Fostriecin: chemistry and biology

scientific article

Fostriecin: chemistry and biology is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.2174/0929867023368809
P698PubMed publication ID12369868

P2093author name stringBoger DL
Soenen DR
Gauss CM
Lewy DS
P2860cites workSultriecin, a new antifungal and antitumor antibiotic from Streptomyces roseiscleroticus. Production, isolation, structure and biological activityQ34254005
Novel antitumor antibiotic phospholine. 1. Production, isolation and characterization.Q44064560
Cytostatin, a novel inhibitor of cell adhesion to components of extracellular matrix produced by Streptomyces sp. MJ654-NF4. I. Taxonomy, fermentation, isolation and biological activitiesQ48796464
Novel microbial metabolites of the phoslactomycins family induce production of colony-stimulating factors by bone marrow stromal cells. II. Isolation, physico-chemical properties and structure determinationQ71599514
Cytostatin, a novel inhibitor of cell adhesion to components of extracellular matrix produced by Streptomyces sp. MJ654-NF4. II. Physico-chemical properties and structure determinationQ72081242
Studies of new phosphate ester antifungal antibiotics phoslactomycins. II. Structure elucidation of phoslactomycins A to F.Q78420416
P433issue22
P304page(s)2005-2032
P577publication date2002-11-01
P1433published inCurrent Medicinal ChemistryQ3007710
P1476titleFostriecin: chemistry and biology
P478volume9

Reverse relations

cites work (P2860)
Q37293324A critical role for phosphatase haplodeficiency in the selective suppression of deletion 5q MDS by lenalidomide
Q46832008A pH-stability study of phoslactomycin B and analysis of the acid and base degradation products
Q34611818Anticancer agents from the Australian tropical rainforest: Spiroacetals EBC-23, 24, 25, 72, 73, 75 and 76.
Q57007024Biology-Oriented Synthesis of Stereochemically Diverse Natural-Product-Derived Compound Collections by Iterative Allylations on a Solid Support
Q43193407Catalytic asymmetric formation of delta-lactones from unsaturated acyl halides
Q42714607Catalytic, asymmetric reactions of ketenes and ketene enolates.
Q37196185Chemical biology--identification of small molecule modulators of cellular activity by natural product inspired synthesis
Q38409152Coibacins A and B: total synthesis and stereochemical revision
Q50456709Construction of the co-expression plasmids of fostriecin polyketide synthases and heterologous expression in Streptomyces
Q37874134De novo synthesis of natural products via the asymmetric hydration of polyenes
Q44486148Enhancement and selective production of phoslactomycin B, a protein phosphatase IIa inhibitor, through identification and engineering of the corresponding biosynthetic gene cluster
Q35046849Formal synthesis of leustroducsin B via Reformatsky/Claisen condensation of silyl glyoxylates
Q36446220Genetic manipulation of the biosynthetic process leading to phoslactomycins, potent protein phosphatase 2A inhibitors.
Q24299472Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4.
Q34070349Inhibition of protein phosphatase 2A (PP2A) prevents Mcl-1 protein dephosphorylation at the Thr-163/Ser-159 phosphodegron, dramatically reducing expression in Mcl-1-amplified lymphoma cells
Q34777845Inhibition of protein phosphatase 2A radiosensitizes pancreatic cancers by modulating CDC25C/CDK1 and homologous recombination repair
Q34365755Inhibition of protein phosphatase 2A with a small molecule LB100 radiosensitizes nasopharyngeal carcinoma xenografts by inducing mitotic catastrophe and blocking DNA damage repair
Q38341387Modulation by the BK accessory β4 subunit of phosphorylation-dependent changes in excitability of dentate gyrus granule neurons.
Q39913573Norcantharidin analogues: synthesis, anticancer activity and protein phosphatase 1 and 2A inhibition
Q36954084Oxidative impairment of hippocampal long-term potentiation involves activation of protein phosphatase 2A and is prevented by ketone bodies
Q34504365PP2A inhibition overcomes acquired resistance to HER2 targeted therapy
Q44739424Phase I and pharmacokinetic study of fostriecin given as an intravenous bolus daily for five consecutive days
Q35131775Phosphorylation of Chk1 by ATR is antagonized by a Chk1-regulated protein phosphatase 2A circuit
Q24318289Positive regulation of IkappaB kinase signaling by protein serine/threonine phosphatase 2A
Q34590509Protein phosphatase 2A regulates central sensitization in the spinal cord of rats following intradermal injection of capsaicin
Q34612927Protein phosphatases 1 and 2A are both required for long‐term depression and associated dephosphorylation of cAMP response element binding protein in hippocampal area CA1 in vivo
Q34089484Rubratoxin A specifically and potently inhibits protein phosphatase 2A and suppresses cancer metastasis.
Q36698092Small-molecule inhibitors of ser/thr protein phosphatases: specificity, use and common forms of abuse
Q47888353Stereospecific Formation of E- and Z-Disubstituted Double Bonds by Dehydratase Domains from Modules 1 and 2 of the Fostriecin Polyketide Synthase
Q48323397Stereospecific Formation of Z-Trisubstituted Double Bonds by the Successive Action of Ketoreductase and Dehydratase Domains from trans-AT Polyketide Synthases.
Q27680680Structure and Stereospecificity of the Dehydratase Domain from the Terminal Module of the Rifamycin Polyketide Synthase
Q37397236Structure-activity relationship studies of fostriecin, cytostatin, and key analogs, with PP1, PP2A, PP5, and( beta12-beta13)-chimeras (PP1/PP2A and PP5/PP2A), provide further insight into the inhibitory actions of fostriecin family inhibitors
Q30543238Suppression of Ser/Thr phosphatase 4 (PP4C/PPP4C) mimics a novel post-mitotic action of fostriecin, producing mitotic slippage followed by tetraploid cell death
Q35937999Synthesis of cyclic alkenylsiloxanes by semihydrogenation: a stereospecific route to (Z)-alkenyl polyenes.
Q39058997Synthetic Strategies Employed for the Construction of Fostriecin and Related Natural Products
Q24658001Targeting protein serine/threonine phosphatases for drug development
Q46236467The Difference a Single Atom Can Make: Synthesis and Design at the Chemistry-Biology Interface.
Q37834642The phosphoprotein phosphatase family of Ser/Thr phosphatases as principal targets of naturally occurring toxins
Q34300129Total Synthesis and Evaluation of Phostriecin and Key Structural Analogues
Q34088341Total Synthesis of Fostriecin: Via a Regio- and Stereoselective Polyene Hydration, Oxidation, and Hydroboration Sequence
Q30484031Total synthesis and evaluation of cytostatin, its C10-C11 diastereomers, and additional key analogues: impact on PP2A inhibition
Q51224710Total synthesis of phoslactomycin B and its biosynthetic deamino precursor.
Q33665560Total synthesis, assignment of the relative and absolute stereochemistry, and structural reassignment of phostriecin (aka Sultriecin)
Q35146774Viewing serine/threonine protein phosphatases through the eyes of drug designers

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