The synergistic effect of IFN-alpha and IFN-gamma against HSV-2 replication in Vero cells is not interfered by the plant antiviral 1-cinnamoyl-3, 11-dihydroxymeliacarpin

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The synergistic effect of IFN-alpha and IFN-gamma against HSV-2 replication in Vero cells is not interfered by the plant antiviral 1-cinnamoyl-3, 11-dihydroxymeliacarpin is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1186/1743-422X-3-45
P932PMC publication ID1525181
P698PubMed publication ID16772029

P2093author name stringCelia E Coto
Erina Petrera
P2860cites workNF-kappaB activation is responsible for the synergistic effect of herpes simplex virus type 2 infection on interferon-gamma-induced nitric oxide production in macrophagesQ40994333
Treatment with meliacine, a plant derived antiviral, prevents the development of herpetic stromal keratitis in miceQ43428645
An Antiviral Meliacarpin from Leaves of Melia azedarach LQ44413630
Antiherpes virus activities of new 6-19 carbon-bridged steroids and some synthetic precursors.Q44705793
Block of vesicular stomatitis virus endocytic and exocytic pathways by 1-cinnamoyl-3,11-dihydroxymeliacarpin, a tetranortriterpenoid of natural originQ44760556
An antiviral principle present in a purified fraction from Melia azedarach L. leaf aqueous extract restrains herpes simplex virus type 1 propagationQ45119664
Antiviral activity of meliacine on the replication of a thymidine kinase-deficient mutant of Herpes simplex virus type 1 alone and in combination with acyclovirQ45393862
Mathematical analysis demonstrates that interferons-beta and -gamma interact in a multiplicative manner to disrupt herpes simplex virus replicationQ45493060
Interferon (IFN)-alpha/beta, interleukin (IL)-12 and IL-18 coordinately induce production of IFN-gamma during infection with herpes simplex virus type 2.Q45722227
Autocrine secretion of interferon-alpha/beta and tumour necrosis factor-alpha synergistically activates mouse macrophages after infection with herpes simplex virus type 2.Q45774418
Differences in Neurovirulence among Isolates of Herpes Simplex Virus Types 1 and 2 in Mice using Four Routes of InfectionQ45801083
Enhanced inhibition of herpes simplex virus type 1 growth in human corneal fibroblasts by combinations of interferon-alpha and -gammaQ45876703
Nonoxynol-9 protects mice against vaginal transmission of genital herpes infectionsQ70476280
In vitro antiphagocytic effect of Melia azedarach leaf extracts on mouse peritoneal exudate cellsQ72823430
Effect of meliacine, a plant derived antiviral, on tumor necrosis factor alphaQ73104605
In vitro and in vivo activities of Melia azedarach L. aqueous leaf extracts on murine lymphocytesQ85571937
Antiviral actions of interferonsQ24550676
Synergistic inhibition of human cytomegalovirus replication by interferon-alpha/beta and interferon-gammaQ24802610
Anti-herpesvirus activity of the acyclic nucleoside 9-(1,3-dihydroxy-2-propoxymethyl)guanineQ28366255
Cellular responses to interferon-gammaQ29618567
Therapeutic action of meliacine, a plant-derived antiviral, on HSV-induced ocular disease in miceQ31114491
The second-site mutation in the herpes simplex virus recombinants lacking the gamma134.5 genes precludes shutoff of protein synthesis by blocking the phosphorylation of eIF-2alphaQ33783719
Evidence that herpes simplex virus VP16 is required for viral egress downstream of the initial envelopment eventQ33807388
Alpha and gamma interferons inhibit herpes simplex virus type 1 infection and spread in epidermal cells after axonal transmissionQ33850188
Beta interferon and gamma interferon synergize to block viral DNA and virion synthesis in herpes simplex virus-infected cells.Q34350245
Alpha/Beta interferon and gamma interferon synergize to inhibit the replication of herpes simplex virus type 1.Q34356255
Specific phenotypic restoration of an attenuated virus by knockout of a host resistance geneQ35760833
HSV.com: maneuvering the internetworks of viral neuropathogenesis and evasion of the host defenseQ36100226
Interferons regulate the phenotype of wild-type and mutant herpes simplex viruses in vivoQ36367805
Inhibition of different Lassa virus strains by alpha and gamma interferons and comparison with a less pathogenic arenavirusQ36509774
Interplay between alpha/beta and gamma interferons with B, T, and natural killer cells in the defense against herpes simplex virus type 1.Q37093565
Effect of Immunization on Acute and Latent Infections of Vaginouterine Tissue with Herpes Simplex Virus Types 1 and 2Q40066760
Role of the protein kinase PKR in the inhibition of varicella-zoster virus replication by beta interferon and gamma interferon.Q40479815
Interferon-beta and interferon-gamma synergistically inhibit the replication of severe acute respiratory syndrome-associated coronavirus (SARS-CoV).Q40505474
The immediate-early protein, ICP0, is essential for the resistance of herpes simplex virus to interferon-alpha/betaQ40745643
Herpes simplex virus type 2 induces secretion of IL-12 by macrophages through a mechanism involving NF-kappaB.Q40841212
P921main subjectHuman herpesvirus 2Q18965147
P304page(s)45
P577publication date2006-06-13
P1433published inVirology JournalQ7934868
P1476titleThe synergistic effect of IFN-alpha and IFN-gamma against HSV-2 replication in Vero cells is not interfered by the plant antiviral 1-cinnamoyl-3, 11-dihydroxymeliacarpin
P478volume3

Reverse relations

cites work (P2860)
Q26852421Cytokine synergy: an underappreciated contributor to innate anti-viral immunity
Q43433965Effect of the potent antiviral 1-cinnamoyl-3,11-dihydroxymeliacarpin on cytokine production by murine macrophages stimulated with HSV-2.
Q91643940IFNα and IFNγ Impede Marek's Disease Progression
Q43215263The addition of tumor necrosis factor plus beta interferon induces a novel synergistic antiviral state against poxviruses in primary human fibroblasts
Q37205363Tumor necrosis factor and interferon: cytokines in harmony

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