Pax6 downregulation mediates abnormal lineage commitment of the ocular surface epithelium in aqueous-deficient dry eye disease

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Pax6 downregulation mediates abnormal lineage commitment of the ocular surface epithelium in aqueous-deficient dry eye disease is …
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scholarly articleQ13442814

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P819ADS bibcode2013PLoSO...877286C
P356DOI10.1371/JOURNAL.PONE.0077286
P932PMC publication ID3797128
P698PubMed publication ID24143217
P5875ResearchGate publication ID258061496

P2093author name stringMarianne Gallup
Nancy A McNamara
Denise N Stephens
Trinka Vijmasi
Ying Ting Chen
Feeling Y T Chen
P2860cites workA new mathematical model for relative quantification in real-time RT-PCRQ27860781
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Corticosteroid and doxycycline suppress MMP-9 and inflammatory cytokine expression, MAPK activation in the corneal epithelium in experimental dry eye.Q30813799
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Expression of Th-1 Chemokines and Chemokine Receptors on the Ocular Surface of C57BL/6 Mice: Effects of Desiccating StressQ61851325
Staging of conjunctival squamous metaplasia by impression cytologyQ69906040
Identification of the cornea-specific keratin 12 promoter by in vivo particle-mediated gene transferQ77695566
Down-regulation of Pax6 is associated with abnormal differentiation of corneal epithelial cells in severe ocular surface diseases.Q33714424
An autoimmune response to odorant binding protein 1a is associated with dry eye in the Aire-deficient mouseQ33776473
Transdifferentiation of corneal epithelium into epidermis occurs by means of a multistep process triggered by dermal developmental signals.Q33928542
Interleukin-1 as a phenotypic immunomodulator in keratinizing squamous metaplasia of the ocular surface in Sjögren's syndromeQ34086947
Interleukin-6 promotes tumorigenesis by altering DNA methylation in oral cancer cells.Q34196062
Transcription Factors Pax6 and AP-2alpha Interact To Coordinate Corneal Epithelial Repair by Controlling Expression of Matrix Metalloproteinase Gelatinase BQ34550279
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Human amniotic epithelial cells as novel feeder layers for promoting ex vivo expansion of limbal epithelial progenitor cellsQ35391377
Critical involvement of macrophage infiltration in the development of Sjögren's syndrome-associated dry eye.Q36204121
Differentiation-related expression of a major 64K corneal keratin in vivo and in culture suggests limbal location of corneal epithelial stem cellsQ36212986
Spontaneous autoimmunity prevented by thymic expression of a single self-antigenQ36228141
A simplified quantitative method for assessing keratoconjunctivitis sicca from the Sjögren's Syndrome International RegistryQ36283986
Altered phenotype of cultured urothelial and other stratified epithelial cells: implications for wound healing.Q36446014
Air exposure induced squamous metaplasia of human limbal epitheliumQ36478497
An immunoprotective privilege of corneal epithelial stem cells against Th17 inflammatory stress by producing glial cell-derived neurotrophic factorQ36625070
Small proline-rich protein 1B (SPRR1B) is a biomarker for squamous metaplasia in dry eye diseaseQ36951627
Interleukin-1 receptor mediates the interplay between CD4+ T cells and ocular resident cells to promote keratinizing squamous metaplasia in Sjögren's syndromeQ37050342
Immune profile of squamous metaplasia development in autoimmune regulator-deficient dry eye.Q37139290
The Pax-6 homeobox gene is expressed throughout the corneal and conjunctival epithelia.Q38350189
Pax6 overexpression suppresses cell proliferation and retards the cell cycle in corneal epithelial cellsQ40275696
Precise temporal control of the eye regulatory gene Pax6 via enhancer-binding site affinity.Q40461239
Corneal limbal microenvironment can induce transdifferentiation of hair follicle stem cells into corneal epithelial-like cellsQ41846862
Fluorescence microscopic and flow cytometric analysis of bone marrow-derived cells in human epidermis: a search for the human analogue of the murine dendritic Thy-1+ epidermal cellQ43857316
Requirement for Pax6 in corneal morphogenesis: a role in adhesionQ44401219
Corneal development, limbal stem cell function, and corneal epithelial cell migration in the Pax6(+/-) mouseQ44810065
Calcium-induced abnormal epidermal-like differentiation in cultures of mouse corneal-limbal epithelial cells.Q45081334
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue10
P407language of work or nameEnglishQ1860
P921main subjecteye diseaseQ3041498
cell fate commitmentQ14860192
P304page(s)e77286
P577publication date2013-10-15
P1433published inPLOS OneQ564954
P1476titlePax6 downregulation mediates abnormal lineage commitment of the ocular surface epithelium in aqueous-deficient dry eye disease
P478volume8

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cites work (P2860)
Q57021254A conditional Pax6 depletion study with no morphological effect on the adult mouse corneal epithelium
Q41677137Aire-deficient mice provide a model of corneal and lacrimal gland neuropathy in Sjögren's syndrome
Q38682356Autophagy mediates cell cycle response by regulating nucleocytoplasmic transport of PAX6 in limbal stem cells under ultraviolet-A stress
Q34473772Establishing PAX6 as a biomarker to detect early loss of ocular phenotype in human patients with Sjögren's syndrome
Q33688996Inhibition of lysophosphatidic acid receptor ameliorates Sjögren's syndrome in NOD mice.
Q40282178LIM Homeobox Domain 2 Is Required for Corneal Epithelial Homeostasis
Q38197286Macrophages: important players in primary Sjögren's syndrome?
Q33838722Pathological Analysis of Ocular Lesions in a Murine Model of Sjögren's Syndrome

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