Altered cellular dynamics and endosteal location of aged early hematopoietic progenitor cells revealed by time-lapse intravital imaging in long bones

scientific article

Altered cellular dynamics and endosteal location of aged early hematopoietic progenitor cells revealed by time-lapse intravital imaging in long bones is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1182/BLOOD-2008-12-195644
P932PMC publication ID2714205
P698PubMed publication ID19357397
P5875ResearchGate publication ID24267562

P2093author name stringMatthias Gunzer
Anja Köhler
Hartmut Geiger
Vince Schmithorst
Marie-Dominique Filippi
Deidre Daria
Marnie A Ryan
P2860cites workIntegrin ligands at a glanceQ24600618
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Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitorsQ28506397
Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulationQ28585627
SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cellsQ29615006
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Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell nichesQ29617460
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Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertionQ29618089
CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearanceQ29620412
The power of single and multibeam two-photon microscopy for high-resolution and high-speed deep tissue and intravital imagingQ30480017
In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftmentQ30484167
Centrosome misorientation reduces stem cell division during ageingQ30488902
Live-animal tracking of individual haematopoietic stem/progenitor cells in their nicheQ30493093
T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activationQ37233655
Antigen presentation in extracellular matrix: interactions of T cells with dendritic cells are dynamic, short lived, and sequentialQ39549098
Leukemic cells create bone marrow niches that disrupt the behavior of normal hematopoietic progenitor cellsQ39903574
Migration of dendritic cells within 3-D collagen lattices is dependent on tissue origin, state of maturation, and matrix structure and is maintained by proinflammatory cytokines.Q40879924
Changes in integrin expression are associated with altered homing properties of Lin(-/lo)Thy1.1(lo)Sca-1(+)c-kit(+) hematopoietic stem cells following mobilization by cyclophosphamide/granulocyte colony-stimulating factorQ43873789
Localization of Rac2 via the C terminus and aspartic acid 150 specifies superoxide generation, actin polarity and chemotaxis in neutrophils.Q44915718
The alpha4beta1 and alpha5beta1 integrins mediate engraftment of granulocyte-colony-stimulating factor-mobilized human hematopoietic progenitor cellsQ46574561
The neuronal chemokine CX3CL1/fractalkine selectively recruits NK cells that modify experimental autoimmune encephalomyelitis within the central nervous systemQ48554549
Cell-to-cell contact is critical for the survival of hematopoietic progenitor cells on osteoblasts.Q51328919
Stem cells, aging, niche, adhesion and Cdc42: a model for changes in cell-cell interactions and hematopoietic stem cell aging.Q53561950
The Biology of Hematopoietic Stem CellsQ58043095
Dynamic Visualization of Thrombopoiesis Within Bone MarrowQ58450371
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Spatial localization of transplanted hemopoietic stem cells: inferences for the localization of stem cell nichesQ73720271
Analysis of the hematopoietic potential of muscle-derived cells in miceQ74389195
Differential role for very late antigen-5 in mobilization and homing of hematopoietic stem cellsQ79331162
Imaging receptor microdomains on leukocyte subsets in live miceQ79831888
Rho GTPase CDC42 regulates directionality and random movement via distinct MAPK pathways in neutrophilsQ80165067
A spectrum of biophysical interaction modes between T cells and different antigen-presenting cells during priming in 3-D collagen and in vivoQ80345969
Perivascular clusters of dendritic cells provide critical survival signals to B cells in bone marrow nichesQ80799375
Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cellsQ81676385
Homing and engraftment potential of Sca-1(+)lin(-) cells fractionated on the basis of adhesion molecule expression and position in cell cycleQ33180893
Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulationQ33293158
Intravital two-photon microscopy: focus on speed and time resolved imaging modalitiesQ33319889
Cell intrinsic alterations underlie hematopoietic stem cell aging.Q33858894
Regulation of hematopoietic stem cell aging in vivo by a distinct genetic elementQ33935807
Regulation of hematopoiesis through adhesion receptors.Q34191587
Stem cells, aging, and cancer: inevitabilities and outcomesQ34349679
Combinatorial Gata2 and Sca1 expression defines hematopoietic stem cells in the bone marrow nicheQ34479030
Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptorQ34480347
The aging of lympho-hematopoietic stem cellsQ34580295
Tuning immune responses: diversity and adaptation of the immunological synapse.Q34650772
Detection of functional haematopoietic stem cell niche using real-time imaging.Q34893423
Endochondral ossification is required for haematopoietic stem-cell niche formationQ34902854
Imaging of T-cell interactions with antigen presenting cells in culture and in intact lymphoid tissue.Q35005860
The role of stem cells in agingQ35193690
Adult stem cells for tissue repair - a new therapeutic concept?Q35194623
Increased hematopoietic stem cell mobilization in aged miceQ35849168
Senescence and functional failure in hematopoietic stem cellsQ35946173
Hematopoietic stem cells and their niche.Q36175339
The actin cytoskeleton: a key regulator of apoptosis and ageing?Q36216135
Cellular memory and hematopoietic stem cell agingQ36385580
Bone-marrow haematopoietic-stem-cell nichesQ36402226
Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool sizeQ36403763
The hematopoietic stem cell in its placeQ36426799
Telomeres, stem cells, and hematologyQ36445787
The retinoblastoma tumor suppressor is a critical intrinsic regulator for hematopoietic stem and progenitor cells under stressQ36445809
The stem cell niches in boneQ36467113
Integrin-dependent anchoring of a stem-cell nicheQ36487005
Stem cells, ageing and the quest for immortality.Q36523915
Mutual, reciprocal SDF-1/CXCR4 interactions between hematopoietic and bone marrow stromal cells regulate human stem cell migration and development in NOD/SCID chimeric miceQ36545262
Maintaining hematopoietic stem cells in the vascular nicheQ36686619
The molecular makeup and function of regulatory and effector synapsesQ36877341
Analyzing the physicodynamics of immune cells in a three-dimensional collagen matrixQ36944561
Stems cells and the pathways to aging and cancerQ37092874
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)290-298
P577publication date2009-04-08
P1433published inBloodQ885070
P1476titleAltered cellular dynamics and endosteal location of aged early hematopoietic progenitor cells revealed by time-lapse intravital imaging in long bones
P478volume114

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