Identification of small molecule NPR-B antagonists by high throughput screening--potential use in heart failure

scientific article

Identification of small molecule NPR-B antagonists by high throughput screening--potential use in heart failure is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S00210-013-0940-6
P698PubMed publication ID24297249

P50authorErik QvigstadQ63762835
P2093author name stringFinn Olav Levy
Jan-Bjørn Osnes
Tor Skomedal
Trond Bach
Jon Riise
Stine Bergholtz
P2860cites workInhibition of beta- but not alpha 1-mediated adrenergic responses in isolated hearts and cardiomyocytes by nitric oxide and 8-bromo cyclic GMPQ71706666
Comparison between alpha-1 adrenoceptor-mediated and beta adrenoceptor-mediated inotropic components elicited by norepinephrine in failing human ventricular muscleQ73045813
Phosphodiesterase III inhibitors for heart failureQ24244978
Structural insights into the ligand binding domains of membrane bound guanylyl cyclases and natriuretic peptide receptorsQ28216173
Effect of nesiritide in patients with acute decompensated heart failureQ28242547
Short-term risk of death after treatment with nesiritide for decompensated heart failure: a pooled analysis of randomized controlled trialsQ28246006
Cardiac hypertrophy in transgenic rats expressing a dominant-negative mutant of the natriuretic peptide receptor B.Q28569799
Development of a selective peptide antagonist for the human natriuretic peptide receptor-B.Q31141579
5HT4(a) and 5-HT4(b) receptors have nearly identical pharmacology and are both expressed in human atrium and ventricleQ32059490
Effect of oral milrinone on mortality in severe chronic heart failure. The PROMISE Study Research GroupQ33157410
Design of chemical libraries with potentially bioactive molecules applying a maximum common substructure conceptQ33494087
Allosteric binding sites on cell-surface receptors: novel targets for drug discoveryQ34139176
Cyclic guanosine monophosphate signaling and phosphodiesterase-5 inhibitors in cardioprotectionQ34277031
Natriuretic peptides: their structures, receptors, physiologic functions and therapeutic applicationsQ34906050
Agents increasing cyclic GMP amplify 5-HT4-elicited positive inotropic response in failing rat cardiac ventricleQ35563508
Cardioprotective actions of cyclic GMP: lessons from genetic animal modelsQ36164755
The role of natriuretic peptides in cardioprotectionQ36313449
Natriuretic peptides, their receptors, and cyclic guanosine monophosphate-dependent signaling functionsQ36314468
Natriuretic peptide C receptor signalling in the heart and vasculatureQ37002318
Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disordersQ37360436
Cyclic GMP-dependent signaling in cardiac myocytesQ38025552
Ring-deleted analogs of atrial natriuretic factor inhibit adenylate cyclase/cAMP system. Possible coupling of clearance atrial natriuretic factor receptors to adenylate cyclase/cAMP signal transduction systemQ41733809
Protein kinase G-dependent cardioprotective mechanism of phosphodiesterase-5 inhibition involves phosphorylation of ERK and GSK3betaQ41817597
Hormone-stimulated desensitization of hormone-dependent adenylyl cyclase. Dual action of luteninizing hormone on pig graafian follicle membranesQ42443756
Dynamics of atrial natriuretic factor-guanylate cyclase receptors and receptor-ligand complexes in cultured glomerular mesangial and renomedullary interstitial cellsQ43625344
Influence of phosphodiesterases and cGMP on cAMP generation and on phosphorylation of phospholamban and troponin I by 5-HT4 receptor activation in porcine left atriumQ44824819
Cardiac PDEs and crosstalk between cAMP and cGMP signalling pathways in the regulation of contractilityQ46599816
A highly sensitive adenylate cyclase assayQ47871494
Natriuretic peptides increase beta1-adrenoceptor signalling in failing hearts through phosphodiesterase 3 inhibitionQ48412668
Study of the regulation of the inotropic response to 5-HT4 receptor activation via phosphodiesterases and its cross-talk with C-type natriuretic peptide in porcine left atriumQ49168980
Cardiac production of C-type natriuretic peptide in heart failureQ60570705
P433issue1
P304page(s)5-14
P577publication date2013-12-03
P1433published inNaunyn-Schmiedeberg's Archives of PharmacologyQ1468251
P1476titleIdentification of small molecule NPR-B antagonists by high throughput screening--potential use in heart failure
P478volume387

Reverse Query: null

Search more.