The effects of the selective 5-HT(2C) receptor antagonist SB 242084 on learned helplessness in male Fischer 344 rats

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The effects of the selective 5-HT(2C) receptor antagonist SB 242084 on learned helplessness in male Fischer 344 rats is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1038499177
P356DOI10.1007/S00213-008-1413-3
P698PubMed publication ID19037632

P50authorMonika FleshnerQ38590235
P2093author name stringBenjamin N Greenwood
Paul V Strong
P2860cites workAcute selective serotonin reuptake inhibitors increase conditioned fear expression: blockade with a 5-HT(2C) receptor antagonistQ24684698
5-HT2 receptor activation in the midbrain periaqueductal grey (PAG) reduces anxiety-like behaviour in miceQ28253222
Anxiogenic-like effects of mCPP and TFMPP in animal models are opposed by 5-HT1C receptor antagonistsQ28278816
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Influence of the 5-HT2C receptor antagonist, SB-242084, in tests of anxietyQ34117794
5-HT1c receptor is a prominent serotonin receptor subtype in the central nervous systemQ34302096
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SB 242084, a selective and brain penetrant 5-HT2C receptor antagonistQ34432766
CP-809,101, a selective 5-HT2C agonist, shows activity in animal models of antipsychotic activityQ34562888
Antidepressant-like effects of the novel, selective, 5-HT2C receptor agonist WAY-163909 in rodentsQ34575450
5-Hydroxytryptamine2C receptor contribution to m-chlorophenylpiperazine and N-methyl-beta-carboline-3-carboxamide-induced anxiety-like behavior and limbic brain activationQ34653174
Exercise, learned helplessness, and the stress-resistant brainQ34755419
Anxiety-like behaviors produced by acute fluoxetine administration in male Fischer 344 rats are prevented by prior exerciseQ35167108
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Behavioral control, the medial prefrontal cortex, and resilienceQ35236897
Learned helplessness is independent of levels of brain-derived neurotrophic factor in the hippocampusQ35741506
Serotonin, the periaqueductal gray and panicQ35822444
Stressor controllability and learned helplessness: the roles of the dorsal raphe nucleus, serotonin, and corticotropin-releasing factorQ36127587
Previous experience with behavioral control over stress blocks the behavioral and dorsal raphe nucleus activating effects of later uncontrollable stress: role of the ventral medial prefrontal cortex.Q39271534
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Role of the amygdala and periaqueductal gray in anxiety and panicQ40729187
Immunohistochemical localisation of the 5-HT2C receptor protein in the rat CNS.Q40901462
Role of 5-HT in stress, anxiety, and depression.Q41052750
6-Chloro-5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]- indoline (SB-242084): the first selective and brain penetrant 5-HT2C receptor antagonistQ41081403
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Freewheel running prevents learned helplessness/behavioral depression: role of dorsal raphe serotonergic neurons.Q42439467
Anxiogenic-like effects of mCPP microinfusions into the amygdala (but not dorsal or ventral hippocampus) in mice exposed to elevated plus-maze.Q42608283
Anxiolytic properties of the selective, non-peptidergic CRF(1) antagonists, CP154,526 and DMP695: a comparison to other classes of anxiolytic agentQ43737575
Role of fear in mediating shuttle escape learning deficit produced by inescapable shockQ43804783
Serotonin 5- HT (2C) receptor knockout mice: autoradiographic analysis of multiple serotonin receptorsQ43831286
Anxiety-like effects induced by acute fluoxetine, sertraline or m-CPP treatment are reversed by pretreatment with the 5-HT2C receptor antagonist SB-242084 but not the 5-HT1A receptor antagonist WAY-100635.Q43863844
5-HT2C receptor mediation of unconditioned escape behaviour in the unstable elevated exposed plus mazeQ44196920
Brain region-specific alterations of 5-HT2A and 5-HT2C receptors in serotonin transporter knockout miceQ44339812
Serotonin 2C receptors within the basolateral amygdala induce acute fear-like responses in an open-field environmentQ44671980
Effect of number of tailshocks on learned helplessness and activation of serotonergic and noradrenergic neurons in the rat.Q46507484
Serotonergic systems associated with arousal and vigilance behaviors following administration of anxiogenic drugs.Q46510078
Activation of the serotonin 5-HT2C receptor is involved in the enhanced anxiety in rats after single-prolonged stressQ46859474
Distribution of the serotonin 5-HT2 receptor family mRNAs: comparison between 5-HT2A and 5-HT2C receptorsQ48149092
Chlordiazepoxide microinjected into the region of the dorsal raphe nucleus eliminates the interference with escape responding produced by inescapable shock whether administered before inescapable shock or escape testingQ48179075
Activation of serotonin-immunoreactive cells in the dorsal raphe nucleus in rats exposed to an uncontrollable stressorQ48228048
The role of the amygdala and dorsal raphe nucleus in mediating the behavioral consequences of inescapable shockQ48308817
5-HT2 receptor mechanisms of the dorsal periaqueductal gray in the conditioned and unconditioned fear in rats.Q48318130
Anxiolytic activity of a novel potent serotonin 5-HT2C receptor antagonist FR260010: a comparison with diazepam and buspironeQ48383010
Effects of acute and subchronic treatments with fluoxetine and desipramine on the memory of fear in moderate and high-intensity contextual conditioningQ48475382
Exposure to inescapable but not escapable shock increases extracellular levels of 5-HT in the dorsal raphe nucleus of the rat.Q48482061
The effects of chronic treadmill and wheel running on behavior in ratsQ48529334
Distribution of the 5-hydroxytryptamine2C receptor protein in adult rat brain and spinal cord determined using a receptor-directed antibody: effect of 5,7-dihydroxytryptamineQ48632854
Neuroanatomical targets of anxiogenic drugs in the hindbrain as revealed by Fos immunocytochemistry.Q51079466
mCPP-induced anxiety in the light-dark box in rats--a new method for screening anxiolytic activity.Q51098050
The dorsal raphe nucleus is a site of action mediating the behavioral effects of the benzodiazepine receptor inverse agonist DMCM.Q51122690
8-OH-DPAT microinjected in the region of the dorsal raphe nucleus blocks and reverses the enhancement of fear conditioning and interference with escape produced by exposure to inescapable shock.Q51124130
Exposure to the stressor environment prevents the temporal dissipation of behavioral depression/learned helplessness.Q52135989
Librium prevents the analgesia and shuttlebox escape deficit typically observed following inescapable shock.Q52271807
Comparative localization of serotonin1A, 1C, and2 receptor subtype mRNAs in rat brainQ60681181
P433issue4
P921main subjectlearned helplessnessQ618018
P1104number of pages11
P304page(s)665-675
P577publication date2008-11-27
P1433published inPsychopharmacologyQ1422802
P1476titleThe effects of the selective 5-HT(2C) receptor antagonist SB 242084 on learned helplessness in male Fischer 344 rats
P478volume203

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