Small molecule binding, docking, and characterization of the interaction between Pth1 and peptidyl-tRNA

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Small molecule binding, docking, and characterization of the interaction between Pth1 and peptidyl-tRNA is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3390/IJMS141122741
P932PMC publication ID3856088
P698PubMed publication ID24256814
P5875ResearchGate publication ID258822750

P50authorChristopher B. StanleyQ42374656
Mary C HamesQ86809401
Volker S. UrbanQ40140856
P2093author name stringHana McFeeters
Robert L McFeeters
W Blake Holloway
P2860cites workEssential role of histidine 20 in the catalytic mechanism of Escherichia coli peptidyl-tRNA hydrolaseQ44839755
Crystal structure at 1.8 A resolution and identification of active site residues of Sulfolobus solfataricus peptidyl-tRNA hydrolaseQ46377124
Toward a more complete view of tRNA biologyQ47652203
Non-hydrolyzable RNA-peptide conjugates: a powerful advance in the synthesis of mimics for 3'-peptidyl tRNA terminiQ47935071
Direct analysis of aminoacylation levels of tRNAs in vivo. Application to studying recognition of Escherichia coli initiator tRNA mutants by glutaminyl-tRNA synthetaseQ54687239
Processivity errors of gene expression in Escherichia coli.Q54707242
Mutant E. coli Strain with Temperature Sensitive Peptidyltransfer RNA HydrolaseQ54795371
Absolute calibration of small-angle neutron scattering dataQ56001892
Automated matching of high- and low-resolution structural modelsQ56444545
The structural basis for the resistance of Escherichia coli formylmethionyl transfer ribonucleic acid to cleavage by Escherichia coli peptidyl transfer ribonucleic acid hydrolaseQ66892126
The site of hydrolysis by rabbit reticulocyte peptidyl-tRNA hydrolase is the 3'-AMP terminus of susceptible tRNA substratesQ67728454
Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealingQ24537302
Structural plasticity and enzyme action: crystal structures of mycobacterium tuberculosis peptidyl-tRNA hydrolaseQ27646597
Solution structure and dynamics of peptidyl-tRNA hydrolase from Mycobacterium tuberculosis H37RvQ27650084
Solution structure of tRNAVal from refinement of homology model against residual dipolar coupling and SAXS dataQ27652122
Structure of the K-turn U4 RNA: a combined NMR and SANS studyQ27661620
Structure ofFrancisella tularensispeptidyl-tRNA hydrolaseQ27667581
Structural basis for the substrate recognition and catalysis of peptidyl-tRNA hydrolaseQ27671700
Recombinant production, crystallization and X-ray crystallographic structure determination of the peptidyl-tRNA hydrolase ofPseudomonas aeruginosaQ27675311
AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreadingQ27860652
UCSF Chimera--a visualization system for exploratory research and analysisQ27860666
Orthologs of a novel archaeal and of the bacterial peptidyl-tRNA hydrolase are nonessential in yeastQ27929796
Python: a programming language for software integration and developmentQ29614317
Inhibition of translation and cell growth by minigene expressionQ30649858
The Rate of Peptidyl-tRNA Dissociation from the Ribosome during Minigene Expression Depends on the Nature of the Last Decoding InteractionQ30920558
Initiation factors IF1 and IF2 synergistically remove peptidyl-tRNAs with short polypeptides from the P-site of translating Escherichia coli ribosomesQ32041244
Crystal structure at 1.2 A resolution and active site mapping of Escherichia coli peptidyl-tRNA hydrolaseQ33887219
Ribosome release factor RF4 and termination factor RF3 are involved in dissociation of peptidyl-tRNA from the ribosomeQ33888227
NMR-based substrate analog docking to Escherichia coli peptidyl-tRNA hydrolaseQ33947565
Role of the 1-72 base pair in tRNAs for the activity of Escherichia coli peptidyl-tRNA hydrolase.Q34998809
Experimental and computational determination of tRNA dynamicsQ37636974
Peptidyl-tRNA hydrolase screening combined with molecular docking reveals the antibiotic potential of Syzygium johnsonii bark extractQ39050635
Inhibition of essential bacterial peptidyl-tRNA hydrolase activity by tropical plant extractsQ39233643
Molecular basis for the temperature sensitivity of Escherichia coli pth(Ts).Q39499457
Synthesis and degradation of termination and premature-termination fragments of β-galactosidase in vitro and in vivoQ39645655
RNA-binding site of Escherichia coli peptidyl-tRNA hydrolaseQ39707528
Constraints on the accuracy of messenger RNA movementQ39844036
The accumulation as peptidyl-transfer RNA of isoaccepting transfer RNA families in Escherichia coli with temperature-sensitive peptidyl-transfer RNA hydrolaseQ40934059
Crystallization and preliminary X-ray analysis of Escherichia coli peptidyl-tRNA hydrolase.Q41113837
Selective desulfurization significantly expands sequence variety of 3'-peptidyl-tRNA mimics obtained by native chemical ligationQ42155357
lambda bar minigene-mediated inhibition of protein synthesis involves accumulation of peptidyl-tRNA and starvation for tRNA.Q42191620
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)22741-22752
P577publication date2013-11-19
P1433published inInternational Journal of Molecular SciencesQ3153277
P1476titleSmall molecule binding, docking, and characterization of the interaction between Pth1 and peptidyl-tRNA
P478volume14

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cites work (P2860)
Q27684609Recombinant production, crystallization and X-ray crystallographic structure determination of peptidyl-tRNA hydrolase fromSalmonella typhimurium
Q39772710Small Molecule Docking Supports Broad and Narrow Spectrum Potential for the Inhibition of the Novel Antibiotic Target Bacterial Pth1.
Q30397610Unraveling the stereochemical and dynamic aspects of the catalytic site of bacterial peptidyl-tRNA hydrolase.

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