| review article | Q7318358 |
| scholarly article | Q13442814 |
| P50 | author | Silvano Ferrini | Q39791275 |
| Raffaella Meazza | Q57739819 | ||
| P2093 | author name string | Bruno Azzarone | |
| Anna Maria Orengo | |||
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| High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993 | Q29619885 | ||
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| An open-label, two-arm, phase I trial of recombinant human interleukin-21 in patients with metastatic melanoma | Q33375582 | ||
| Interleukin-21 induces the differentiation of human umbilical cord blood CD34-lineage- cells into pseudomature lytic NK cells | Q33497623 | ||
| Novel IL-21 signaling pathway up-regulates c-Myc and induces apoptosis of diffuse large B-cell lymphomas. | Q33608757 | ||
| The activation of natural killer cell effector functions by cetuximab-coated, epidermal growth factor receptor positive tumor cells is enhanced by cytokines | Q40061963 | ||
| The opposite effects of IL-15 and IL-21 on CLL B cells correlate with differential activation of the JAK/STAT and ERK1/2 pathways | Q40067429 | ||
| Molecular analysis of the methylprednisolone-mediated inhibition of NK-cell function: evidence for different susceptibility of IL-2- versus IL-15-activated NK cells | Q40181761 | ||
| CD25+ regulatory T cell depletion augments immunotherapy of micrometastases by an IL-21-secreting cellular vaccine | Q40327357 | ||
| IL-21 enhances tumor rejection through a NKG2D-dependent mechanism | Q40388482 | ||
| Membrane-bound and soluble IL-15/IL-15Ralpha complexes display differential signaling and functions on human hematopoietic progenitors. | Q40405349 | ||
| Monocyte surface-bound IL-15 can function as an activating receptor and participate in reverse signaling. | Q40575844 | ||
| IL-21 induces tumor rejection by specific CTL and IFN-gamma-dependent CXC chemokines in syngeneic mice | Q40597291 | ||
| Transduction of the IL-21 and IL-23 genes in human pancreatic carcinoma cells produces natural killer cell-dependent and -independent antitumor effects | Q40632761 | ||
| T cell growth factor: parameters of production and a quantitative microassay for activity | Q40680131 | ||
| Lack of HLA-class I antigens in human neuroblastoma cells: analysis of its relationship to TAP and tapasin expression | Q40819482 | ||
| Dissimilar anti-tumour reactions induced by tumour cells engineered with the interleukin-2 or interleukin-15 gene in nude mice | Q40872618 | ||
| Genotypes of NK cell KIR receptors, their ligands, and Fcγ receptors in the response of neuroblastoma patients to Hu14.18-IL2 immunotherapy. | Q41115922 | ||
| Interleukin 15 induction of lymphokine-activated killer cell function against autologous tumor cells in melanoma patient lymphocytes by a CD18-dependent, perforin-related mechanism | Q41278393 | ||
| Constitutive expression of high affinity interleukin 2 receptors on human CD16-natural killer cells in vivo | Q41900284 | ||
| IL-21 augments natural killer effector functions in chronically HIV-infected individuals | Q41948983 | ||
| Identification of a novel interleukin-15 (IL-15) transcript isoform generated by alternative splicing in human small cell lung cancer cell lines | Q42632475 | ||
| Expression of two interleukin-15 mRNA isoforms in human tumors does not correlate with secretion: role of different signal peptides | Q42657580 | ||
| IL-21 down-regulates NKG2D/DAP10 expression on human NK and CD8+ T cells | Q42678415 | ||
| Membrane-bound IL-15 stimulation on peripheral blood natural kiler progenitors leads to the generation of an adherent subset co-expressing dendritic cells and natural kiler functional markers | Q42724163 | ||
| Abnormal development of intestinal intraepithelial lymphocytes and peripheral natural killer cells in mice lacking the IL-2 receptor beta chain | Q42947625 | ||
| Human natural killer cells: a unique innate immunoregulatory role for the CD56(bright) subset | Q43600819 | ||
| A human CD34(+) subset resides in lymph nodes and differentiates into CD56bright natural killer cells | Q43660307 | ||
| Defective expression of the interleukin-2/interleukin-15 receptor beta subunit leads to a natural killer cell-deficient form of severe combined immunodeficiency | Q43684733 | ||
| Clinical and biological efficacy of recombinant human interleukin-21 in patients with stage IV malignant melanoma without prior treatment: a phase IIa trial. | Q44173880 | ||
| NXS2 murine neuroblastomas express increased levels of MHC class I antigens upon recurrence following NK-dependent immunotherapy. | Q44593124 | ||
| Natural killer cell-mediated killing of freshly isolated neuroblastoma cells: critical role of DNAX accessory molecule-1-poliovirus receptor interaction. | Q44686821 | ||
| Adjuvanticity of plasmid DNA encoding cytokines fused to immunoglobulin Fc domains | Q44945460 | ||
| Natural soluble interleukin-15Ralpha is generated by cleavage that involves the tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17). | Q44950435 | ||
| Roles for common cytokine receptor gamma-chain-dependent cytokines in the generation, differentiation, and maturation of NK cell precursors and peripheral NK cells in vivo | Q45231990 | ||
| The innate NK cells, allograft rejection, and a key role for IL-15. | Q45732081 | ||
| Interleukin (IL)-21 and IL-15 genetic transfer synergistically augments therapeutic antitumor immunity and promotes regression of metastatic lymphoma. | Q45869303 | ||
| Gene transfer of a secretable form of IL-15 in murine adenocarcinoma cells: effects on tumorigenicity, metastatic potential and immune response | Q45869546 | ||
| Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans | Q45874932 | ||
| Interleukin-15 liver gene transfer increases the number and function of IKDCs and NK cells. | Q45875117 | ||
| Immunotherapy of neuroblastoma by an Interleukin-21-secreting cell vaccine involves survivin as antigen | Q45875783 | ||
| Macrophage- and dendritic-cell-derived interleukin-15 receptor alpha supports homeostasis of distinct CD8+ T cell subsets | Q46076652 | ||
| IL-12 or IL-4 prime human NK cells to mediate functionally divergent interactions with dendritic cells or tumors | Q46391158 | ||
| Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis | Q47992184 | ||
| Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency | Q22008480 | ||
| Interleukin-22-producing innate immune cells: new players in mucosal immunity and tissue repair? | Q51752115 | ||
| T cell- and B cell-independent adaptive immunity mediated by natural killer cells. | Q51983250 | ||
| The tumour-targeting human L19-IL2 immunocytokine: preclinical safety studies, phase I clinical trial in patients with solid tumours and expansion into patients with advanced renal cell carcinoma. | Q52901931 | ||
| Acquisition of murine NK cell cytotoxicity requires the translation of a pre-existing pool of granzyme B and perforin mRNAs. | Q53549440 | ||
| Transient depletion of CD4(+) T cells augments IL-21-based immunotherapy of disseminated neuroblastoma in syngeneic mice. | Q54448307 | ||
| Cytokine requirements for the growth and development of mouse NK cells in vitro. | Q54763101 | ||
| Safety and Clinical Effect of Subcutaneous Human Interleukin-21 in Patients with Metastatic Melanoma or Renal Cell Carcinoma: A Phase I Trial | Q56838211 | ||
| CD56bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2: a potential new link between adaptive and innate immunity | Q57265370 | ||
| Enhancement of the antitumor properties of interleukin-2 by its targeted delivery to the tumor blood vessel extracellular matrix | Q57912149 | ||
| A thymic pathway of mouse natural killer cell development characterized by expression of GATA-3 and CD127 | Q58478714 | ||
| IL-15 is an essential mediator of peripheral NK-cell homeostasis | Q58478746 | ||
| The Interactions of Multiple Cytokines Control NK Cell Maturation | Q60489383 | ||
| Extravasation of intravascular fluid mediated by the systemic administration of recombinant interleukin 2 | Q68895797 | ||
| New insights into the regulation of T cells by gamma(c) family cytokines | Q33623326 | ||
| IL-7 and IL-15 independently program the differentiation of intestinal CD3-NKp46+ cell subsets from Id2-dependent precursors | Q33656197 | ||
| Interleukin-21 can efficiently restore impaired antibody-dependent cell-mediated cytotoxicity in patients with oesophageal squamous cell carcinoma | Q33658562 | ||
| Cytokines as Adjuvants for Vaccine and Cellular Therapies for Cancer | Q33680566 | ||
| Differential effects of IL-2 and IL-21 on expansion of the CD4+ CD25+ Foxp3+ T regulatory cells with redundant roles in natural killer cell mediated antibody dependent cellular cytotoxicity in chronic lymphocytic leukemia | Q33688225 | ||
| Expansion of human NK-22 cells with IL-7, IL-2, and IL-1beta reveals intrinsic functional plasticity | Q33934522 | ||
| Memory-like responses of natural killer cells | Q34007381 | ||
| Cytokine signaling in 2002: new surprises in the Jak/Stat pathway | Q34126053 | ||
| Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1. | Q34184126 | ||
| Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells | Q34289467 | ||
| The p75 peptide is the receptor for interleukin 2 expressed on large granular lymphocytes and is responsible for the interleukin 2 activation of these cells | Q34334821 | ||
| Transient and persistent effects of IL-15 on lymphocyte homeostasis in nonhuman primates | Q34369832 | ||
| RORgammat and commensal microflora are required for the differentiation of mucosal interleukin 22-producing NKp46+ cells | Q34441341 | ||
| Interleukin-21 receptor (IL-21R) is up-regulated by CD40 triggering and mediates proapoptotic signals in chronic lymphocytic leukemia B cells | Q34481433 | ||
| Revisiting human natural killer cell subset function revealed cytolytic CD56(dim)CD16+ NK cells as rapid producers of abundant IFN-gamma on activation | Q34490829 | ||
| Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance | Q34503328 | ||
| CD34+ hematopoietic precursors are present in human decidua and differentiate into natural killer cells upon interaction with stromal cells. | Q34572976 | ||
| Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain. | Q34759631 | ||
| Natural killer-cell differentiation by myeloid progenitors | Q34773999 | ||
| Phase I trial of interleukin-12 plasmid electroporation in patients with metastatic melanoma | Q34887442 | ||
| What does it take to make a natural killer? | Q35136013 | ||
| The interleukin (IL) 2 receptor beta chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer cells | Q35329030 | ||
| Unravelling natural killer cell function: triggering and inhibitory human NK receptors | Q35611389 | ||
| NK cell and DC interactions | Q35617660 | ||
| Immunologic influences on allergy and the TH1/TH2 balance | Q35646852 | ||
| Cytokines and immunodeficiency diseases: critical roles of the gamma(c)-dependent cytokines interleukins 2, 4, 7, 9, 15, and 21, and their signaling pathways | Q35951801 | ||
| Dendritic cells prime natural killer cells by trans-presenting interleukin 15 | Q36157184 | ||
| Human natural killer cell development and biology | Q36346630 | ||
| Lymphokine-activated killer cell phenomenon. III. Evidence that IL-2 is sufficient for direct activation of peripheral blood lymphocytes into lymphokine-activated killer cells | Q36349100 | ||
| Functional consequences of interleukin 2 receptor expression on resting human lymphocytes. Identification of a novel natural killer cell subset with high affinity receptors | Q36351101 | ||
| Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor | Q36363861 | ||
| Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice | Q36364066 | ||
| Fatal leukemia in interleukin 15 transgenic mice follows early expansions in natural killer and memory phenotype CD8+ T cells. | Q36369031 | ||
| T cell-independent interleukin 15Ralpha signals are required for bystander proliferation | Q36369574 | ||
| Interleukin (IL)-15Rα–deficient Natural Killer Cells Survive in Normal but Not IL-15Rα–deficient Mice | Q36370673 | ||
| Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization | Q36402763 | ||
| The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design | Q36547207 | ||
| IL-21 mediates apoptosis through up-regulation of the BH3 family member BIM and enhances both direct and antibody-dependent cellular cytotoxicity in primary chronic lymphocytic leukemia cells in vitro | Q36591370 | ||
| Structure and expression of a cloned cDNA for human interleukin-2. | Q36603382 | ||
| IL-15Ralpha chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation | Q36640049 | ||
| Effector and regulatory events during natural killer-dendritic cell interactions | Q36652210 | ||
| Human natural killer cells | Q36787596 | ||
| Role of IL-21 in immune-regulation and tumor immunotherapy | Q36796924 | ||
| IL-15 trans-presentation promotes human NK cell development and differentiation in vivo | Q37061837 | ||
| Cytokine-induced memory-like natural killer cells | Q37100910 | ||
| Expansion of highly cytotoxic human natural killer cells for cancer cell therapy | Q37277554 | ||
| Cellular sources and immune functions of interleukin-9. | Q37309989 | ||
| A potential role for interleukin-15 in the regulation of human natural killer cell survival | Q37364381 | ||
| IL-21: an executor of B cell fate | Q37388253 | ||
| Interleukin-22-producing natural killer cells and lymphoid tissue inducer-like cells in mucosal immunity | Q37552151 | ||
| Trans-presentation: a novel mechanism regulating IL-15 delivery and responses | Q37612151 | ||
| Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs | Q37692292 | ||
| Novel gamma-chain cytokines as candidate immune modulators in immune therapies for cancer. | Q37778700 | ||
| Killer Ig-like receptor-mediated control of natural killer cell alloreactivity in haploidentical hematopoietic stem cell transplantation | Q37796492 | ||
| The intrathymic crossroads of T and NK cell differentiation | Q37802422 | ||
| IL-21 is an immune activator that also mediates suppression via IL-10. | Q37822815 | ||
| Different dynamics of IL-15R activation following IL-15 cis- or trans-presentation | Q39631642 | ||
| Heterogeneous expression and function of IL-21R and susceptibility to IL-21-mediated apoptosis in follicular lymphoma cells | Q39733717 | ||
| Natural Cell-Mediated Immunity | Q39770020 | ||
| Phenotypic and functional characterization of recombinant interleukin 2 (rIL 2)-induced activated killer cells: analysis at the population and clonal levels | Q70322716 | ||
| Studies evaluating the antitumor activity and toxicity of interleukin-15, a new T cell growth factor: comparison with interleukin-2 | Q71729737 | ||
| Regulation of IL-15 secretion via the leader peptide of two IL-15 isoforms | Q71929898 | ||
| Interleukin-15 triggers the proliferation and cytotoxicity of granular lymphocytes in patients with lymphoproliferative disease of granular lymphocytes | Q71933630 | ||
| Interleukin-15-induced maturation of human natural killer cells from early thymic precursors: selective expression of CD94/NKG2-A as the only HLA class I-specific inhibitory receptor | Q73481205 | ||
| The long signal peptide isoform and its alternative processing direct the intracellular trafficking of interleukin-15 | Q73929921 | ||
| In vivo antitumor activity of interleukin 21 mediated by natural killer cells | Q75207776 | ||
| Differential cytokine and chemokine gene expression by human NK cells following activation with IL-18 or IL-15 in combination with IL-12: implications for the innate immune response | Q77320555 | ||
| Dendritic cells directly trigger NK cell functions: cross-talk relevant in innate anti-tumor immune responses in vivo | Q77323598 | ||
| Differential intracellular trafficking, secretion and endosomal localization of two IL-15 isoforms | Q77402511 | ||
| Human monocytes constitutively express membrane-bound, biologically active, and interferon-gamma-upregulated interleukin-15 | Q77419664 | ||
| IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation | Q77658417 | ||
| Immunocytokines: a promising approach to cancer immunotherapy | Q77795103 | ||
| IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity | Q77995572 | ||
| In vivo evidence for a dependence on interleukin 15 for survival of natural killer cells | Q78410347 | ||
| A novel myeloid-like NK cell progenitor in human umbilical cord blood | Q78728698 | ||
| The interaction between NK cells and dendritic cells in bacterial infections results in rapid induction of NK cell activation and in the lysis of uninfected dendritic cells | Q78842088 | ||
| Phase I study of recombinant interleukin-21 in patients with metastatic melanoma and renal cell carcinoma | Q80888484 | ||
| Multiple cytokines regulate the NK gene complex-encoded receptor repertoire of mature NK cells and T cells | Q81099181 | ||
| Interleukin-21: biology and application to cancer therapy | Q94705788 | ||
| Human Monocytes Constitutively Express Membrane-Bound, Biologically Active, and Interferon-γ–Upregulated Interleukin-15 | Q114738362 | ||
| P275 | copyright license | Creative Commons Attribution 3.0 Unported | Q14947546 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | peptide | Q172847 |
| membrane protein | Q423042 | ||
| immunotherapy | Q1427096 | ||
| cell surface receptor | Q2476074 | ||
| neoplasm | Q1216998 | ||
| cell | Q7868 | ||
| hemic and immune systems | Q70202933 | ||
| cancer | Q12078 | ||
| P304 | page(s) | 861920 | |
| P577 | publication date | 2011-06-13 | |
| P1433 | published in | Journal of Biomedicine and Biotechnology | Q15752146 |
| P1476 | title | Role of common-gamma chain cytokines in NK cell development and function: perspectives for immunotherapy | |
| P478 | volume | 2011 |
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| Q34507367 | A potential novel spontaneous preterm birth gene, AR, identified by linkage and association analysis of X chromosomal markers |
| Q36145575 | Active immunization with human interleukin-15 induces neutralizing antibodies in non-human primates |
| Q36760722 | CD300c is uniquely expressed on CD56 bright Natural Killer Cells and differs from CD300a upon ligand recognition |
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| Q37692713 | Functional NK cell repertoires are maintained through IL-2Rα and Fas ligand. |
| Q90579253 | Highly cytotoxic natural killer cells are associated with poor prognosis in patients with cutaneous T-cell lymphoma |
| Q46279062 | IL-2 inhibited the generation of CD4+ memory T cells |
| Q39259470 | IL-2- or IL-15-activated NK cells enhance Cetuximab-mediated activity against triple-negative breast cancer in xenografts and in breast cancer patients |
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| Q38050510 | Immunotherapeutic applications of IL-15. |
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