TOX4 and NOVA1 proteins are partners of the LEDGF PWWP domain and affect HIV-1 replication

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TOX4 and NOVA1 proteins are partners of the LEDGF PWWP domain and affect HIV-1 replication is …
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scholarly articleQ13442814

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P819ADS bibcode2013PLoSO...881217M
P356DOI10.1371/JOURNAL.PONE.0081217
P932PMC publication ID3842248
P698PubMed publication ID24312278
P5875ResearchGate publication ID259208508

P50authorMarc LavigneQ57452834
Pierre CharneauQ63098586
Francesca Di NunzioQ104058388
Yves JacobQ39835141
P2093author name stringJohan Xavier
Mehdi Morchikh
Monica Naughtin
P2860cites workTOX defines a conserved subfamily of HMG-box proteinsQ21093380
Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activationQ22008025
A novel transcriptional coactivator, p52, functionally interacts with the essential splicing factor ASF/SF2Q22008652
Identification and targeting of an interaction between a tyrosine motif within hepatitis C virus core protein and AP2M1 essential for viral assemblyQ24297412
Tudor, MBT and chromo domains gauge the degree of lysine methylationQ24301294
The transcriptional co-activator LEDGF/p75 displays a dynamic scan-and-lock mechanism for chromatin tetheringQ24304357
Regulation of chromatin architecture by the PWWP domain-containing DNA damage-responsive factor EXPAND1/MUM1Q24304951
The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcriptionQ24316236
The onconeural antigen Nova-1 is a neuron-specific RNA-binding protein, the activity of which is inhibited by paraneoplastic antibodiesQ24316787
Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifically expressed in the developing motor systemQ24317395
WHSC1, a 90 kb SET domain-containing gene, expressed in early development and homologous to a Drosophila dysmorphy gene maps in the Wolf-Hirschhorn syndrome critical region and is fused to IgH in t(4;14) multiple myelomaQ24322575
The neuronal RNA binding protein Nova-1 recognizes specific RNA targets in vitro and in vivoQ24646213
Transcriptional co-activator LEDGF interacts with Cdc7-activator of S-phase kinase (ASK) and stimulates its enzymatic activityQ24648278
SALL3 interacts with DNMT3A and shows the ability to inhibit CpG island methylation in hepatocellular carcinomaQ24657710
LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integrationQ24671948
Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen interacts with bromodomain protein Brd4 on host mitotic chromosomesQ24673761
Chromatin and epigenetic regulation of pre-mRNA processingQ26999294
The PWWP domain of mammalian DNA methyltransferase Dnmt3b defines a new family of DNA-binding foldsQ27637719
PWWP module of human hepatoma-derived growth factor forms a domain-swapped dimer with much higher affinity for heparinQ27643714
Molecular basis of histone H3K36me3 recognition by the PWWP domain of Brpf1Q27660605
Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replicationQ27661671
Structural and Histone Binding Ability Characterizations of Human PWWP DomainsQ27670629
Protein-RNA and Protein-Protein Recognition by Dual KH1/2 Domains of the Neuronal Splicing Factor Nova-1Q27670739
Solution structure of the Pdp1 PWWP domain reveals its unique binding sites for methylated H4K20 and DNAQ27676028
Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomesQ27676304
TOX4 and its binding partners recognize DNA adducts generated by platinum anticancer drugsQ56918884
Role of Dimerization in KH/RNA Complexes: The Example of Nova KH3Q57586998
LEDGF binds to heat shock and stress-related element to activate the expression of stress-related genesQ73875961
Oligomerization within virions and subcellular localization of human immunodeficiency virus type 1 integraseQ39594236
Retroviral cDNA integration: stimulation by HMG I family proteinsQ39597653
High-resolution profiling of the LEDGF/p75 chromatin interaction in the ENCODE regionQ39702396
Human immunodeficiency virus type 1 Vif- mutant particles from restrictive cells: role of Vif in correct particle assembly and infectivity.Q39869526
Lens epithelium-derived growth factor/p75 interacts with the transposase-derived DDE domain of PogZ.Q39879606
DNA methyltransferase 3B mutant in ICF syndrome interacts non-covalently with SUMO-1.Q39944664
Analysis of early human immunodeficiency virus type 1 DNA synthesis by use of a new sensitive assay for quantifying integrated provirusQ39996408
A role for LEDGF/p75 in targeting HIV DNA integrationQ40346940
Generation of high-titer pseudotyped retroviral vectors with very broad host rangeQ40571115
Chromatin targeting of de novo DNA methyltransferases by the PWWP domainQ40582721
A quantitative assay for HIV DNA integration in vivoQ40809319
HIV-1 Reverse Transcription A Termination Step at the Center of the GenomeQ41443092
LEDGF/p75 interacts with divergent lentiviral integrases and modulates their enzymatic activity in vitroQ41844861
Heterochromatin protein 1 (HP1a) positively regulates euchromatic gene expression through RNA transcript association and interaction with hnRNPs in DrosophilaQ41951844
Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicingQ41999449
Histone H3 lysine 36 methylation targets the Isw1b remodeling complex to chromatinQ42233474
Identification of the LEDGF/p75 HIV-1 integrase-interaction domain and NLS reveals NLS-independent chromatin tetheringQ42816444
Human mismatch repair protein MSH6 contains a PWWP domain that targets double stranded DNA.Q44728794
Transportin-SR2 imports HIV into the nucleusQ45879860
D77, one benzoic acid derivative, functions as a novel anti-HIV-1 inhibitor targeting the interaction between integrase and cellular LEDGF/p75.Q46437340
Integrase mutants defective for interaction with LEDGF/p75 are impaired in chromosome tethering and HIV-1 replicationQ46458488
An RNA map predicting Nova-dependent splicing regulationQ47600767
The many roles of TOX in the immune systemQ37972419
LEDGF (p75) promotes DNA-end resection and homologous recombinationQ39318006
Overexpression of the lens epithelium-derived growth factor/p75 integrase binding domain inhibits human immunodeficiency virus replicationQ39320408
Small-molecule inhibitors of the LEDGF/p75 binding site of integrase block HIV replication and modulate integrase multimerizationQ39337204
Nucleosomal DNA binding drives the recognition of H3K36-methylated nucleosomes by the PSIP1-PWWP domainQ27678049
New Class of HIV-1 Integrase (IN) Inhibitors with a Dual Mode of ActionQ27678745
HMGB1-facilitated p53 DNA binding occurs via HMG-Box/p53 transactivation domain interaction, regulated by the acidic tailQ27682786
HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cellsQ28212168
Benchmarking a luciferase complementation assay for detecting protein complexesQ28254299
Interaction of the bovine papillomavirus E2 protein with Brd4 tethers the viral DNA to host mitotic chromosomesQ28258520
An essential role for LEDGF/p75 in HIV integrationQ28262502
Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integraseQ28282487
HIV-1 cDNA integration: requirement of HMG I(Y) protein for function of preintegration complexes in vitroQ28303975
LEDGF/p75 proteins with alternative chromatin tethers are functional HIV-1 cofactorsQ28475761
Solution structure of the PWWP domain of the hepatoma-derived growth factor familyQ28506043
The PWWP domain of Dnmt3a and Dnmt3b is required for directing DNA methylation to the major satellite repeats at pericentric heterochromatinQ28507079
Hepatoma-derived growth factor belongs to a gene family in mice showing significant homology in the amino terminusQ28510570
Nova-1 regulates neuron-specific alternative splicing and is essential for neuronal viabilityQ28586051
The Tudor domain 'Royal Family': Tudor, plant Agenet, Chromo, PWWP and MBT domainsQ29614228
The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosisQ29618035
Identification and characterization of the chromatin-binding domains of the HIV-1 integrase interactor LEDGF/p75.Q30159754
Solution structure and heparin interaction of human hepatoma-derived growth factorQ30160825
High resolution structure of the HDGF PWWP domain: a potential DNA binding domain.Q30439092
Differential effects of human immunodeficiency virus type 1 capsid and cellular factors nucleoporin 153 and LEDGF/p75 on the efficiency and specificity of viral DNA integrationQ30452981
Building protein-protein networks by two-hybrid mating strategyQ30736292
Human nucleoporins promote HIV-1 docking at the nuclear pore, nuclear import and integrationQ31103609
Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV.Q33280633
Differential interaction of HIV-1 integrase and JPO2 with the C terminus of LEDGF/p75.Q33292744
Role of PSIP1/LEDGF/p75 in lentiviral infectivity and integration targetingQ33311290
The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replicationQ33325927
HMG protein family members stimulate human immunodeficiency virus type 1 and avian sarcoma virus concerted DNA integration in vitroQ33644040
Cyclic peptide inhibitors of HIV-1 integrase derived from the LEDGF/p75 proteinQ33727544
Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integrationQ33733818
The Neuronal Splicing Factor Nova Co-Localizes with Target RNAs in the DendriteQ33797879
Nova autoregulation reveals dual functions in neuronal splicingQ33841797
HIV integration targeting: a pathway involving Transportin-3 and the nuclear pore protein RanBP2Q33851502
The PWWP domain: a potential protein-protein interaction domain in nuclear proteins influencing differentiation?Q33901159
Regulation of alternative splicing by histone modificationsQ34035543
The Dnmt3a PWWP domain reads histone 3 lysine 36 trimethylation and guides DNA methylationQ34074317
Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75.Q34161123
Psip1/Ledgf p52 binds methylated histone H3K36 and splicing factors and contributes to the regulation of alternative splicingQ34276472
HMGB1 protein binds to influenza virus nucleoprotein and promotes viral replicationQ34303782
Large scale genotype comparison of human papillomavirus E2-host interaction networks provides new insights for e2 molecular functionsQ34325506
Nova regulates brain-specific splicing to shape the synapseQ34436585
New insights into BS69 functionsQ34505578
The 53BP1-EXPAND1 connection in chromatin structure regulationQ34521556
Transcriptional co-activator p75 binds and tethers the Myc-interacting protein JPO2 to chromatinQ34532019
Dynamic histone acetylation is critical for cotranscriptional spliceosome assembly and spliceosomal rearrangementsQ34549852
LEDGF, a survival factor, activates stress-related genes.Q34674424
The multidomain protein Brpf1 binds histones and is required for Hox gene expression and segmental identityQ34777741
Disruption of Ledgf/Psip1 results in perinatal mortality and homeotic skeletal transformationsQ35071334
Regulatory roles of heterogeneous nuclear ribonucleoprotein M and Nova-1 protein in alternative splicing of dopamine D2 receptor pre-mRNA.Q35107580
Retroviral integration site selection.Q35260206
Role of the PWWP domain of lens epithelium-derived growth factor (LEDGF)/p75 cofactor in lentiviral integration targetingQ35842252
Concerted integration of linear retroviral DNA by the avian sarcoma virus integrase in vitro: dependence on both long terminal repeat terminiQ35861200
Human cell proteins and human immunodeficiency virus DNA integrationQ35880771
Combinatorial complexity in chromatin structure and function: revisiting the histone codeQ35936019
TNPO3 is required for HIV-1 replication after nuclear import but prior to integration and binds the HIV-1 coreQ35943450
HMGB1 interacts with human topoisomerase IIalpha and stimulates its catalytic activity.Q35990915
High-mobility group boxes mediate cell proliferation and radiosensitivity via retinoblastoma-interaction-dependent and -independent mechanismsQ36031702
Quantification of dynamic protein complexes using Renilla luciferase fragment complementation applied to protein kinase A activities in vivoQ36089402
Nucleosome dynamics: HMGB1 relaxes canonical nucleosome structure to facilitate estrogen receptor bindingQ36368838
Chromatinized templates reveal the requirement for the LEDGF/p75 PWWP domain during HIV-1 integration in vitroQ36509143
Comparative analysis of virus-host interactomes with a mammalian high-throughput protein complementation assay based on Gaussia princeps luciferaseQ36536947
Identification and characterization of PWWP domain residues critical for LEDGF/p75 chromatin binding and human immunodeficiency virus type 1 infectivity.Q36974724
BET proteins promote efficient murine leukemia virus integration at transcription start sitesQ37031911
Nova-1 mediates glucocorticoid-induced inhibition of pre-mRNA splicing of gonadotropin-releasing hormone transcriptsQ37176402
Langerhans cell protein 1 (LCP1) binds to PNUTS in the nucleus: implications for this complex in transcriptional regulationQ37184767
Menin critically links MLL proteins with LEDGF on cancer-associated target genesQ37217351
Nup153 and Nup98 bind the HIV-1 core and contribute to the early steps of HIV-1 replication.Q37386004
Determination and augmentation of RNA sequence specificity of the Nova K-homology domainsQ37537318
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)e81217
P577publication date2013-11-27
P1433published inPLOS OneQ564954
P1476titleTOX4 and NOVA1 proteins are partners of the LEDGF PWWP domain and affect HIV-1 replication
P478volume8

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cites work (P2860)
Q50126703Cellular and molecular mechanisms of HIV-1 integration targeting
Q35663664DNA Physical Properties and Nucleosome Positions Are Major Determinants of HIV-1 Integrase Selectivity
Q27318263Embryonic Lethality Due to Arrested Cardiac Development in Psip1/Hdgfrp2 Double-Deficient Mice
Q26782046Impact of Chromatin on HIV Replication
Q38912198Integration site selection by retroviruses and transposable elements in eukaryotes
Q36286785LEDGF/p75 interacts with mRNA splicing factors and targets HIV-1 integration to highly spliced genes
Q39231453Neuro-oncological ventral antigen 1 (NOVA1): Implications in neurological diseases and cancers
Q39310736PWWP domains and their modes of sensing DNA and histone methylated lysines.
Q27704293Solution structure of TbTFIIS2-1 PWWP domain from Trypanosoma brucei
Q37079758The Structure-Specific Recognition Protein 1 Associates with Lens Epithelium-Derived Growth Factor Proteins and Modulates HIV-1 Replication
Q38531451The significance of autoantibodies to DFS70/LEDGFp75 in health and disease: integrating basic science with clinical understanding
Q90100218Tox4 modulates cell fate reprogramming
Q90003817Twenty years of research on the DFS70/LEDGF autoantibody-autoantigen system: many lessons learned but still many questions

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