Reduced thrombosis in Klkb1-/- mice is mediated by increased Mas receptor, prostacyclin, Sirt1, and KLF4 and decreased tissue factor

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Reduced thrombosis in Klkb1-/- mice is mediated by increased Mas receptor, prostacyclin, Sirt1, and KLF4 and decreased tissue factor is …
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scholarly articleQ13442814

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P356DOI10.1182/BLOOD-2014-01-550285
P932PMC publication ID4304115
P698PubMed publication ID25339356
P5875ResearchGate publication ID267328068

P50authorEvi X StavrouQ58784883
Silvio AntoniakQ90480777
P2093author name stringOmar Alhalabi
Chao Fang
Nigel Mackman
Alvin H Schmaier
Alona Merkulova
Nadja Grobe
P2860cites workModulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylaseQ24293656
Defective thrombus formation in mice lacking coagulation factor XIIQ24646366
Platelet polyphosphates are proinflammatory and procoagulant mediators in vivoQ24655664
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factorQ28299224
Endothelial Kruppel-like factor 4 protects against atherothrombosis in miceQ30423011
Deletion of murine kininogen gene 1 (mKng1) causes loss of plasma kininogen and delays thrombosisQ33305420
ACE2 activation promotes antithrombotic activityQ33611250
Identification and characterization of prolylcarboxypeptidase as an endothelial cell prekallikrein activatorQ34112923
WATERFALL SEQUENCE FOR INTRINSIC BLOOD CLOTTING.Q34257361
Hyperglycemia-induced cerebral hematoma expansion is mediated by plasma kallikreinQ34572652
Identification of prolyl carboxypeptidase as an alternative enzyme for processing of renal angiotensin II using mass spectrometry.Q34580630
Increased vascular permeability in C1 inhibitor-deficient mice mediated by the bradykinin type 2 receptorQ34790892
The kallikrein-kinin and the renin-angiotensin systems have a multilayered interactionQ35148421
Studies on the prekallikrein (kallikreinogen)--kallikrein enzyme system of human plasma. I. Isolation and purification of plasma kallikreinsQ35566578
Bradykinin B2 receptor knockout mice are protected from thrombosis by increased nitric oxide and prostacyclinQ35849803
COX-2 suppresses tissue factor expression via endocannabinoid-directed PPARdelta activationQ36229672
Angiotensin 1-7 and Mas decrease thrombosis in Bdkrb2-/- mice by increasing NO and prostacyclin to reduce platelet spreading and glycoprotein VI activationQ36761576
The arrestin-selective angiotensin AT1 receptor agonist [Sar1,Ile4,Ile8]-AngII negatively regulates bradykinin B2 receptor signaling via AT1-B2 receptor heterodimersQ36967299
Function and immunochemistry of prekallikrein-high molecular weight kininogen complex in plasmaQ37020391
The antithrombotic effect of angiotensin-(1-7) involves mas-mediated NO release from plateletsQ40119975
Selective depletion of plasma prekallikrein or coagulation factor XII inhibits thrombosis in mice without increased risk of bleeding.Q40470385
Surface and fluid phase activities of two forms of activated Hageman factor produced during contact activation of plasmaQ41814564
Receptor-mediated internalization of bradykinin. DDT1 MF-2 smooth muscle cells process internalized bradykinin via multiple degradative pathwaysQ41940728
Sirt1 inhibition promotes in vivo arterial thrombosis and tissue factor expression in stimulated cellsQ42846641
Factor XIIa inhibitor recombinant human albumin Infestin-4 abolishes occlusive arterial thrombus formation without affecting bleedingQ43121714
Assembly and activation of HK-PK complex on endothelial cells results in bradykinin liberation and NO formationQ43541656
Antithrombotic effect of captopril and losartan is mediated by angiotensin-(1-7).Q44201695
Inhibition of vascular permeability by antisense-mediated inhibition of plasma kallikrein and coagulation factor 12.Q44770285
The role of prekallikrein and high-molecular-weight kininogen in the contact activation of Hageman factor (factor XII) by sulfatides and other agentsQ47249791
Fletcher factor deficiency: family study and detection.Q47879341
Plasma levels of bradykinin are suppressed in factor XII-deficient mice.Q51802842
Kruppel-like factor 4 regulates endothelial inflammation.Q55043476
Cyclooxygenase-2–Derived Prostacyclin Regulates Arterial Thrombus Formation by Suppressing Tissue Factor in a Sirtuin-1–Dependent-MannerQ57398730
Tissue plasminogen activator release in vivo in response to vasoactive agentsQ69963419
Bradykinin regulates the expression of kininogen binding sites on endothelial cellsQ70457136
Bradykinin and its metabolite, Arg-Pro-Pro-Gly-Phe, are selective inhibitors of alpha-thrombin-induced platelet activationQ71401438
Effect of bradykinin and thrombin on prostacyclin synthesis in endothelial cells from calf and pig aorta and human umbilical cord veinQ71516712
Plasma prekallikrein assay: reversible inhibition of C-1 inhibitor by chloroform and its use in measuring prekallikrein in different mammalian speciesQ72750770
Regulation of tissue factor expression in human microvascular endothelial cells by nitric oxideQ73762592
Thrombosis in patients with connective tissue diseases treated with specific cyclooxygenase 2 inhibitors. A report of four casesQ74175903
Macrovascular thrombosis is driven by tissue factor derived primarily from the blood vessel wallQ80512468
Effects of plasma kallikrein deficiency on haemostasis and thrombosis in mice: murine ortholog of the Fletcher traitQ83593225
An official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animalsQ84005909
Hereditary angioedema: a bradykinin-mediated swelling disorderQ85888097
P4510describes a project that usesImageJQ1659584
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectthrombosisQ261327
P1104number of pages10
P304page(s)710-719
P577publication date2014-10-22
P1433published inBloodQ885070
P1476titleReduced thrombosis in Klkb1-/- mice is mediated by increased Mas receptor, prostacyclin, Sirt1, and KLF4 and decreased tissue factor
P478volume125