Computer-aided discovery of Trypanosoma brucei RNA-editing terminal uridylyl transferase 2 inhibitors

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Computer-aided discovery of Trypanosoma brucei RNA-editing terminal uridylyl transferase 2 inhibitors is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/CBDD.12302
P932PMC publication ID4317284
P698PubMed publication ID24903413

P50authorÖzlem DemirQ91061836
P2093author name stringChris Merritt
Mehdi Labaied
Rommie E Amaro
Ken Stuart
P2860cites workEfficient RNA polyuridylation by noncanonical poly(A) polymerasesQ24299853
Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'Q24305376
TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylationQ24308810
Structural basis for dimerization and activity of human PAPD1, a noncanonical poly(A) polymeraseQ24338955
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Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trialQ28250035
Navigating chemical space for biology and medicineQ28298611
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Novel naphthalene-based inhibitors of Trypanosoma brucei RNA editing ligase 1Q28475269
Identification of compounds with anti-proliferative activity against Trypanosoma brucei brucei strain 427 by a whole cell viability based HTS campaignQ28485372
A mechanism for all polymerasesQ29618812
A luciferase based viability assay for ATP detection in 384-well format for high throughput whole cell screening of Trypanosoma brucei brucei bloodstream form strain 427.Q30883740
A ‘Rule of Three’ for fragment-based lead discovery?Q33973131
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A family of poly(U) polymerasesQ34621372
Naphthalene-based RNA editing inhibitor blocks RNA editing activities and editosome assembly in Trypanosoma bruceiQ34800149
Arsenicals (melarsoprol), pentamidine and suramin in the treatment of human African trypanosomiasisQ35126182
Chemotherapy of human African trypanosomiasis: current and future prospectsQ35569065
Elements of nucleotide specificity in the Trypanosoma brucei mitochondrial RNA editing enzyme RET2.Q35994201
Discovery of drug-like inhibitors of an essential RNA-editing ligase in Trypanosoma bruceiQ36960711
Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine storyQ37317284
Inhibitors of RNA editing as potential chemotherapeutics against trypanosomatid pathogensQ37390528
Lead- and drug-like compounds: the rule-of-five revolutionQ38225014
NECT trial: more than a small victory over sleeping sicknessQ38874230
Nifurtimox-eflornithine combination therapy for second-stage gambiense human African trypanosomiasis: Médecins Sans Frontières experience in the Democratic Republic of the CongoQ39223286
The Alamar Blue assay to determine drug sensitivity of African trypanosomes (T.b. rhodesiense and T.b. gambiense) in vitroQ39416311
Structural basis for UTP specificity of RNA editing TUTases from Trypanosoma bruceiQ43192506
Development of an Alamar Blue viability assay in 384-well format for high throughput whole cell screening of Trypanosoma brucei brucei bloodstream form strain 427.Q43264845
TbMP57 is a 3' terminal uridylyl transferase (TUTase) of the Trypanosoma brucei editosomeQ44487520
Nifurtimox-eflornithine combination therapy for second-stage Trypanosoma brucei gambiense sleeping sickness: a randomized clinical trial in CongoQ46309751
RNA editing uridylyltransferases of trypanosomatidsQ46610701
Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity.Q50509935
Folding-unfolding thermodynamics of a beta-heptapeptide from equilibrium simulationsQ74452346
Molecular biology. A tail tale for UQ80828890
P433issue2
P921main subjectTrypanosoma bruceiQ33244
P304page(s)131-139
P577publication date2014-06-05
P1433published inChemical Biology and Drug DesignQ15749458
P1476titleComputer-aided discovery of Trypanosoma brucei RNA-editing terminal uridylyl transferase 2 inhibitors
P478volume84

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cites work (P2860)
Q33836840A Comparative Study of the Structural Dynamics of Four Terminal Uridylyl Transferases
Q58862088Binding of anti-Trypanosoma natural products from African flora against selected drug targets: a docking study
Q35860043Characterization of Trypanosoma cruzi Sirtuins as Possible Drug Targets for Chagas Disease
Q28543858Charge reduction and thermodynamic stabilization of substrate RNAs inhibit RNA editing
Q89662547Computational approaches for drug discovery against trypanosomatid-caused diseases
Q42320200Enhancing Virtual Screening Performance of Protein Kinases with Molecular Dynamics Simulations
Q36938240Knowledge-Based Methods To Train and Optimize Virtual Screening Ensembles

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