Three checkpoints in lupus development: central tolerance in adaptive immunity, peripheral amplification by innate immunity and end-organ inflammation

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Three checkpoints in lupus development: central tolerance in adaptive immunity, peripheral amplification by innate immunity and end-organ inflammation is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P6179Dimensions Publication ID1017313283
P356DOI10.1038/GENE.2009.6
P698PubMed publication ID19262576
P5875ResearchGate publication ID24178507

P2093author name stringC Mohan
H Kanta
P2860cites workCr2, a candidate gene in the murine Sle1c lupus susceptibility locus, encodes a dysfunctional proteinQ24291950
Dendritic cells and the control of immunityQ27860918
Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosisQ28145757
The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signalingQ28306258
BANK regulates BCR-induced calcium mobilization by promoting tyrosine phosphorylation of IP(3) receptorQ28344730
Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNAQ28507714
Tolerance is dependent on complement C3 fragment iC3b binding to antigen-presenting cellsQ28565650
Type I interferons in host defenseQ29615912
The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responsesQ29616349
Predominant autoantibody production by early human B cell precursorsQ29619656
Disruption of mutually negative regulatory feedback loop between interferon-inducible p202 protein and the E2F family of transcription factors in lupus-prone miceQ33605468
Familial occurrence of systemic vasculitis and rapidly progressive glomerulonephritisQ33701963
Genetic dissection of systemic lupus erythematosusQ33814991
T cell hyperactivity in lupus as a consequence of hyperstimulatory antigen-presenting cellsQ33842929
Genetic dissection of lupus pathogenesis: a recipe for nephrophilic autoantibodiesQ33853007
Genetics of systemic autoimmunity in mouse models of lupusQ34051987
The major murine systemic lupus erythematosus susceptibility locus, Sle1, is a cluster of functionally related genesQ34104677
Delineating the genetic basis of systemic lupus erythematosusQ34376876
A Tlr7 translocation accelerates systemic autoimmunity in murine lupusQ34773105
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Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains.Q35795846
Genetics of human systemic lupus erythematosus: the emerging pictureQ35931590
A ROLE OF POLYMORPHONUCLEAR LEUKOCYTES AND COMPLEMENT IN NEPHROTOXIC NEPHRITISQ36267532
The T cell-B cell interaction via OX40-OX40L is necessary for the T cell-dependent humoral immune responseQ36365985
Genetic dissection of SLE: SLE1 and FAS impact alternate pathways leading to lymphoproliferative autoimmunityQ36370883
A role for Mac-1 (CDIIb/CD18) in immune complex-stimulated neutrophil function in vivo: Mac-1 deficiency abrogates sustained Fcgamma receptor-dependent neutrophil adhesion and complement-dependent proteinuria in acute glomerulonephritisQ36398862
Defective B cell tolerance checkpoints in systemic lupus erythematosusQ36402748
PTPN22: setting thresholds for autoimmunityQ36491114
Intracellular pattern recognition receptors in the host responseQ36528528
Experimental anti-GBM disease as a tool for studying spontaneous lupus nephritisQ36886558
Genetics of clinical expression in SLE.Q37030643
Synovium as a source of increased amino-terminal parathyroid hormone-related protein expression in rheumatoid arthritis. A possible role for locally produced parathyroid hormone-related protein in the pathogenesis of rheumatoid arthritisQ37380147
Autoimmune accelerating genes, lpr and Yaa, in murine systemic lupus erythematosusQ37836360
Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplicationQ38313174
Regulation of B cell tolerance by the lupus susceptibility gene Ly108.Q40267209
A y chromosome associated factor in strain bxsb producing accelerated autoimmunity and lymphoproliferationQ40728079
Production of congenic mouse strains carrying genomic intervals containing SLE-susceptibility genes derived from the SLE-prone NZM2410 strainQ40941667
Nephritogenic autoantibodies in lupus: current concepts and continuing controversiesQ40999659
Effect of the BXSB Y chromosome accelerating gene on autoantibody productionQ41386762
Antibodies to DNA.Q41756806
Familial clustering of end-stage renal disease in blacks with lupus nephritisQ43532820
Mac-1, but not LFA-1, uses intercellular adhesion molecule-1 to mediate slow leukocyte rolling in TNF-alpha-induced inflammationQ44899051
Association of extensive polymorphisms in the SLAM/CD2 gene cluster with murine lupusQ45180946
Familial predisposition to nephropathy in African-Americans with non-insulin-dependent diabetes mellitusQ46604389
The familial risk of end-stage renal disease in African AmericansQ46726027
Kidney disease in the first-degree relatives of African-Americans with hypertensive end-stage renal diseaseQ46789333
The genetics of systemic lupus erythematosus stratified by renal disease: linkage at 10q22.3 (SLEN1), 2q34-35 (SLEN2), and 11p15.6 (SLEN3).Q46919587
The centromeric region of chromosome 7 from MRL mice (Lmb3) is an epistatic modifier of Fas for autoimmune disease expression.Q51024901
Augmentation of NZB autoimmune phenotypes by the Sle1c murine lupus susceptibility interval.Q51760370
Effects of MHC and gender on lupus-like autoimmunity in Nba2 congenic mice.Q51835981
Pivotal role of Stat4 and Stat6 in the pathogenesis of the lupus-like disease in the New Zealand mixed 2328 mice.Q52012264
Mechanisms of peritoneal B-1a cells accumulation induced by murine lupus susceptibility locus Sle2.Q52085933
Uncoupling of immune complex formation and kidney damage in autoimmune glomerulonephritis.Q52529090
Aberrant phenotype and function of myeloid dendritic cells in systemic lupus erythematosus.Q53592228
Acute nephrotoxic serum nephritis in complement knockout mice: relative roles of the classical and alternate pathways in neutrophil recruitment and proteinuria.Q53679155
Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus.Q53718320
Polygenic control of susceptibility to murine systemic lupus erythematosusQ57903408
The Y chromosome from autoimmune BXSB/MpJ mice induces a lupus-like syndrome in (NZW x C57BL/6)F1 male mice, but not in C57BL/6 male miceQ68094972
PD-1: an inhibitory immunoreceptor involved in peripheral toleranceQ73807451
A role for the Cr2 gene in modifying autoantibody production in systemic lupus erythematosusQ74500174
Evidence for an interferon-inducible gene, Ifi202, in the susceptibility to systemic lupusQ74540694
Genetic susceptibility to systemic lupus erythematosusQ74578130
Genetic dissection of systemic lupus erythematosus pathogenesis: evidence for functional expression of Sle3/5 by non-T cellsQ74817353
Accumulation of splenic B1a cells with potent antigen-presenting capability in NZM2410 lupus-prone miceQ77341412
Distinct contribution of Fc receptors and angiotensin II-dependent pathways in anti-GBM glomerulonephritisQ77394400
Epistatic modifiers of autoimmunity in a murine model of lupus nephritisQ78257965
Several genes contribute to the production of autoreactive B and T cells in the murine lupus susceptibility locus Sle1cQ80345175
CD19 hyperexpression augments Sle1-induced humoral autoimmunity but not clinical nephritisQ80974221
Genetic dissection of lupus pathogenesis: Sle3/5 impacts IgH CDR3 sequences, somatic mutations, and receptor editingQ81111426
Increased expression of Ifi202, an IFN-activatable gene, in B6.Nba2 lupus susceptible mice inhibits p53-mediated apoptosisQ83276319
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)390-396
P577publication date2009-03-05
P1433published inGenes and ImmunityQ15745246
P1476titleThree checkpoints in lupus development: central tolerance in adaptive immunity, peripheral amplification by innate immunity and end-organ inflammation
P478volume10

Reverse relations

cites work (P2860)
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Q33877996Type I interferons produced by resident renal cells may promote end-organ disease in autoantibody-mediated glomerulonephritis.
Q35854962Unbiased modifier screen reveals that signal strength determines the regulatory role murine TLR9 plays in autoantibody production

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