scholarly article | Q13442814 |
P50 | author | Gang G Wang | Q80521785 |
Deyou Zheng | Q37390105 | ||
P2093 | author name string | Masoud Vedadi | |
Benjamin A Garcia | |||
Fengling Li | |||
Ying Liu | |||
Shichong Liu | |||
Stephen V Frye | |||
Jian Jin | |||
Ling Cai | |||
Samantha G Pattenden | |||
Shira Rockowitz | |||
Anqi Ma | |||
Bowen Xu | |||
David F Allison | |||
Doan M On | |||
Kyle D Konze | |||
Trevor Parton | |||
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NUP98-NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis. | Q46277256 | ||
Ectopic expression of the histone methyltransferase Ezh2 in haematopoietic stem cells causes myeloproliferative disease. | Q50594569 | ||
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EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency | Q24645960 | ||
Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger | Q27655436 | ||
Structure of the Catalytic Domain of EZH2 Reveals Conformational Plasticity in Cofactor and Substrate Binding Sites and Explains Oncogenic Mutations | Q27681082 | ||
Structural Context of Disease-Associated Mutations and Putative Mechanism of Autoinhibition Revealed by X-Ray Crystallographic Analysis of the EZH2-SET Domain | Q27681087 | ||
Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin | Q27851546 | ||
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The Polycomb complex PRC2 supports aberrant self-renewal in a mouse model of MLL-AF9;Nras(G12D) acute myeloid leukemia. | Q33915185 | ||
Polycomb repressor complex 2 regulates HOXA9 and HOXA10, activating ID2 in NK/T-cell lines | Q33951701 | ||
Examining histone posttranslational modification patterns by high-resolution mass spectrometry | Q33978003 | ||
Chromatin immunoprecipitation and microarray-based analysis of protein location | Q34003310 | ||
DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation. | Q34017960 | ||
The role of mutations in epigenetic regulators in myeloid malignancies | Q34033164 | ||
Chromatin proteins and modifications as drug targets | Q34038652 | ||
Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes | Q34080062 | ||
A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells | Q34302726 | ||
Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation | Q34317380 | ||
An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1 | Q34341058 | ||
Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas | Q34397318 | ||
Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells | Q34619655 | ||
Identification of EZH2 and EZH1 small molecule inhibitors with selective impact on diffuse large B cell lymphoma cell growth | Q35030824 | ||
Inhibition of histone methyltransferase EZH2 depletes leukemia stem cell of mixed lineage leukemia fusion leukemia through upregulation of p16. | Q35051547 | ||
Polycomb repressive complex 2 is required for MLL-AF9 leukemia | Q35882496 | ||
Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms | Q36810306 | ||
Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2. | Q36835530 | ||
EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation | Q36926825 | ||
The molecular biology of mixed lineage leukemia | Q37522825 | ||
Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma | Q39021479 | ||
DZNep, inhibitor of S-adenosylhomocysteine hydrolase, down-regulates expression of SETDB1 H3K9me3 HMTase in human lung cancer cells | Q39112529 | ||
P433 | issue | 2 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | leukemia | Q29496 |
P1104 | number of pages | 12 | |
P304 | page(s) | 346-357 | |
P577 | publication date | 2014-11-13 | |
P1433 | published in | Blood | Q885070 |
P1476 | title | Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia | |
P478 | volume | 125 |
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