Deficits in endogenous adenosine formation by ecto-5'-nucleotidase/CD73 impair neuromuscular transmission and immune competence in experimental autoimmune myasthenia gravis

scientific article

Deficits in endogenous adenosine formation by ecto-5'-nucleotidase/CD73 impair neuromuscular transmission and immune competence in experimental autoimmune myasthenia gravis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1155/2015/460610
P932PMC publication ID4322825
P698PubMed publication ID25691808
P5875ResearchGate publication ID272514135

P50authorManuel VilanovaQ40685979
Alexandra CorreiaQ40686002
Laura OliveiraQ46815248
Paulo Correia-de-SáQ46815257
Fátima FerreirinhaQ47504323
P2093author name stringMaria Teresa Magalhães-Cardoso
Ana Cristina Costa
Sónia Guerra-Gomes
P2860cites workThe changes in the motor end-plate in myasthenia gravisQ51310113
Naturally occurring CD4+CD25+ regulatory T cells prevent but do not improve experimental myasthenia gravisQ56899334
Adaptation of quantal content to decreased postsynaptic sensitivity at single endplates in alpha-bungarotoxin-treated ratsQ67482323
Adenosine uptake and deamination regulate tonic A2a receptor facilitation of evoked [3H]acetylcholine release from the rat motor nerve terminalsQ71474409
Presynaptic A1 inhibitory/A2A facilitatory adenosine receptor activation balance depends on motor nerve stimulation paradigm at the rat hemidiaphragmQ71951018
Role of adenosine deaminase in the early stages of precursor T cell maturationQ72092665
Isozyme analysis of the high serum adenosine deaminase activity in patients with myasthenia gravisQ72184903
Activation of the adenosine A2A receptor attenuates experimental autoimmune myasthenia gravis severityQ84007875
ATP released by electrical stimuli elicits calcium transients and gene expression in skeletal muscle.Q39788355
Preferential activation of excitatory adenosine receptors at rat hippocampal and neuromuscular synapses by adenosine formed from released adenine nucleotidesQ42011931
Inhibitory and excitatory effects of adenosine receptor agonists on evoked transmitter release from phrenic nerve endings of the ratQ42052807
Disequilibrium of T helper type 1, 2 and 17 cells and regulatory T cells during the development of experimental autoimmune myasthenia gravisQ43279093
Localization and function of adenosine receptor subtypes at the longitudinal muscle--myenteric plexus of the rat ileumQ43798111
Tetanic failure due to decreased endogenous adenosine A(2A) tonus operating neuronal Ca(v) 1 (L-type) influx in Myasthenia gravisQ44056136
Selective activation of adenosine A2A receptors on immune cells by a CD73-dependent prodrug suppresses joint inflammation in experimental rheumatoid arthritisQ44114291
Blockade of neuronal facilitatory nicotinic receptors containing alpha 3 beta 2 subunits contribute to tetanic fade in the rat isolated diaphragm.Q44436825
Breakdown of tolerance to a self-peptide of acetylcholine receptor alpha-subunit induces experimental myasthenia gravis in ratsQ44757052
Sources of adenosine released during neuromuscular transmission in the rat.Q44838181
Adverse effects of myasthenia gravis on rat phrenic diaphragm contractile performanceQ44859084
Nucleoside-5'-monophosphates as prodrugs of adenosine A2A receptor agonists activated by ecto-5'-nucleotidase.Q45938453
The role of FoxP3+CD4+CD25hi Tregs in the pathogenesis of myasthenia gravisQ46434729
Myasthenia gravisQ21202960
Neuromuscular junction in health and diseaseQ22337158
Myasthenia gravis: past, present, and futureQ24678531
Role of A2a extracellular adenosine receptor-mediated signaling in adenosine-mediated inhibition of T-cell activation and expansionQ28507222
Ecto-AMP deaminase blunts the ATP-derived adenosine A2A receptor facilitation of acetylcholine release at rat motor nerve endingsQ28570271
Tetanic depression is overcome by tonic adenosine A(2A) receptor facilitation of L-type Ca(2+) influx into rat motor nerve terminalsQ28573178
Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppressionQ29615344
A2A receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells.Q30440525
Generation and accumulation of immunosuppressive adenosine by human CD4+CD25highFOXP3+ regulatory T cellsQ33748026
Acetylcholine receptors and myastheniaQ33862589
Rat models as tool to develop new immunotherapiesQ34579742
Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression.Q34621389
Functional defect of regulatory CD4(+)CD25+ T cells in the thymus of patients with autoimmune myasthenia gravisQ35740840
Coexpression of ecto-5'-nucleotidase/CD73 with specific NTPDases differentially regulates adenosine formation in the rat liver.Q35780855
Alterations in the adenosine metabolism and CD39/CD73 adenosinergic machinery cause loss of Treg cell function and autoimmunity in ADA-deficient SCIDQ36185196
Adenosine A2A receptor activation inhibits T helper 1 and T helper 2 cell development and effector function.Q36879416
31P MR spectroscopic assessment of muscle in patients with myasthenia gravis before and after thymectomy: initial experienceQ37083170
Histamine induces ATP release from human subcutaneous fibroblasts, via pannexin-1 hemichannels, leading to Ca2+ mobilization and cell proliferationQ37189598
Impairment of regulatory T cells in myasthenia gravis: studies in an experimental modelQ38093706
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P921main subjectmyasthenia gravisQ8285
P304page(s)460610
P577publication date2015-01-27
P1433published inMediators of InflammationQ2144494
P1476titleDeficits in endogenous adenosine formation by ecto-5'-nucleotidase/CD73 impair neuromuscular transmission and immune competence in experimental autoimmune myasthenia gravis
P478volume2015

Reverse relations

cites work (P2860)
Q59256385Metabolic control of T cell immune response through glycans in inflammatory bowel disease
Q90192554Opposing Effects of Adenosine and Inosine in Human Subcutaneous Fibroblasts May Be Regulated by Third Party ADA Cell Providers
Q42367885Purinergic Signalling: Therapeutic Developments
Q47647759Purines and Carotid Body: New Roles in Pathological Conditions.
Q38416292Repeated Electroacupuncture Persistently Elevates Adenosine and Ameliorates Collagen-Induced Arthritis in Rats
Q39261822Synaptic Homeostasis and Its Immunological Disturbance in Neuromuscular Junction Disorders
Q92999338The Purinergic System as a Pharmacological Target for the Treatment of Immune-Mediated Inflammatory Diseases
Q28069199The role of adenosinergic pathway in human autoimmune diseases

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