The optimal corepressor function of nuclear receptor corepressor (NCoR) for peroxisome proliferator-activated receptor γ requires G protein pathway suppressor 2.

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The optimal corepressor function of nuclear receptor corepressor (NCoR) for peroxisome proliferator-activated receptor γ requires G protein pathway suppressor 2. is …
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scholarly articleQ13442814

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P356DOI10.1074/JBC.M114.598797
P8608Fatcat IDrelease_eurofl3e35ay7dl3uxhc3cel5i
P932PMC publication ID4319032
P698PubMed publication ID25519902
P5875ResearchGate publication ID269766050

P50authorJinsong ZhangQ42280146
Thomas BurrisQ67982842
P2093author name stringYongjun Wang
Jikun Zha
Chun Guo
Yali Li
Chunxia Yan
Chien-Hung Gow
Hongqi Liu
Madeline Wong
P2860cites workA core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafnessQ22254089
A novel zinc finger protein TReP-132 interacts with CBP/p300 to regulate human CYP11A1 gene expressionQ24291218
The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2Q24293216
Adipocyte NCoR knockout decreases PPARγ phosphorylation and enhances PPARγ activity and insulin sensitivityQ24296924
Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1Q24297437
Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressorQ24311650
Cooperative regulation in development by SMRT and FOXP1Q24312072
Reading and function of a histone code involved in targeting corepressor complexes for repressionQ24322748
Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cellsQ24324018
AMF-1/Gps2 binds p300 and enhances its interaction with papillomavirus E2 proteinsQ24525249
The peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signalingQ24530668
AMF1 (GPS2) modulates p53 transactivationQ24550865
Involvement of corepressor complex subunit GPS2 in transcriptional pathways governing human bile acid biosynthesisQ24564745
Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3Q24599788
Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identitiesQ24617969
SMRT repression of nuclear receptors controls the adipogenic set point and metabolic homeostasisQ24647529
Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNAQ24655111
Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machineryQ27666601
Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alphaQ27730245
Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gammaQ27765353
Crystal structure of the ligand binding domain of the human nuclear receptor PPARgammaQ27766012
The nuclear receptor superfamily: the second decadeQ27860725
A signature motif in transcriptional co-activators mediates binding to nuclear receptorsQ27860938
The coregulator exchange in transcriptional functions of nuclear receptorsQ28131759
Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor alpha interacting proteinQ28144400
The transcriptional regulating protein of 132 kDa (TReP-132) enhances P450scc gene transcription through interaction with steroidogenic factor-1 in human adrenal cellsQ28213229
A transcriptional co-repressor that interacts with nuclear hormone receptorsQ28289864
Corepressors selectively control the transcriptional activity of PPARgamma in adipocytesQ28508812
G-protein pathway suppressor 2 (GPS2) interacts with the regulatory factor X4 variant 3 (RFX4_v3) and functions as a transcriptional co-activatorQ28513891
SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuronQ28589681
Combinatorial roles of the nuclear receptor corepressor in transcription and developmentQ28591431
A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gammaQ28593737
The SMRT and N-CoR corepressors are activating cofactors for histone deacetylase 3Q28609763
Adipocyte differentiation from the inside outQ29615690
Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptorsQ29616455
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxiaQ29616650
PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathwayQ31793810
GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRbeta in the hepatic acute phase responseQ33631156
The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptorsQ33881484
Stoichiometric and steric principles governing repression by nuclear hormone receptorsQ73231880
IDH1 gene transcription is sterol regulated and activated by SREBP-1a and SREBP-2 in human hepatoma HepG2 cells: evidence that IDH1 may regulate lipogenesis in hepatic cellsQ34223219
A human suppressor of c-Jun N-terminal kinase 1 activation by tumor necrosis factor alphaQ34441662
Nuclear receptor corepressor SMRT regulates mitochondrial oxidative metabolism and mediates aging-related metabolic deteriorationQ34551754
Corepressor SMRT promotes oxidative phosphorylation in adipose tissue and protects against diet-induced obesity and insulin resistanceQ34602651
ToppGene Suite for gene list enrichment analysis and candidate gene prioritizationQ34982758
Mechanism of corepressor binding and release from nuclear hormone receptors.Q35210560
Molecular determinants of nuclear receptor-corepressor interactionQ35210593
Resistance to thyroid hormone is modulated in vivo by the nuclear receptor corepressor (NCOR1).Q35408730
Ligand and receptor dynamics contribute to the mechanism of graded PPARγ agonism.Q35753031
Regulated clearance of histone deacetylase 3 protects independent formation of nuclear receptor corepressor complexes.Q35874448
The nuclear receptor corepressor (NCoR) controls thyroid hormone sensitivity and the set point of the hypothalamic-pituitary-thyroid axisQ36067452
Controlling nuclear receptors: the circular logic of cofactor cyclesQ36163600
SMRT-GPS2 corepressor pathway dysregulation coincides with obesity-linked adipocyte inflammationQ36497213
Histone H3K9 methyltransferase G9a represses PPARγ expression and adipogenesisQ36533638
Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage controlQ36639688
Emerging roles of the corepressors NCoR1 and SMRT in homeostasisQ36832163
Differential involvement of E2A-corepressor interactions in distinct leukemogenic pathways.Q37416999
G protein pathway suppressor 2 (GPS2) is a transcriptional corepressor important for estrogen receptor alpha-mediated transcriptional regulationQ37479355
Effects of SOCS 1/3 gene silencing on the expression of C/EBPα and PPARγ during differentiation and maturation of rat preadipocytesQ38319454
Peroxisome proliferator-activated receptor γ regulates genes involved in insulin/insulin-like growth factor signaling and lipid metabolism during adipogenesis through functionally distinct enhancer classes.Q39052256
A protective strategy against hyperinflammatory responses requiring the nontranscriptional actions of GPS2.Q39378494
A novel role for helix 12 of retinoid X receptor in regulating repressionQ39447809
The N-CoR/histone deacetylase 3 complex is required for repression by thyroid hormone receptorQ39791268
GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locusQ39845171
Multivalent binding of the ETO corepressor to E proteins facilitates dual repression controls targeting chromatin and the basal transcription machinery.Q39872185
A functional peroxisome proliferator-activated receptor-gamma ligand-binding domain is not required for adipogenesisQ39962094
A dominant-negative peroxisome proliferator-activated receptor gamma (PPARgamma) mutant is a constitutive repressor and inhibits PPARgamma-mediated adipogenesisQ40899355
Cell-specific determinants of peroxisome proliferator-activated receptor gamma function in adipocytes and macrophagesQ41821503
The Bcl6-SMRT/NCoR cistrome represses inflammation to attenuate atherosclerosisQ42050945
GPS2/KDM4A pioneering activity regulates promoter-specific recruitment of PPARγ.Q42740797
Peroxisome proliferator activated receptor gamma, CCAAT/enhancer-binding protein alpha, and cell cycle status regulate the commitment to adipocyte differentiationQ42796360
SGK1 is regulated by metabolic-related factors in 3T3-L1 adipocytes and overexpressed in the adipose tissue of subjects with obesity and diabetesQ42813553
The nuclear receptor corepressors NCoR and SMRT decrease peroxisome proliferator-activated receptor gamma transcriptional activity and repress 3T3-L1 adipogenesis.Q42818488
A structural role for hormone in the thyroid hormone receptor.Q46828407
Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actionsQ57249776
Loss-of-Function Mutations in PPARγ Associated with Human Colon CancerQ57567933
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectG protein pathway suppressor 2Q43374104
P304page(s)3666-3679
P577publication date2014-12-17
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe optimal corepressor function of nuclear receptor corepressor (NCoR) for peroxisome proliferator-activated receptor γ requires G protein pathway suppressor 2
P478volume290