Use of canakinumab in the cryopyrin-associated periodic syndrome

scientific article

Use of canakinumab in the cryopyrin-associated periodic syndrome is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1056/NEJMOA0810787
P698PubMed publication ID19494217

P50authorHelen J LachmannQ56426736
Éric HachullaQ57413861
Pierre QuartierQ37838790
P2093author name stringPhilip N Hawkins
Albert Widmer
Canakinumab in CAPS Study Group
Isabelle Kone-Paut
Jasmin B Kuemmerle-Deschner
Kieron S Leslie
Neha Patel
Xavier Gitton
P433issue23
P407language of work or nameEnglishQ1860
P921main subjectcryopyrin-associated periodic syndromeQ1771331
P304page(s)2416-2425
P577publication date2009-06-01
P1433published inThe New England Journal of MedicineQ582728
P1476titleUse of canakinumab in the cryopyrin-associated periodic syndrome
P478volume360

Reverse relations

cites work (P2860)
Q34423486A 24-month open-label study of canakinumab in neonatal-onset multisystem inflammatory disease
Q38805718A Comprehensive Overview of the Hereditary Periodic Fever Syndromes
Q99240141A Review on Current Repurposing Drugs for the Treatment of COVID-19: Reality and Challenges
Q33622218A case of cryopyrin-associated periodic syndrome with kidney transplant failure
Q90289994A case report of locally invasive Aspergillus fumigatus infection in a patient on canakinumab
Q37869439A clinical perspective of IL-1β as the gatekeeper of inflammation
Q34632661A phase II, multicenter, open-label study evaluating dosing and preliminary safety and efficacy of canakinumab in systemic juvenile idiopathic arthritis with active systemic features.
Q27687429A preliminary score for the assessment of disease activity in hereditary recurrent fevers: results from the AIDAI (Auto-Inflammatory Diseases Activity Index) Consensus Conference.
Q38633441A safety evaluation of canakinumab for the treatment of systemic onset juvenile idiopathic arthritis
Q38773387A systematic approach to autoinflammatory syndromes: a spelling booklet for the beginner
Q84100413Accelerate medical breakthroughs by ending disease earmarks
Q84801790Acute inflammatory arthritis: interleukin-1 blockade: a magic wand for gout?
Q39016299An Update on the Use of Immunomodulators in Primary Immunodeficiencies
Q34254955An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome
Q35219001An expanding role for interleukin-1 blockade from gout to cancer
Q64110826An innate interaction between IL-18 and the propeptide that inactivates its precursor form
Q59136398Anakinra Therapy for Non-cancer Inflammatory Diseases
Q38993312Anakinra and related drugs targeting interleukin-1 in the treatment of cryopyrin-associated periodic syndromes
Q37277309Anakinra as a diagnostic challenge and treatment option for systemic autoinflammatory disorders of undefined etiology
Q38168948Anakinra for cryopyrin-associated periodic syndrome
Q40852651Analysis of clinical trials with biologics using dose-time-response models
Q27495968Anti-Interleukin-1 Agents in Adult Onset Still's Disease
Q37118156Anti-inflammatory Agents: Present and Future
Q55293840Anti-inflammatory cytokine and angiogenic factors levels in vitreous samples of diabetic retinopathy patients.
Q51722492Applying physiological and biochemical concepts to optimize biological drug development.
Q38085854Autoinflammation: From monogenic syndromes to common skin diseases
Q34369278Autoinflammation: the prominent role of IL-1 in monogenic autoinflammatory diseases and implications for common illnesses
Q35558406Autoinflammation: translating mechanism to therapy
Q37048084Autoinflammatory Skin Disorders: The Inflammasomme in Focus
Q38715104Autoinflammatory Syndromes in Children
Q36520994Autoinflammatory disease reloaded: a clinical perspective
Q40376307Autoinflammatory diseases in childhood
Q40153519Autoinflammatory syndromes as causes of fever of unknown origin
Q40326095Autoinflammatory syndromes/fever syndromes
Q37784856Autoinflammatory syndromes: diagnosis and management
Q34135558Averting inflammation by targeting the cytokine environment
Q27011650Beyond the NLRP3 inflammasome: autoinflammatory diseases reach adolescence
Q38060204Bioanalysis of target biomarker and PK/PD relevancy during the development of biotherapeutics
Q37887422Biologic modulators in allergic and autoinflammatory diseases
Q37077564Biological treatments: new weapons in the management of monogenic autoinflammatory disorders
Q39084627Biologics for Targeting Inflammatory Cytokines, Clinical Uses, and Limitations.
Q37765830Biologics in children's autoimmune disorders: efficacy and safety
Q37696271Blockade of interleukin 1 in type 1 diabetes mellitus
Q34822708Blocking interleukin-1 in rheumatic diseases
Q37821071Blocking interleukin-1β in acute and chronic autoinflammatory diseases
Q48088115Bone involvement in monogenic autoinflammatory syndromes
Q36702456Bridging Clinical Outcomes of Canakinumab Treatment in Patients With Rheumatoid Arthritis With a Population Model of IL-1β Kinetics
Q54237287CANTOS: A breakthrough that proves the inflammatory hypothesis of atherosclerosis.
Q38473823CAPS--pathogenesis, presentation and treatment of an autoinflammatory disease
Q24642193Canakinumab
Q35620372Canakinumab (ACZ885, a fully human IgG1 anti-IL-1β mAb) induces sustained remission in pediatric patients with cryopyrin-associated periodic syndrome (CAPS)
Q35535362Canakinumab as rescue therapy in familial Mediterranean fever refractory to conventional treatment
Q54806476Canakinumab for the cryopyrin-associated periodic syndromes
Q38814103Canakinumab for the treatment of TNF-receptor associated periodic syndrome
Q40199493Canakinumab for the treatment of children with colchicine-resistant familial Mediterranean fever: a 6-month open-label, single-arm pilot study
Q38865019Canakinumab for the treatment of familial Mediterranean fever.
Q38255582Canakinumab for the treatment of systemic juvenile idiopathic arthritis
Q37800938Canakinumab for treatment of cryopyrin-associated periodic syndrome
Q40427207Canakinumab in adults with steroid-refractory pyoderma gangrenosum.
Q37331996Canakinumab in patients with cryopyrin-associated periodic syndrome: an update for clinicians
Q38085662Canakinumab in pediatric rheumatic diseases
Q35012174Canakinumab reduces the risk of acute gouty arthritis flares during initiation of allopurinol treatment: results of a double-blind, randomised study
Q35092969Canakinumab relieves symptoms of acute flares and improves health-related quality of life in patients with difficult-to-treat Gouty Arthritis by suppressing inflammation: results of a randomized, dose-ranging study
Q98648527Canakinumab to reduce deterioration of cardiac and respiratory function in SARS-CoV-2 associated myocardial injury with heightened inflammation (canakinumab in Covid-19 cardiac injury: The three C study)
Q37604504Canakinumab treatment for patients with active recurrent or chronic TNF receptor-associated periodic syndrome (TRAPS): an open-label, phase II study
Q54806474Canakinumab: a human anti-IL-1β monoclonal antibody for the treatment of cryopyrin-associated periodic syndromes
Q37968285Canakinumab: in patients with cryopyrin-associated periodic syndromes
Q34336335Caspase functions in cell death and disease
Q89526718Caspases in Cell Death, Inflammation, and Gasdermin-Induced Pyroptosis
Q92665944Cell death-mediated cytokine release and its therapeutic implications
Q40231494Challenges in diagnosing Muckle-Wells syndrome: identifying two distinct phenotypes
Q28066948Chronic Infantile Neurological Cutaneous and Articular (CINCA) syndrome: a review
Q35928265Chronic inflammation in cancer development.
Q37942581Clinical and biochemical landmarks in systemic autoinflammatory diseases
Q40049062Clinical and molecular phenotypes of low-penetrance variants in NLRP3: Diagnostic and therapeutic challenges
Q42075063Clinical and transcriptional response to the long-acting interleukin-1 blocker canakinumab in Blau syndrome-related uveitis
Q36903004Clinical characteristics in subjects with NLRP3 V198M diagnosed at a single UK center and a review of the literature
Q37026106Closing the loop on inflammation and atherothrombosis: why perform the CIRT and CANTOS trials?
Q37986236Cold-induced urticaria with a familial transmission: a case report and review of the literature
Q35886682Conformational Sampling and Binding Site Assessment of Suppression of Tumorigenicity 2 Ectodomain
Q50051013Confounding role of tumor necrosis factor in cryopyrin-associated periodic syndromes.
Q89746290Consensus protocols for the diagnosis and management of the hereditary autoinflammatory syndromes CAPS, TRAPS and MKD/HIDS: a German PRO-KIND initiative
Q33673719Constitutively active inflammasome in human melanoma cells mediating autoinflammation via caspase-1 processing and secretion of interleukin-1beta
Q38845570Cooling down inflammation in type 2 diabetes: how strong is the evidence for cardiometabolic benefit?
Q43701983Corneal response to canakinumab in cryopyrin associated periodic fever syndrome
Q40356964Critical appraisal of canakinumab in the treatment of adults and children with cryopyrin-associated periodic syndrome (CAPS).
Q36137849Critical role for mast cells in interleukin-1β-driven skin inflammation associated with an activating mutation in the nlrp3 protein
Q40289375Cryopyrin-associated periodic syndrome
Q51533520Cryopyrin-associated periodic syndrome: an autoinflammatory disease manifested as neutrophilic urticarial dermatosis with additional perieccrine involvement
Q37811988Cryopyrin-associated periodic syndrome: an update on diagnosis and treatment response
Q37688957Cryopyrin-associated periodic syndromes: background and therapeutics
Q37984096Cryopyrin-associated periodic syndromes: diagnosis and management
Q97521410Current Therapeutic Options for the Main Monogenic Autoinflammatory Diseases and PFAPA Syndrome: Evidence-Based Approach and Proposal of a Practical Guide
Q27693189Current concepts and future directions in the pathogenesis and treatment of non-infectious intraocular inflammation
Q93095137Current perspectives on the interleukin-1 family as targets for inflammatory disease
Q37871438Current status of understanding the pathogenesis and management of patients with NOMID/CINCA.
Q38574807Current treatment recommendations and considerations for cryopyrin-associated periodic syndrome
Q93158334Cytokine Circuits in Cardiovascular Disease
Q37875779Danger signals activating innate immunity in graft-versus-host disease
Q34212591Deregulated inflammasome signaling in disease
Q45772071Detailed mechanistic analysis of gevokizumab, an allosteric anti-IL-1β antibody with differential receptor-modulating properties
Q37496388Determination of the starting dose in the first-in-human clinical trials with monoclonal antibodies: a systematic review of papers published between 1990 and 2013
Q34623105Development trends for human monoclonal antibody therapeutics
Q40210237Diagnostic validity of colchicine in patients with Familial Mediterranean fever
Q37919837Does this patient have periodic fever syndrome?
Q64042641Dosage Considerations for Canakinumab in Children With Periodic Fever Syndromes
Q36250852Dry Eye Signs and Symptoms Persist During Systemic Neutralization of IL-1β by Canakinumab or IL-17A by Secukinumab
Q58594489Early canakinumab therapy for the sensorineural deafness in a family with Muckle-Wells syndrome due to a novel mutation of NLRP3 gene
Q37602644Early changes in gene expression and inflammatory proteins in systemic juvenile idiopathic arthritis patients on canakinumab therapy
Q27303524Early detection of sensorineural hearing loss in Muckle-Wells-syndrome
Q51355147Effect of anti-IL-1β antibody (canakinumab) on insulin secretion rates in impaired glucose tolerance or type 2 diabetes: results of a randomized, placebo-controlled trial.
Q40051587Effects of Anakinra on Health-Related Quality of Life in a Patient with 1129G>A/928G>A Mutations in MVK Gene and Heterozygosity for the Mutation 2107C>A in CIAS1 Gene
Q40053587Efficacy and safety analysis of off-label treatment with biologics in autoinflammatory diseases : Experiences from a German registry (GRAID2)
Q36027314Efficacy and safety of canakinumab in adolescents and adults with colchicine-resistant familial Mediterranean fever
Q45325652Efficacy and safety of canakinumab therapy in paediatric patients with cryopyrin-associated periodic syndrome: a single-centre, real-world experience.
Q33953931Efficacy and safety of the human anti-IL-1β monoclonal antibody canakinumab in rheumatoid arthritis: results of a 12-week, Phase II, dose-finding study
Q40287066Efficacy and safety of the interleukin-1 antagonist rilonacept in Schnitzler syndrome: an open-label study
Q36798016Efficacy of anti-IL-1 treatment in familial Mediterranean fever: a systematic review of the literature
Q49071287Emerging inflammasome effector mechanisms
Q54316388Enhanced chondrogenesis of induced pluripotent stem cells from patients with neonatal-onset multisystem inflammatory disease occurs via the caspase 1-independent cAMP/protein kinase A/CREB pathway.
Q62658633Etiopatogenia de los síndromes asociados a criopirina: genética, bases moleculares y el inflamasoma
Q28082757Evasion of inflammasome activation by microbial pathogens
Q40179129Evidence of treatment of chronic inflammation in childhood and adolescence with biologics
Q37800842Fevers and the Rheumatologist
Q26770209From C-Reactive Protein to Interleukin-6 to Interleukin-1: Moving Upstream To Identify Novel Targets for Atheroprotection
Q38528624From bench to bedside and back again: translational research in autoinflammation
Q37077793From the Mediterranean to the sea of Japan: the transcontinental odyssey of autoinflammatory diseases
Q26776120Functional Amyloid Signaling via the Inflammasome, Necrosome, and Signalosome: New Therapeutic Targets in Heart Failure
Q51716028Functional relevance of NLRP3 inflammasome-mediated interleukin (IL)-1β during acute allergic airway inflammation.
Q40252367Genetic fever syndromes. Hereditary recurrent (periodic) fever syndromes
Q38053858Guidance on the use of canakinumab in patients with cryopyrin-associated periodic syndrome in Japan
Q34142714Have we overestimated the benefit of human(ized) antibodies?
Q50357559Hearing loss in Muckle-Wells syndrome.
Q38043522How not to miss autoinflammatory diseases masquerading as urticaria.
Q34262561IL-1 blockade in autoinflammatory syndromes
Q37696955IL-1 pathways in inflammation and human diseases
Q63214372IL-1-Antagonisten
Q37702138IL-1: discoveries, controversies and future directions
Q84324600IL-1beta-targeted antibody approved for rare autoinflammatory disorders
Q30251741IL-1β at the crossroad between rheumatoid arthritis and type 2 diabetes: may we kill two birds with one stone?
Q38074355IL-1β biological treatment of familial Mediterranean fever.
Q64040007Idiopathic Pericarditis-an Autoinflammatory Disease?
Q35190461Immunological loss-of-function due to genetic gain-of-function in humans: autosomal dominance of the third kind
Q37979861Immunology in clinic review series; focus on autoinflammatory diseases: role of inflammasomes in autoinflammatory syndromes
Q37979862Immunology in clinic review series; focus on autoinflammatory diseases: update on monogenic autoinflammatory diseases: the role of interleukin (IL)-1 and an emerging role for cytokines beyond IL-1.
Q38542409Impact of IL-1 inhibition on fatigue associated with autoinflammatory syndromes
Q37273133In vivo regulation of interleukin 1beta in patients with cryopyrin-associated periodic syndromes
Q37738096Inflammasome and IL-1beta-mediated disorders
Q93050768Inflammasome inhibitors: promising therapeutic approaches against cancer
Q36829403Inflammasome-Mediated Autoinflammatory Disorders
Q34431953Influenza and meningococcal vaccinations are effective in healthy subjects treated with the interleukin-1 beta-blocking antibody canakinumab: results of an open-label, parallel group, randomized, single-center study
Q44182155Inhibition of the NF-κB pathway as a candidate therapeutic strategy for cryopyrin-associated periodic syndrome
Q92172322Inhibitor of apoptosis proteins in human health and disease
Q37761419Innate immunity and rheumatoid arthritis
Q88781397Interleukin 1 receptor (IL-1R1) activation exacerbates toxin-induced acute kidney injury
Q47599422Interleukin-1 Beta as a Target for Atherosclerosis Therapy: Biological Basis of CANTOS and Beyond
Q42412163Interleukin-1 antagonism in acute gout: is targeting a single cytokine the answer?
Q38993264Interleukin-1 antagonists in the treatment of autoinflammatory syndromes, including cryopyrin-associated periodic syndrome
Q35133812Interleukin-1 as a common denominator from autoinflammatory to autoimmune disorders: premises, perils, and perspectives
Q92636027Interleukin-1 blockade treatment decreasing cardiovascular risk
Q37986227Interleukin-1 gene polymorphisms and chronic periodontitis in adult whites: a systematic review and meta-analysis
Q24606766Interleukin-1 in the pathogenesis and treatment of inflammatory diseases
Q92700384Interleukin-1β Inhibition for Chronic Kidney Disease in Obese Mice With Type 2 Diabetes
Q42109190Interleukin-1β inhibitors for the treatment of cryopyrin-associated periodic syndrome
Q41928389International multi-centre study of pregnancy outcomes with interleukin-1 inhibitors.
Q37925070Intracellular sensing of microbes and danger signals by the inflammasomes
Q34681333Intratumor T helper type 2 cell infiltrate correlates with cancer-associated fibroblast thymic stromal lymphopoietin production and reduced survival in pancreatic cancer
Q51834131Investigational drugs in systemic vasculitis.
Q41934684Is the inflammasome a potential therapeutic target in renal disease?
Q85204858Is there any treatment for inflammatory amyloidosis?
Q39243858Juvenile idiopathic arthritis: management and therapeutic options
Q37773243Kinoids: a family of immunogens for active anticytokine immunotherapy applied to autoimmune diseases and cancer
Q56962731Kälteinduzierte Quaddeln und Angioödeme
Q38177270Licensing Adaptive Immunity by NOD-Like Receptors
Q57273753Lifelong urticaria and multiple unexplained systemic symptoms
Q47104503Live-attenuated vaccines in a cryopyrin-associated periodic syndrome patient receiving canakinumab treatment during infancy
Q34240472MRP8 and MRP14, phagocyte-specific danger signals, are sensitive biomarkers of disease activity in cryopyrin-associated periodic syndromes
Q37874889Managing your patient with gout: a review of treatment options
Q64074554MicroRNA Post-transcriptional Regulation of the NLRP3 Inflammasome in Immunopathologies
Q34240460Microarray-based gene expression profiling in patients with cryopyrin-associated periodic syndromes defines a disease-related signature and IL-1-responsive transcripts
Q47248926Molecular genetic investigation, clinical features and response to treatment in 21 patients with Schnitzler's syndrome
Q33798590Monogenic IL-1 mediated autoinflammatory and immunodeficiency syndromes: finding the right balance in response to danger signals
Q39301708Monogenic Periodic Fever Syndromes: Treatment Options for the Pediatric Patient
Q38211947Monogenic autoinflammatory diseases
Q90744138Monogenic autoinflammatory diseases in adults - a challenge to rheumatologic practice at the onset of the Polish national programme of interleukin 1 inhibitor treatment
Q37162157Monogenic autoinflammatory diseases: concept and clinical manifestations
Q37466515Monogenic autoinflammatory diseases: disorders of amplified danger sensing and cytokine dysregulation
Q34489840Monogenic autoinflammatory diseases: new insights into clinical aspects and pathogenesis
Q37299354Monogenic autoinflammatory syndromes: state of the art on genetic, clinical, and therapeutic issues
Q40230708Muckle-Wells cryopyrinopathy: complex phenotyping and response to therapy in a new multiplex kindred.
Q37941886Muckle-Wells syndrome effectively treated with canakinumab: is the recommended dosing schedule mandatory?
Q39458288Muckle-Wells syndrome: clinical perspectives.
Q40657289Musculoskeletal symptoms in patients with cryopyrin-associated periodic syndromes: a large database study
Q34254942Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation
Q84474094Mutations in the IL1RN locus lead to autoinflammation
Q35907763NLRP3 E311K mutation in a large family with Muckle-Wells syndrome--description of a heterogeneous phenotype and response to treatment
Q98177717NLRP3 Inflammasome Activation in Cancer: A Double-Edged Sword
Q28387817NLRP3 inflammasome activation induced by engineered nanomaterials
Q35045146NLRP3 inflammasome: from a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases.
Q37642879Neurological outcome of patients with cryopyrin-associated periodic syndrome (CAPS).
Q39863212New drugs approved in 2009
Q37059551New insights into the nature of autoinflammatory diseases from mice with Nlrp3 mutations
Q33823177Nlrp3: an immune sensor of cellular stress and infection
Q51061979Novel NLRC4 Mutation Causes a Syndrome of Perinatal Autoinflammation With Hemophagocytic Lymphohistiocytosis, Hepatosplenomegaly, Fetal Thrombotic Vasculopathy, and Congenital Anemia and Ascites.
Q47644899OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation.
Q40237271Obvious optic disc swelling in a patient with cryopyrin-associated periodic syndrome
Q38038253Ocular manifestations of the autoinflammatory syndromes
Q40057989Open-Label, Phase II Study to Assess the Efficacy and Safety of Canakinumab Treatment in Active Hyperimmunoglobulinemia D With Periodic Fever Syndrome
Q37358329Oral Administration of Interleukin-10 and Anti-IL-1 Antibody Ameliorates Experimental Intestinal Inflammation
Q97905633Overview of the rarest causes of fever in newborns: handy hints for the neonatologist
Q46049018P02-027 - Quality of life in CAPS treated by Canakinumab
Q57452740Pathophysiology of Sickle Cell Disease
Q37991471Pattern recognition receptors in immune disorders affecting the skin.
Q84794425Periodic Fever Syndromes
Q40346170Periodic fever syndrome and autoinflammatory diseases
Q38959923Periodic fevers and autoinflammatory syndromes in childhood
Q36644667Pharmacokinetic and pharmacodynamic properties of canakinumab, a human anti-interleukin-1β monoclonal antibody
Q53122163Pharmacokinetics and Pharmacodynamics of Canakinumab in Patients With Systemic Juvenile Idiopathic Arthritis.
Q38291356Pharmacokinetics and pharmacokinetic-pharmacodynamic relationships of monoclonal antibodies in children
Q38674213Pharmacological treatment options for cryopyrin-associated periodic syndromes
Q34274075Pharmacotherapy for uveitis: current management and emerging therapy
Q38015260Physical urticaria
Q33710807Potential of IL-1, IL-18 and Inflammasome Inhibition for the Treatment of Inflammatory Skin Diseases.
Q26771462Preclinical characterization and clinical development of ILARIS(®) (canakinumab) for the treatment of autoinflammatory diseases
Q35184223Preclinical efficacy and safety of an anti-IL-1β vaccine for the treatment of type 2 diabetes
Q36375787Prolonged urticaria and fever in a toddler
Q38431249Protective and detrimental roles of inflammasomes in disease
Q39064225Protein inhibitor of acid deoxyribonucleases. Improved purification procedure and properties
Q44328410Quantitative analysis to guide orphan drug development
Q92508435Rapid and Sustained Long-Term Efficacy and Safety of Canakinumab in Patients With Cryopyrin-Associated Periodic Syndrome Ages Five Years and Younger
Q48399830Rationale for IL-1beta-targeted therapy to minimize hypoxic-ischemic encephalopathy
Q39382198Real-World Experience and Impact of Canakinumab in Cryopyrin-Associated Periodic Syndrome: Results From a French Observational Study
Q40212229Real-life effectiveness of canakinumab in cryopyrin-associated periodic syndrome
Q38537504Recommendations for the management of autoinflammatory diseases.
Q40379845Recommendations on therapy using interleukin-1beta-blocking agents
Q38560502Redox distress and genetic defects conspire in systemic autoinflammatory diseases
Q38522837Regulating against the dysregulation: new treatment options in autoinflammation
Q37750913Regulation of inflammasome activity.
Q41659293Relative contribution of IL-1α, IL-1β and TNF to the host response to Mycobacterium tuberculosis and attenuated M. bovis BCG.
Q37848210Renal amyloidosis in children
Q58326117Renal involvement in secondary amyloidosis of Muckle-Wells syndrome: marked improvement of renal function and reduction of proteinuria after therapy with human anti-interleukin-1β monoclonal antibody canakinumab
Q38091387Research progress on the NLRP3 inflammasome and its role in the central nervous system
Q91735391Retrospective case series describing the efficacy, safety and cost-effectiveness of a vial-sharing programme for canakinumab treatment for paediatric patients with cryopyrin-associated periodic syndrome
Q38993829Review: Found in Translation: International Initiatives Pursuing Interleukin-1 Blockade for Treatment of Acute Kawasaki Disease
Q41769940Rilonacept and canakinumab
Q35557377Rilonacept in the management of cryopyrin-associated periodic syndromes (CAPS).
Q38450662Role of biologics in intractable urticaria
Q38095844Role of interleukin-1 inhibitors in the management of gout
Q92711301Roles of Inflammasomes in Inflammatory Kidney Diseases
Q33661359Safety and tolerability of canakinumab, an IL-1β inhibitor, in type 2 diabetes mellitus patients: a pooled analysis of three randomised double-blind studies
Q35623130Sensors of the innate immune system: their link to rheumatic diseases
Q52720398Subcutaneous administration of a Neutralizing IL-1β antibody prolongs limb allograft survival.
Q40338012Successful renal transplantation in Muckle-Wells syndrome treated with anti-IL-1β-monoclonal antibody
Q53842436Successful treatment with canakinumab of a paediatric patient with resistant Behçet's disease.
Q35468003Sudden cardiac arrest secondary to cardiac amyloidosis in a young woman with cryopyrin-associated periodic syndrome
Q40270754Sustained efficacy of the monoclonal anti-interleukin-1 beta antibody canakinumab in a 9-month trial in Schnitzler's syndrome
Q35907804Sustained remission of symptoms and improved health-related quality of life in patients with cryopyrin-associated periodic syndrome treated with canakinumab: results of a double-blind placebo-controlled randomized withdrawal study
Q36327767Sustained response and prevention of damage progression in patients with neonatal-onset multisystem inflammatory disease treated with anakinra: a cohort study to determine three- and five-year outcomes
Q30251986Systemic amyloidosis
Q38843398Systemic and organ involvement in monogenic autoinflammatory disorders: a global review filtered through internists' lens
Q35659928Systemic arthritis in children: a review of clinical presentation and treatment
Q35662883Systemic autoimmune disease in asbestosis rapidly responding to anti-interleukin-1beta antibody canakinumab: a case report
Q90566954Targeting NLRP3 Inflammasome Activation in Severe Asthma
Q38137848Targeting cholesterol crystal-induced inflammation for the secondary prevention of cardiovascular disease
Q34167205Targeting cytokines in inflammatory diseases: focus on interleukin-1-mediated autoinflammation
Q38106621Targeting inflammasomes in rheumatic diseases
Q37901025Targeting of the innate immunity/inflammation as complementary anti-tumor therapies
Q26744359Targeting the Innate Immune Response to Improve Cardiac Graft Recovery after Heart Transplantation: Implications for the Donation after Cardiac Death
Q37270409The Central Role of Anti-IL-1 Blockade in the Treatment of Monogenic and Multi-Factorial Autoinflammatory Diseases
Q91973492The Emerging Jamboree of Transformative Therapies for Autoimmune Diseases
Q37848193The Eurofever Project: towards better care for autoinflammatory diseases
Q92579132The First Case Series of Cryopyrin-Associated Periodic Syndrome in Korea
Q90084199The IL-1 family of cytokines and receptors in rheumatic diseases
Q37676929The IL-1 family: regulators of immunity
Q39132605The NLRP3 and Pyrin Inflammasomes: Implications in the Pathophysiology of Autoinflammatory Diseases.
Q37901519The NLRP3 inflammasome in health and disease: the good, the bad and the ugly
Q28242527The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response
Q37702149The NLRP3 inflammasome, a target for therapy in diverse disease states
Q38948602The Role of Interleukin-1 in Inflammatory and Malignant Human Skin Diseases and the Rationale for Targeting Interleukin-1 Alpha
Q33785735The Therapeutic Role of Interleukin-1 Inhibition in Idiopathic Recurrent Pericarditis: Current Evidence and Future Challenges.
Q38496586The autoinflammatory diseases: a fashion with blurred boundaries!
Q38967233The burgeoning field of innate immune-mediated disease and autoinflammation
Q28070297The challenge of autoinflammatory syndromes: with an emphasis on hyper-IgD syndrome
Q57160539The classification, genetic diagnosis and modelling of monogenic autoinflammatory disorders
Q26825459The emerging role of biotechnological drugs in the treatment of gout
Q37802305The emerging role of interleukin-1β in autoinflammatory diseases
Q37897494The emerging role of interleukin-1β in autoinflammatory diseases
Q92124367The emerging roles of inflammasome-dependent cytokines in cancer development
Q38182645The expanding role of therapeutic antibodies
Q51786270The future of drug development: advancing clinical trial design.
Q84612714The importance of biologicals in the treatment of SoJIA
Q37800522The inflammasome regulatory pathway and infections: Role in pathophysiology and clinical implications
Q24613816The inflammasome: in memory of Dr. Jurg Tschopp
Q24304087The inflammasomes
Q42225483The inflammasomes in autoinflammatory diseases with skin involvement
Q34489972The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1β.
Q39443996The monogenic autoinflammatory diseases define new pathways in human innate immunity and inflammation
Q38070133The role of inflammasome-derived IL-1 in driving IL-17 responses
Q92525889The role of inflammasomes in kidney disease
Q37957867The role of the NLRP3 inflammasome in gout
Q36903288The schedule of administration of canakinumab in cryopyrin associated periodic syndrome is driven by the phenotype severity rather than the age.
Q37810218Therapeutic monoclonal antibody concentration monitoring: free or total?
Q35868028Therapy of autoinflammatory syndromes
Q35122583Tolerance and efficacy of off-label anti-interleukin-1 treatments in France: a nationwide survey
Q34088555Transcript abundance patterns in Kawasaki disease patients with intravenous immunoglobulin resistance
Q36816872Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases
Q37636664Treating inflammation by blocking interleukin-1 in humans
Q26799747Treating rheumatological diseases and co-morbidities with interleukin-1 blocking therapies
Q33767097Treatment of Muckle-Wells syndrome: analysis of two IL-1-blocking regimens
Q38993330Treatment of systemic-onset juvenile arthritis with canakinumab
Q37642763Treatment strategies for juvenile idiopathic arthritis
Q98471241Triacylglycerol synthesis enhances macrophage inflammatory function
Q38004932Type I IFN-mediated regulation of IL-1 production in inflammatory disorders.
Q40147920Unified Modeling of Familial Mediterranean Fever and Cryopyrin Associated Periodic Syndromes
Q38871098Unintended Immunological Consequences of Biologic Therapy.
Q64249669Unveiling the Efficacy, Safety, and Tolerability of Anti-Interleukin-1 Treatment in Monogenic and Multifactorial Autoinflammatory Diseases
Q38071693Update on biologicals for treatment of juvenile idiopathic arthritis
Q38189469Urticaria mimickers in children
Q34607687Validation of the auto-inflammatory diseases activity index (AIDAI) for hereditary recurrent fever syndromes
Q39044487What do we know about the inflammasome in humans?
Q43805795What's new in internal medicine?
Q33833871Why not treat human cancer with interleukin-1 blockade?
Q33357128Working the endless puzzle of hereditary autoinflammatory disorders
Q84148894[CAPS treatment]
Q84148897[Canakinumab, a monoclonal antibody against IL-1β, with potential utility in different inflammatory processes]
Q84589751[Treatment of autoinflamatory diseases: which projections?]