Host genetic determinants of spontaneous hepatitis C clearance

scientific article

Host genetic determinants of spontaneous hepatitis C clearance is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.2217/PGS.09.121
P698PubMed publication ID19891557

P50authorChloe L ThioQ92964327
Pierre-Yves BochudQ50877821
Silvana GaudieriQ89100814
Andri RauchQ92034483
P2860cites workInfluence of MHC class II genotype on outcome of infection with hepatitis C virus. The HENCORE group. Hepatitis C European Network for Cooperative ResearchQ22010973
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controlsQ24550675
Genetic variation in IL28B and spontaneous clearance of hepatitis C virusQ24596340
Sustained Dysfunction of Antiviral CD8+ T Lymphocytes after Infection with Hepatitis C VirusQ27469800
Decreased frequency of the HLA-DRB1*11 allele in patients with chronic hepatitis C virus infectionQ27472839
HLA-Cw*04 and hepatitis C virus persistenceQ27472874
Broad Specificity of Virus-Specific CD4+ T-Helper-Cell Responses in Resolved Hepatitis C Virus InfectionQ27472915
A comparison of the molecular clock of hepatitis C virus in the United States and Japan predicts that hepatocellular carcinoma incidence in the United States will increase over the next two decadesQ27473000
Viral and immunological determinants of hepatitis C virus clearance, persistence, and diseaseQ27473001
The CCR5- 32 mutation: impact on disease outcome in individuals with hepatitis C infection from a single sourceQ27477986
Correlates of spontaneous clearance of hepatitis C virus among people with hemophiliaQ27480307
CD8 Epitope Escape and Reversion in Acute HCV InfectionQ27485189
Mutational escape from CD8+ T cell immunity: HCV evolution, from chimpanzees to manQ27485215
Interaction of NK inhibitory receptor genes with HLA-C and MHC class II alleles in Hepatitis C virus infection outcomeQ27486089
Interferon-inducible antiviral effectorsQ27486790
Host Genetic Factors and Antiviral Immune Responses to Hepatitis C VirusQ27487445
Regulatory Polymorphisms in the Interleukin‐18 Promoter Are Associated with Hepatitis C Virus ClearanceQ27488349
Genetic Markers of IgG Influence the Outcome of Infection with Hepatitis C VirusQ27488362
Ethnic and geographical differences in HLA associations with the outcome of hepatitis C virus infectionQ27488372
Human leukocyte antigen class II associations with hepatitis C virus clearance and virus‐specific CD4 T cell response among Caucasians and African AmericansQ27489728
MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignmentQ27860726
Replication of hepatitis C virusQ27860957
Determinants of viral clearance and persistence during acute hepatitis C virus infectionQ28131757
HLA and HIV-1: heterozygote advantage and B*35-Cw*04 disadvantageQ28138607
The influence of HLA genotype on AIDSQ28202903
MHC class II genes influence the susceptibility to chronic active hepatitis CQ28248437
Genetic variations in humans associated with differences in the course of hepatitis CQ28254610
Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearanceQ28255243
Peginterferon Alfa-2a plus ribavirin for chronic hepatitis C virus infection in HIV-infected patientsQ28274666
Peginterferon Alfa-2a plus ribavirin versus interferon alfa-2a plus ribavirin for chronic hepatitis C in HIV-coinfected personsQ28274676
A comparative review of HLA associations with hepatitis B and C viral infections across global populationsQ28299722
Regulation of Interferon Regulatory Factor-3 by the Hepatitis C Virus Serine ProteaseQ29614208
Common genetic variation and human traitsQ29614445
Interleukin-12 and the regulation of innate resistance and adaptive immunityQ29614602
A whole-genome association study of major determinants for host control of HIV-1Q29614891
Prevention of hepatitis C virus infection in chimpanzees after antibody-mediated in vitro neutralizationQ29615898
Immunology of hepatitis B virus and hepatitis C virus infectionQ29618957
Evasion of intracellular host defence by hepatitis C virusQ29618976
Adaptive immune responses in acute and chronic hepatitis C virus infectionQ29619722
Cellular immune responses persist and humoral responses decrease two decades after recovery from a single-source outbreak of hepatitis CQ29620614
HCV Persistence and Immune Evasion in the Absence of Memory T Cell HelpQ29620766
Impaired effector function of hepatitis C virus-specific CD8+ T cells in chronic hepatitis C virus infectionQ29620795
Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune responseQ29620891
Hepatitis C virus and human immunodeficiency virus coinfection in an urban population: low eligibility for interferon treatmentQ31122023
Missingness in the T1DGC MHC fine-mapping SNP data: association with HLA genotype and potential influence on genetic association studiesQ33399899
Designing genome-wide association studies: sample size, power, imputation, and the choice of genotyping chipQ33459119
Genomics of the major histocompatibility complex: haplotypes, duplication, retroviruses and diseaseQ33630704
Persistence of viremia and the importance of long-term follow-up after acute hepatitis C infectionQ33853655
Spontaneous elimination of serum hepatitis C virus (HCV) RNA in chronic HCV carriers: a population-based cohort studyQ33967148
Association of genetic variants of the chemokine receptor CCR5 and its ligands, RANTES and MCP-2, with outcome of HCV infectionQ33974291
The natural history of hepatitis C virus infection: host, viral, and environmental factorsQ33974693
High rate of spontaneous negativity for hepatitis C virus RNA after establishment of chronic infection in Alaska NativesQ33993892
Global challenges in liver diseaseQ33999114
Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavirQ34117815
The differential ability of HLA B*5701+ long-term nonprogressors and progressors to restrict human immunodeficiency virus replication is not caused by loss of recognition of autologous viral gag sequencesQ34200151
Immunity to hepatitis C virus: stunned but not defeatedQ34515852
Spontaneous elimination of hepatitis C virus infection: a retrospective study on demographic, clinical, and serological correlatesQ34604833
Evidence for human leukocyte antigen heterozygote advantage against hepatitis C virus infectionQ34700869
Toll-like receptor 2 (TLR2) polymorphisms are associated with reversal reaction in leprosyQ34797664
Follow-up studies of treatment for hepatitis C virus infection among injection drug usersQ42991341
Single nucleotide polymorphisms and haplotypes in the IL10 region associated with HCV clearanceQ42991714
Clinical outcomes after hepatitis C infection from contaminated anti-D immune globulin. Irish Hepatology Research GroupQ42993140
Increased frequency of the HLA-DR15 (B1*15011) allele in German patients with self-limited hepatitis C virus infection.Q42993377
Spontaneous negativation of serum hepatitis C virus RNA is a rare event in type C chronic liver diseases: analysis of HCV RNA in 320 patients who were followed for more than 3 yearsQ42995243
Dominant influence of an HLA-B27 restricted CD8+ T cell response in mediating HCV clearance and evolutionQ42998504
Viral clearance in hepatitis C (1b) infection: relationship with human leukocyte antigen class II in a homogeneous populationQ42998786
HLA-C and KIR genes in hepatitis C virus infection.Q42999215
Association of transforming growth factor-beta 1 functional polymorphisms with natural clearance of hepatitis C virusQ42999490
Study of host- and virus-related factors associated with spontaneous hepatitis C virus clearanceQ43000404
Hepatitis C virus clearance is prominent in women in an endemic areaQ43000829
Racial differences in HLA class II associations with hepatitis C virus outcomesQ43032027
Stability of HCV-RNA level and its lack of correlation with disease severity in asymptomatic chronic hepatitis C virus carriersQ43032783
Does the clinical outcome of hepatitis C infection vary with the infecting hepatitis C virus type?Q43036063
Influence of inhibitory killer immunoglobulin-like receptors and their HLA-C ligands on resolving hepatitis C virus infectionQ43037291
Clearance of hepatitis C virus in HIV-infected patients with multiple chronic viral hepatitisQ43037726
Protective effect of HLA-B57 on HCV genotype 2 infection in a West African populationQ43038195
Association of low-density lipoprotein receptor polymorphisms and outcome of hepatitis C infectionQ43039746
Polymorphisms in interferon-induced genes and the outcome of hepatitis C virus infection: roles of MxA, OAS-1 and PKR.Q43046800
Polymorphisms in tumour necrosis factor-alpha, transforming growth factor-beta, interleukin-10, interleukin-6, interferon-gamma, and outcome of hepatitis C virus infectionQ43438665
An approach to the localization of the susceptibility genes for generalized myasthenia gravis by mapping recombinant ancestral haplotypesQ43491662
Surprisingly small effect of antiviral treatment in patients with hepatitis C.Q43889137
Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA.Q44291572
HCV chronic infection and CCR5-delta32/delta32.Q44350295
Polymorphisms in the IL-12B gene and outcome of HCV infectionQ44752498
Low-density lipoprotein receptor variants are associated with spontaneous and treatment-induced recovery from hepatitis C virus infection.Q44865251
Hepatitis C virus core protein impairs in vitro priming of specific T cell responses by dendritic cells and hepatocytes.Q45399299
Innate immunity in hepatitis C virus infection: Interplay among dendritic cells, natural killer cells and natural killer T cellsQ45399738
Influence of IL-10RA and IL-22 polymorphisms on outcome of hepatitis C virus infectionQ45400167
Polymorphisms in TLR2 are associated with increased viral shedding and lesional rate in patients with genital herpes simplex virus Type 2 infectionQ45402052
Interferon regulatory factor-1 promoter polymorphism and the outcome of hepatitis C virus infection.Q45413597
Association between human leukocytes antigen alleles and chronic hepatitis C virus infection in the Korean populationQ45421753
RIGing a virus trapQ45424053
Influence of interleukin 12B (IL12B) polymorphisms on spontaneous and treatment-induced recovery from hepatitis C virus infectionQ45569965
Interleukin-10 promoter polymorphisms and the outcome of hepatitis C virus infectionQ45722071
Hepatitis C virus-specific cytolytic T lymphocyte and T helper cell responses in seronegative personsQ45760124
HLA class II genes in chronic hepatitis C virus-infection and associated immunological disordersQ45766137
High frequency of CCR5-delta32 homozygosity in HCV-infected, HIV-1-uninfected hemophiliacs results from resistance to HIV-1.Q45858918
Maintenance of MHC polymorphismQ47864601
The reverse stop-signal model for CTLA4 function.Q48540784
Chronic hepatitis C in HIV-infected patients: low eligibility and applicability of therapy with pegylated interferon-alpha plus ribavirin.Q50579778
Acute hepatitis C: high rate of both spontaneous and treatment-induced viral clearance.Q50582782
Polymorphisms in the interleukin-10, tumor necrosis factor-alpha, and transforming growth factor-beta1 genes in chronic hepatitis C patients treated with interferon and ribavirin.Q50585022
Polymorphisms in Toll-like receptor 9 influence the clinical course of HIV-1 infection.Q51922292
Frequency of the HIV-protective CC chemokine receptor 5-Delta32/Delta32 genotype is increased in hepatitis C.Q52039136
IL-10 and TNF-α polymorphisms and the recovery from HCV infectionQ58803426
Gender susceptibility to chronic hepatitis C virus infection associated with interleukin 10 promoter polymorphismQ35024327
A functional SNP of interferon-gamma gene is important for interferon-alpha-induced and spontaneous recovery from hepatitis C virus infectionQ35612409
Host genetic determinants in hepatitis C virus infectionQ35753723
Metabolic and cardiovascular risk profiles and hepatitis C virus infection in rural EgyptQ35956085
Associations between KIR epitope combinations expressed by HLA-B/-C haplotypes found in an HIV-1 infected study population may influence NK mediated immune responsesQ35988436
Association of interleukin-12 p40 gene 3'-untranslated region polymorphism and outcome of HCV infectionQ36076518
T cells and viral persistence: lessons from diverse infectionsQ36238129
Spontaneous viral clearance following acute hepatitis C infection: a systematic review of longitudinal studiesQ36346436
Type 1 interferons and the virus-host relationship: a lesson in détente .Q36475884
Flying under the radar: the immunobiology of hepatitis C.Q36635544
Impact of the genetic restriction of virus-specific T-cell responses in hepatitis C virus infectionQ36710738
Genetics, genomics, and proteomics: implications for the diagnosis and the treatment of chronic hepatitis C.Q36733943
Altered innate immunity in chronic hepatitis C infection: cause or effect?Q36948514
Toll-like receptor 4 polymorphisms and aspergillosis in stem-cell transplantationQ37130676
Predisposition to abacavir hypersensitivity conferred by HLA-B*5701 and a haplotypic Hsp70-Hom variantQ37356747
Comprehensive analyses of CD8+ T cell responses during longitudinal study of acute human hepatitis C.Q37381208
Epistatic effects of immunoglobulin GM and KM allotypes on outcome of infection with hepatitis C virusQ37423211
Long-term mortality and morbidity of transfusion-associated non-A, non-B, and type C hepatitis: A National Heart, Lung, and Blood Institute collaborative studyQ38462606
Clearance and persistence of hepatitis C virus in a Tunisian population: association with HLA class I and class II.Q39149612
Divergent adaptation of hepatitis C virus genotypes 1 and 3 to human leukocyte antigen-restricted immune pressureQ39956342
Interleukin-1, interleukin-10 and tumour necrosis factor-alpha gene polymorphisms in hepatitis C virus infection: an investigation of the relationships with spontaneous viral clearance and response to alpha-interferon therapyQ40626254
Cutting edge: a Toll-like receptor 2 polymorphism that is associated with lepromatous leprosy is unable to mediate mycobacterial signalingQ40662613
Gender-dependent association of CTLA4 polymorphisms with resolution of hepatitis C virus infectionQ41604090
Protective KIR-HLA interactions for HCV infection in intravenous drug users.Q41903533
High resolution analysis of cellular immune responses in resolved and persistent hepatitis C virus infectionQ42635673
Hepatitis C virus-infected hepatocytes extrinsically modulate dendritic cell maturation to activate T cells and natural killer cellsQ42978974
IL-10 haplotypes as possible predictors of spontaneous clearance of HCV infectionQ42982169
Pervasive influence of hepatitis C virus on the phenotype of antiviral CD8+ T cellsQ42982580
Epidemiology and risk factors for hepatitis C in Alaska NativesQ42982924
An analysis of tumor necrosis factor alpha gene polymorphisms and haplotypes with natural clearance of hepatitis C virus infectionQ42984292
Effects of the CCR5-Delta32 mutation on hepatitis C virus-specific immune responses in patients with haemophilia.Q42984759
Distinct MHC class I and II alleles are associated with hepatitis C viral clearance, originating from a single sourceQ42986139
Comparison of HCV-specific intrahepatic CD4+ T cells in HIV/HCV versus HCV.Q42986154
HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infectionQ42986755
Association between HLA class II alleles and protection from or susceptibility to chronic hepatitis C.Q42987325
Association between MHC class II alleles and clearance of circulating hepatitis C virus. Members of the Trent Hepatitis C Virus Study GroupQ42988856
Clearance of hepatitis C virus is not associated with single nucleotide polymorphisms in the IL-1, -6, or -10 genesQ42990497
P433issue11
P921main subjecthepatitis CQ154869
P304page(s)1819-1837
P577publication date2009-11-01
P1433published inPharmacogenomicsQ15724625
P1476titleHost genetic determinants of spontaneous hepatitis C clearance
P478volume10

Reverse relations

cites work (P2860)
Q35356926A polymorphism in IL28B distinguishes exposed, uninfected individuals from spontaneous resolvers of HCV infection.
Q31066011Analysis of IL28B variants in an Egyptian population defines the 20 kilobases minimal region involved in spontaneous clearance of hepatitis C virus
Q52589250Association between human leucocyte antigen-DO polymorphisms and interferon/ribavirin treatment response in hepatitis C virus type 1 infection in Chinese population: a prospective study.
Q28534715Association of IFNL3 rs12979860 and rs8099917 with biochemical predictors of interferon responsiveness in chronic hepatitis C virus infection
Q47108259Clinical Evaluation of Terap C Vaccine in Combined Treatment with Interferon and Ribavirin in Patients with Hepatitis C.
Q36194392Combined Effects of 2 Interleukin 28B Polymorphisms on the Therapeutic Outcome of Hepatitis C Patients With Circulating Cryoglobulins
Q45360519Combined effects of different interleukin-28B gene variants on the outcome of dual combination therapy in chronic hepatitis C virus type 1 infection.
Q36535789Dendritic cells, regulatory T cells and the pathogenesis of chronic hepatitis C.
Q37683126Divergent contributions of regulatory T cells to the pathogenesis of chronic hepatitis C
Q33912466Effects of the Chemokine Receptor 5 (CCR5)-Delta32 Mutation on Hepatitis C Virus-Specific Immune Responses and Liver Tissue Pathology in HCV Infected Patients
Q35083980Estimating the net contribution of interleukin-28B variation to spontaneous hepatitis C virus clearance
Q42256995Functional polymorphisms of TLR8 are associated with hepatitis C virus infection
Q34787490Genetic variants in antigen presentation-related genes influence susceptibility to hepatitis C virus and viral clearance: a case control study
Q40104336Genetic variations in toll-like receptors 7 and 8 modulate natural hepatitis C outcomes and liver disease progression.
Q42917996Genetics of spontaneous clearance of hepatitis C virus infection: a complex topic with much to learn.
Q37857571Genome-wide association studies and susceptibility to infectious diseases
Q35374519HLA-B alleles B*15:01 and B*15:02: opposite association with hepatitis C virus infection in Chinese voluntary blood donors
Q33735206Hepatic flares in chronic hepatitis C: spontaneous exacerbation vs hepatotropic viruses superinfection
Q26862729Hepatitis C virus adaptation to T-cell immune pressure
Q36717008Hepatitis C virus clearance, reinfection, and persistence, with insights from studies of injecting drug users: towards a vaccine
Q37781667Host genetic basis for hepatitis C virus clearance: a role for blood collection centers
Q37862746Host genetics in immune-mediated hepatitis C virus clearance
Q38740771Host-virus interactions in hepatitis B and hepatitis C infection
Q37216063IFN-λ3 polymorphism indirectly influences NK cell phenotype and function during acute HCV infection
Q34287407IL28B genetic variation is associated with spontaneous clearance of hepatitis C virus, treatment response, serum IL-28B levels in Chinese population
Q38334024Immune mechanisms of vaccine induced protection against chronic hepatitis C virus infection in chimpanzees.
Q43864701Impact of interleukin 28B polymorphisms on spontaneous clearance of hepatitis C virus infection: a meta-analysis
Q26999264Influence of HIV and HCV on T cell antigen presentation and challenges in the development of vaccines
Q28087595Influence of host resistance on viral adaptation: hepatitis C virus as a case study
Q43038060Innate and adaptive immunity shape circulating HCV strains
Q37613481Interleukin 28B Polymorphisms and Hepatitis C-Translating the Association into Clinical Decision Making
Q40995329Polymorphisms in EGFR and IL28B are associated with spontaneous clearance in an HCV-infected Iranian population.
Q33759224Protective immunity against hepatitis C: many shades of gray.
Q41740477Single nucleotide polymorphisms of toll-like receptor 7 in hepatitis C virus infection patients from a high-risk chinese population
Q34493947Spontaneous control of HCV is associated with expression of HLA-B 57 and preservation of targeted epitopes
Q34056191TLR7 and TLR8 gene variations and susceptibility to hepatitis C virus infection
Q41216716The Impact of IFN-γ Gene Polymorphisms on Spontaneous Clearance of HCV Infection in Fars Province, Southern of Iran.
Q34575747The association of IL28B polymorphism and graft survival in patients with hepatitis C undergoing liver transplantation
Q37997042The interferon signaling pathway genes as biomarkers of hepatitis C virus disease progression and response to treatment
Q37855530Treatment of acute HCV infection
Q37528605Type III Interferons in Hepatitis C Virus Infection.
Q35839496Update on hepatitis C virus-specific immunity

Search more.