Identification and characterization of a ross river virus variant that grows persistently in macrophages, shows altered disease kinetics in a mouse model, and exhibits resistance to type I interferon

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Identification and characterization of a ross river virus variant that grows persistently in macrophages, shows altered disease kinetics in a mouse model, and exhibits resistance to type I interferon is …
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scholarly articleQ13442814

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P356DOI10.1128/JVI.01189-10
P932PMC publication ID3094974
P698PubMed publication ID21430046

P50authorAli ZaidQ47098735
Brett A. LidburyQ55189293
Suresh MahalingamQ55190793
Andreas SuhrbierQ60127341
Michael S RolphQ115653667
Nestor E RulliQ115653669
P2093author name stringCristina M Musso
Harald S Rothenfluh
Susan B Cossetto
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Ross River virus mutant with a deletion in the E2 gene: properties of the virion, virus-specific macromolecule synthesis, and attenuation of virulence for miceQ44636263
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Suppression of lipopolysaccharide-induced antiviral transcription factor (STAT-1 and NF-kappa B) complexes by antibody-dependent enhancement of macrophage infection by Ross River virusQ27472728
Resistance to Alpha/Beta Interferon Is a Determinant of West Nile Virus Replication Fitness and VirulenceQ27477539
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Capsid Protein of Eastern Equine Encephalitis Virus Inhibits Host Cell Gene ExpressionQ27478382
Entry kinetics and mouse virulence of Ross River virus mutants altered in neutralization epitopesQ27480336
Structural and Nonstructural Protein Genome Regions of Eastern Equine Encephalitis Virus Are Determinants of Interferon Sensitivity and Murine VirulenceQ27485898
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Characterization of Ross River virus tropism and virus-induced inflammation in a mouse model of viral arthritis and myositisQ34301840
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An arthrogenic alphavirus induces monocyte chemoattractant protein-1 and interleukin-8.Q39223918
Amelioration of alphavirus-induced arthritis and myositis in a mouse model by treatment with bindarit, an inhibitor of monocyte chemotactic proteinsQ39818590
Ross River virus envelope glycans contribute to type I interferon production in myeloid dendritic cellsQ39929062
Persistent Ross River virus infection of murine macrophages: an in vitro model for the study of viral relapse and immune modulation during long-term infectionQ40700261
Expression of hepatitis C virus NS5A natural mutants in a hepatocytic cell line inhibits the antiviral effect of interferon in a PKR-independent mannerQ40801087
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Venezuelan equine encephalitis virus disrupts STAT1 signaling by distinct mechanisms independent of host shutoff.Q42172413
P4510describes a project that usesImageJQ1659584
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectRoss River virusQ660537
Chikungunya virusQ15794049
P304page(s)5651-5663
P577publication date2011-03-23
P1433published inJournal of VirologyQ1251128
P1476titleIdentification and characterization of a ross river virus variant that grows persistently in macrophages, shows altered disease kinetics in a mouse model, and exhibits resistance to type I interferon
P478volume85