Comparison of gene expression patterns across 12 tumor types identifies a cancer supercluster characterized by TP53 mutations and cell cycle defects

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Comparison of gene expression patterns across 12 tumor types identifies a cancer supercluster characterized by TP53 mutations and cell cycle defects is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/ONC.2014.216
P932PMC publication ID4317393
P698PubMed publication ID25088195
P5875ResearchGate publication ID264462524

P50authorVictor TrevinoQ41044719
Kosuke YoshiharaQ51394156
Hoon KimQ59545155
P2093author name stringE Martínez
G M Mills
R G W Verhaak
P2860cites workPerturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanismsQ24339394
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profilesQ24536351
The Reactome pathway knowledgebaseQ24567743
Data, information, knowledge and principle: back to metabolism in KEGGQ24568332
Significance analysis of microarrays applied to the ionizing radiation responseQ24606608
Comprehensive molecular characterization of human colon and rectal cancerQ24630415
Comprehensive molecular portraits of human breast tumoursQ24630844
Safety, activity, and immune correlates of anti-PD-1 antibody in cancerQ24633070
Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1Q24651548
Comprehensive genomic characterization defines human glioblastoma genes and core pathwaysQ24656128
PID: the Pathway Interaction DatabaseQ24656193
Nivolumab plus ipilimumab in advanced melanomaQ27852310
Comprehensive molecular characterization of clear cell renal cell carcinomaQ27852374
Integrated genomic analyses of ovarian carcinomaQ27860518
Safety and Tumor Responses with Lambrolizumab (Anti–PD-1) in MelanomaQ27860650
A gene-expression signature as a predictor of survival in breast cancerQ27860945
Improved Survival with Ipilimumab in Patients with Metastatic MelanomaQ27861062
Molecular portraits of human breast tumoursQ28032461
Comprehensive genomic characterization of squamous cell lung cancersQ28274701
Integrated genomic characterization of endometrial carcinomaQ28289962
Temporal regulation of EGF signalling networks by the scaffold protein Shc1Q28294401
The somatic genomic landscape of glioblastomaQ28300185
Comprehensive molecular characterization of urothelial bladder carcinomaQ28306864
Cyclin-dependent kinase-associated proteins Cks1 and Cks2 are essential during early embryogenesis and for cell cycle progression in somatic cellsQ28585746
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivityQ29547693
Diagnosis of multiple cancer types by shrunken centroids of gene expressionQ29615528
Genomic and epigenomic landscapes of adult de novo acute myeloid leukemiaQ29615735
Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclassesQ29616071
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1Q29617043
Supervised risk predictor of breast cancer based on intrinsic subtypesQ29617404
Inferring tumour purity and stromal and immune cell admixture from expression dataQ30674996
Inference of patient-specific pathway activities from multi-dimensional cancer genomics data using PARADIGM.Q33597322
Absolute quantification of somatic DNA alterations in human cancerQ34271693
Molecular subtypes in head and neck cancer exhibit distinct patterns of chromosomal gain and loss of canonical cancer genes.Q34602664
Emerging landscape of oncogenic signatures across human cancersQ35058708
Subtype and pathway specific responses to anticancer compounds in breast cancerQ35779241
Prognostically relevant gene signatures of high-grade serous ovarian carcinomaQ36497294
What is a support vector machine?Q36679246
A survey of intragenic breakpoints in glioblastoma identifies a distinct subset associated with poor survivalQ37019200
Prediction of molecular subtypes in acute myeloid leukemia based on gene expression profilingQ37059396
Metagenes and molecular pattern discovery using matrix factorizationQ37356699
Pan-cancer patterns of somatic copy number alterationQ37666205
Prognostically useful gene-expression profiles in acute myeloid leukemia.Q51999490
Cluster AnalysisQ57585102
P433issue21
P407language of work or nameEnglishQ1860
P304page(s)2732-2740
P577publication date2014-08-04
P1433published inOncogeneQ1568657
P1476titleComparison of gene expression patterns across 12 tumor types identifies a cancer supercluster characterized by TP53 mutations and cell cycle defects
P478volume34

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cites work (P2860)
Q55437282AUCTSP: an improved biomarker gene pair class predictor.
Q55287292Double agents: genes with both oncogenic and tumor-suppressor functions.
Q37174032Expression signature distinguishing two tumour transcriptome classes associated with progression-free survival among rare histological types of epithelial ovarian cancer
Q45870735Harnessing OLIG2 function in tumorigenicity and plasticity to target malignant gliomas
Q41557019Identification of a multi-cancer gene expression biomarker for cancer clinical outcomes using a network-based algorithm
Q36848243Immunomediated Pan-cancer Regulation Networks are Dominant Fingerprints After Treatment of Cell Lines with Demethylation.
Q35899607Informative gene selection and the direct classification of tumors based on relative simplicity
Q34123261Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin
Q92692775NUQA: Estimating Cancer Spatial and Temporal Heterogeneity and Evolution through Alignment-Free Methods
Q47547178Network analysis revealed aurora kinase dysregulation in five gynecological types of cancer
Q58097633Network integration of multi-tumour omics data suggests novel targeting strategies
Q47193672Optimizing prognosis-related key miRNA-target interactions responsible for cancer metastasis
Q36830260Pan-cancer subtyping in a 2D-map shows substructures that are driven by specific combinations of molecular characteristics
Q41243664Pan-urologic cancer genomic subtypes that transcend tissue of origin
Q35838819Profiling of Discrete Gynecological Cancers Reveals Novel Transcriptional Modules and Common Features Shared by Other Cancer Types and Embryonic Stem Cells
Q86068877Pseudogene: promising signature for cancer reclassification : comment on "The Pan-Cancer analysis of pseudogene expression reveals biologically and clinically relevant tumour subtypes", Nat Commun. 2014; 5:3963
Q55315462Sorting Five Human Tumor Types Reveals Specific Biomarkers and Background Classification Genes.
Q41521817Systematic analysis of telomere length and somatic alterations in 31 cancer types.
Q36350773Systematic pan-cancer analysis of tumour purity
Q31103785TP53 Mutations and Survival in Osteosarcoma Patients: A Meta-Analysis of Published Data
Q64101370The landscape of the mesenchymal signature in brain tumours
Q41092592Transcriptional response profiles of paired tumor-normal samples offer novel perspectives in pan-cancer analysis
Q46410671Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment.

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