomonas stutzeri
Q35624837Stereochemical course of two arene-cis-diol dehydrogenases specifically induced in Pseudomonas putida
Q34537346Stereoisomeric specificity of the retinoid cycle in the vertebrate retina
Q73065750Steroids, fatty acyl-CoA, and sterols are substrates of 80-kDa multifunctional protein
Q27660735Structural Insight into Substrate Differentiation of the Sugar-metabolizing Enzyme Galactitol Dehydrogenase from Rhodobacter sphaeroides D
Q37499064Structural Insights into the Drosophila melanogaster Retinol Dehydrogenase, a Member of the Short-Chain Dehydrogenase/Reductase Family
Q39916644Structural and functional analysis of the nor-1 gene involved in the biosynthesis of aflatoxins by Aspergillus parasiticus
Q35495709Structural and mechanistic characteristics of dihydropteridine reductase: a member of the Tyr-(Xaa)3-Lys-containing family of reductases and dehydrogenases
Q41812445Structural comparisons lead to the definition of a new superfamily of NAD(P)(H)-accepting oxidoreductases: the single-domain reductases/epimerases/dehydrogenases (the 'RED' family).
Q27679828Structure of formaldehyde dehydrogenase fromPseudomonas aeruginosa: the binary complex with the cofactor NAD+
Q27729862Structure of human estrogenic 17β-hydroxysteroid dehydrogenase at 2.20 å resolution
Q50774145Substrate and inhibitor specificities of the thermostable alcohol dehydrogenase allozymes ADH-71k and ADH-FCh.D. of Drosophila melanogaster.
Q39840269Suppression of a signaling defect during Myxococcus xanthus development
Q35630719Testosterone-regulated expression of enzymes involved in steroid and aromatic hydrocarbon catabolism in Comamonas testosteroni
Q27640654The 2.3-A crystal structure of the shikimate 5-dehydrogenase orthologue YdiB from Escherichia coli suggests a novel catalytic environment for an NAD-dependent dehydrogenase
Q36909694The Alcohol Dehydrogenase Gene Family in Melon (Cucumis melo L.): Bioinformatic Analysis and Expression Patterns
Q24620663The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative
Q98163351The alcohol dehydrogenase gene family in sugarcane and its involvement in cold stress regulation
Q33895617The cinnamyl alcohol dehydrogenase gene family in melon (Cucumis melo L.): bioinformatic analysis and expression patterns
Q27666698The crystal structure of SDR-type pyridoxal 4-dehydrogenase of Mesorhizobium loti
Q27933857The enzymes with benzil reductase activity conserved from bacteria to mammals
Q37450698The final step of hygromycin A biosynthesis, oxidation of C-5''-dihydrohygromycin A, is linked to a putative proton gradient-dependent efflux
Q42686986The granaticin biosynthetic gene cluster of Streptomyces violaceoruber Tü22: sequence analysis and expression in a heterologous host
Q28303450The key role of 17 beta-hydroxysteroid dehydrogenases in sex steroid biology
Q27730706The refined three-dimensional structure of 3 alpha,20 beta-hydroxysteroid dehydrogenase and possible roles of the residues conserved in short-chain dehydrogenases
Q28306316The retinal pigment epithelial-specific 11-cis retinol dehydrogenase belongs to the family of short chain alcohol dehydrogenases
Q39845061The rkpGHI and -J genes are involved in capsular polysaccharide production by Rhizobium meliloti.
Q54102489The role of protein surface charge in catalytic activity and chloroplast membrane association of the pea NADPH: protochlorophyllide oxidoreductase (POR) as revealed by alanine scanning mutagenesis.
Q24554257The short-chain alcohol dehydrogenase ABA2 catalyzes the conversion of xanthoxin to abscisic aldehyde
Q40442158The stringent response in Myxococcus xanthus is regulated by SocE and the CsgA C-signaling protein
Q27641869The structure of an alcohol dehydrogenase from the hyperthermophilic archaeon Aeropyrum pernix
Q44760968The type II O-antigenic polysaccharide moiety of Burkholderia pseudomallei lipopolysaccharide is required for serum resistance and virulence
Q28268564Three-dimensional model of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase and relationships to the NADP(+)-dependent enzyme (carbonyl reductase)
Q41973592Topology prediction of membrane proteins
Q36784829Transcriptome exploration of the sex pheromone gland of Lutzomyia longipalpis (Diptera: Psychodidae: Phlebotominae).
Q39492441Transformation of chlorinated benzenes and toluenes by Ralstonia sp. strain PS12 tecA (tetrachlorobenzene dioxygenase) and tecB (chlorobenzene dihydrodiol dehydrogenase) gene products
Q48085501Two highly divergent alcohol dehydrogenases of melon exhibit fruit ripening-specific expression and distinct biochemical characteristics.
Q24564609Two tropinone reductases with different stereospecificities are short-chain dehydrogenases evolved from a common ancestor
Q42844278UDP-glucose dehydrogenase from bovine liver: primary structure and relationship to other dehydrogenases
Q55880012[24] Short-chain dehydrogenases/reductases in retina
Q34318309barS1, a gene for biosynthesis of a gamma-butyrolactone autoregulator, a microbial signaling molecule eliciting antibiotic production in Streptomyces species
Q39857486bdhA-patD operon as a virulence determinant, revealed by a novel large-scale approach for identification of Legionella pneumophila mutants defective for amoeba infection
Q48088575cDNA encoding tropinone reductase-II from Hyoscyamus niger
Q28378923p-Cymene catabolic pathway in Pseudomonas putida F1: cloning and characterization of DNA encoding conversion of p-cymene to p-cumate

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