Alpha-synuclein and presynaptic function: implications for Parkinson's disease.

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Alpha-synuclein and presynaptic function: implications for Parkinson's disease. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1015209834
P356DOI10.1385/NMM:2:2:115
P698PubMed publication ID12428807

P50authorPoul Henning JensenQ60892576
P2093author name stringSimon Lykkebo
P2860cites workalpha-Synuclein immunoreactivity in dementia with Lewy bodies: morphological staging and comparison with ubiquitin immunostainingQ73727325
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Microtubule-associated protein 1B is a component of cortical Lewy bodies and binds alpha-synuclein filamentsQ28141728
Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-IQ28141879
Protein-protein interactions of alpha-synuclein in brain homogenates and transfected cellsQ28202923
Alpha-synuclein and neurodegenerative diseasesQ28204386
Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brainQ28509158
Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neuronsQ28567029
Membrane-bound alpha-synuclein has a high aggregation propensity and the ability to seed the aggregation of the cytosolic formQ28567172
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alpha-synuclein binds to Tau and stimulates the protein kinase A-catalyzed tau phosphorylation of serine residues 262 and 356.Q33872332
Membrane association and protein conformation of alpha-synuclein in intact neurons. Effect of Parkinson's disease-linked mutationsQ33893738
alpha-Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteinsQ33929879
Differential expression and distribution of alpha-, beta-, and gamma-synuclein in the developing human substantia nigraQ33938966
Direct binding and functional coupling of alpha-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis.Q33941736
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Assignment of human alpha-synuclein (SNCA) and beta-synuclein (SNCB) genes to chromosomes 4q21 and 5q35.Q34295323
Characterization of a novel protein regulated during the critical period for song learning in the zebra finch.Q34303003
Tissue-dependent alternative splicing of mRNA for NACP, the precursor of non-A beta component of Alzheimer's disease amyloidQ34314680
Alpha-synuclein and the Lewy body disordersQ34318165
The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous systemQ34318718
Identification of two distinct synucleins from human brainQ34341909
The dopamine transporter is localized to dendritic and axonal plasma membranes of nigrostriatal dopaminergic neuronsQ34370362
Kinesin, dynein and neurofilament transportQ34416231
Slow axonal transport: fast motors in the slow lane.Q34495166
Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapyQ34964783
Selective insolubility of alpha-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse modelQ35747138
Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.Q35764504
Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminalQ36455215
???Q64767196
Axon pathology in Parkinson's disease and Lewy body dementia hippocampus contains alpha-, beta-, and gamma-synucleinQ36677512
NACP, a protein implicated in Alzheimer's disease and learning, is natively unfoldedQ36830682
Oxygen free radicals and Parkinson's diseaseQ37693669
Retention and redistribution of proteins in mammalian nerve fibres by axoplasmic transportQ39366873
Ultrastructural localization of the vesicular monoamine transporter-2 in midbrain dopaminergic neurons: potential sites for somatodendritic storage and release of dopamine.Q39757944
The neuronal cytoskeleton: roles in neuronal morphogenesis and organelle transport.Q40399871
Lipid droplet binding and oligomerization properties of the Parkinson's disease protein alpha-synucleinQ40763309
Induction of alpha-synuclein aggregation by intracellular nitrative insult.Q40776570
Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's diseaseQ40795664
Alpha-synuclein and the Parkinson's disease-related mutant Ala53Thr-alpha-synuclein do not undergo proteasomal degradation in HEK293 and neuronal cellsQ40882515
Regulation of phospholipase D2: selective inhibition of mammalian phospholipase D isoenzymes by alpha- and beta-synucleinsQ41043578
The NACP/synuclein gene: chromosomal assignment and screening for alterations in Alzheimer diseaseQ41359019
Oxidative stress induces amyloid-like aggregate formation of NACP/alpha-synuclein in vitroQ41646793
alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's diseaseQ41676981
Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloidQ42620617
Conformational properties of alpha-synuclein in its free and lipid-associated statesQ43564642
alpha-synuclein metabolism and aggregation is linked to ubiquitin-independent degradation by the proteasomeQ43816254
Cytosolic O-glycosylation is abundant in nerve terminalsQ43820039
Chemotropic responses of retinal growth cones mediated by rapid local protein synthesis and degradationQ43832078
Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system.Q43940212
Expression pattern of synucleins (non-Abeta component of Alzheimer's disease amyloid precursor protein/alpha-synuclein) during murine brain developmentQ43995715
Is there a cause-and-effect relationship between alpha-synuclein fibrillization and Parkinson's disease?Q45300712
Human recombinant NACP/alpha-synuclein is aggregated and fibrillated in vitro: relevance for Lewy body diseaseQ46084408
Identification, localization and characterization of the human gamma-synuclein geneQ48023048
Neural expression profile of alpha-synuclein in developing human cortexQ48097777
Developmental expression of alpha-synuclein in rat hippocampus and cerebral cortexQ48189089
The Lewy body in Parkinson's disease.Q48254020
Accumulation of alpha-synuclein/NACP is a cytopathological feature common to Lewy body disease and multiple system atrophyQ48342277
Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson diseaseQ48353748
Synthetic filaments assembled from C-terminally truncated alpha-synucleinQ48360396
Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation.Q48384247
Multiple-system atrophy: a new alpha-synuclein disease?Q48406192
Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease.Q48830095
Distribution of phosphoneuroprotein 14 (PNP 14) in vertebrates: its levels as determined by enzyme immunoassay.Q48858580
Characterization of the precursor protein of the non-A beta component of senile plaques (NACP) in the human central nervous system.Q48958079
Interaction of human alpha-Synuclein and Parkinson's disease variants with phospholipids. Structural analysis using site-directed mutagenesis.Q52165843
Cell and tissue distribution and developmental change of neuron specific 14 kDa protein (phosphoneuroprotein 14).Q52222873
Membrane binding and self-association of alpha-synucleins.Q52543652
Metal-catalyzed oxidation of alpha-synuclein in the presence of Copper(II) and hydrogen peroxide.Q53235896
Nonsaturable binding indicates clustering of tau on the microtubule surface in a paired helical filament-like conformation.Q53236118
Mutant and wild type human alpha-synucleins assemble into elongated filaments with distinct morphologies in vitroQ64865343
Alpha-synuclein immunoisolation of glial inclusions from multiple system atrophy brain tissue reveals multiprotein componentsQ73120774
Axonal transport of synucleins is mediated by all rate componentsQ73189158
Dityrosine cross-linking promotes formation of stable alpha -synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathiesQ73626218
P433issue2
P921main subjectParkinson's diseaseQ11085
SynucleinQ24767155
P304page(s)115-129
P577publication date2002-01-01
P1433published inNeuroMolecular MedicineQ15716731
P1476titleAlpha-synuclein and presynaptic function: implications for Parkinson's disease
P478volume2

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cites work (P2860)
Q47069000A Caenorhabditis elegans Parkin mutant with altered solubility couples alpha-synuclein aggregation to proteotoxic stress
Q44852323Abnormal alpha-synuclein interactions with Rab proteins in alpha-synuclein A30P transgenic mice.
Q36063269Alterations in axonal transport motor proteins in sporadic and experimental Parkinson's disease
Q89529472Alternative Structures of α-Synuclein
Q36527246Calcium(II) selectively induces alpha-synuclein annular oligomers via interaction with the C-terminal domain
Q42705823Exogenous Alpha-Synuclein Alters Pre- and Post-Synaptic Activity by Fragmenting Lipid Rafts
Q42119505GRP78 clustering at the cell surface of neurons transduces the action of exogenous alpha-synuclein.
Q38647359Macroautophagy and the proteasome are differently involved in the degradation of alpha-synuclein wild type and mutated A30P in an in vitro inducible model (PC12/TetOn).
Q36100354Mannose 6-Phosphate Receptor Is Reduced in -Synuclein Overexpressing Models of Parkinsons Disease
Q38488082Mechanisms of alpha-synuclein action on neurotransmission: cell-autonomous and non-cell autonomous role
Q39998122RNA interference mediated silencing of alpha-synuclein in MN9D cells and its effects on cell viability
Q38038126Recent advances in α-synuclein functions, advanced glycation, and toxicity: implications for Parkinson's disease
Q53875651Regional distribution of proteinase K-resistant alpha-synuclein correlates with Lewy body disease stage.
Q33326619Retracted: DJ-1 Modulates α-Synuclein Aggregation State in a Cellular Model of Oxidative Stress: Relevance for Parkinson's Disease and Involvement of HSP70
Q36700077Silencing alpha-synuclein gene expression enhances tyrosine hydroxylase activity in MN9D cells

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