A small-molecule blocking ribonucleotide reductase holoenzyme formation inhibits cancer cell growth and overcomes drug resistance

scientific article

A small-molecule blocking ribonucleotide reductase holoenzyme formation inhibits cancer cell growth and overcomes drug resistance is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1158/0008-5472.CAN-13-1094
P932PMC publication ID3823501
P698PubMed publication ID24072748

P50authorTimothy SynoldQ78536675
P2093author name stringJun Wu
Bingsen Zhou
Shuya Hu
Yun Yen
Leila Su
Weidong Hu
Yate-Ching Yuan
M L Richard Yip
Shikha Gaur
D Lynne Smith
David Horne
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Flavone and isoflavone phytoestrogens are agonists of estrogen-related receptorsQ28187466
Structure, function, and mechanism of ribonucleotide reductasesQ30164061
Deoxyribonucleoside triphosphate pool imbalances in vivo are associated with an increased retroviral mutation rateQ33784748
Ribonucleotide reductasesQ34067559
p53R2 inhibits the proliferation of human cancer cells in association with cell-cycle arrest.Q34592077
Structural basis on the dityrosyl-diiron radical cluster and the functional differences of human ribonucleotide reductase small subunits hp53R2 and hRRM2.Q34632044
Clofarabine 5'-di and -triphosphates inhibit human ribonucleotide reductase by altering the quaternary structure of its large subunitQ35049193
Radical initiation in the class I ribonucleotide reductase: long-range proton-coupled electron transfer?Q35150156
Ribonucleotide reductase inhibitors and future drug designQ36569850
The R1 component of mammalian ribonucleotide reductase has malignancy-suppressing activity as demonstrated by gene transfer experimentsQ36721355
Ribonucleotide reductase: a critical enzyme for cancer chemotherapy and antiviral agentsQ37066981
A phase I/II study of GTI-2040 plus docetaxel as second-line treatment in advanced non-small cell lung cancer: a study of the PMH phase II consortiumQ37327229
Group epitope mapping by saturation transfer difference NMR to identify segments of a ligand in direct contact with a protein receptorQ38299722
Ribonucleotide reductase inhibition by metal complexes of Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone): a combined experimental and theoretical studyQ39466509
Ribonucleotide reductase subunits M2 and p53R2 are potential biomarkers for metastasis of colon cancerQ40240925
Overexpression of ribonucleotide reductase as a mechanism of resistance to 2,2-difluorodeoxycytidine in the human KB cancer cell lineQ40929262
Ribonucleotide reductase inhibitors: new strategies for cancer chemotherapyQ41014828
The mammalian ribonucleotide reductase R2 component cooperates with a variety of oncogenes in mechanisms of cellular transformationQ41048019
Overexpression of transfected human ribonucleotide reductase M2 subunit in human cancer cells enhances their invasive potentialQ41058506
Identification of the stable free radical tyrosine residue in ribonucleotide reductase.Q42572329
SOS-NMR: a saturation transfer NMR-based method for determining the structures of protein-ligand complexesQ44775677
A phase I trial of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone in combination with gemcitabine for patients with advanced cancerQ44899958
Determination of the potency and subunit-selectivity of ribonucleotide reductase inhibitors with a recombinant-holoenzyme-based in vitro assayQ45238116
Overexpression of ribonucleotide reductase in transfected human KB cells increases their resistance to hydroxyurea: M2 but not M1 is sufficient to increase resistance to hydroxyurea in transfected cells.Q46579981
pH Rate profiles of FnY356-R2s (n = 2, 3, 4) in Escherichia coli ribonucleotide reductase: evidence that Y356 is a redox-active amino acid along the radical propagation pathwayQ46920321
Site-specific replacement of Y356 with 3,4-dihydroxyphenylalanine in the beta2 subunit of E. coli ribonucleotide reductaseQ46955368
P433issue21
P407language of work or nameEnglishQ1860
P921main subjectcell growthQ189159
drug resistanceQ12147416
P304page(s)6484-6493
P577publication date2013-09-26
P1433published inCancer ResearchQ326097
P1476titleA small-molecule blocking ribonucleotide reductase holoenzyme formation inhibits cancer cell growth and overcomes drug resistance
P478volume73

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cites work (P2860)
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