Astragaloside IV attenuates experimental autoimmune encephalomyelitis of mice by counteracting oxidative stress at multiple levels

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Astragaloside IV attenuates experimental autoimmune encephalomyelitis of mice by counteracting oxidative stress at multiple levels is …
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scholarly articleQ13442814

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P819ADS bibcode2013PLoSO...876495H
P356DOI10.1371/JOURNAL.PONE.0076495
P932PMC publication ID3790693
P698PubMed publication ID24124567
P5875ResearchGate publication ID257757257

P2093author name stringYan Gao
Hongwei Wang
Min Du
Xiaojun Wu
Zhengtao Wang
Yixin He
Hongshuai Liu
P2860cites workEmerging Therapies for Relapsing Multiple SclerosisQ22253063
A novel transcription factor, T-bet, directs Th1 lineage commitmentQ22253874
Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivoQ28253554
Glutamate and multiple sclerosisQ28258908
Multiple sclerosisQ28299151
Bax involvement in p53-mediated neuronal cell deathQ28510439
Current and emerging therapies in multiple sclerosis: a systematic reviewQ29010983
The Bcl2 family: regulators of the cellular life-or-death switchQ29614982
Mechanisms underlying inflammation in neurodegenerationQ29617977
Neurodegenerative tauopathiesQ29619895
Microglia: a sensor for pathological events in the CNSQ29620556
Astragaloside IV inhibits spontaneous synaptic transmission and synchronized Ca2+ oscillations on hippocampal neuronsQ33312341
Cerebral interleukin-15 shows upregulation and beneficial effects in experimental autoimmune encephalomyelitisQ33903242
Increase in Th17 and T-reg lymphocytes and decrease of IL22 correlate with the recovery phase of acute EAE in rat.Q34081554
T cell response in experimental autoimmune encephalomyelitis (EAE): role of self and cross-reactive antigens in shaping, tuning, and regulating the autopathogenic T cell repertoireQ34542240
Lipoic acid affects cellular migration into the central nervous system and stabilizes blood-brain barrier integrityQ34554148
Increase of uric acid and purine compounds in biological fluids of multiple sclerosis patientsQ34606170
The role of oxidative stress in the pathogenesis of multiple sclerosis: the need for effective antioxidant therapyQ35688436
Oxidative and antioxidative potential of brain microglial cells.Q36237582
Multiple sclerosis--the plaque and its pathogenesisQ36410882
Cell death pathways in Parkinson's disease: proximal triggers, distal effectors, and final stepsQ37376117
Common themes emerge in the transcriptional control of T helper and developmental cell fate decisions regulated by the T-box, GATA and ROR familiesQ37419449
The role of astragaloside in regeneration of the peripheral nerve system.Q53646874
Antiinflammatory activity of astragaloside IV is mediated by inhibition of NF-kappaB activation and adhesion molecule expressionQ79248996
A model of experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mice for the characterisation of intervention therapiesQ80262405
Oxidative stress in serum and peripheral blood leukocytes in patients with different disease courses of multiple sclerosisQ81470372
Abnormally phosphorylated tau is associated with neuronal and axonal loss in experimental autoimmune encephalomyelitis and multiple sclerosisQ81489801
[Effect of ERK1/2 signaling pathway on astragaloside IV protects H9c2 cells against H2O2-induced oxidative injury]Q82580007
Peripheral oxidative stress in relapsing-remitting multiple sclerosisQ83436985
Evaluation of serum oxidant/antioxidant balance in multiple sclerosisQ83748737
Astragaloside IV dilates aortic vessels from normal and spontaneously hypertensive rats through endothelium-dependent and endothelium-independent waysQ83865856
Oxidative stress in multiple sclerosis patients in clinical remission: association with the expanded disability status scaleQ84774058
The effect of Astragaloside IV on immune function of regulatory T cell mediated by high mobility group box 1 protein in vitroQ84975984
Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53.Q37694644
Radical changes in multiple sclerosis pathogenesisQ37769906
Neuroinflammation: modulation by flavonoids and mechanisms of actionQ37959586
Astragaloside IV prevents MPP⁺-induced SH-SY5Y cell death via the inhibition of Bax-mediated pathways and ROS productionQ39406072
Protective effects of peroxiredoxin-1 at the injured blood-brain barrierQ39985913
Molecular basis of anti-apoptotic effect of immunophilin ligands on hydrogen peroxide-induced apoptosis in human glioma cellsQ40534149
Transendothelial permeability changes induced by free radicals in an in vitro model of the blood-brain barrierQ40928488
The role of p53 in cell cycle regulationQ41176248
p53 expression in nitric oxide‐induced apoptosisQ41428409
Mechanisms of oxidative damage in multiple sclerosis and a cell therapy approach to treatment.Q41486306
Dephosphorylation targets Bcl-2 for ubiquitin-dependent degradation: a link between the apoptosome and the proteasome pathway.Q42110512
Amelioration of experimental colitis by Astragalus membranaceus through anti-oxidation and inhibition of adhesion molecule synthesis.Q42407979
Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer's diseaseQ42855049
Astragaloside IV improves homocysteine-induced acute phase endothelial dysfunction via antioxidationQ43089679
Effects of astragaloside IV on myocardial calcium transport and cardiac function in ischemic rats.Q44171971
Blood-brain barrier permeability and monocyte infiltration in experimental allergic encephalomyelitis: a quantitative MRI studyQ44703173
Astragaloside IV protects against ischemic brain injury in a murine model of transient focal ischemiaQ44925844
Hyperphosphorylation and aggregation of tau in experimental autoimmune encephalomyelitisQ45115027
Neuroprotective effects of Astragaloside IV in 6-hydroxydopamine-treated primary nigral cell culture.Q46028556
Induction of Bcl-2 and Bax was related to hyperphosphorylation of tau and neuronal death induced by okadaic acid in rat brainQ46787321
Inhibition of the myosin light chain kinase prevents hypoxia-induced blood-brain barrier disruptionQ48210868
Relationship between the clinical scoring and demyelination in central nervous system with total antioxidant capacity of plasma during experimental autoimmune encephalomyelitis development in miceQ48342866
The activities of antioxidant enzymes and the level of malondialdehyde in cerebellum of rats subjected to methotrexate: protective effect of caffeic acid phenethyl esterQ48526958
Severe oxidative damage in multiple sclerosis lesions coincides with enhanced antioxidant enzyme expressionQ48874616
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectexperimental autoimmune encephalomyelitisQ494066
P304page(s)e76495
P577publication date2013-10-04
P1433published inPLOS OneQ564954
P1476titleAstragaloside IV attenuates experimental autoimmune encephalomyelitis of mice by counteracting oxidative stress at multiple levels
P478volume8