| scholarly article | Q13442814 |
| P50 | author | Sarah-maria Fendt | Q42815646 |
| Sophia Y Lunt | Q57243133 | ||
| Scott Manalis | Q58783901 | ||
| William J Israelsen | Q64517228 | ||
| Gregory Stephanopoulos | Q88097878 | ||
| Eran R Andrechek | Q37369665 | ||
| P2093 | author name string | Michael B Yaffe | |
| Matthew G Vander Heiden | |||
| Gary Bellinger | |||
| Talya L Dayton | |||
| Stefan Christen | |||
| Ilaria Elia | |||
| Vinayak Muralidhar | |||
| Dan Y Gui | |||
| Daniel P Hollern | |||
| Aaron M Hosios | |||
| Vivian Hecht | |||
| Kali Xu | |||
| Anh T Dinh | |||
| Lauren Newhouse | |||
| Martin Ogrodzinski | |||
| Paula N Marín Acevedo | |||
| P2860 | cites work | Hallmarks of Cancer: The Next Generation | Q22252312 |
| Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1 | Q24304533 | ||
| SAICAR induces protein kinase activity of PKM2 that is necessary for sustained proliferative signaling of cancer cells | Q24338861 | ||
| A biomarker that identifies senescent human cells in culture and in aging skin in vivo | Q24562644 | ||
| Pyruvate kinase M2 is a phosphotyrosine-binding protein | Q27650067 | ||
| Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis | Q27671695 | ||
| Serine is a natural ligand and allosteric activator of pyruvate kinase M2 | Q27674495 | ||
| Regulation of cancer cell metabolism | Q28303890 | ||
| Intracellular water exchange for measuring the dry mass, water mass and changes in chemical composition of living cells | Q28534481 | ||
| The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth | Q29547680 | ||
| Aerobic glycolysis: meeting the metabolic requirements of cell proliferation | Q29615178 | ||
| Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia | Q29616650 | ||
| A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry | Q29617253 | ||
| Otto Warburg's contributions to current concepts of cancer metabolism | Q29617601 | ||
| Metabolic reprogramming: a cancer hallmark even warburg did not anticipate | Q29617612 | ||
| Coordination of growth with cell division in the yeast Saccharomyces cerevisiae | Q29619674 | ||
| Regulation of pyruvate kinase M gene expression | Q33541536 | ||
| The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism | Q33726100 | ||
| Expression of pyruvate kinase M2 in preneoplastic hepatic foci of N-nitrosomorpholine-treated rats | Q33857650 | ||
| Antifolate-induced depletion of intracellular glycine and purines inhibits thymineless death in E. coli | Q34154105 | ||
| The M1- and M2-type isozymes of rat pyruvate kinase are produced from the same gene by alternative RNA splicing | Q34162536 | ||
| The fusion of myoblasts | Q39821959 | ||
| Turnover Rates of Hexokinase I, Phosphofructokinase, Pyruvate Kinase and Creatine Kinase in Slow-Twitch Soleus Muscle and Heart of the Rabbit | Q39893072 | ||
| Guanine nucleotide depletion triggers cell cycle arrest and apoptosis in human neuroblastoma cell lines | Q40601158 | ||
| Enhancement of the therapeutic effectiveness of methotrexate and protection of normal proliferating tissues with purines and pyrimidines | Q40653405 | ||
| Elementary metabolite units (EMU): a novel framework for modeling isotopic distributions | Q41374953 | ||
| Allosteric regulation of PKM2 allows cellular adaptation to different physiological states | Q43423481 | ||
| Drosophila S6 kinase: a regulator of cell size | Q47072437 | ||
| Logic of the yeast metabolic cycle: temporal compartmentalization of cellular processes. | Q47701307 | ||
| The L- and R-type isozymes of rat pyruvate kinase are produced from a single gene by use of different promoters | Q48336855 | ||
| An elementary metabolite unit (EMU) based method of isotopically nonstationary flux analysis. | Q50919450 | ||
| Weighing of biomolecules, single cells and single nanoparticles in fluid. | Q51017766 | ||
| Dynamics of DNA replication in mammalian somatic cells: nucleotide pool modulates origin choice and interorigin spacing. | Q51834619 | ||
| Pyruvate kinase isoenzyme shift from L-type to M2-type is a late event in hepatocarcinogenesis induced in rats by a choline-deficient/DL-ethionine-supplemented diet. | Q53437107 | ||
| Factors determining cell sensitivity to methotrexate: Studies of folate and deoxyribonucleoside triphosphate pools in five mammalian cell lines | Q53717539 | ||
| The mechanism of action of methotrexate in cultured L5178Y leukemia cells | Q66841187 | ||
| Consequences of methotrexate inhibition of purine biosynthesis in L5178Y cells | Q66842794 | ||
| Immunohistological demonstration of pyruvate kinase isoenzyme type L in rat with monoclonal antibodies | Q67534988 | ||
| Pyruvate kinase isozymes from rat | Q70548195 | ||
| Purine and pyrimidine metabolism in human T lymphocytes. Regulation of deoxyribonucleotide metabolism | Q70995783 | ||
| Alteration of isozyme gene expression during cell differentiation and oncogenesis | Q71850344 | ||
| Cellular senescence in the pathogenesis of benign prostatic hyperplasia | Q73135522 | ||
| Effects of guanine nucleotide depletion on cell cycle progression in human T lymphocytes | Q74412879 | ||
| Cytochemical detection of a senescence-associated beta-galactosidase in endothelial and smooth muscle cells from human and rabbit blood vessels | Q74690451 | ||
| A quick and simple method for the quantitation of lactate dehydrogenase release in measurements of cellular cytotoxicity and tumor necrosis factor (TNF) activity | Q34169361 | ||
| Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth. | Q34195003 | ||
| Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses | Q34230044 | ||
| The essence of senescence | Q34288983 | ||
| PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells. | Q34377342 | ||
| Dihydrofolate reductase inhibitors as antibacterial agents | Q34477235 | ||
| The molecular basis of mutations induced by deoxyribonucleoside triphosphate pool imbalances in mammalian cells | Q34498295 | ||
| Recent advances in classical and non-classical antifolates as antitumor and antiopportunistic infection agents: part I. | Q34693482 | ||
| Cellular senescence: putting the paradoxes in perspective | Q34777425 | ||
| Regulation of G1 Cell Cycle Progression: Distinguishing the Restriction Point from a Nutrient-Sensing Cell Growth Checkpoint(s) | Q34972742 | ||
| Conversion of 3T3 fibroblasts into adipose cells: triggering of differentiation by prostaglandin F2alpha and 1-methyl-3-isobutyl xanthine | Q35042812 | ||
| Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation | Q35607137 | ||
| Myoblast fusion: lessons from flies and mice | Q35691569 | ||
| Pyrimidine homeostasis is accomplished by directed overflow metabolism | Q35751186 | ||
| Nutrient regulation of cell cycle progression | Q35799906 | ||
| Guanine ribonucleotide depletion inhibits T cell activation. Mechanism of action of the immunosuppressive drug mizoribine | Q35819812 | ||
| Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase | Q35822985 | ||
| PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis | Q36199783 | ||
| ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect | Q36437994 | ||
| SAICAR stimulates pyruvate kinase isoform M2 and promotes cancer cell survival in glucose-limited conditions | Q36480143 | ||
| Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids | Q36895786 | ||
| Nucleotide deficiency promotes genomic instability in early stages of cancer development | Q37087191 | ||
| Unbiased metabolite profiling indicates that a diminished thymidine pool is the underlying mechanism of colon cancer chemoprevention by alpha-difluoromethylornithine | Q37164803 | ||
| PKM2 regulates chromosome segregation and mitosis progression of tumor cells. | Q37638990 | ||
| Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells | Q37692621 | ||
| How to become immortal: let MEFs count the ways | Q37727739 | ||
| Protein and nucleotide biosynthesis are coupled by a single rate-limiting enzyme, PRPS2, to drive cancer | Q38992372 | ||
| Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells. | Q39117748 | ||
| Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism. | Q39149779 | ||
| Suppression of nucleotide metabolism underlies the establishment and maintenance of oncogene-induced senescence | Q39170489 | ||
| Alanine inhibition of pyruvate kinase in gliomas and meningiomas. A diagnostic tool in surgery for gliomas? | Q39450213 | ||
| Interactions between deoxyribonucleotide and DNA synthesis | Q39532113 | ||
| Global assessment of protein turnover in recombinant antibody producing myeloma cells. | Q39694320 | ||
| P4510 | describes a project that uses | ImageJ | Q1659584 |
| P433 | issue | 1 | |
| P304 | page(s) | 95-107 | |
| P577 | publication date | 2014-12-04 | |
| P1433 | published in | Molecular Cell | Q3319468 |
| P1476 | title | Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation | |
| P478 | volume | 57 |
| Q27003299 | A roadmap for interpreting (13)C metabolite labeling patterns from cells |
| Q95930009 | ATP synthase c-subunit ring as the channel of mitochondrial permeability transition: Regulator of metabolism in development and degeneration |
| Q26829985 | Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes |
| Q38961789 | Altered metabolite levels in cancer: implications for tumour biology and cancer therapy. |
| Q42651807 | An engineered photoswitchable mammalian pyruvate kinase |
| Q92586137 | Analysing central metabolism in ultra-high resolution: At the crossroads of carbon and nitrogen |
| Q36583289 | Biophysical changes reduce energetic demand in growth factor-deprived lymphocytes. |
| Q64899590 | Cancer Cells Tune the Signaling Pathways to Empower de Novo Synthesis of Nucleotides. |
| Q26770819 | Cancer Metabolism: A Modeling Perspective |
| Q89870061 | Classification of clear cell renal cell carcinoma based on PKM alternative splicing |
| Q89608997 | Crotonylation at serine 46 impairs p53 activity |
| Q92358997 | Cysteine catabolism and the serine biosynthesis pathway support pyruvate production during pyruvate kinase knockdown in pancreatic cancer cells |
| Q36269797 | De novo transcriptome sequencing and analysis of male, pseudo-male and female yellow perch, Perca flavescens. |
| Q47836759 | Deciphering metabolic rewiring in breast cancer subtypes |
| Q26865192 | Defining the metabolome: size, flux, and regulation |
| Q92102948 | Dihydropyrimidinase protects from DNA replication stress caused by cytotoxic metabolites |
| Q42693950 | Dose-Dependent Metabolic Reprogramming and Differential Gene Expression in TCDD-Elicited Hepatic Fibrosis |
| Q47850962 | Dual loss of succinate dehydrogenase (SDH) and complex I activity is necessary to recapitulate the metabolic phenotype of SDH mutant tumors |
| Q38694204 | Emerging Approaches for Targeting Metabolic Vulnerabilities in Malignant Glioma |
| Q47128955 | Exploring Non-Metabolic Functions of Glycolytic Enzymes in Immunity |
| Q35122371 | Famine versus feast: understanding the metabolism of tumors in vivo. |
| Q35548351 | Fatty acid carbon is essential for dNTP synthesis in endothelial cells |
| Q58769406 | Fueling the Cycle: CDKs in Carbon and Energy Metabolism |
| Q83231303 | Functional cross-talk between allosteric effects of activating and inhibiting ligands underlies PKM2 regulation |
| Q38680916 | Genetic compensation: A phenomenon in search of mechanisms. |
| Q36891677 | Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma |
| Q46763707 | Glucose Catabolism in Liver Tumors Induced by c-MYC Can Be Sustained by Various PKM1/PKM2 Ratios and Pyruvate Kinase Activities |
| Q52658149 | Glucose Metabolism in Cancer: The Saga of Pyruvate Kinase Continues. |
| Q41887078 | Glutaminase and poly(ADP-ribose) polymerase inhibitors suppress pyrimidine synthesis and VHL-deficient renal cancers |
| Q38742768 | Glyoxalase 2 Is Involved in Human Prostate Cancer Progression as Part of a Mechanism Driven By PTEN/PI3K/AKT/mTOR Signaling With Involvement of PKM2 and ERα. |
| Q52590030 | HIF1 mediates a switch in pyruvate kinase isoforms after myocardial infarction. |
| Q89506754 | Hidden features: exploring the non-canonical functions of metabolic enzymes |
| Q42353414 | Histone modification as a reflection of metabolism |
| Q37511801 | Homocysteine Activates B Cells via Regulating PKM2-Dependent Metabolic Reprogramming |
| Q58582517 | Hyperactivity of the transcription factor Nrf2 causes metabolic reprogramming in mouse esophagus |
| Q38806898 | In silico gene expression analysis reveals glycolysis and acetate anaplerosis in IDH1 wild-type glioma and lactate and glutamate anaplerosis in IDH1-mutated glioma |
| Q64245246 | LINC01554-Mediated Glucose Metabolism Reprogramming Suppresses Tumorigenicity in Hepatocellular Carcinoma via Downregulating PKM2 Expression and Inhibiting Akt/mTOR Signaling Pathway |
| Q38841449 | Lack of Evidence for PKM2 Protein Kinase Activity |
| Q98665193 | Lactate modulation of immune responses in inflammatory versus tumour microenvironments |
| Q64106807 | Loss of PKM2 in Lgr5 intestinal stem cells promotes colitis-associated colorectal cancer |
| Q57291573 | Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells |
| Q47709977 | Metabolic and Proliferative State of Vascular Adventitial Fibroblasts in Pulmonary Hypertension Is Regulated Through a MicroRNA-124/PTBP1 (Polypyrimidine Tract Binding Protein 1)/Pyruvate Kinase Muscle Axis |
| Q38442728 | Metabolic control of signalling pathways and metabolic auto-regulation |
| Q39983817 | Metabolic control of the cell cycle. |
| Q38600506 | Metabolic interactions in cancer: cellular metabolism at the interface between the microenvironment, the cancer cell phenotype and the epigenetic landscape. |
| Q92198053 | Metabolic modulation regulates cardiac wall morphogenesis in zebrafish |
| Q93072823 | Metabolic regulation of T cell development by Sin1-mTORC2 is mediated by pyruvate kinase M2 |
| Q37131345 | Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation |
| Q28069081 | Metabolic rewiring in melanoma |
| Q53555801 | Moderate DNA damage promotes metabolic flux into PPP via PKM2 Y-105 phosphorylation: a feature that favours cancer cells. |
| Q90390640 | Mst1/2 kinases restrain transformation in a novel transgenic model of Ras driven non-small cell lung cancer |
| Q98471249 | Novel ginsenoside derivative 20(S)-Rh2E2 suppresses tumor growth and metastasis in vivo and in vitro via intervention of cancer cell energy metabolism |
| Q46325763 | Origins of cancer symposium 2016: exploring tumor complexity |
| Q36515067 | PKLR promotes colorectal cancer liver colonization through induction of glutathione synthesis |
| Q47128334 | PKM2 is not required for colon cancer initiated by APC loss. |
| Q58570870 | PKM2 is not required for pancreatic ductal adenocarcinoma |
| Q47421505 | PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis |
| Q94106923 | PKM2 regulates endothelial cell junction dynamics and angiogenesis via ATP production |
| Q38794311 | PKM2 uses control of HuR localization to regulate p27 and cell cycle progression in human glioblastoma cells. |
| Q39011310 | PKM2, cancer metabolism, and the road ahead |
| Q92632027 | Phenotypic selection with an intrabody library reveals an anti-apoptotic function of PKM2 requiring Mitofusin-1 |
| Q54119543 | Preservation of renal function in chronic diabetes by enhancing glomerular glucose metabolism. |
| Q90400064 | Proteomics Analysis Reveals that Warburg Effect along with Modification in Lipid Metabolism Improves In Vitro Embryo Development under Low Oxygen |
| Q44872362 | Pyruvate Kinase Inhibits Proliferation during Postnatal Cerebellar Neurogenesis and Suppresses Medulloblastoma Formation. |
| Q36987470 | Pyruvate Kinase Isoform Switching and Hepatic Metabolic Reprogramming by the Environmental Contaminant 2,3,7,8-Tetrachlorodibenzo-p-Dioxin |
| Q38731939 | Pyruvate and Metabolic Flexibility: Illuminating a Path Toward Selective Cancer Therapies |
| Q38706335 | Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction. |
| Q27005722 | Pyruvate kinase M2 at a glance |
| Q47239224 | Pyruvate kinase M2 phosphorylates H2AX and promotes genomic instability in human tumor cells |
| Q92143115 | Pyruvate kinase variant of fission yeast tunes carbon metabolism, cell regulation, growth and stress resistance |
| Q26798084 | Pyruvate kinase: Function, regulation and role in cancer |
| Q36560029 | RBM4a-regulated splicing cascade modulates the differentiation and metabolic activities of brown adipocytes |
| Q46614710 | Reverse engineering the cancer metabolic network using flux analysis to understand drivers of human disease |
| Q91710984 | Revisiting glucose metabolism in cancer: lessons from a PKM knock-in model |
| Q38800502 | Rh2E2, a novel metabolic suppressor, specifically inhibits energy-based metabolism of tumor cells. |
| Q54978303 | Role of PKM2 in directing the metabolic fate of glucose in cancer: a potential therapeutic target. |
| Q89791401 | Small molecule activation of metabolic enzyme pyruvate kinase muscle isozyme 2, PKM2, circumvents photoreceptor apoptosis |
| Q38847446 | Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells. |
| Q61306968 | The ERK and JNK pathways in the regulation of metabolic reprogramming |
| Q57491556 | The Krebs Cycle Connection: Reciprocal Influence Between Alternative Splicing Programs and Cell Metabolism |
| Q38622978 | The Role of Pyruvate Kinase M2 in Cancer Metabolism |
| Q28385023 | The cellular and compartmental profile of mouse retinal glycolysis, tricarboxylic acid cycle, oxidative phosphorylation, and ~P transferring kinases |
| Q37145927 | The importance of serine metabolism in cancer |
| Q64240133 | The ubiquitin ligase KBTBD8 regulates PKM1 levels via Erk1/2 and Aurora A to ensure oocyte quality |
| Q55386576 | Understanding D-Ribose and Mitochondrial Function. |
| Q39130440 | Understanding the Intersections between Metabolism and Cancer Biology |
| Q33909654 | Xue-fu-Zhu-Yu decoction protects rats against retinal ischemia by downregulation of HIF-1α and VEGF via inhibition of RBP2 and PKM2. |
Search more.