EMMPRIN promotes angiogenesis, proliferation, invasion and resistance to sunitinib in renal cell carcinoma, and its level predicts patient outcome

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EMMPRIN promotes angiogenesis, proliferation, invasion and resistance to sunitinib in renal cell carcinoma, and its level predicts patient outcome is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2013PLoSO...874313S
P356DOI10.1371/JOURNAL.PONE.0074313
P932PMC publication ID3779201
P698PubMed publication ID24073208
P5875ResearchGate publication ID257136569

P50authorWataru NakataQ57068752
Kazutoshi FujitaQ57068763
P2093author name stringTakahiro Yoshida
Koji Hatano
Norio Nonomura
Motohide Uemura
Hitoshi Takayama
Yasutomo Nakai
Atsunari Kawashima
Mototaka Sato
P2860cites workCharacterization of the gene for human EMMPRIN, a tumor cell surface inducer of matrix metalloproteinasesQ22003941
Over-expression of the mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK in hepatocellular carcinoma: its role in tumor progression and apoptosisQ24805089
Expression of CD147 on monocytes/macrophages in rheumatoid arthritis: its potential role in monocyte accumulation and matrix metalloproteinase productionQ24812313
Cancer statistics, 2012Q27860574
Basigin (CD147) is expressed on melanoma cells and induces tumor cell invasion by stimulating production of matrix metalloproteinases by fibroblastsQ28216628
Sunitinib versus interferon alfa in metastatic renal-cell carcinomaQ28282757
The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamilyQ28304981
Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumorsQ29615445
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeuticsQ29615944
What Is the Evidence That Tumors Are Angiogenesis Dependent?Q29620029
RNAi-mediated silencing of CD147 inhibits tumor cell proliferation, invasion and increases chemosensitivity to cisplatin in SGC7901 cells in vitroQ33946429
Monocarboxylate transporter 4 (MCT4) and CD147 overexpression is associated with poor prognosis in prostate cancer.Q33970452
Role of emmprin in endometrial cancerQ34284285
Pathobiology, prognosis, and targeted therapy for renal cell carcinoma: exploiting the hypoxia-induced pathway.Q35569214
Combination angiostatic therapy completely inhibits ocular and tumor angiogenesisQ35575003
Tumor angiogenesis in advanced stage ovarian carcinoma.Q35796308
EMMPRIN/CD147, an MMP modulator in cancer, development and tissue repair.Q36076520
Increasing expression of extracellular matrix metalloprotease inducer in ovary tumors: tissue microarray analysis of immunostaining score with clinicopathological parameters.Q53626180
Expression of emmprin (CD147), a cell surface inducer of matrix metalloproteinases, in normal human brain and gliomas.Q55475249
Quantitative relationships of intravascular tumor cells, tumor vessels, and pulmonary metastases following tumor implantationQ69795457
Microvessel density and vessel invasion in lymph-node-negative breast cancer: effect on recurrence-free survivalQ71920372
5A11 antigen is a cell recognition molecule which is involved in neuronal-glial interactions in avian neural retinaQ72554209
Quantification of angiogenesis by a computerized image analysis system in renal cell carcinomaQ73369400
Prognostic significance of microscopic vascularity for clear cell renal cell carcinomaQ73739723
A null mutation in basigin, an immunoglobulin superfamily member, indicates its important roles in peri-implantation development and spermatogenesisQ74311247
CD147 expression as a significant prognostic factor in differentiated thyroid carcinomaQ81935887
CD147 and VEGF expression in advanced renal cell carcinoma and their prognostic valueQ84110576
Emmprin (basigin/CD147): matrix metalloproteinase modulator and multifunctional cell recognition molecule that plays a critical role in cancer progressionQ36515358
Upregulated EMMPRIN/CD147 might contribute to growth and angiogenesis of gastric carcinoma: a good marker for local invasion and prognosisQ36611964
Vascular endothelial growth factor C induces angiogenesis in vivo.Q36734917
Current pathologic methods for measuring intratumoral microvessel density within breast carcinoma and other solid tumorsQ36787960
EAU guidelines on renal cell carcinoma: the 2010 updateQ37773064
Characterization of an established cell line from human renal carcinomaQ39280597
A small interfering CD147-targeting RNA inhibited the proliferation, invasiveness, and metastatic activity of malignant melanomaQ40200798
Macrophages induce invasiveness of epithelial cancer cells via NF-kappa B and JNK.Q40400391
Extracellular matrix metalloproteinase inducer stimulates tumor angiogenesis by elevating vascular endothelial cell growth factor and matrix metalloproteinasesQ40434433
Expression of extracellular matrix metalloproteases inducer on micrometastatic and primary mammary carcinoma cellsQ40552173
Emmprin promotes anchorage-independent growth in human mammary carcinoma cells by stimulating hyaluronan productionQ40585893
Expression of emmprin by oral squamous cell carcinomaQ40903185
Quantitative microvessel density. A staging and prognostic marker for human prostatic carcinomaQ40933435
Tumor-derived EMMPRIN (extracellular matrix metalloproteinase inducer) stimulates collagenase transcription through MAPK p38.Q40983568
Expression patterns of emmprin and monocarboxylate transporter-1 in ovarian epithelial tumorsQ42511831
Expression of CD147 as a significantly unfavorable prognostic factor in hepatocellular carcinomaQ43658784
Regulation of Multidrug Resistance in Cancer Cells by HyaluronanQ44435256
How well do angiogenesis inhibitors work? Biomarkers of response prove elusive.Q45976068
Tumor angiogenesis correlates with lymph node metastases in invasive bladder cancerQ46448808
Antiangiogenesis research is booming, as questions and studies proliferateQ47721584
HAb18G (CD147), a cancer-associated biomarker and its role in cancer detectionQ47811362
Evaluation of microvessel density by computerised image analysis in human renal cell carcinoma. Correlation to pT category, nuclear grade, proliferative activity and occurrence of metastasisQ47995669
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectpatientQ181600
renal cell carcinomaQ1164529
P304page(s)e74313
P577publication date2013-09-20
P1433published inPLOS OneQ564954
P1476titleEMMPRIN promotes angiogenesis, proliferation, invasion and resistance to sunitinib in renal cell carcinoma, and its level predicts patient outcome
P478volume8

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cites work (P2860)
Q38720430A decade of pharmacogenomics research on tyrosine kinase inhibitors in metastatic renal cell cancer: a systematic review
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Q58790703Characterisation of the Morphological, Functional and Molecular Changes in Sunitinib-Resistant Renal Cell Carcinoma Cells
Q38294622Clinical and molecular prognostic and predictive biomarkers in clear cell renal cell cancer
Q33633431Clinical response to sunitinib as a multitargeted tyrosine-kinase inhibitor (TKI) in solid cancers: a review of clinical trials
Q41335207Cytoplasmic fragment of CD147 generated by regulated intramembrane proteolysis contributes to HCC by promoting autophagy
Q40219212EMMPRIN expression is involved in the development of interstitial fibrosis and tubular atrophy in human kidney allografts
Q38757525EMMPRIN, SP1 and microRNA-27a mediate physcion 8-O-β-glucopyranoside-induced apoptosis in osteosarcoma cells
Q35833138EMMPRIN/CD147 is a novel coreceptor of VEGFR-2 mediating its activation by VEGF.
Q36841347Hispidulin induces mitochondrial apoptosis in acute myeloid leukemia cells by targeting extracellular matrix metalloproteinase inducer
Q38836365Icaritin inhibits the invasion and epithelial-to-mesenchymal transition of glioblastoma cells by targeting EMMPRIN via PTEN/AKt/HIF-1α signalling
Q44398546Integrative analysis of BSG expression in NPC through immunohistochemistry and public high-throughput gene expression data
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Q36544390MCT4 surpasses the prognostic relevance of the ancillary protein CD147 in clear cell renal cell carcinoma
Q41672137Overexpression of CD147 is associated with poor prognosis, tumor cell migration and ERK signaling pathway activation in hepatocellular carcinoma
Q40767732Physcion induces mitochondria-driven apoptosis in colorectal cancer cells via downregulating EMMPRIN.
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