Differential effects of acute and repeat dosing with the H3 antagonist GSK189254 on the sleep-wake cycle and narcoleptic episodes in Ox-/- mice

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Differential effects of acute and repeat dosing with the H3 antagonist GSK189254 on the sleep-wake cycle and narcoleptic episodes in Ox-/- mice is …
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scholarly articleQ13442814

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P356DOI10.1111/J.1476-5381.2009.00205.X
P8608Fatcat IDrelease_qjkanbglfrbyjnviizauev7tgu
P932PMC publication ID2697793
P698PubMed publication ID19413575
P5875ResearchGate publication ID24399943

P2093author name stringM Zhang
S H Brown
J Q Feng
C Anaclet
R Parmentier
J S Lin
A D Medhurst
N Upton
P Franco
J C Roberts
R X Guo
C Buda
G Guidon
J P Sastre
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Sleep and waking during acute histamine H3 agonist BP 2.94 or H3 antagonist carboperamide (MR 16155) administration in ratsQ71512241
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Acute wake-promoting actions of JNJ-5207852, a novel, diamine-based H3 antagonistQ24671207
Anatomical, physiological, and pharmacological characteristics of histidine decarboxylase knock-out mice: evidence for the role of brain histamine in behavioral and sleep-wake controlQ28219144
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GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's disease brain and improves cognitive performance in preclinical modelsQ28574369
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Keynote review: histamine H3 receptor antagonists reach out for the clinicQ34479438
BF2.649 [1-{3-[3-(4-Chlorophenyl)propoxy]propyl}piperidine, hydrochloride], a nonimidazole inverse agonist/antagonist at the human histamine H3 receptor: Preclinical pharmacologyQ34569432
Neuronal activity of histaminergic tuberomammillary neurons during wake-sleep states in the mouse.Q34571598
Histamine H3 receptor antagonists: from target identification to drug leadsQ34585004
Brain structures and mechanisms involved in the control of cortical activation and wakefulness, with emphasis on the posterior hypothalamus and histaminergic neuronsQ34599381
Novel histamine H3 receptor antagonists GSK189254 and GSK334429 are efficacious in surgically-induced and virally-induced rat models of neuropathic painQ34731433
An inverse agonist of the histamine H(3) receptor improves wakefulness in narcolepsy: studies in orexin-/- mice and patientsQ34754308
Narcolepsy: genetic predisposition and neuropharmacological mechanisms. REVIEW ARTICLE.Q35046857
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P433issue1
P407language of work or nameEnglishQ1860
P921main subjectnarcolepsyQ189561
P304page(s)104-117
P577publication date2009-05-01
P1433published inBritish Journal of PharmacologyQ919631
P1476titleDifferential effects of acute and repeat dosing with the H3 antagonist GSK189254 on the sleep-wake cycle and narcoleptic episodes in Ox-/- mice
P478volume157