review article | Q7318358 |
scholarly article | Q13442814 |
P356 | DOI | 10.2174/0929867023368809 |
P698 | PubMed publication ID | 12369868 |
P2093 | author name string | Boger DL | |
Soenen DR | |||
Gauss CM | |||
Lewy DS | |||
P2860 | cites work | Sultriecin, a new antifungal and antitumor antibiotic from Streptomyces roseiscleroticus. Production, isolation, structure and biological activity | Q34254005 |
Novel antitumor antibiotic phospholine. 1. Production, isolation and characterization. | Q44064560 | ||
Cytostatin, a novel inhibitor of cell adhesion to components of extracellular matrix produced by Streptomyces sp. MJ654-NF4. I. Taxonomy, fermentation, isolation and biological activities | Q48796464 | ||
Novel microbial metabolites of the phoslactomycins family induce production of colony-stimulating factors by bone marrow stromal cells. II. Isolation, physico-chemical properties and structure determination | Q71599514 | ||
Cytostatin, a novel inhibitor of cell adhesion to components of extracellular matrix produced by Streptomyces sp. MJ654-NF4. II. Physico-chemical properties and structure determination | Q72081242 | ||
Studies of new phosphate ester antifungal antibiotics phoslactomycins. II. Structure elucidation of phoslactomycins A to F. | Q78420416 | ||
P433 | issue | 22 | |
P304 | page(s) | 2005-2032 | |
P577 | publication date | 2002-11-01 | |
P1433 | published in | Current Medicinal Chemistry | Q3007710 |
P1476 | title | Fostriecin: chemistry and biology | |
P478 | volume | 9 |
Q37293324 | A critical role for phosphatase haplodeficiency in the selective suppression of deletion 5q MDS by lenalidomide |
Q46832008 | A pH-stability study of phoslactomycin B and analysis of the acid and base degradation products |
Q34611818 | Anticancer agents from the Australian tropical rainforest: Spiroacetals EBC-23, 24, 25, 72, 73, 75 and 76. |
Q57007024 | Biology-Oriented Synthesis of Stereochemically Diverse Natural-Product-Derived Compound Collections by Iterative Allylations on a Solid Support |
Q43193407 | Catalytic asymmetric formation of delta-lactones from unsaturated acyl halides |
Q42714607 | Catalytic, asymmetric reactions of ketenes and ketene enolates. |
Q37196185 | Chemical biology--identification of small molecule modulators of cellular activity by natural product inspired synthesis |
Q38409152 | Coibacins A and B: total synthesis and stereochemical revision |
Q50456709 | Construction of the co-expression plasmids of fostriecin polyketide synthases and heterologous expression in Streptomyces |
Q37874134 | De novo synthesis of natural products via the asymmetric hydration of polyenes |
Q44486148 | Enhancement and selective production of phoslactomycin B, a protein phosphatase IIa inhibitor, through identification and engineering of the corresponding biosynthetic gene cluster |
Q35046849 | Formal synthesis of leustroducsin B via Reformatsky/Claisen condensation of silyl glyoxylates |
Q36446220 | Genetic manipulation of the biosynthetic process leading to phoslactomycins, potent protein phosphatase 2A inhibitors. |
Q24299472 | Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4. |
Q34070349 | Inhibition of protein phosphatase 2A (PP2A) prevents Mcl-1 protein dephosphorylation at the Thr-163/Ser-159 phosphodegron, dramatically reducing expression in Mcl-1-amplified lymphoma cells |
Q34777845 | Inhibition of protein phosphatase 2A radiosensitizes pancreatic cancers by modulating CDC25C/CDK1 and homologous recombination repair |
Q34365755 | Inhibition of protein phosphatase 2A with a small molecule LB100 radiosensitizes nasopharyngeal carcinoma xenografts by inducing mitotic catastrophe and blocking DNA damage repair |
Q38341387 | Modulation by the BK accessory β4 subunit of phosphorylation-dependent changes in excitability of dentate gyrus granule neurons. |
Q39913573 | Norcantharidin analogues: synthesis, anticancer activity and protein phosphatase 1 and 2A inhibition |
Q36954084 | Oxidative impairment of hippocampal long-term potentiation involves activation of protein phosphatase 2A and is prevented by ketone bodies |
Q34504365 | PP2A inhibition overcomes acquired resistance to HER2 targeted therapy |
Q44739424 | Phase I and pharmacokinetic study of fostriecin given as an intravenous bolus daily for five consecutive days |
Q35131775 | Phosphorylation of Chk1 by ATR is antagonized by a Chk1-regulated protein phosphatase 2A circuit |
Q24318289 | Positive regulation of IkappaB kinase signaling by protein serine/threonine phosphatase 2A |
Q34590509 | Protein phosphatase 2A regulates central sensitization in the spinal cord of rats following intradermal injection of capsaicin |
Q34612927 | Protein phosphatases 1 and 2A are both required for long‐term depression and associated dephosphorylation of cAMP response element binding protein in hippocampal area CA1 in vivo |
Q34089484 | Rubratoxin A specifically and potently inhibits protein phosphatase 2A and suppresses cancer metastasis. |
Q36698092 | Small-molecule inhibitors of ser/thr protein phosphatases: specificity, use and common forms of abuse |
Q47888353 | Stereospecific Formation of E- and Z-Disubstituted Double Bonds by Dehydratase Domains from Modules 1 and 2 of the Fostriecin Polyketide Synthase |
Q48323397 | Stereospecific Formation of Z-Trisubstituted Double Bonds by the Successive Action of Ketoreductase and Dehydratase Domains from trans-AT Polyketide Synthases. |
Q27680680 | Structure and Stereospecificity of the Dehydratase Domain from the Terminal Module of the Rifamycin Polyketide Synthase |
Q37397236 | Structure-activity relationship studies of fostriecin, cytostatin, and key analogs, with PP1, PP2A, PP5, and( beta12-beta13)-chimeras (PP1/PP2A and PP5/PP2A), provide further insight into the inhibitory actions of fostriecin family inhibitors |
Q30543238 | Suppression of Ser/Thr phosphatase 4 (PP4C/PPP4C) mimics a novel post-mitotic action of fostriecin, producing mitotic slippage followed by tetraploid cell death |
Q35937999 | Synthesis of cyclic alkenylsiloxanes by semihydrogenation: a stereospecific route to (Z)-alkenyl polyenes. |
Q39058997 | Synthetic Strategies Employed for the Construction of Fostriecin and Related Natural Products |
Q24658001 | Targeting protein serine/threonine phosphatases for drug development |
Q46236467 | The Difference a Single Atom Can Make: Synthesis and Design at the Chemistry-Biology Interface. |
Q37834642 | The phosphoprotein phosphatase family of Ser/Thr phosphatases as principal targets of naturally occurring toxins |
Q34300129 | Total Synthesis and Evaluation of Phostriecin and Key Structural Analogues |
Q34088341 | Total Synthesis of Fostriecin: Via a Regio- and Stereoselective Polyene Hydration, Oxidation, and Hydroboration Sequence |
Q30484031 | Total synthesis and evaluation of cytostatin, its C10-C11 diastereomers, and additional key analogues: impact on PP2A inhibition |
Q51224710 | Total synthesis of phoslactomycin B and its biosynthetic deamino precursor. |
Q33665560 | Total synthesis, assignment of the relative and absolute stereochemistry, and structural reassignment of phostriecin (aka Sultriecin) |
Q35146774 | Viewing serine/threonine protein phosphatases through the eyes of drug designers |
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