Disulfiram modulated ROS-MAPK and NFκB pathways and targeted breast cancer cells with cancer stem cell-like properties

scientific article

Disulfiram modulated ROS-MAPK and NFκB pathways and targeted breast cancer cells with cancer stem cell-like properties is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/BJC.2011.126
P932PMC publication ID3101904
P698PubMed publication ID21487404
P5875ResearchGate publication ID51046046

P50authorWeiguang WangQ43084075
P2093author name stringA L Armesilla
S Brown
B Xu
P Liu
J Cassidy
J L Darling
V Kannappan
I S Fombon
N C Yip
P2860cites workDisulfiram facilitates intracellular Cu uptake and induces apoptosis in human melanoma cells.Q40477833
Disulfiram-mediated inhibition of NF-kappaB activity enhances cytotoxicity of 5-fluorouracil in human colorectal cancer cell linesQ40670865
Pharmacogenomic dissection of resistance to thymidylate synthase inhibitors.Q40792397
Copper and zinc levels in normal and malignant tissuesQ41607676
The Effect of Copper Compounds upon the Growth of Carcinoma in the RatQ42565254
Synergistic activity of sorafenib and sulforaphane abolishes pancreatic cancer stem cell characteristicsQ43041593
Antineoplastic mechanisms of niclosamide in acute myelogenous leukemia stem cells: inactivation of the NF-kappaB pathway and generation of reactive oxygen speciesQ43136797
Disulfiram induces apoptosis in human melanoma cells: a redox-related process.Q44239182
Suppressing glioblastoma stem cell function by aldehyde dehydrogenase inhibition with chloramphenicol or disulfiram as a new treatment adjunct: an hypothesis.Q45981295
Phase I study of bortezomib with weekly paclitaxel in patients with advanced solid tumours.Q46474270
Disulfiram, a clinically used anti-alcoholism drug and copper-binding agent, induces apoptotic cell death in breast cancer cultures and xenografts via inhibition of the proteasome activityQ48381026
Effects of the pH dependence of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide-formazan absorption on chemosensitivity determined by a novel tetrazolium-based assay.Q50886497
Targeting breast cancer stem cellsQ57139325
Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaBQ64381570
Trace-metal analysis of cancerous and noncancerous human tissuesQ68629379
Selective protection against cis-diamminedichloroplatinum(II)-induced toxicity in kidney, gut, and bone marrow by diethyldithiocarbamateQ70137123
Comparison between concentrations of trace elements in normal and neoplastic human breast tissueQ70641092
Dithiocarbamates Induce Apoptosis in Thymocytes by Raising the Intracellular Level of Redox-active CopperQ71823842
Modification of the sensitivity and repair of potentially lethal damage by diethyldithiocarbamate during and following exposure of plateau-phase cultures of mammalian cells to radiation and cis-diamminedichloroplatinum(II)Q72935637
Effect of disulfiram (tetraethylthiuram disulfide) amd diethyldithiocarbamate on the bladder toxicity and antitumor activity of cyclophosphamide in miceQ72957176
Inhibition of recombinant human mitochondrial and cytosolic aldehyde dehydrogenases by two candidates for the active metabolites of disulfiramQ73838734
Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamilyQ24655095
ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcomeQ24657877
ALDH3A1: a corneal crystallin with diverse functionsQ28248140
Pharmacological profiling of disulfiram using human tumor cell lines and human tumor cells from patientsQ28267360
Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitorsQ29547463
IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancerQ29614599
NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activationQ29618715
Cancer stem cells: models and conceptsQ29620611
High-throughput cell-based screening of 4910 known drugs and drug-like small molecules identifies disulfiram as an inhibitor of prostate cancer cell growthQ33507489
TNFalpha up-regulates SLUG via the NF-kappaB/HIF1alpha axis, which imparts breast cancer cells with a stem cell-like phenotypeQ34130168
Targeting aldehyde dehydrogenase cancer stem cells in ovarian cancerQ34420393
Dual role of hydrogen peroxide in cancer: possible relevance to cancer chemoprevention and therapyQ34588238
Clonogenic assay of cells in vitro.Q34615431
Human aldehyde dehydrogenases: potential pathological, pharmacological, and toxicological impactQ35077713
A review of the pharmacokinetics and pharmacodynamics of disulfiram and its metabolitesQ35625458
Reactive oxygen species mediate crosstalk between NF-kappaB and JNK.Q36337991
NF-kappaB activation by reactive oxygen species: fifteen years laterQ36488422
Reactive oxygen species-induced activation of the MAP kinase signaling pathwaysQ36598861
Current insights into the regulation of programmed cell death by NF-kappaB.Q36637900
Reactive oxygen species: a breath of life or death?Q36731940
Neurotoxicity and metabolism of the catecholamine-derived 3,4-dihydroxyphenylacetaldehyde and 3,4-dihydroxyphenylglycolaldehyde: the role of aldehyde dehydrogenase.Q36767402
Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survivalQ37015135
Inhibition of tumor proteasome activity by gold-dithiocarbamato complexes via both redox-dependent and -independent processesQ37158093
Elevated copper and oxidative stress in cancer cells as a target for cancer treatmentQ37262037
Finding cancer stem cells: are aldehyde dehydrogenases fit for purpose?Q37789712
Constitutive nuclear factor-kappa B mRNA, protein overexpression and enhanced DNA-binding activity in thymidylate synthase inhibitor-resistant tumour cellsQ38310149
Mechanistic and predictive profiling of 5-Fluorouracil resistance in human cancer cells.Q38334174
Aldehyde dehydrogenase activity of breast cancer stem cells is primarily due to isoform ALDH1A3 and its expression is predictive of metastasisQ39600418
Relationships between multidrug resistance (MDR) and stem cell markers in human chronic myeloid leukemia cell lines.Q39765844
Disulfiram induces copper-dependent stimulation of reactive oxygen species and activation of the extrinsic apoptotic pathway in melanomaQ39766253
Triptolide simultaneously induces reactive oxygen species, inhibits NF-kappaB activity and sensitizes 5-fluorouracil in colorectal cancer cell linesQ39776662
Disulfiram/copper complex inhibiting NFkappaB activity and potentiating cytotoxic effect of gemcitabine on colon and breast cancer cell lines.Q39794951
The actions of metabolic fate of disulfiramQ40307000
Bortezomib (VELCADE) in metastatic breast cancer: pharmacodynamics, biological effects, and prediction of clinical benefitsQ40359103
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectbreast cancerQ128581
neoplastic stem cellsQ1638475
P304page(s)1564-1574
P577publication date2011-04-12
P1433published inBritish Journal of CancerQ326309
P1476titleDisulfiram modulated ROS-MAPK and NFκB pathways and targeted breast cancer cells with cancer stem cell-like properties
P478volume104

Reverse relations

cites work (P2860)
Q92330354A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells
Q26851160A conceptually new treatment approach for relapsed glioblastoma: coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the International Initiative for Accelerated Improvement of Glioblastoma Care
Q90352375ALDH-Dependent Glycolytic Activation Mediates Stemness and Paclitaxel Resistance in Patient-Derived Spheroid Models of Uterine Endometrial Cancer
Q46185130Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4.
Q26786476Aldehyde dehydrogenase as a marker and functional mediator of metastasis in solid tumors
Q90481740An evolving paradigm of cancer stem cell hierarchies: therapeutic implications
Q90045611Annurca apple polyphenol extract selectively kills MDA-MB-231 cells through ROS generation, sustained JNK activation and cell growth and survival inhibition
Q58744474Anti-cancer effects of disulfiram in head and neck squamous cell carcinoma via autophagic cell death
Q38406751Antileishmanial Activity of Disulfiram and Thiuram Disulfide Analogs in an Ex Vivo Model System Is Selectively Enhanced by the Addition of Divalent Metal Ions
Q93049389Application of Nanotechnology in Targeting of Cancer Stem Cells: A Review
Q33977045Blocking the formation of radiation-induced breast cancer stem cells
Q49181990Brain- and brain tumor-penetrating disulfiram nanoparticles: Sequence of cytotoxic events and efficacy in human glioma cell lines and intracranial xenografts.
Q27024816Cancer Stem and Progenitor-Like Cells as Pharmacological Targets in Breast Cancer Treatment
Q38540375Cancer stem cells in hepatocellular carcinoma: Therapeutic implications based on stem cell biology
Q42371594Cell cycle specific radiosensitisation by the disulfiram and copper complex
Q28484299Chemical biology drug sensitivity screen identifies sunitinib as synergistic agent with disulfiram in prostate cancer cells
Q28085377Chemotherapy targeting cancer stem cells
Q35542866Concise review: bullseye: targeting cancer stem cells to improve the treatment of gliomas by repurposing disulfiram
Q44845181Condurango-glycoside-A fraction of Gonolobus condurango induces DNA damage associated senescence and apoptosis via ROS-dependent p53 signalling pathway in HeLa cells
Q38947366Copper signaling axis as a target for prostate cancer therapeutics
Q38792695Crystal structure and chemotherapeutic efficacy of the novel compound, gallium tetrachloride betaine, against breast cancer using nanotechnology.
Q38736335Curcumin analog EF24 induces apoptosis via ROS-dependent mitochondrial dysfunction in human colorectal cancer cells
Q39266662Cytotoxic effect of disulfiram/copper on human glioblastoma cell lines and ALDH-positive cancer-stem-like cells
Q36820304Delivery of disulfiram into breast cancer cells using folate-receptor-targeted PLGA-PEG nanoparticles: in vitro and in vivo investigations
Q96128478Diethyldithiocarbamate-copper nanocomplex reinforces disulfiram chemotherapeutic efficacy through light-triggered nuclear targeting
Q57163862Discovering proteasomal deubiquitinating enzyme inhibitors for cancer therapy: lessons from rational design, nature and old drug reposition
Q64892039Disulfiram (Antabuse) Activates ROS-Dependent ER Stress and Apoptosis in Oral Cavity Squamous Cell Carcinoma.
Q35825566Disulfiram (DSF) acts as a copper ionophore to induce copper-dependent oxidative stress and mediate anti-tumor efficacy in inflammatory breast cancer.
Q28546890Disulfiram attenuates osteoclast differentiation in vitro: a potential antiresorptive agent
Q89595843Disulfiram causes selective hypoxic cancer cell toxicity and radio-chemo-sensitization via redox cycling of copper
Q36063610Disulfiram chelated with copper promotes apoptosis in human breast cancer cells by impairing the mitochondria functions
Q47096948Disulfiram combined with copper inhibits metastasis and epithelial-mesenchymal transition in hepatocellular carcinoma through the NF-κB and TGF-β pathways.
Q37472766Disulfiram eradicates tumor-initiating hepatocellular carcinoma cells in ROS-p38 MAPK pathway-dependent and -independent manners
Q36562209Disulfiram inhibits TGF-β-induced epithelial-mesenchymal transition and stem-like features in breast cancer via ERK/NF-κB/Snail pathway
Q64073074Disulfiram inhibits epithelial-mesenchymal transition through TGFβ-ERK-Snail pathway independently of Smad4 to decrease oral squamous cell carcinoma metastasis
Q90478009Disulfiram reduces metastatic osteosarcoma tumor burden in an immunocompetent Balb/c or-thotopic mouse model
Q90609993Disulfiram suppressed ethanol promoted RANKL-induced osteoclastogenesis in vitro and ethanol-induced osteoporosis in vivo via ALDH1A1-NFATc1 axis
Q28541751Disulfiram suppresses growth of the malignant pleural mesothelioma cells in part by inducing apoptosis
Q37214346Disulfiram targets cancer stem-like cells and reverses resistance and cross-resistance in acquired paclitaxel-resistant triple-negative breast cancer cells
Q92483795Disulfiram's anti-cancer activity reflects targeting NPL4, not inhibition of aldehyde dehydrogenase
Q39263561Disulfiram, a drug widely used to control alcoholism, suppresses the self-renewal of glioblastoma and over-rides resistance to temozolomide
Q35054730Disulfiram-induced cytotoxicity and endo-lysosomal sequestration of zinc in breast cancer cells
Q38930082Disulfiram-loaded immediate and extended release vaginal tablets for the localised treatment of cervical cancer
Q92630095Disulfiram/Copper Induces Antitumor Activity against Both Nasopharyngeal Cancer Cells and Cancer-Associated Fibroblasts through ROS/MAPK and Ferroptosis Pathways
Q41575123Disulfiram/copper causes redox-related proteotoxicity and concomitant heat shock response in ovarian cancer cells that is augmented by auranofin-mediated thioredoxin inhibition
Q41082509Disulfiram/copper selectively eradicates AML leukemia stem cells in vitro and in vivo by simultaneous induction of ROS-JNK and inhibition of NF-κB and Nrf2.
Q36837031Dithiocarbamate-based coordination compounds as potent proteasome inhibitors in human cancer cells
Q36734783EM23, A Natural Sesquiterpene Lactone from Elephantopus mollis, Induces Apoptosis in Human Myeloid Leukemia Cells through Thioredoxin- and Reactive Oxygen Species-Mediated Signaling Pathways
Q37696104Effective elimination of adult B-lineage acute lymphoblastic leukemia by disulfiram/copper complex in vitro and in vivo in patient-derived xenograft models
Q47278890GNA13 expression promotes drug resistance and tumor-initiating phenotypes in squamous cell cancers.
Q34481639High-throughput chemical screens identify disulfiram as an inhibitor of human glioblastoma stem cells
Q37420053High-throughput screen identifies disulfiram as a potential therapeutic for triple-negative breast cancer cells: interaction with IQ motif-containing factors
Q44452857How could a drug used to treat alcoholism also be effective against glioblastoma?
Q57070043Hydroxycobalamin catalyzes the oxidation of diethyldithiocarbamate and increases its cytotoxicity independently of copper ions
Q52560420IL-6 family cytokines: Key inflammatory mediators as biomarkers and potential therapeutic targets.
Q36595072Identification and characterization of small molecule inhibitors of a plant homeodomain finger
Q92239454Immunocyte Profiling Using Single-Cell Mass Cytometry Reveals EpCAM+ CD4+ T Cells Abnormal in Colon Cancer
Q38819831In Vitro Selective Anti-Proliferative Effect of Zinc Oxide Nanoparticles Against Co-Cultured C2C12 Myoblastoma Cancer and 3T3-L1 Normal Cells
Q91726656Induction of autophagy-dependent apoptosis in cancer cells through activation of ER stress: an uncovered anti-cancer mechanism by anti-alcoholism drug disulfiram
Q90079560Induction of immunogenic cell death in radiation-resistant breast cancer stem cells by repurposing anti-alcoholism drug disulfiram
Q90382769Investigation of the key chemical structures involved in the anticancer activity of disulfiram in A549 non-small cell lung cancer cell line
Q42365079Leptin signaling and cancer chemoresistance: Perspectives
Q91905865Lipid-polymer hybrid nanoparticles for controlled delivery of hydrophilic and lipophilic doxorubicin for breast cancer therapy
Q34365729Liposome encapsulated Disulfiram inhibits NFκB pathway and targets breast cancer stem cells in vitro and in vivo.
Q37424042Low-dose triptolide in combination with idarubicin induces apoptosis in AML leukemic stem-like KG1a cell line by modulation of the intrinsic and extrinsic factors
Q34675192Luteolin is a novel p90 ribosomal S6 kinase (RSK) inhibitor that suppresses Notch4 signaling by blocking the activation of Y-box binding protein-1 (YB-1)
Q36591484Mechanisms of chemoresistance in cancer stem cells
Q36163766Metabolic activation of mitochondria in glioma stem cells promotes cancer development through a reactive oxygen species-mediated mechanism
Q64061518Metabolism-Based Therapeutic Strategies Targeting Cancer Stem Cells
Q39321461MicroRNA expression analysis of mammospheres cultured from human breast cancers
Q49385440Modeling of a Hybrid Langmuir Adsorption Isotherm for Describing Interactions Between Drug Molecules and Silica Surfaces.
Q48209273Nanocarrier based approaches for targeting breast cancer stem cells.
Q28066297Nanomedicine-Mediated Therapies to Target Breast Cancer Stem Cells
Q35606242Ovarian cancer stem cell markers: prognostic and therapeutic implications
Q52373664Pharmacological targets of breast cancer stem cells: a review.
Q37719254Poly lactic-co-glycolic acid controlled delivery of disulfiram to target liver cancer stem-like cells.
Q94564542Potential Patient-Reported Toxicities With Disulfiram Treatment in Late Disseminated Lyme Disease
Q54538158Protein phosphatases 2A as well as reactive oxygen species involved in tributyltin-induced apoptosis in mouse livers.
Q35966191Radiosensitization by a novel Bcl-2 and Bcl-XL inhibitor S44563 in small-cell lung cancer
Q47609532Recent Advances in Antabuse (Disulfiram): the importance of its metal-binding ability to its anticancer activity.
Q90223689Redox regulation of cell state and fate
Q43234285Reply: Cytotoxic effect of disulfiram/copper on human glioblastoma cell lines and ALDH-positive cancer-stem-like cells
Q36461628Role of a polyphenol-enriched preparation on chemoprevention of mammary carcinoma through cancer stem cells and inflammatory pathways modulation
Q101049273Roles of Ion fluxes, metabolism and redox balance in cancer therapy
Q35667050Selective killing of gastric cancer cells by a small molecule targeting ROS-mediated ER stress activation
Q46768943Selective killing of hepatocellular carcinoma HepG2 cells by three-dimensional nanographene nanoparticles based on triptycene
Q36088183Sensitization of pancreatic cancer stem cells to gemcitabine by Chk1 inhibition
Q92451410Soybean lecithin stabilizes disulfiram nanosuspensions with a high drug-loading content: remarkably improved antitumor efficacy
Q33572252Stemness in Cancer: Stem Cells, Cancer Stem Cells, and Their Microenvironment.
Q58744510Synthesis and biological evaluation of dithiocarbamate esters of parthenolide as potential anti-acute myelogenous leukaemia agents
Q39171958Tanshinone IIA inhibits breast cancer stem cells growth in vitro and in vivo through attenuation of IL-6/STAT3/NF-kB signaling pathways
Q37629056Targeting ALDH1A1 by disulfiram/copper complex inhibits non-small cell lung cancer recurrence driven by ALDH-positive cancer stem cells
Q49860324Targeting ALDH2 with disulfiram/copper reverses the resistance of cancer cells to microtubule inhibitors
Q37264685The cytotoxic mechanisms of disulfiram and copper(ii) in cancer cells.
Q26775232The fate of chemoresistance in triple negative breast cancer (TNBC)
Q38498021The therapeutic potential of vaginal drug delivery in the treatment of cervical cancer
Q39361267Vaginal drug delivery for the localised treatment of cervical cancer
Q36962758Yap1 promotes the survival and self-renewal of breast tumor initiating cells via inhibiting Smad3 signaling
Q35787510Zinc oxide nanoparticles selectively induce apoptosis in human cancer cells through reactive oxygen species.
Q53794454[Cancer stem cells as the therapeutic target of tomorrow].