Tyrosine Kinase Inhibition Regulates Early Systemic Immune Changes and Modulates the Neuroimmune Response in α-Synucleinopathy

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Tyrosine Kinase Inhibition Regulates Early Systemic Immune Changes and Modulates the Neuroimmune Response in α-Synucleinopathy is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4172/2155-9899.1000259
P932PMC publication ID4308054
P698PubMed publication ID25635231
P5875ResearchGate publication ID271592124

P2093author name stringCharbel E-H Moussa
Irina Lonskaya
Michaeline L Hebron
Fernando Pagan
Paul Olopade
Sandra T Selby
P2860cites workThe chemokine fractalkine in patients with severe traumatic brain injury and a mouse model of closed head injuryQ80969187
Chemokine CCL2 and its receptor CCR2 are increased in the hippocampus following pilocarpine-induced status epilepticusQ21245234
RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytesQ22008771
Fractalkine-mediated endothelial cell injury by NK cellsQ22253856
Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activitiesQ24295053
VEGF: once regarded as a specific angiogenic factor, now implicated in neuroprotectionQ24302846
Parkinson-related parkin reduces α-Synuclein phosphorylation in a gene transfer modelQ24305472
Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesionQ24311291
c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's diseaseQ24318974
Isolation of interleukin 2-induced immediate-early genesQ24563249
Engineering of Lactobacillus jensenii to secrete RANTES and a CCR5 antagonist analogue as live HIV-1 blockersQ24620129
Interferon-gamma and interleukin-4 reciprocally regulate CD8 expression in CD8+ T cellsQ24643390
Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicityQ24650569
Human immune interferon gene is located on chromosome 12Q24683596
DNA array analysis of interleukin-2-regulated immediate/early genesQ24799770
Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse modelQ28115206
Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse modelsQ28119018
Inflammation and Alzheimer's diseaseQ28138617
Transcriptional regulation of RANTES expression in T lymphocytesQ28141636
Dysregulation of the IgE/Fc epsilon RI network in HIV-1 infectionQ28142215
Neuronal fractalkine expression in HIV-1 encephalitis: roles for macrophage recruitment and neuroprotection in the central nervous systemQ28142879
Chemokines and diseaseQ28200068
Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophilsQ28205971
Neurotactin, a membrane-anchored chemokine upregulated in brain inflammationQ28240071
Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractantQ28252699
Regulation of interferon-gamma during innate and adaptive immune responsesQ28256001
Highly regionalized neuronal expression of monocyte chemoattractant protein-1 (MCP-1/CCL2) in rat brain: evidence for its colocalization with neurotransmitters and neuropeptidesQ28262316
Astrocyte expression of mRNA encoding cytokines IP-10 and JE/MCP-1 in experimental autoimmune encephalomyelitisQ28268096
Role of CCL2 (MCP-1) in traumatic brain injury (TBI): evidence from severe TBI patients and CCL2-/- miceQ28268523
Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cellsQ28270680
Mechanisms of mononuclear phagocyte recruitment in Alzheimer's diseaseQ28275105
CC chemokines induce the generation of killer cells from CD56+ cellsQ28277084
The emerging role for chemokines in epilepsyQ28285051
Human recombinant monocyte chemotactic protein and other C-C chemokines bind and induce directional migration of dendritic cells in vitroQ28291482
A new class of membrane-bound chemokine with a CX3C motifQ28303204
Expression of monocyte chemoattractant protein-1 and macrophage inflammatory protein-1 after focal cerebral ischemia in the ratQ28307447
A human T cell-specific molecule is a member of a new gene familyQ28307933
Control of microglial neurotoxicity by the fractalkine receptorQ28513748
Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathwayQ28571359
Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microgliaQ28573077
Obesity induces a phenotypic switch in adipose tissue macrophage polarizationQ29547686
Ranibizumab for neovascular age-related macular degenerationQ29617549
Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cgamma1, Grb2, and Src family kinasesQ30157679
Tau and src family tyrosine kinasesQ30160372
Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's diseaseQ30581719
Nitrated alpha-synuclein and microglial neuroregulatory activitiesQ33315262
Nilotinib (formerly AMN107), a highly selective BCR-ABL tyrosine kinase inhibitor, is effective in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase following imatinib resistance and intoleranceQ33376325
Altered subcellular distribution of c-Abl in Alzheimer's diseaseQ33429538
A mechanism for the initiation of allergen-induced T helper type 2 responsesQ34010133
Interleukins for B lymphocytesQ34056680
Regulation of Tau Pathology by the Microglial Fractalkine ReceptorQ34179654
Human IL-3 (multi-CSF): identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3.Q34180710
CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models.Q34254575
An update on dual Src/Abl inhibitorsQ34270677
Targeting interleukin-4 in asthma: lost in translation?Q34271232
Regulation of T cell differentiation: in vitro induction of 20 alpha-hydroxysteroid dehydrogenase in splenic lymphocytes from athymic mice by a unique lymphokine.Q34274355
Role of VEGF in developmental angiogenesis and in tumor angiogenesis in the brain.Q34305062
Microglia in neurodegeneration: molecular aspectsQ34349294
Interleukin-4 receptor signaling pathways in asthma pathogenesisQ34355560
VEGF at the neurovascular interface: therapeutic implications for motor neuron diseaseQ34539899
CX3CL1 reduces neurotoxicity and microglial activation in a rat model of Parkinson's disease.Q34576624
CX3CR1 in microglia regulates brain amyloid deposition through selective protofibrillar amyloid-β phagocytosisQ34796584
Ubiquitination increases parkin activity to promote autophagic α-synuclein clearanceQ35080740
CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease.Q35213298
Neuronal c-Abl overexpression leads to neuronal loss and neuroinflammation in the mouse forebrain.Q35949689
Microglia as a potential bridge between the amyloid beta-peptide and tau.Q36024909
Neuronal c-Abl activation leads to induction of cell cycle and interferon signaling pathwaysQ36369785
Scavenging roles of chemokine receptors: chemokine receptor deficiency is associated with increased levels of ligand in circulation and tissuesQ36742483
Decreased parkin solubility is associated with impairment of autophagy in the nigrostriatum of sporadic Parkinson's diseaseQ36746491
Immunological features of alpha-synuclein in Parkinson's diseaseQ37232067
c-Abl in neurodegenerative diseaseQ37897502
Nilotinib-induced autophagic changes increase endogenous parkin level and ubiquitination, leading to amyloid clearanceQ38615100
Interleukin-2: inception, impact, and implicationsQ39603037
Tau phosphorylated at tyrosine 394 is found in Alzheimer's disease tangles and can be a product of the Abl-related kinase, Arg.Q39746633
Wild type and P301L mutant Tau promote neuro-inflammation and α-Synuclein accumulation in lentiviral gene delivery modelsQ39994322
Neuroprotective activities of CD4+CD25+ regulatory T cells in an animal model of Parkinson's diseaseQ40098160
Synuclein activates microglia in a model of Parkinson's diseaseQ40126232
Fractalkine signaling and Tau hyper-phosphorylation are associated with autophagic alterations in lentiviral Tau and Aβ1-42 gene transfer modelsQ40392115
Tyrosine 394 is phosphorylated in Alzheimer's paired helical filament tau and in fetal tau with c-Abl as the candidate tyrosine kinase.Q40398116
Fractalkine and fractalkine receptors in human neurons and glial cellsQ40717328
Tyrosine kinase inhibition increases functional parkin-Beclin-1 interaction and enhances amyloid clearance and cognitive performanceQ42003730
Tyrosine kinase inhibition facilitates autophagic SNCA/α-synuclein clearanceQ42220307
In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's diseaseQ42484469
Microglial activation parallels system degeneration in progressive supranuclear palsy and corticobasal degenerationQ42505583
Interleukin-2 induction of T-cell G1 progression and c-myb expressionQ42521592
Nilotinib reverses loss of dopamine neurons and improves motor behavior via autophagic degradation of α-synuclein in Parkinson's disease modelsQ42711308
Induction of vascular endothelial growth factor receptor-3 mRNA in glial cells following focal cerebral ischemia in ratsQ42943835
Interleukin-6 induces Alzheimer-type phosphorylation of tau protein by deregulating the cdk5/p35 pathway.Q44820147
Manganese potentiates in vitro production of proinflammatory cytokines and nitric oxide by microglia through a nuclear factor kappa B-dependent mechanismQ45188778
Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's diseaseQ46404588
New evidences for fractalkine/CX3CL1 involved in substantia nigral microglial activation and behavioral changes in a rat model of Parkinson's diseaseQ48003429
Production and neuroprotective functions of fractalkine in the central nervous systemQ48258224
Increased intrathecal release of soluble fractalkine in HIV-infected patientsQ48363839
Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synucleinQ48581887
Role of CX3CR1 (fractalkine receptor) in brain damage and inflammation induced by focal cerebral ischemia in mouseQ49160789
Astrocytic nitric oxide triggers tau hyperphosphorylation in hippocampal neurons.Q54703574
The interleukin-2 T-cell system: a new cell growth model.Q55062562
Obituaries: Mrs Annie Isabella Anslow, Eileen Georgina SherrardQ66898562
CSF and serum levels of soluble fractalkine (CX3CL1) in inflammatory diseases of the nervous systemQ73197840
P304page(s)259
P577publication date2014-09-01
P1433published inJournal of Clinical & Cellular ImmunologyQ27723807
P1476titleTyrosine Kinase Inhibition Regulates Early Systemic Immune Changes and Modulates the Neuroimmune Response in α-Synucleinopathy
P478volume5

Reverse relations

cites work (P2860)
Q37137895Activation of tyrosine kinase c-Abl contributes to α-synuclein-induced neurodegeneration
Q53371980Amelioration of experimentally induced diabetic nephropathy and renal damage by nilotinib.
Q42291075An enhanced recombinant amino-terminal acetylation system and novel in vivo high-throughput screen for molecules affecting α-synuclein oligomerisation.
Q90293280Biomedical Implications of Autophagy in Macromolecule Storage Disorders
Q41634845Microglial-mediated PDGF-CC activation increases cerebrovascular permeability during ischemic stroke.
Q64938069Multikinase Abl/DDR/Src Inhibition Produces Optimal Effects for Tyrosine Kinase Inhibition in Neurodegeneration.
Q58737028Neurodegenerative Diseases: Regenerative Mechanisms and Novel Therapeutic Approaches
Q38840128Nilotinib - Differentiating the Hope from the Hype
Q37225128Nilotinib Effects in Parkinson's disease and Dementia with Lewy bodies
Q92007135Nilotinib Effects on Safety, Tolerability, and Potential Biomarkers in Parkinson Disease: A Phase 2 Randomized Clinical Trial
Q64988558Nilotinib: A Tyrosine Kinase Inhibitor Mediates Resistance to Intracellular Mycobacterium Via Regulating Autophagy.
Q47860695Pazopanib Reduces Phosphorylated Tau Levels and Alters Astrocytes in a Mouse Model of Tauopathy
Q64104966Pharmacokinetics and pharmacodynamics of a single dose Nilotinib in individuals with Parkinson's disease
Q34554401Recent advances in treating Parkinson's disease
Q97527711Targeting dementias through cancer kinases inhibition
Q38752798Tyrosine kinase inhibition reverses TDP-43 effects on synaptic protein expression, astrocytic function and amino acid dis-homeostasis

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