Complexomics study of two Helicobacter pylori strains of two pathological origins: potential targets for vaccine development and new insight in bacteria metabolism

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Complexomics study of two Helicobacter pylori strains of two pathological origins: potential targets for vaccine development and new insight in bacteria metabolism is …
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scholarly articleQ13442814

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P356DOI10.1074/MCP.M110.001065
P932PMC publication ID3101863
P698PubMed publication ID20610778

P50authorFrancis MégraudQ33105790
Armelle MénardQ59137849
P2093author name stringMarc Bonneu
Cédric Bernarde
Jean-Paul Lasserre
Philippe Lehours
Michel Castroviejo
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Structural basis for catalytic and inhibitory mechanisms of beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ)Q27649373
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IDP3 encodes a peroxisomal NADP-dependent isocitrate dehydrogenase required for the beta-oxidation of unsaturated fatty acidsQ27936703
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Helicobacter pylori infection and gastric lymphomaQ28251488
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The druggable genomeQ29547361
The heat-shock proteinsQ29617227
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Blue native electrophoresis for isolation of membrane protein complexes in enzymatically active formQ29619372
Functional expression in Escherichia coli and membrane topology of porin HopE, a member of a large family of conserved proteins in Helicobacter pyloriQ30175172
Genetic and functional characterization of the alpAB gene locus essential for the adhesion of Helicobacter pylori to human gastric tissueQ30175791
The progress of membrane protein structure determinationQ30342003
The antioxidant protein alkylhydroperoxide reductase of Helicobacter pylori switches from a peroxide reductase to a molecular chaperone function.Q30352980
Flavodoxin:quinone reductase (FqrB): a redox partner of pyruvate:ferredoxin oxidoreductase that reversibly couples pyruvate oxidation to NADPH production in Helicobacter pylori and Campylobacter jejuniQ30443522
Urea protects Helicobacter (Campylobacter) pylori from the bactericidal effect of acid.Q30456762
Cloning and characterization of a 22 kDa outer-membrane protein (Omp22) from Helicobacter pyloriQ30654732
Conservation, localization and expression of HopZ, a protein involved in adhesion of Helicobacter pyloriQ30755698
Heat-shock proteins DnaK and GroEL facilitate export of LacZ hybrid proteins in E. coli.Q38341113
Helicobacter pylori genotyping in gastric adenocarcinoma and MALT lymphoma by multiplex PCR analyses of paraffin wax embedded tissuesQ38453575
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Identification of potential diagnostic and vaccine candidates of Helicobacter pylori by two-dimensional gel electrophoresis, sequence analysis, and serum profilingQ39505854
Identification of immunodominant antigens from Helicobacter pylori and evaluation of their reactivities with sera from patients with different gastroduodenal pathologiesQ39514203
A revised annotation and comparative analysis of Helicobacter pylori genomesQ39744669
Capacity of Helicobacter pylori to generate ionic gradients at low pH is similar to that of bacteria which grow under strongly acidic conditionsQ39824745
Metabolic activities of metronidazole-sensitive and -resistant strains of Helicobacter pylori: repression of pyruvate oxidoreductase and expression of isocitrate lyase activity correlate with resistanceQ39842339
Cloning and characterization of the Helicobacter pylori flbA gene, which codes for a membrane protein involved in coordinated expression of flagellar genesQ39844397
Evaluation of the clinical significance of homB, a novel candidate marker of Helicobacter pylori strains associated with peptic ulcer diseaseQ39936792
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The RecA protein of Helicobacter pylori requires a posttranslational modification for full activity.Q40469116
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The structure of CCT-Hsc70 NBD suggests a mechanism for Hsp70 delivery of substrates to the chaperonin.Q41393753
Genes acrA and acrB encode a stress-induced efflux system of Escherichia coliQ41681401
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Protein subassemblies of the Helicobacter pylori Cag type IV secretion system revealed by localization and interaction studiesQ41789821
Peroxisomal beta-oxidation of polyunsaturated fatty acids in Saccharomyces cerevisiae: isocitrate dehydrogenase provides NADPH for reduction of double bonds at even positionsQ41874920
Expression screening of integral membrane proteins from Helicobacter pylori 26695.Q41910049
Compound efflux in Helicobacter pyloriQ42050537
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.Q42506619
Syntheses and evaluation of benzodiazaborine compounds against M. tuberculosis H37Rv in vitroQ42537251
Conservative region of the genes encoding four adhesins of Helicobacter pylori: cloning, sequence analysis and biological information analysisQ42685506
Proteomic Helicobacter pylori biomarkers discriminating between duodenal ulcer and gastric cancerQ42726573
Helicobacter pylori-derived neutrophil-activating protein increases the lifespan of monocytes and neutrophilsQ43462020
Isoniazid affects multiple components of the type II fatty acid synthase system of Mycobacterium tuberculosis.Q43509450
Key importance of the Helicobacter pylori adherence factor blood group antigen binding adhesin during chronic gastric inflammation.Q43561119
Role of the Helicobacter pylori outer-membrane proteins AlpA and AlpB in colonization of the guinea pig stomach.Q43590288
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Conservative treatment of primary gastric low-grade B-cell lymphoma of mucosa-associated lymphoid tissue: predictive factors of response and outcomeQ43897248
Specific identification of three low molecular weight membrane-associated antigens of Helicobacter pyloriQ43904286
Identification of surface proteins of Helicobacter pylori by selective biotinylation, affinity purification, and two-dimensional gel electrophoresisQ44002728
NetAlign: a web-based tool for comparison of protein interaction networksQ44070985
Comparative analysis of two-dimensional electrophoresis maps (2-DE) of Helicobacter pylori from Brazilian patients with chronic gastritis and duodenal ulcer: a preliminary reportQ44550430
Assembly of Respiratory Complexes I, III, and IV into NADH Oxidase Supercomplex Stabilizes Complex I in Paracoccus denitrificansQ44650520
Two-dimensional Blue native/SDS gel electrophoresis of multi-protein complexes from whole cellular lysates: a proteomics approachQ44686525
Crystallization and preliminary X-ray analysis of an acetone carboxylase from Xanthobacter autotrophicus strain Py2.Q44745426
AcrA, AcrB, and TolC of Escherichia coli Form a Stable Intermembrane Multidrug Efflux ComplexQ44904796
Dynein light chain family in Tetrahymena thermophilaQ46046081
The cell as a collection of protein machines: preparing the next generation of molecular biologistsQ46148013
In vivo interactome of Helicobacter pylori urease revealed by tandem affinity purification.Q46444379
Infection by Helicobacter pylori expressing the BabA adhesin is influenced by the secretor phenotypeQ46580526
Helicobacter pylori thioredoxin is an arginase chaperone and guardian against oxidative and nitrosative stressesQ46851289
Functional assembly of the Na+/H+ antiporter of Helicobacter pylori from partial fragments in vivoQ46898952
How to analyze protein complexes by 2D blue native SDS-PAGE.Q46982968
Recombinant antigen from Helicobacter pylori urease as vaccine against H. pylori-associated disease.Q47431013
The thioredoxin system of Helicobacter pyloriQ47885417
Cloning and functional characterization of Helicobacter pylori fumarate reductase operon comprising three structural genes coding for subunits C, A and B.Q48041059
Characterization of four members of a multigene family encoding outer membrane proteins of Helicobacter pylori and their potential for vaccination.Q48364347
[Difference analysis on proteome of Helicobacter pylori in patients with peptic ulcer, gastritis, and gastric cancer].Q30828963
Identification and characterization of Helicobacter pylori genes essential for gastric colonizationQ30909822
Comparative analysis of proteome maps of Helicobacter pylori clinical isolates.Q30916472
Helicobacter pylori proteomics by 2-DE/MS, 1-DE-LC/MS and functional data miningQ30920306
Translocation of the Helicobacter pylori CagA protein in gastric epithelial cells by a type IV secretion apparatusQ30981200
Identification of protein complexes by comparative analysis of yeast and bacterial protein interaction dataQ31000652
Analysis of automatically generated peptide mass fingerprints of cellular proteins and antigens from Helicobacter pylori 26695 separated by two-dimensional electrophoresisQ31004720
Proteomic analysis of the sarcosine-insoluble outer membrane fraction of Helicobacter pylori strain 26695.Q31040627
Identification of a genetic marker of Helicobacter pylori strains involved in gastric extranodal marginal zone B cell lymphoma of the MALT-type.Q31078515
Identification of potential diagnostic and vaccine candidates of Helicobacter pylori by "proteome" technologiesQ32024441
How reliable are experimental protein-protein interaction data?Q33186555
Identification of NdhL and Ssl1690 (NdhO) in NDH-1L and NDH-1M complexes of Synechocystis sp. PCC 6803.Q33209035
Identification of Helicobacter pylori surface proteins by selective proteinase K digestion and antibody phage displayQ33216572
Protein complexes of the Escherichia coli cell envelope.Q33221063
Comparative proteomic analysis of Helicobacter pylori strains associated with iron deficiency anemiaQ33231322
Structure-based development of target-specific compound librariesQ33238328
Effects of cadmium stress on growth, morphology, and protein expression in Rhodobacter capsulatus B10.Q33259909
Inhibitors of FabI, an enzyme drug target in the bacterial fatty acid biosynthesis pathwayQ33314589
The human gastric pathogen Helicobacter pylori has a potential acetone carboxylase that enhances its ability to colonize miceQ33316212
Comparative genomics of Helicobacter pylori: analysis of the outer membrane protein familiesQ33597903
From array-based hybridization of Helicobacter pylori isolates to the complete genome sequence of an isolate associated with MALT lymphomaQ33600348
Metabolism and genetics of Helicobacter pylori: the genome era.Q33637624
OipA plays a role in Helicobacter pylori-induced focal adhesion kinase activation and cytoskeletal re-organizationQ33708500
Helicobacter pylori porCDAB and oorDABC genes encode distinct pyruvate:flavodoxin and 2-oxoglutarate:acceptor oxidoreductases which mediate electron transport to NADPQ33725283
Helicobacter pylori physiology predicted from genomic comparison of two strainsQ33728784
Alignment and structure prediction of divergent protein families: periplasmic and outer membrane proteins of bacterial efflux pumpsQ33856199
Helicobacter pylori uptake and efflux: basis for intrinsic susceptibility to antibiotics in vitroQ33978620
Essential thioredoxin-dependent peroxiredoxin system from Helicobacter pylori: genetic and kinetic characterizationQ33995790
Biosynthesis pathway of ADP-L-glycero-beta-D-manno-heptose in Escherichia coliQ34105897
Predicting protein-protein interactions using signature products.Q48528189
Two-dimensional blue native/SDS gel electrophoresis of multiprotein complexes from Helicobacter pylori.Q50474343
Two-dimensional Blue Native/sodium dodecyl sulfate gel electrophoresis for analysis of multimeric proteins in platelets.Q50486105
Purification of multisubunit membrane protein complexes: isolation of chloroplast FoF1-ATP synthase, CFo and CF1 by blue native electrophoresis.Q50518357
Fumarate reductase of Helicobacter pylori--an immunogenic protein.Q50771144
Direct analysis of the extracellular proteome from two strains of Helicobacter pylori.Q50993599
In silico identification of potential therapeutic targets in the human pathogen Helicobacter pylori.Q51175682
Composition of the ANTIGENome of Helicobacter pylori defined by human serum antibodies.Q51834472
Insertion of inverted Ter sites into the terminus region of the Escherichia coli chromosome delays completion of DNA replication and disrupts the cell cycle.Q52519012
Subproteomes of soluble and structure-bound Helicobacter pylori proteins analyzed by two-dimensional gel electrophoresis and mass spectrometry.Q52940101
Comparative proteome analysis of Helicobacter pylori.Q52971585
Comparative immunoproteomics of identification and characterization of virulence factors from Helicobacter pylori related to gastric cancer.Q53345167
A past history of gastric ulcers and Helicobacter pylori infection increase the risk of gastric malignant lymphoma.Q53641567
[Cloning and immunogenicity of conservative region of adhesin gene of Helicobacter pylori].Q53856413
Molecular construction of a multidrug exporter system, AcrAB: molecular interaction between AcrA and AcrB, and cleavage of the N-terminal signal sequence of AcrA.Q54042757
Up-expression of NapA and other oxidative stress proteins is a compensatory response to loss of major Helicobacter pylori stress resistance factors.Q54474980
The enoyl-[acyl-carrier-protein] reductase (FabI) of Escherichia coli, which catalyzes a key regulatory step in fatty acid biosynthesis, accepts NADH and NADPH as cofactors and is inhibited by palmitoyl-CoA.Q54575241
Helicobacter pylori virulence genotypes in Portuguese children and adults with gastroduodenal pathology.Q54785233
The beta subunit of the Escherichia coli ATP synthase exhibits a tight membrane binding property.Q54798789
Helicobacter pyloriInfectionQ56157319
New roles for structure in biology and drug discoveryQ57881359
Comparative proteomics and immunoproteomics of Helicobacter pylori related to different gastric pathologies☆Q60631644
Helicobacter pyloriimmunoproteomes in case reports of rosacea and chronic urticariaQ60631684
Helicobacter pylori and gastric carcinoma. Serum antibody prevalence in populations with contrasting cancer risksQ68617138
Sialylated Lewis determinant CA 19-9 in benign and malignant gastric tissueQ68739099
A monosialoganglioside is a monoclonal antibody-defined antigen of colon carcinomaQ70708620
Kinetics of substrate oxidation by whole cells and cell membranes of Helicobacter pyloriQ72314996
Gastric lymphoma and Helicobacter pyloriQ72334796
The autoregulatory HspR repressor protein governs chaperone gene transcription in Helicobacter pyloriQ73189500
MALT-type lymphoma of the stomach is associated with Helicobacter pylori strains expressing the CagA proteinQ73309459
Immunoproteomics of Helicobacter pylori infection and relation to gastric diseaseQ77841562
Duodenal ulcer-related antigens from Helicobacter pylori: immunoproteome and protein microarray approachesQ79818078
In vitro proinflammatory properties of Helicobacter pylori strains causing low-grade gastric MALT lymphomaQ79830281
Interaction between host gastric Sialyl-Lewis X and H. pylori SabA enhances H. pylori density in patients lacking gastric Lewis B antigenQ82232156
Proteomic Helicobacter pylori biomarkers discriminative of low-grade gastric MALT lymphoma and duodenal ulcerQ82776340
Proteome analysis of secreted proteins of the gastric pathogen Helicobacter pyloriQ34126268
Therapeutic vaccination against Helicobacter pylori in the beagle dog experimental model: safety, immunogenicity, and efficacyQ34143589
Role of the alpAB proteins and lipopolysaccharide in adhesion of Helicobacter pylori to human gastric tissueQ34156153
Heat shock proteins: molecular chaperones of protein biogenesis.Q34351628
Frequencies of the expression of main protein antigens from Helicobacter pylori isolates and production of specific serum antibodies in infected patientsQ34382356
Proteome analysis of the common human pathogen Helicobacter pyloriQ34420186
Global topology analysis of the Escherichia coli inner membrane proteomeQ34421914
Helicobacter pylori adhesin binding fucosylated histo-blood group antigens revealed by retaggingQ34452414
Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretionQ34507324
Protein-protein interactions among Helicobacter pylori cag proteinsQ34697771
Potential of fumarate reductase as a novel therapeutic target in Helicobacter pylori infectionQ34837506
Expression of Helicobacter pylori AlpA protein and its immunogenicityQ35010862
Functional and intracellular signaling differences associated with the Helicobacter pylori AlpAB adhesin from Western and East Asian strainsQ35087443
A Mr 34,000 proinflammatory outer membrane protein (oipA) of Helicobacter pyloriQ35162651
Evaluation of the association of nine Helicobacter pylori virulence factors with strains involved in low-grade gastric mucosa-associated lymphoid tissue lymphomaQ35549290
Analysis of F1F0-ATPase from Helicobacter pyloriQ35550616
Catalase, a novel antigen for Helicobacter pylori vaccinationQ35558213
Identification of carboxylation enzymes and characterization of a novel four-subunit pyruvate:flavodoxin oxidoreductase from Helicobacter pyloriQ35589915
Isolation and characterization of a conserved porin protein from Helicobacter pyloriQ35595289
Helicobacter pylori outer membrane proteins and gastroduodenal diseaseQ35760550
A whole-genome microarray reveals genetic diversity among Helicobacter pylori strainsQ35852799
Helicobacter pylori vaccine development based on combined subproteome analysisQ35892400
High-resolution crystallography and drug designQ36076881
Events at the host-microbial interface of the gastrointestinal tract IV. The pathogenesis of Helicobacter pylori persistenceQ36165808
Type IV secretion systems and their effectors in bacterial pathogenesis.Q36418304
Clinical relevance of the Helicobacter pylori gene for blood-group antigen-binding adhesinQ36556507
Modification of Helicobacter pylori outer membrane protein expression during experimental infection of rhesus macaquesQ36604828
Helicobacter pylori induces beta3GnT5 in human gastric cell lines, modulating expression of the SabA ligand sialyl-Lewis xQ36655027
Pathogenomics of helicobacterQ36784788
Detection and evaluation of antibodies against neutrophil-activating protein of Helicobacter pylori in patients with gastric cancerQ37198330
Efflux pump gene hefA of Helicobacter pylori plays an important role in multidrug resistanceQ37346953
Urease-associated heat shock protein of Helicobacter pyloriQ37893189
The orphan response regulator HP1021 of Helicobacter pylori regulates transcription of a gene cluster presumably involved in acetone metabolismQ38305859
P433issue12
P921main subjectHelicobacter pyloriQ180556
P304page(s)2796-2826
P577publication date2010-07-07
P1433published inMolecular & Cellular ProteomicsQ6895932
P1476titleComplexomics study of two Helicobacter pylori strains of two pathological origins: potential targets for vaccine development and new insight in bacteria metabolism
P478volume9

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