Enantioselective analytical methods in pharmacokinetics with specific reference to genetic polymorphic metabolism

scientific article

Enantioselective analytical methods in pharmacokinetics with specific reference to genetic polymorphic metabolism is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/S0165-022X(02)00128-8
P698PubMed publication ID12543491

P2093author name stringAntonio Marzo
Erich Heftmann
P2860cites workA theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailabilityQ28293773
Stereoselective pharmacokinetics of pantoprazole, a proton pump inhibitor, in extensive and poor metabolizers of S-mephenytoinQ32156812
Stereochemistry, a basis for sophisticated nonsense in pharmacokinetics and clinical pharmacologyQ34054672
Pharmacokinetic evaluation in man of terbutaline given as separate enantiomers and as the racemateQ34396966
Stereoselective synthesis from a process research perspectiveQ34537678
Enzymes in stereoselective pharmacokinetics of endogenous substancesQ35357721
Stereoselective drug disposition: potential for misinterpretation of drug disposition data.Q36442244
Stereoselectivity in clinical pharmacokinetics and drug developmentQ37946823
The metabolic chiral inversion of 2-arylpropionic acids—a novel route with pharmacological consequencesQ40092311
Some pharmacokinetic considerations about homeostatic equilibrium of endogenous substancesQ40781757
Pharmacokinetics of endogenous substances: some problems and some solutionsQ40827266
Investigation of xenobiotic metabolism by CYP2D6 and CYP2C19: importance of enantioselective analytical methodsQ41155424
The biological properties of the optical isomers of propranolol and their effects on cardiac arrhythmiasQ41357289
Differential stereoselective metabolism of metoprolol in extensive and poor debrisoquin metabolizersQ41588910
L-carnitine and carnitine ester transport in the rat small intestineQ43837127
Enantioselective hydroxylation of nortriptyline in human liver microsomes, intestinal homogenate, and patients treated with nortriptylineQ44636210
Combined phenotypic assessment of CYP1A2, CYP2C19, CYP2D6, CYP3A, N-acetyltransferase-2, and xanthine oxidase with the "Cooperstown cocktail".Q51373538
Relationship between plasma level and therapeutic effect of nortriptyline.Q55365453
Determination of the enantiomers of mianserin, desmethylmianserin, and 8-hydroxymianserin in the plasma and urine of mianserin-treated patientsQ57550460
Enantioselective amitriptyline metabolism in patients phenotyped for two cytochrome P450 isozymesQ67574360
Plasma levels of trimipramine and metabolites in four patients: determination of the enantiomer concentrations of the hydroxy metabolitesQ67591494
Enantiospecific analysis of ketoprofen in plasma by high-performance liquid chromatographyQ67868868
Liquid chromatographic analysis of propranolol enantiomers in human blood using precolumn derivatization with (+)-1-(9-fluorenyl)ethyl chloroformateQ67868871
Chromatographic and non-chromatographic assay of L-carnitine family componentsQ68534951
Enantiomer analysis of E- and Z-10-hydroxyamitriptyline in human urineQ68883972
Racemization kinetics of enantiomeric oxazepams and stereoselective hydrolysis of enantiomeric oxazepam 3-acetates in rat liver microsomes and brain homogenateQ69408786
Stereoselective high-performance liquid chromatographic determination of ketoprofen, ibuprofen and fenoprofen in plasma using a chiral alpha 1-acid glycoprotein columnQ70261466
Determination of (R)-AND (S)-alprenolol-and (R)- and (S)-metoprolol as their diastereomeric derivatives in human plasma by reversed-phase liquid chromatographyQ70273633
A gas chromatographic method for the quantitative determination of nortriptyline and some of its metabolites in human plasma and urineQ70396938
E- and Z-10-hydroxylation of nortriptyline: relationship to polymorphic debrisoquine hydroxylationQ70823716
Determination of salbutamol enantiomers in human plasma and urine by chiral high-performance liquid chromatographyQ70975987
Open questions in bioequivalenceQ71675149
Stereoselective disposition of mianserin is related to debrisoquin hydroxylation polymorphismQ72133298
Steady-state plasma concentrations of cis- and trans-10-OH amitriptyline metabolitesQ72525459
Differential stereoselective pharmacokinetics of pantoprazole, a proton pump inhibitor in extensive and poor metabolizers of pantoprazole--a preliminary studyQ73204570
Validation of the five-drug "Pittsburgh cocktail" approach for assessment of selective regulation of drug-metabolizing enzymesQ73846452
Pharmacokinetics and tolerability of formoterol in healthy volunteers after a single high dose of Foradil dry powder inhalation via AerolizerQ77769784
P433issue1-3
P921main subjectpharmacokineticsQ323936
enantioselectivityQ1339952
P304page(s)57-70
P577publication date2002-12-01
P1433published inJournal of ProteomicsQ15767060
P1476titleEnantioselective analytical methods in pharmacokinetics with specific reference to genetic polymorphic metabolism
P478volume54

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cites work (P2860)
Q46901371Chiral HPLC analysis of milnacipran and its FMOC-derivative on cellulose-based stationary phases
Q34344756Chiral drugs: an overview
Q50349770Synergic development of pharmacokinetics and bioanalytical methods as support of pharmaceutical research

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