Pre- and post-translational regulation of osteopontin in cancer

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Pre- and post-translational regulation of osteopontin in cancer is …
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review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1041572643
P356DOI10.1007/S12079-011-0130-6
P932PMC publication ID3088790
P698PubMed publication ID21516514
P5875ResearchGate publication ID51073539

P50authorAnn F. ChambersQ37828718
P2093author name stringAlan B Tuck
Jennifer C Mutrie
Pieter H Anborgh
P2860cites workThe Hallmarks of CancerQ221226
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New dual monoclonal ELISA for measuring plasma osteopontin as a biomarker associated with survival in prostate cancer: clinical validation and comparison of multiple ELISAs.Q51749238
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An osteopontin fragment is essential for tumor cell invasion in hepatocellular carcinoma.Q53334223
Proteomics discovery of metalloproteinase substrates in the cellular context by iTRAQ labeling reveals a diverse MMP-2 substrate degradome.Q53579885
Matricellular proteins as modulators of wound healing and the foreign body response.Q53701819
Identification of the Phosphorylated Sites of Metabolically32P-Labeled Osteopontin from Cultured Chicken OsteoblastsQ58487930
Serial Plasma Osteopontin Levels Have Prognostic Value in Metastatic Breast CancerQ62496092
Osteopontin-induced, integrin-dependent migration of human mammary epithelial cells involves activation of the hepatocyte growth factor receptor (Met)Q62496773
Osteopontin expression in a group of lymph node negative breast cancer patientsQ62497180
Osteopontin expression in lung cancerQ62497417
Altered sialylation of osteopontin prevents its receptor-mediated binding on the surface of oncogenically transformed tsB77 cellsQ73343556
Osteopontin and p53 expression are associated with tumor progression in a case of synchronous, bilateral, invasive mammary carcinomasQ73451082
Phosphorylation of osteopontin by Golgi apparatus casein kinaseQ73941062
Osteopontin expression in primary sarcomas of the pulmonary arteryQ77412582
Elevated plasma osteopontin in metastatic breast cancer associated with increased tumor burden and decreased survivalQ77554252
Expression of osteopontin and vascular endothelial growth factor in benign and malignant bone tumorsQ78439155
Enhanced production of osteopontin in multiple myeloma: clinical and pathogenic implicationsQ79129548
Osteopontin upregulation and polymerization by transglutaminase 2 in calcified arteries of Matrix Gla protein-deficient miceQ79451630
Osteopontin in metastatic lesions as a prognostic marker in ovarian cancersQ79548087
Asbestos exposure, pleural mesothelioma, and serum osteopontin levelsQ81344951
Expression of osteopontin and HGF/met in adult soft tissue tumorsQ81419450
The immunohistochemical expression profile of osteopontin in normal human tissues using two site-specific antibodies reveals a wide distribution of positive cells and extensive expression in the central and peripheral nervous systemsQ84590916
Tissue transglutaminase and its substrates in boneQ28573074
The integrin alpha(9)beta(1) binds to a novel recognition sequence (SVVYGLR) in the thrombin-cleaved amino-terminal fragment of osteopontinQ28647119
Osteopontin N-terminal domain contains a cryptic adhesive sequence recognized by alpha9beta1 integrinQ28647308
N-Glycan structures of an osteopontin from human boneQ30840026
An integrated procedure of selective injection, sample stacking and fractionation of phosphopeptides for MALDI MS analysisQ33280052
The RGD domain of human osteopontin promotes tumor growth and metastasis through activation of survival pathwaysQ33540190
Elevated tumor and serum levels of the hypoxia-associated protein osteopontin are associated with prognosis for soft tissue sarcoma patients.Q33551004
Reduction of elevated plasma osteopontin levels with resection of non-small-cell lung cancerQ33710746
RNA aptamer blockade of osteopontin inhibits growth and metastasis of MDA-MB231 breast cancer cellsQ33713013
Plasma osteopontin: associations with survival and metastasis to bone in men with hormone-refractory prostate carcinoma.Q33961207
Tumour-associated carbohydrate antigens in breast cancerQ34048052
Osteopontin: a versatile regulator of inflammation and biomineralizationQ34096200
The functional and clinical roles of osteopontin in cancer and metastasis.Q34119050
Osteopontin identified as lead marker of colon cancer progression, using pooled sample expression profilingQ34121777
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Adhesive properties of osteopontin: regulation by a naturally occurring thrombin-cleavage in close proximity to the GRGDS cell-binding domainQ34442820
The metastasis gene osteopontin: a candidate target for cancer therapyQ34515780
The role of osteopontin in breast cancer: clinical and experimental studiesQ34639848
Osteopontin knockdown suppresses tumorigenicity of human metastatic breast carcinoma, MDA-MB-435Q35046540
Functional heterogeneity of osteopontin isoforms in non-small cell lung cancer.Q35065341
Role of the integrin-binding protein osteopontin in lymphatic metastasis of breast cancerQ35221922
Role of osteopontin in tumour progressionQ35770935
Splice variants as cancer biomarkersQ35826741
Osteopontin expression and distribution in human carcinomas.Q35839272
Down-regulation of osteopontin attenuates breast tumour progression in vivoQ35886642
Posttranslational modifications of bovine osteopontin: identification of twenty-eight phosphorylation and three O-glycosylation sitesQ36278922
Osteopontin expression in normal skin and non-melanoma skin tumorsQ36570295
Osteopontin overexpression in breast cancer: knowledge gained and possible implications for clinical management.Q36920211
Control of osteopontin signaling and function by post-translational phosphorylation and protein foldingQ36957636
Osteopontin: regulation in tumor metastasisQ37020157
Transglutaminase 2 cross-linking of matrix proteins: biological significance and medical applicationsQ37316687
Expression of a prometastatic splice variant of osteopontin, OPNC, in human pancreatic ductal adenocarcinomaQ37421879
Osteopontin: a multifunctional protein at the crossroads of inflammation, atherosclerosis, and vascular calcificationQ37441275
Role of the metastasis-promoting protein osteopontin in the tumour microenvironmentQ37769582
Osteopontin induces multiple changes in gene expression that reflect the six "hallmarks of cancer" in a model of breast cancer progressionQ38327011
Thrombin-cleaved osteopontin regulates hemopoietic stem and progenitor cell functions through interactions with alpha9beta1 and alpha4beta1 integrins.Q38354428
Osteopontin-induced migration of human mammary epithelial cells involves activation of EGF receptor and multiple signal transduction pathwaysQ38357217
Elevated expression of secreted phosphoprotein I (osteopontin, 2ar) as a consequence of neoplastic transformation.Q38728996
Overexpression of osteopontin in hepatocellular carcinoma and its relationships with metastasis, invasion of tumor cellsQ39614988
Down-regulation of osteopontin inhibits metastasis of hepatocellular carcinoma cells via a mechanism involving MMP-2 and uPA.Q39617638
Expression pattern of osteopontin splice variants and its functions on cell apoptosis and invasion in glioma cellsQ39698825
A short-hairpin RNA targeting osteopontin downregulates MMP-2 and MMP-9 expressions in prostate cancer PC-3 cellsQ39731482
Osteopontin splice variants differentially modulate the migratory activity of hepatocellular carcinoma cell linesQ39780008
Lung cancer osteopontin isoforms exhibit angiogenic functional heterogeneity.Q39789110
Clinical significance of the upregulated osteopontin mRNA expression in human colorectal cancerQ39798008
A humanized anti-osteopontin antibody inhibits breast cancer growth and metastasis in vivoQ39810957
Sialyl-Tn vaccine induces antibody-mediated tumour protection in a relevant murine modelQ39852463
Tumorigenic properties of alternative osteopontin isoforms in mesotheliomaQ39872992
Multiple and specific mRNA processing targets for the major human hnRNP proteinsQ39958784
Osteopontin expression profiles predict pathological and clinical outcome in breast cancer.Q40005261
The thrombin inhibitor Argatroban reduces breast cancer malignancy and metastasis via osteopontin-dependent and osteopontin-independent mechanismsQ40032019
Enhanced biological activity of polymeric osteopontinQ40127298
Cell type-specific post-translational modifications of mouse osteopontin are associated with different adhesive propertiesQ40133189
Thrombin-cleaved COOH(-) terminal osteopontin peptide binds with cyclophilin C to CD147 in murine breast cancer cellsQ40136588
Abrogation of the interaction between osteopontin and alphavbeta3 integrin reduces tumor growth of human lung cancer cells in mice.Q40136876
Tissue transglutaminase expression promotes cell attachment, invasion and survival in breast cancer cellsQ40219915
Prognostic significance of osteopontin expression in human prostate cancerQ40343105
Phosphorylated osteopontin promotes migration of human choriocarcinoma cells via a p70 S6 kinase-dependent pathway.Q40461079
Prognostic significance of tissue transglutaminase in drug resistant and metastatic breast cancerQ40483302
Nuclear factor-inducing kinase plays a crucial role in osteopontin-induced MAPK/IkappaBalpha kinase-dependent nuclear factor kappaB-mediated promatrix metalloproteinase-9 activationQ40536966
Differential osteopontin expression in lung cancerQ40784031
Osteopontin induces increased invasiveness and plasminogen activator expression of human mammary epithelial cellsQ40937384
Cloning and characterization of the human osteopontin gene and its promoterQ41437628
Recombinant GST-human osteopontin fusion protein is functional in RGD-dependent cell adhesionQ41490633
Localization of transglutaminase-reactive glutamine residues in bovine osteopontin.Q41770359
Osteopontin is a marker for cancer aggressiveness and patient survivalQ42393441
The carboxyl-terminal fragment of osteopontin suppresses arginine-glycine-asparatic acid-dependent cell adhesionQ42820752
Prognostic significance of the metastasis-associated protein osteopontin in human breast cancer.Q44030350
A novel functional motif of osteopontin for human lymphocyte migration and survivalQ44759478
Osteopontin as a potential biomarker of proliferation and invasiveness for lung cancerQ44832836
Bone sialoprotein II synthesized by cultured osteoblasts contains tyrosine sulfateQ45227229
Osteopontin regulates multiple functions contributing to human colon cancer development and progressionQ45243201
Predicting hepatitis B virus-positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learningQ45728735
Immunohistochemical expression of osteopontin in gastric cancerQ45760104
The clinical significance of serum markers of bone turnover in NSCLC patients: surveillance, management and prognostic implications.Q46011523
Sulphation of secreted phosphoprotein I (SPPI, osteopontin) is associated with mineralized tissue formationQ46274469
Comprehensive identification of post-translational modifications of rat bone osteopontin by mass spectrometryQ46467646
Osteopontin, a substrate for transglutaminase and Factor XIII activityQ46850555
Post-translational modification and proteolytic processing of urinary osteopontinQ46855720
Expression of osteopontin in human glioma. Its correlation with the malignancyQ48076092
Correlation of osteopontin protein expression and pathological stage across a wide variety of tumor histologiesQ48089758
Identification of potential serum biomarkers of glioblastoma: serum osteopontin levels correlate with poor prognosisQ48173788
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)111-122
P577publication date2011-04-26
P1433published inJournal of Cell Communication and SignalingQ26841964
P1476titlePre- and post-translational regulation of osteopontin in cancer
P478volume5

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